The utility of HepG2 cells to identify direct mitochondrial dysfunction in the absence of cell death
Tóm tắt
Từ khóa
Tài liệu tham khảo
Boelsterli, 2007, Mitochondrial abnormalities – a link to idiosyncratic drug hepatotoxicity?, Toxicol. Appl. Pharmacol., 220, 92, 10.1016/j.taap.2006.12.013
Clement, 2003, Characterization of in vitro biotransformation of new, orally active, direct thrombin inhibitor ximelagatran, an amidoxime and ester prodrug, Drug Metab. Dispos., 31, 645, 10.1124/dmd.31.5.645
Dykens, 2008, In vitro assessment of mitochondrial dysfunction and cytotoxicity of nefazodone, trazodone, and buspirone, Toxicol. Sci., 103, 335, 10.1093/toxsci/kfn056
Eriksson, 2003, Absorption, distribution, metabolism, and excretion of ximelagatran, an oral direct thrombin inhibitor, in rats, dogs, and humans, Drug Metab. Dispos., 31, 294, 10.1124/dmd.31.3.294
Fattinger, 2001, The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions, Clin. Pharmacol. Ther., 69, 223, 10.1067/mcp.2001.114667
Fischer, 2010, Capture compound mass spectrometry sheds light on the molecular mechanisms of liver toxicity of two parkinson drugs, Toxicol. Sci., 113, 243, 10.1093/toxsci/kfp236
Fromenty, 1990, Dual effect of amiodarone on mitochondrial respiration – initial protonophoric uncoupling effect followed by inhibition of the respiratory-chain at the levels of Complex-I and Complex-Ii, J. Pharmacol. Exp. Ther., 255, 1377
Gerets, 2012, Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins, Cell Biol. Toxicol., 28, 69, 10.1007/s10565-011-9208-4
Hussaini, 2014, Idiosyncratic drug-induced liver injury: an update on the 2007 overview, Expert Opin. Drug Safety, 13, 67, 10.1517/14740338.2013.828032
Kenne, 2008, Prediction of drug-induced liver injury in humans by using in vitro methods: the case of ximelagatran, Toxicol. In Vitro, 22, 730, 10.1016/j.tiv.2007.11.014
Kennedy, 1996, Inhibition of carnitine palmitoyltransferase-1 in rat heart and liver by perhexiline and amiodarone, Biochem. Pharmacol., 52, 273, 10.1016/0006-2952(96)00204-3
Korlipara, 2004, Differences in toxicity of the catechol-O-methyl transferase inhibitors, tolcapone and entacapone to cultured human neuroblastoma cells, Neuropharmacol., 46, 562, 10.1016/j.neuropharm.2003.10.015
Kon, 2004, Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes, Hepatology, 40, 1170, 10.1002/hep.20437
Labbe, 2008, Drug-induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studies, Fundam. Clin. Pharmacol., 22, 335, 10.1111/j.1472-8206.2008.00608.x
Lofrumento, 2011, Valinomycin induced energy-dependent mitochondrial swelling, cytochrome c release, cytosolic NADH/cytochrome c oxidation and apoptosis, Apoptosis, 16, 1004, 10.1007/s10495-011-0628-7
Marroquin, 2007, Circumventing the crabtree effect: replacing media glucose with galactose increases susceptibility of HepG2 cells to mitochondrial toxicants, Toxicol. Sci., 97, 539, 10.1093/toxsci/kfm052
Moreno-Sanchez, 1999, Inhibition and uncoupling of oxidative phosphorylation by nonsteroidal anti-inflammatory drugs - Study in mitochondria, submitochondrial particles, cells, and whole heart, Biochem. Pharmacol., 57, 743, 10.1016/S0006-2952(98)00330-X
Nadanaciva, 2007, Target identification of drug induced mitochondrial toxicity using immunocapture based OXPHOS activity assays, Toxicol. In Vitro, 21, 902, 10.1016/j.tiv.2007.01.011
Nelson, 1990, Molecular mechanisms of the hepatotoxicity caused by acetaminophen, Semin. Liver Dis., 10, 267, 10.1055/s-2008-1040482
Ong, 2007, Troglitazone-induced hepatic necrosis in an animal model of silent genetic mitochondrial abnormalities, Toxicol. Sci., 97, 205, 10.1093/toxsci/kfl180
Parmar, 1995, Mitochondrial ATPase: a target for paracetamol-induced hepatotoxicity, Eur. J. Pharmacol., 293, 225, 10.1016/0926-6917(95)00021-6
Pereira, 2012, Mitochondrial bioenergetics and drug-induced toxicity in a panel of mouse embryonic fibroblasts with mitochondrial DNA single nucleotide polymorphisms, Toxicol. Appl. Pharmacol., 264, 167, 10.1016/j.taap.2012.07.030
Pike, 2011, Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells, Biochim. Biophys. Acta – Bioenergetics, 1807, 726, 10.1016/j.bbabio.2010.10.022
Ramachandran, 2011, The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity, Toxicol. Appl. Pharmacol., 251, 226, 10.1016/j.taap.2011.01.004
Scatena, 2004, Mitochondrial dysfunction by synthetic ligands of peroxisome proliferator activated receptors (PPARs), IUBMB Life, 56, 477, 10.1080/15216540400008416
Swiss, 2013, Validation of a HTS-amenable assay to detect drug-induced mitochondrial toxicity in the absence and presence of cell death, Toxicol. In Vitro, 27, 1789, 10.1016/j.tiv.2013.05.007