The use of animal models in cancer research

Eugenio Santos de Dios1
1Centro de Investigación del Cáncer, CSIC-Universidad de Salamanca, Spain

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ESF. European Science Foundation Policy Briefing. August 2001. p. 1–6. IREG Strasbourg-Dépot légal: juillet 2001, No d’ordre 012442.

http://grants.nih.gov/grants/guide/noticefiles/not93-071.html. Position Statement on Use of Animals in Research. NIH Guide, vol 22, Number 8, February 1993.

Stokstad, E. Human science finds sharper and kinder tools. Science 1999;286:1068–71.

http://www.nih.gov/science/models/

Choquet-Kastylevsky G, Descotes J. Value of animal models for predicting hypersensitivity reactions to medicinal products. Toxicology 1998;129:27–35.

Rudmann DG, Durham SK. Utilization of genetically altered animals in the pharmaceutical industry. Toxicol Pathol 1999;27:111–4.

Brusa R. Genetically modified mice in neuropharmacology. Pharmacol Res 1999;39:405–19.

Eynon EE, Flavell RA. Walking through the forest of transgenic models of human disease. Immunol Rev 1999;169:5–10.

Lau A, Matzuk MM. Transgenic models in the study of reproduction. Gravit Space Biol Bull 1999;12(2):75–82.

Taneja V, David CS. Lessons from animal models for human autoimmune diseases. Nat Immunol 2001;2: 781–4.

Gainetdinov RR, Mohn AR, Caron MG. Genetic animal models: focus on schizophrenia. Trends Neurosci 2001; 24:527–33.

Bowers BJ. Applications of transgenic and knockout mice in alcohol research. Alcohol Res Health 2000;24:175–84.

Brouillet E. Animal models of Huntington’s disease: from basic research on neuronal death to assessment of new therapeutic strategies. Funct Neurol 2000;15:239–51.

Price DL, Wong PC, Markowska AL, et al. The value of transgenic models for the study of neurodegenerative diseases. Ann N Y Acad Sci 2000;920:179–91.

Janus C, Westaway D. Transgenic mouse models of Alzheimer’s disease. Physiol Behav 2001;73:873–86.

Nagel RL, Fabry ME. The panoply of animal models for sickle cell anaemia. Br J Haematol 2001;112:19–25.

Dalloz F, Osinska H, Robbins J. Manipulating the contractile apparatus: genetically defined animal models of cardiovascular disease. J Mol Cell Cardiol 2001;33:9–25.

Taneja V, David CS. Association of MHC and rheumatoid arthritis. Regulatory role of HLA class II molecules in animal models of RA: studies on transgenic/knockout mice. Arthritis Res 2000;2:205–7.

Zhang Z, Bedard E, Luo Y, et al. Animal models in xenotransplantation. Expert Opin Investig Drugs 2000;9:2051–68.

Frederick J, Bronson JD, Baehr W. Animal models of inherited retinal diseases. Methods Enzymol 2000;316: 515–26.

Wong FS, Dittel BN, Janeway CA Jr. Transgenes and knockout mutations in animal models of type 1 diabetes and multiple sclerosis. Immunol Rev 1999;169:93–104.

Viney JL. Transgenic and gene knockout mice in cancer research. Cancer Metastasis Rev 1995;14:77–90.

Webb CP, Vande Woude GF. Animal models for Ras-induced metastasis. Methods Enzymol 2001;333:318–29.

Hakem R, Mak TW. Animal models of tumor-suppressor genes. Annu Rev Genet 2001;35:209–41.

Ihle J. The challenges of translating knockout phenotypes into gene function. Cell 2000;102:131–4.

Clarke AR. Manipulating the germline: its impact on the study of carcinogenesis. Carcinogenesis 2000;21:435–41.

Greenhalgh DA, Wang XJ, Roop DR. Multistage epidermal carcinogenesis in transgenic mice: cooperativity and paradox. J Investig Dermatol Symp Proc 1996;1:162–76.

Brown K, Burns PA, Balmain A. Transgenic approaches to understanding the mechanisms of chemical carcinogenesis in mouse skin. Toxicol Lett 1995;82-83:123–30.

Rovigatti U, Afanasyeva T, Brandner S, et al. Transgenic mice as research tools in neurocarcinogenesis. J Neurovirol 1998;4:159–74.

Deng CX, Brodie SG. Knockout mouse models and mammary carcinogenesis. Semin Cancer Biol 2001;11: 387–94.

Standop J, Schneider MB, Ulrich A, Pour PM. Experimental models in pancreatic carcinogenesis: lessons for human pancreatic cancer. Dig Dis 2001;19:24–31.

D’Angelo MG, Afanasieva T, Aguzzi A. Angiogenesis in transgenic models of multistep carcinogenesis. J Neurooncol 2000;50:89–98.

Bergers G, Hanahan D, Coussens LM. Angiogenesis and apoptosis are cellular parameters of neoplastic progression in transgenic mouse models of tumorigenesis. Int J Dev Biol 1998;42:995–1002.

Hursting SD, Perkins SN, Phang JM, Barrett JC. Diet and cancer prevention studies in p53-deficient mice. J Nutr 2001;131(11 Suppl):3092S-4S.

Hursting SD, Slaga TJ, Fischer SM, DiGiovanni J, Phang JM. Mechanism-based cancer prevention approaches: targets, examples, and the use of transgenic mice. J Natl Cancer Inst 1999;91:215–25.

Setlow RB. Human cancer: etiologic agents/dose responses/DNA repair/ cellular and animal models. Mutat Res 2001;477:1–6.

Ludwig T, Fisher P, Murty V, Efstratiadis A. Development of mammary adenocarcinomas by tissue-specific knockouts of Brac2 in mice. Oncogene 2001;20:3937–48.

Cardiff RD, Anver MR, Gusterson BA, et al. The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting. Oncogene 2000;19:968–88.

Watson AJ, Pritchard DM. Lessons from genetically engineered animal models. VII. Apoptosis in intestinal epithelium: lessons from transgenic and knockout mice. Am J Physiol Gastrointest Liver Physiol 2000;278(1):G1–5.

Holland EC. Animal models of cell cycle dysregulation and the pathogenesis of gliomas. J Neurooncol 2001;51:265–76.

McLaughlin PM, Kroesen B, Harmsen MC, de Leij LF. Cancer immunotherapy: insights from transgenic animal models. Crit Rev Oncol Hematol 2001;40:53–76.

Hsieh CL, Chung LW. New prospectives of prostate cancer gene therapy: molecular targets and animal models. Crit Rev Eukaryot Gene Expr 2001;11:77–120.

Rosenberg MP, Bortner D. Why transgenic and knockout animal models should be used (for drug efficacy studies in cancer). Cancer Metastasis Rev 1998–99;17:295–9.

West DB, Iakougova O, Olsson C, Ross D, Ohmen J, Chatterjee A. Mouse genetics/genomics: an effective approach for drug target discovery and validation. Med Res Rev 2000;20:216–30.

Bruning JC, Kahn CR, Krone W, Muller-Wieland D. Conditional mutagenesis-second generation knockout mice as models for internal diseases. Med Klin 1999; 94:564–9.

Le Y, Sauer B. Conditional gene knockout using Cre recombinase. Mol Biotechnol 2001;17:269–75.

Nebert DW, Dalton TP, Stuart GW, Carvan MJ III. «Geneswap knock-in» cassette in mice to study allelic differences in human genes. Ann NY Acad Sci 2000;919:148–70.

Peale FV Jr, Gerritsen ME. Gene profiling techniques and their application in angiogenesis and vascular development. J Pathol 2001;195:7–19.

Cibelli JB, Kiessling AA, Cunnif K, Richards C, Planza, RP, West MD. Somatic cell nuclear transfer in humans: pronuclear and early embryonic development. E-bio-Med. J Regen Med 2001;2:25–31.

Adam D. First human clones get a cool response. Nature 2001;414–77.