The tryptophan catabolite or kynurenine pathway in major depressive and bipolar disorder: A systematic review and meta-analysis
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Aarsland, 2019, The effect of electroconvulsive therapy (ECT) on serum tryptophan metabolites, Brain Stimul., 12, 1135, 10.1016/j.brs.2019.05.018
Achtyes, 2020, Inflammation and kynurenine pathway dysregulation in post-partum women with severe and suicidal depression, Brain Behav. Immun., 83, 239, 10.1016/j.bbi.2019.10.017
Almulla, 2022, The tryptophan catabolite or kynurenine pathway's role in major depression, Curr. Top. Med. Chem., 22, 1, 10.2174/1568026622666220428095250
Almulla, 2022, The tryptophan catabolite or kynurenine pathway in Alzheimer's disease: a systematic review and meta-analysis, J Alzheimers Dis, 88, 1325, 10.3233/JAD-220295
Almulla, 2022, The tryptophan catabolite or kynurenine pathway in COVID-19 and critical COVID-19: a systematic review and meta-analysis, BMC Infect. Dis., 22, 615, 10.1186/s12879-022-07582-1
Almulla, 2022, The tryptophan catabolite or kynurenine pathway in schizophrenia: meta-analysis reveals dissociations between central, serum, and plasma compartments, Mol. Psychiatr., 10.1038/s41380-022-01552-4
Anderson, 1990, Decreased plasma tryptophan concentration in major depression: relationship to melancholia and weight loss, J. Affect. Disord., 20, 185, 10.1016/0165-0327(90)90143-V
Andrés-Rodríguez, 2020, Peripheral immune aberrations in fibromyalgia: a systematic review, meta-analysis and meta-regression, Brain Behav. Immun., 87, 881, 10.1016/j.bbi.2019.12.020
Arnone, 2018, Role of Kynurenine pathway and its metabolites in mood disorders: a systematic review and meta-analysis of clinical studies, Neurosci. Biobehav. Rev., 92, 477, 10.1016/j.neubiorev.2018.05.031
Badawy, 2002, Tryptophan metabolism in alcoholism, Nutr. Res. Rev., 15, 123, 10.1079/NRR200133
Baranyi, 2017, Beta-trace protein as a new non-invasive immunological marker for quinolinic acid-induced impaired blood-brain barrier integrity, Sci. Rep., 7, 10.1038/srep43642
Bartoli, 2021, The kynurenine pathway in bipolar disorder: a meta-analysis on the peripheral blood levels of tryptophan and related metabolites, Mol. Psychiatr., 26, 3419, 10.1038/s41380-020-00913-1
Bay-Richter, 2015, A role for inflammatory metabolites as modulators of the glutamate N-methyl-D-aspartate receptor in depression and suicidality, Brain Behav. Immun., 43, 110, 10.1016/j.bbi.2014.07.012
Bellmaine, 2020, Reactivity and degradation products of tryptophan in solution and proteins, Free Radic. Biol. Med., 160, 696, 10.1016/j.freeradbiomed.2020.09.002
Birner, 2017, Increased breakdown of kynurenine towards its neurotoxic branch in bipolar disorder, PLoS One, 12, 10.1371/journal.pone.0172699
Bonaccorso, 2001, Major depression induced by interferon-alpha in patients affected by hepatitis C virus, J. Affect. Disord.
Bonaccorso, 2002, Increased depressive ratings in patients with hepatitis C receiving interferon-α–based immunotherapy are related to interferon-α–induced changes in the serotonergic system, J. Clin. Psychopharmacol., 22, 10.1097/00004714-200202000-00014
Booth, 2015, Substrate oxidation by indoleamine 2,3-dioxygenase: evidence for a common reaction mechanism, J. Biol. Chem., 290, 30924, 10.1074/jbc.M115.695684
Bradley, 2015, The role of the kynurenine pathway in suicidality in adolescent major depressive disorder, Psychiatr. Res., 227, 206, 10.1016/j.psychres.2015.03.031
Brundin, 2016, An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation, Transl. Psychiatry, 6, e865, 10.1038/tp.2016.133
Busse, 2015, Decreased quinolinic acid in the hippocampus of depressive patients: evidence for local anti-inflammatory and neuroprotective responses?, Eur. Arch. Psychiatr. Clin. Neurosci., 265, 321, 10.1007/s00406-014-0562-0
Carrillo-Mora, 2020, Serum kynurenines correlate with depressive symptoms and disability in poststroke patients: a cross-sectional study, Neurorehabilitation Neural Repair, 34, 936, 10.1177/1545968320953671
Castillo, 2019, Celecoxib augmentation of escitalopram in treatment-resistant bipolar depression and the effects on Quinolinic Acid, Neurol. Psychiatr. Brain Res., 32, 22, 10.1016/j.npbr.2019.03.005
Cathomas, 2021, Quinolinic acid is associated with cognitive deficits in schizophrenia but not major depressive disorder, Sci. Rep., 11, 9992, 10.1038/s41598-021-89335-9
Chiaroni, 1990, A multivariate analysis of red blood cell membrane transports and plasma levels of L-tyrosine and L-tryptophan in depressed patients before treatment and after clinical improvement, Neuropsychobiology, 23, 1, 10.1159/000118707
Chiu, 2021, A study of tryptophan, kynurenine and serotonin transporter in first-episode drug-naïve major depressive disorder, Psychiatr. Res. Neuroimaging, 312, 10.1016/j.pscychresns.2021.111296
Cho, 2017, Sleep disturbance and kynurenine metabolism in depression, J. Psychosom. Res., 99, 1, 10.1016/j.jpsychores.2017.05.016
Clark, 2016, Reduced kynurenine pathway metabolism and cytokine expression in the prefrontal cortex of depressed individuals, J. Psychiatry Neurosci., 41, 386, 10.1503/jpn.150226
Cohen, 1988
Colle, 2020, Peripheral tryptophan, serotonin, kynurenine, and their metabolites in major depression: a case-control study, Psychiatr. Clin. Neurosci., 74, 112, 10.1111/pcn.12944
Coppen, 1967, The biochemistry of affective disorders, Br. J. Psychiatry, 113, 1237, 10.1192/bjp.113.504.1237
Coppen, 1972, Tryptophan concentration in the cerebrospinal fluid of depressive patients, Lancet, 1, 1393, 10.1016/S0140-6736(72)91123-3
Coppen, 1973, Total and free tryptophan concentration in the plasma of depressive patients, Lancet, 2, 60, 10.1016/S0140-6736(73)93259-5
Cowen, 1989, Decreased plasma tryptophan levels in major depression, J. Affect. Disord., 16, 27, 10.1016/0165-0327(89)90051-7
Croonenberghs, 2005, Serotonergic disturbances in autistic disorder: L-5-hydroxytryptophan administration to autistic youngsters increases the blood concentrations of serotonin in patients but not in controls, Life Sci., 76, 2171, 10.1016/j.lfs.2004.06.032
Curzon, 1979, Relationships between plasma, CSF and brain tryptophan, 81
Czermak, 2008, Plasma NPY concentrations during tryptophan and sham depletion in medication-free patients with remitted depression, J. Affect. Disord., 110, 277, 10.1016/j.jad.2008.01.014
Dahl, 2015, Ongoing episode of major depressive disorder is not associated with elevated plasma levels of kynurenine pathway markers, Psychoneuroendocrinology, 56, 12, 10.1016/j.psyneuen.2015.02.011
Davidson, 2002, Effects of contamination of blood specimens with liquid potassium-EDTA anticoagulant, Ann. Clin. Biochem., 39, 273, 10.1258/0004563021901973
DeMyer, 1981, Plasma tryptophan and five other amino acids in depressed and normal subjects, Arch. Gen. Psychiatr., 38, 642, 10.1001/archpsyc.1981.01780310042003
DeWitt, 2018, A pilot resting-state functional connectivity study of the kynurenine pathway in adolescents with depression and healthy controls, J. Affect. Disord., 227, 752, 10.1016/j.jad.2017.11.040
Doolin, 2018, Altered tryptophan catabolite concentrations in major depressive disorder and associated changes in hippocampal subfield volumes, Psychoneuroendocrinology, 95, 8, 10.1016/j.psyneuen.2018.05.019
Duval, 2000, A nonparametric “trim and fill” method of accounting for publication bias in meta-analysis, J. Am. Stat. Assoc., 95, 89
Duval, 2000, Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis, Biometrics, 56, 455, 10.1111/j.0006-341X.2000.00455.x
Ebesunun, 2012, Elevated plasma homocysteine in association with decreased vitamin B(12), folate, serotonin, lipids and lipoproteins in depressed patients, Afr. J. Psychiatr., 15, 25, 10.4314/ajpsy.v15i1.3
Erabi, 2020, Kynurenic acid is a potential overlapped biomarker between diagnosis and treatment response for depression from metabolome analysis, Sci. Rep., 10, 10.1038/s41598-020-73918-z
Erhardt, 2013, Connecting inflammation with glutamate agonism in suicidality, Neuropsychopharmacology, 38, 743, 10.1038/npp.2012.248
Fernstrom, 1973, Correlation between brain tryptophan and plasma neutral amino acid levels following food consumption in rats, Life Sci., 13, 517, 10.1016/0024-3205(73)90044-1
Gabbay, 2010, The possible role of the kynurenine pathway in adolescent depression with melancholic features, JCPP (J. Child Psychol. Psychiatry), 51, 935, 10.1111/j.1469-7610.2010.02245.x
Georgin-Lavialle, 2016, Mast cells' involvement in inflammation pathways linked to depression: evidence in mastocytosis, Mol. Psychiatr., 21, 1511, 10.1038/mp.2015.216
Gerner, 1984, CSF neurochemistry in depressed, manic, and schizophrenic patients compared with that of normal controls, Am. J. Psychiatr., 141, 1533, 10.1176/ajp.141.12.1533
Goda, 1999, Radical scavenging properties of tryptophan metabolites. Estimation of their radical reactivity, Adv. Exp. Med. Biol., 467, 397, 10.1007/978-1-4615-4709-9_50
Guicheney, 1988, Platelet serotonin content and plasma tryptophan in peri- and postmenopausal women: variations with plasma oestrogen levels and depressive symptoms, Eur. J. Clin. Invest., 18, 297, 10.1111/j.1365-2362.1988.tb01262.x
Hayward, 2005, Low-dose tryptophan depletion in recovered depressed patients induces changes in cognitive processing without depressive symptoms, Biol. Psychiatr., 57, 517, 10.1016/j.biopsych.2004.11.016
Healy, 1982, Monoamine-related markers of depression: changes following treatment, J. Psychiatr. Res., 17, 251, 10.1016/0022-3956(82)90003-6
Hebbrecht, 2021, Tryptophan catabolites in bipolar disorder: a meta-analysis, Front. Immunol., 12, 10.3389/fimmu.2021.667179
Heilman, 2019, Role of the kynurenine pathway and the endocannabinoid system as modulators of inflammation and personality traits, Psychoneuroendocrinology, 110, 10.1016/j.psyneuen.2019.104434
Hennings, 2013, Exercise affects symptom severity but not biological measures in depression and somatization – results on IL-6, neopterin, tryptophan, kynurenine and 5-HIAA, Psychiatr. Res., 210, 925, 10.1016/j.psychres.2013.09.018
Higgins JPT, 2019
Hoekstra, 2001, Effect of electroconvulsive therapy on biopterin and large neutral amino acids in severe, medication-resistant depression, Psychiatr. Res., 103, 115, 10.1016/S0165-1781(01)00282-7
Hoekstra, 2006, Bipolar mania and plasma amino acids: increased levels of glycine, Eur. Neuropsychopharmacol, 16, 71, 10.1016/j.euroneuro.2005.06.003
Hu, 2017, A simple HPLC-MS/MS method for determination of tryptophan, kynurenine and kynurenic acid in human serum and its potential for monitoring antidepressant therapy, J. Anal. Toxicol., 41, 37, 10.1093/jat/bkw071
Hüfner, 2015, Levels in neurotransmitter precursor amino acids correlate with mental health in patients with breast cancer, Psychoneuroendocrinology, 60, 28, 10.1016/j.psyneuen.2015.06.001
Hughes, 2012, Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation, Brain Behav. Immun., 26, 979, 10.1016/j.bbi.2012.05.010
Joseph, 1984, Plasma L-tryptophan/neutral amino acid ratio and dexamethasone suppression in depression, Psychiatr. Res., 11, 185, 10.1016/0165-1781(84)90067-2
Kanchanatawan, 2018, Deficit, but not nondeficit, schizophrenia is characterized by mucosa-associated activation of the tryptophan catabolite (TRYCAT) pathway with highly specific increases in IgA responses directed to picolinic, xanthurenic, and quinolinic acid, Mol. Neurobiol., 55, 1524, 10.1007/s12035-017-0417-6
Karege, 1994, Platelet serotonin and plasma tryptophan in depressed patients: effect of drug treatment and clinical outcome, Neuropsychopharmacology, 10, 207, 10.1038/npp.1994.23
Krause, 2017, High kynurenine (a tryptophan metabolite) predicts remission in patients with major depression to add-on treatment with celecoxib, Front. Psychiatr., 8, 10.3389/fpsyt.2017.00016
Krause, 2019, Values of cytokines and tryptophan metabolites over a 12 Weeks time course in patients with depression and somatoform disorder, Clin Psychopharmacol Neurosci, 17, 34, 10.9758/cpn.2019.17.1.34
Kulkarni, 2016, Effect of various anticoagulants on the bioanalysis of drugs in rat blood: implication for pharmacokinetic studies of anticancer drugs, SpringerPlus, 5, 2102, 10.1186/s40064-016-3770-4
Kuwano, 2018, Tryptophan-kynurenine and lipid related metabolites as blood biomarkers for first-episode drug-naïve patients with major depressive disorder: an exploratory pilot case-control study, J. Affect. Disord., 231, 74, 10.1016/j.jad.2018.01.014
Lapin, 1969, Intensification of the central serotoninergic processes as a possible determinant of the thymoleptic effect, Lancet, 1, 132, 10.1016/S0140-6736(69)91140-4
Leclercq, 2021, Alterations of kynurenine pathway in alcohol use disorder and abstinence: a link with gut microbiota, peripheral inflammation and psychological symptoms, Transl. Psychiatry, 11, 503, 10.1038/s41398-021-01610-5
Liu, 2015, A meta-analysis of oxidative stress markers in depression, PLoS One, 10, 10.1145/2818302
Liu, 2018, The metabolic factor kynurenic acid of kynurenine pathway predicts major depressive disorder, Front. Psychiatr., 9, 10.3389/fpsyt.2018.00552
Lucca, 1992, Plasma tryptophan levels and plasma tryptophan/neutral amino acids ratio in patients with mood disorder, patients with obsessive-compulsive disorder, and normal subjects, Psychiatr. Res., 44, 85, 10.1016/0165-1781(92)90043-3
Lucini, 1996, Predictive value of tryptophan/large neutral amino acids ratio to antidepressant response, J. Affect. Disord., 36, 129, 10.1016/0165-0327(95)00071-2
Maes, 1993, A review on the acute phase response in major depression, Rev. Neurosci., 4, 407, 10.1515/REVNEURO.1993.4.4.407
Maes, 2015, A review on citation amnesia in depression and inflammation research, Neuroendocrinol. Lett., 36, 1
Maes, 2022, Precision nomothetic medicine in depression research: a new depression model, and new endophenotype classes and pathway phenotypes, and A digital self, J. Personalized Med., 12, 10.3390/jpm12030403
Maes, 2018, The compensatory immune-regulatory reflex system (CIRS) in depression and bipolar disorder, Mol. Neurobiol., 55, 8885, 10.1007/s12035-018-1016-x
Maes, 1995, The serotonin hypothesis of major depression: a review, Rev. Neurosci., 4, 407
Maes, 2012, Diagnostic classifications in depression and somatization should include biomarkers, such as disorders in the tryptophan catabolite (TRYCAT) pathway, Psychiatr. Res., 196, 243, 10.1016/j.psychres.2011.09.029
Maes, 2022, False dogmas in mood disorders research: towards a nomothetic network approach, World J. Psychiatr., 12, 651, 10.5498/wjp.v12.i5.651
Maes, 1990, Suppressant effects of dexamethasone on the availability of plasma L-tryptophan and tyrosine in healthy controls and in depressed patients, Acta Psychiatr. Scand., 81, 19, 10.1111/j.1600-0447.1990.tb06443.x
Maes, 1991, The relationships between the availability ofL-tryptophan to the brain, the spontaneous HPA-axis activity, and the HPA-axis responses to dexamethasone in depressed patients, Amino Acids, 1, 57, 10.1007/BF00808091
Maes, 1991, Anthropometric and biochemical assessment of the nutritional state in depression: evidence for lower visceral protein plasma levels in depression, J. Affect. Disord., 23, 25, 10.1016/0165-0327(91)90032-N
Maes, 1993, Relationships between lower plasma L-tryptophan levels and immune-inflammatory variables in depression, Psychiatr. Res., 49, 151, 10.1016/0165-1781(93)90102-M
Maes, 1995, Increased plasma serine concentrations in depression, Neuropsychobiology, 31, 10, 10.1159/000119166
Maes, 1996, Lower serum L-tryptophan availability in depression as a marker of a more generalized disorder in protein metabolism, Neuropsychopharmacology, 15, 243, 10.1016/0893-133X(95)00181-C
Maes, 1997, Lower serum high-density lipoprotein cholesterol (HDL-C) in major depression and in depressed men with serious suicidal attempts: relationship with immune-inflammatory markers, Acta Psychiatr. Scand., 95, 212, 10.1111/j.1600-0447.1997.tb09622.x
Maes, 1997, Serotonin-immune interactions in major depression: lower serum tryptophan as a marker of an immune-inflammatory response, Eur. Arch. Psychiatr. Clin. Neurosci., 247, 154, 10.1007/BF03033069
Maes, 2001, Treatment with interferon-alpha (IFN alpha) of hepatitis C patients induces lower serum dipeptidyl peptidase IV activity, which is related to IFN alpha-induced depressive and anxiety symptoms and immune activation, Mol. Psychiatr., 6, 475, 10.1038/sj.mp.4000872
Maes, 2001, Treatment with interferon-alpha (IFNα) of hepatitis C patients induces lower serum dipeptidyl peptidase IV activity, which is related to IFNα-induced depressive and anxiety symptoms and immune activation, Mol. Psychiatr., 6, 475, 10.1038/sj.mp.4000872
Maes, 2007, The immune effects of TRYCATs (tryptophan catabolites along the Ido pathway): relevance for depression - and other conditions characterized by tryptophan depletion induced by inflammation, Neuroendocrinol. Lett., 28, 826
Maes, 2008, The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression, Neuroendocrinol. Lett., 29, 117
Maes, 2011, A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness, Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 35, 676, 10.1016/j.pnpbp.2010.05.004
Maes, 2011, Somatization, but not depression, is characterized by disorders in the tryptophan catabolite (TRYCAT) pathway, indicating increased indoleamine 2,3-dioxygenase and lowered kynurenine aminotransferase activity, Neuroendocrinol. Lett., 32, 264
Maes, 2011, Somatization, but not depression, is characterized by disorders in the tryptophan catabolite (TRYCAT) pathway, indicating increased indoleamine 2,3-dioxygenase and lowered kynurenine aminotransferase activity, Neuroendocrinol. Lett., 32, 264
Maes, 2011, Prog. Neuro Psychopharmacol. Biol. Psychiatr., 35, 702, 10.1016/j.pnpbp.2010.12.017
Maes, 2019, Development of a novel staging model for affective disorders using partial least squares bootstrapping: effects of lipid-associated antioxidant defenses and neuro-oxidative stress, Mol. Neurobiol., 56, 6626, 10.1007/s12035-019-1552-z
Maes, 2019, Development of a novel staging model for affective disorders using partial least squares bootstrapping: effects of lipid-associated antioxidant defenses and neuro-oxidative stress, Mol. Neurobiol., 56, 6626, 10.1007/s12035-019-1552-z
Maes, 2019, Upregulation of the nitrosylome in bipolar disorder type 1 (BP1) and major depression, but not BP2: increased IgM antibodies to nitrosylated conjugates are associated with indicants of leaky gut, Nitric Oxide, 91, 67, 10.1016/j.niox.2019.07.003
Maes, 2022, Adverse childhood experiences predict the phenome of affective disorders and these effects are mediated by staging, Neuroimmunotoxic and Growth Factor Profiles
Maes, 2022
Manjarrez-Gutierrez, 2009, Functional change of the auditory cortex related to brain serotonergic neurotransmission in type 1 diabetic adolescents with and without depression, World J. Biol. Psychiatr., 10, 877, 10.1080/15622970902717032
Marx, 2021, The kynurenine pathway in major depressive disorder, bipolar disorder, and schizophrenia: a meta-analysis of 101 studies, Mol. Psychiatr., 26, 4158, 10.1038/s41380-020-00951-9
Mauri, 1998, Plasma and platelet amino acid concentrations in patients affected by major depression and under fluvoxamine treatment, Neuropsychobiology, 37, 124, 10.1159/000026491
Mauri, 2001, Predictive value of amino acids in the treatment of major depression with fluvoxamine, Neuropsychobiology, 44, 134, 10.1159/000054933
Mc, 1958, The specific binding of L-tryptophan to serum albumin, J. Biol. Chem., 233, 1436, 10.1016/S0021-9258(18)49353-2
Meier, 2016, Relationship between neurotoxic kynurenine metabolites and reductions in right medial prefrontal cortical thickness in major depressive disorder, Brain Behav. Immun., 53, 39, 10.1016/j.bbi.2015.11.003
Menna-Perper, 1983, Free tryptophan response to intravenous insulin in depressed patients, Biol. Psychiatr., 18, 771
Milaneschi, 2021, The association between plasma tryptophan catabolites and depression: the role of symptom profiles and inflammation, Brain Behav. Immun., 97, 167, 10.1016/j.bbi.2021.07.007
Miller, 2006, Upregulation of the initiating step of the kynurenine pathway in postmortem anterior cingulate cortex from individuals with schizophrenia and bipolar disorder, Brain Res., 1073–1074, 25, 10.1016/j.brainres.2005.12.056
Moaddel, 2018, Plasma metabolomic profiling of a ketamine and placebo crossover trial of major depressive disorder and healthy control subjects, Psychopharmacology (Berl), 235, 3017, 10.1007/s00213-018-4992-7
Møller, 1993, Plasma amino acid profiles in relation to clinical response to moclobemide in patients with major depression. Danish University Antidepressant Group, J. Affect. Disord., 27, 225, 10.1016/0165-0327(93)90046-M
Moller, 1976, Plasma amino acids as an index for subgroups in manic depressive psychosis: correlation to effect of tryptophan, Psychopharmacology, 49, 205, 10.1007/BF00427292
Møller, 1982, Tryptophan tolerance and metabolism in endogenous depression, Psychopharmacology (Berl), 76, 79, 10.1007/BF00430761
Moreno, 1999, Tryptophan depletion and depressive vulnerability, Biol. Psychiatr., 46, 498, 10.1016/S0006-3223(99)00095-5
Moreno, 2013, Increase in nitric oxide levels and mitochondrial membrane potential in platelets of untreated patients with major depression, Psychiatr. Res., 209, 447, 10.1016/j.psychres.2012.12.024
Morris, 2016, The many neuroprogressive actions of tryptophan catabolites (TRYCATs) that may be associated with the pathophysiology of neuro-immune disorders, Curr. Pharmaceut. Des., 22, 963, 10.2174/1381612822666151215102420
Mukherjee, 2018, Total sleep time and kynurenine metabolism associated with mood symptom severity in bipolar disorder, Bipolar Disord., 20, 27, 10.1111/bdi.12529
Murata, 2020, Effects of adjunctive inflammatory modulation on IL-1β in treatment resistant bipolar depression, Brain Behav. Immun., 87, 369, 10.1016/j.bbi.2020.01.004
Myint, 2007, Tryptophan breakdown pathway in bipolar mania, J. Affect. Disord., 102, 65, 10.1016/j.jad.2006.12.008
Myint, 2007, Kynurenine pathway in major depression: evidence of impaired neuroprotection, J. Affect. Disord., 98, 143, 10.1016/j.jad.2006.07.013
Nelp Micah, 2018, Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form, Proc. Natl. Acad. Sci. USA, 115, 3249, 10.1073/pnas.1719190115
Nikkheslat, 2015, Insufficient glucocorticoid signaling and elevated inflammation in coronary heart disease patients with comorbid depression, Brain Behav. Immun., 48, 8, 10.1016/j.bbi.2015.02.002
Ogawa, 2014, Plasma L-tryptophan concentration in major depressive disorder: new data and meta-analysis, J. Clin. Psychiatr., 75, e906, 10.4088/JCP.13r08908
Ogawa, 2018, Plasma amino acid profile in major depressive disorder: analyses in two independent case-control sample sets, J. Psychiatr. Res., 96, 23, 10.1016/j.jpsychires.2017.09.014
Ogyu, 2018, Kynurenine pathway in depression: a systematic review and meta-analysis, Neurosci. Biobehav. Rev., 90, 16, 10.1016/j.neubiorev.2018.03.023
Olsson, 2010, Elevated levels of kynurenic acid in the cerebrospinal fluid of patients with bipolar disorder, J. Psychiatry Neurosci. : JPN, 35, 195, 10.1503/jpn.090180
Ortiz, 1993, Effects of the antidepressant drug tianeptine on plasma and platelet serotonin of depressive patients and healthy controls, J. Affect. Disord., 29, 227, 10.1016/0165-0327(93)90012-9
Oxenkrug, 2013, Serotonin-kynurenine hypothesis of depression: historical overview and recent developments, Curr. Drug Targets, 14, 514, 10.2174/1389450111314050002
Öztürk, 2021, The role of the kynurenine pathway and quinolinic acid in adolescent major depressive disorder, Int. J. Clin. Pract., 75, 10.1111/ijcp.13739
Page, 2021, The PRISMA 2020 statement: an updated guideline for reporting systematic reviews, PLoS Med., 18, e1003583, 10.1371/journal.pmed.1003583
Pan, 2018, Diagnosis of major depressive disorder based on changes in multiple plasma neurotransmitters: a targeted metabolomics study, Transl. Psychiatry, 8, 130, 10.1038/s41398-018-0183-x
Pardridge, 1979, Tryptophan transport through the blood-brain barrier: in vivo measurement of free and albumin-bound amino acid, Life Sci., 25, 1519, 10.1016/0024-3205(79)90378-3
Parvy, 1983, EDTA in vacutainer tubes can interfere with plasma amino acid analysis, Clin. Chem., 29, 735, 10.1093/clinchem/29.4.735
Paul, 2022, Peripheral and central kynurenine pathway abnormalities in major depression, Brain Behav. Immun., 101, 136, 10.1016/j.bbi.2022.01.002
Perez-Gonzalez, 2014, Tryptophan: antioxidant or target of oxidative stress? A quantum chemistry elucidation, RSC Adv., 4, 56128, 10.1039/C4RA11635F
Pérez-González, 2015, Free-radical scavenging by tryptophan and its metabolites through electron transfer based processes, J. Mol. Model., 21, 213, 10.1007/s00894-015-2758-2
Pinto, 2012, Low plasma levels of l-arginine, impaired intraplatelet nitric oxide and platelet hyperaggregability: implications for cardiovascular disease in depressive patients, J. Affect. Disord., 140, 187, 10.1016/j.jad.2012.02.008
Platzer, 2017, Tryptophan breakdown and cognition in bipolar disorder, Psychoneuroendocrinology, 81, 144, 10.1016/j.psyneuen.2017.04.015
Poletti, 2018, Kynurenine pathway and white matter microstructure in bipolar disorder, Eur. Arch. Psychiatr. Clin. Neurosci., 268, 157, 10.1007/s00406-016-0731-4
Poletti, 2019, Grey and white matter structure associates with the activation of the tryptophan to kynurenine pathway in bipolar disorder, J. Affect. Disord., 259, 404, 10.1016/j.jad.2019.08.034
Pompili, 2019, Tryptophan and kynurenine metabolites: are they related to depression?, Neuropsychobiology, 77, 23, 10.1159/000491604
Porter, 2003, Elevated prolactin responses to L-tryptophan infusion in medication-free depressed patients, Psychopharmacology (Berl), 169, 77, 10.1007/s00213-003-1475-1
Price, 1991, 1518
Quak, 2014, Does tryptophan degradation along the kynurenine pathway mediate the association between pro-inflammatory immune activity and depressive symptoms?, Psychoneuroendocrinology, 45, 202, 10.1016/j.psyneuen.2014.03.013
Quintana, 1992, Platelet serotonin and plasma tryptophan decreases in endogenous depression. Clinical, therapeutic, and biological correlations, J. Affect. Disord., 24, 55, 10.1016/0165-0327(92)90019-3
Rădulescu, 2021, Neuroplasticity and depression: rewiring the brain's networks through pharmacological therapy (Review), Exp. Ther. Med., 22, 1131, 10.3892/etm.2021.10565
Reininghaus, 2014, Tryptophan breakdown is increased in euthymic overweight individuals with bipolar disorder: a preliminary report, Bipolar Disord., 16, 432, 10.1111/bdi.12166
Reiter, 1999, Melatonin and tryptophan derivatives as free radical scavengers and antioxidants, Adv. Exp. Med. Biol., 467, 379, 10.1007/978-1-4615-4709-9_48
Reyes Ocampo, 2014, Kynurenines with neuroactive and redox properties: relevance to aging and brain diseases, Oxid. Med. Cell. Longev., 10.1155/2014/646909
Rief, 2004, Psychobiological aspects of somatoform disorders: contributions of monoaminergic transmitter systems, Neuropsychobiology, 49, 24, 10.1159/000075335
Roiser, 2009, The effects of tryptophan depletion on neural responses to emotional words in remitted depression, Biol. Psychiatr., 66, 441, 10.1016/j.biopsych.2009.05.002
Russ, 1990, Plasma tryptophan to large neutral amino acid ratios in depressed and normal subjects, J. Affect. Disord., 19, 9, 10.1016/0165-0327(90)90003-Q
Ryan, 2020, Tryptophan metabolite concentrations in depressed patients before and after electroconvulsive therapy, Brain Behav. Immun., 83, 153, 10.1016/j.bbi.2019.10.005
Sakurai, 2020, Serum Metabolic Profiles of the Tryptophan-Kynurenine Pathway in the high risk subjects of major depressive disorder, Sci. Rep., 10, 1961, 10.1038/s41598-020-58806-w
Santamaría, 2001, Quinolinic acid induces oxidative stress in rat brain synaptosomes, Neuroreport, 12, 871, 10.1097/00001756-200103260-00049
Savaş, 2002, Possible role of nitric oxide and adrenomedullin in bipolar affective disorder, Neuropsychobiology, 45, 57, 10.1159/000048677
Savitz, 2015, Activation of the kynurenine pathway is associated with striatal volume in major depressive disorder, Psychoneuroendocrinology, 62, 54, 10.1016/j.psyneuen.2015.07.609
Savitz, 2015, Neuroprotective kynurenine metabolite indices are abnormally reduced and positively associated with hippocampal and amygdalar volume in bipolar disorder, Psychoneuroendocrinology, 52, 200, 10.1016/j.psyneuen.2014.11.015
Savitz, 2015, Putative neuroprotective and neurotoxic kynurenine pathway metabolites are associated with hippocampal and amygdalar volumes in subjects with major depressive disorder, Neuropsychopharmacology, 40, 463, 10.1038/npp.2014.194
Savitz, 2015, Reduction of kynurenic acid to quinolinic acid ratio in both the depressed and remitted phases of major depressive disorder, Brain Behav. Immun., 46, 55, 10.1016/j.bbi.2015.02.007
Schwieler, 2016, Electroconvulsive therapy suppresses the neurotoxic branch of the kynurenine pathway in treatment-resistant depressed patients, J. Neuroinflammation, 13, 51, 10.1186/s12974-016-0517-7
Sellgren, 2019, Peripheral and central levels of kynurenic acid in bipolar disorder subjects and healthy controls, Transl. Psychiatry, 9, 37, 10.1038/s41398-019-0378-9
Shaw, 1980, Tryptophan, affective disorder and stress. An hypothesis, J. Affect. Disord., 2, 321, 10.1016/0165-0327(80)90034-8
Smith, 2009, 5-Hydroxyanthranilic acid, a tryptophan metabolite, generates oxidative stress and neuronal death via p38 activation in cultured cerebellar granule neurones, Neurotox. Res., 15, 303, 10.1007/s12640-009-9034-0
Solmi, 2021, Peripheral levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, and interleukin-1β across the mood spectrum in bipolar disorder: a meta-analysis of mean differences and variability, Brain Behav. Immun., 97, 193, 10.1016/j.bbi.2021.07.014
Song, 1998, The inflammatory response system and the availability of plasma tryptophan in patients with primary sleep disorders and major depression, J. Affect. Disord., 49, 211, 10.1016/S0165-0327(98)00025-1
Sorgdrager, 2017, The association between the hypothalamic pituitary adrenal axis and tryptophan metabolism in persons with recurrent major depressive disorder and healthy controls, J. Affect. Disord., 222, 32, 10.1016/j.jad.2017.06.052
Sotelo-Orozco, 2021, A comparison of serum and plasma blood collection tubes for the integration of epidemiological and metabolomics data, Front. Mol. Biosci., 8, 10.3389/fmolb.2021.682134
Steen, 2020, Metabolic dysfunctions in the kynurenine pathway, noradrenergic and purine metabolism in schizophrenia and bipolar disorders, Psychol. Med., 50, 595, 10.1017/S0033291719000400
Steiner, 2011, Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission?, J. Neuroinflammation, 8, 94, 10.1186/1742-2094-8-94
Sublette, 2011, Plasma kynurenine levels are elevated in suicide attempters with major depressive disorder, Brain Behav. Immun., 25, 1272, 10.1016/j.bbi.2011.05.002
Sun, 2020, The relationship between plasma serotonin and kynurenine pathway metabolite levels and the treatment response to escitalopram and desvenlafaxine, Brain Behav. Immun., 87, 404, 10.1016/j.bbi.2020.01.011
Talarowska, 2012, Nitric oxide plasma concentration associated with cognitive impairment in patients with recurrent depressive disorder, Neurosci. Lett., 510, 127, 10.1016/j.neulet.2012.01.018
Teraishi, 2015, (13)C-tryptophan breath test detects increased catabolic turnover of tryptophan along the kynurenine pathway in patients with major depressive disorder, Sci. Rep., 5, 10.1038/srep15994
Trepci, 2021, Central levels of tryptophan metabolites in subjects with bipolar disorder, Eur. Neuropsychopharmacol, 43, 52, 10.1016/j.euroneuro.2020.11.018
Umehara, 2017, Altered KYN/TRP, Gln/Glu, and Met/methionine sulfoxide ratios in the blood plasma of medication-free patients with major depressive disorder, Sci. Rep., 7, 4855, 10.1038/s41598-017-05121-6
van den Ameele, 2020, A mood state-specific interaction between kynurenine metabolism and inflammation is present in bipolar disorder, Bipolar Disord., 22, 59, 10.1111/bdi.12814
Vasupanrajit, 2021, Suicide attempts are associated with activated immune-inflammatory, nitro-oxidative, and neurotoxic pathways: a systematic review and meta-analysis, J. Affect. Disord., 295, 80, 10.1016/j.jad.2021.08.015
Vasupanrajit, 2022, Inflammation and nitro-oxidative stress in current suicidal attempts and current suicidal ideation: a systematic review and meta-analysis, Mol. Psychiatr., 10.1038/s41380-021-01407-4
Veen, 2016, Tryptophan pathway alterations in the postpartum period and in acute postpartum psychosis and depression, J. Affect. Disord., 189, 298, 10.1016/j.jad.2015.09.064
Wan, 2014, Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range, BMC Med. Res. Methodol., 14, 135, 10.1186/1471-2288-14-135
Wichers, 2005, Ido and interferon-alpha-induced depressive symptoms: a shift in hypothesis from tryptophan depletion to neurotoxicity, Mol. Psychiatr., 10, 538, 10.1038/sj.mp.4001600
Wood, 1978, The effect of antidepressant drugs on plasma kynurenine in depressed patients, Psychopharmacology (Berl), 59, 263, 10.1007/BF00426632
Wu, 2018, Kynurenine pathway changes in late-life depression with memory deficit, Psychiatr. Res., 269, 45, 10.1016/j.psychres.2018.08.041
Wu, 2018, Kynurenine pathway changes in late-life depression, J. Affect. Disord., 235, 76, 10.1016/j.jad.2018.04.007
Wurfel, 2017, Serum kynurenic acid is reduced in affective psychosis, Transl. Psychiatry, 7, e1115, 10.1038/tp.2017.88
Xu, 2012, Potential clinical utility of plasma amino acid profiling in the detection of major depressive disorder, Psychiatr. Res., 200, 1054, 10.1016/j.psychres.2012.05.027
Xu, 2018, The tryptophan pathway targeting antioxidant capacity in the placenta, Oxid. Med. Cell. Longev., 2018, 1054797, 10.1155/2018/1054797
Yoshimi, 2016, Blood metabolomics analysis identifies abnormalities in the citric acid cycle, urea cycle, and amino acid metabolism in bipolar disorder, BBA Clin, 5, 151, 10.1016/j.bbacli.2016.03.008
Young, 2016, Kynurenine pathway metabolites are associated with hippocampal activity during autobiographical memory recall in patients with depression, Brain Behav. Immun., 56, 335, 10.1016/j.bbi.2016.04.007
Yuwiler, 1977, Effect of albumin binding and amino acid competition on tryptophan uptake into brain, J. Neurochem., 28, 1015, 10.1111/j.1471-4159.1977.tb10664.x
Zhou, 2018, Antidepressant effect of repeated ketamine administration on kynurenine pathway metabolites in patients with unipolar and bipolar depression, Brain Behav. Immun., 74, 205, 10.1016/j.bbi.2018.09.007
Zhou, 2019, Cross-sectional relationship between kynurenine pathway metabolites and cognitive function in major depressive disorder, Psychoneuroendocrinology, 101, 72, 10.1016/j.psyneuen.2018.11.001