The treatment of segmental bone defects in rabbit tibiae with vascular endothelial growth factor (VEGF)-loaded gelatin/hydroxyapatite “cryogel” scaffold

Giannoudis PV, Dinopoulos H, Tsiridis E (2005) Bone substitutes: an update. Injury 36S(3):20–27

Roberts SJ, Howard D, Buttery LD, Shakesheff KM (2008) Clinical applications of musculoskeletal tissue engineering. Br Med Bull 86:7–22

Bolgen N, Plieva F, Galaev IY, Mattiasson B, Piskin E (2007) “Cryogelation” for preparation of novel biodegradable tissue engineering scaffolds. J Biomater Sci Polymer Ed 18(9):1165–1179

Glowacki J (1998) Angiogenesis in fracture repair. Clin Orthop (355S):82–89

Strydom DJ (1998) The angiogenins. Cell Mol Life Sci 54(8):811–824

Street J, Bao M, deGuzman L, Bunting S, Peale FV Jr, Ferrara N et al (2002) Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover. Proc Natl Acad Sci USA 99(15):9656–9661

Eckardt H, Ding M, Lind M, Hansen ES, Christensen KS, Hvid I (2005) Recombinant human vascular endothelial growth factor enhances bone healing in an experimental nonunion model. J Bone Joint Surg Br 87(10):1434–1438

Maia J, Ferreira L, Carvalho R, Ramos MA, Gil MH (2005) Synthesis and characterization of new injectable and degradable dextran-based hydrogels. Polymer 46(23):9604–9614

Inci I, Kirsebom H, Galaev IG, Mattiasson B, Piskin E (2012) Gelatin cryogels crosslinked with oxidized dextran and containing freshly formed hydroxyapatite as potential bone tissue engineering scaffolds. J Tissue Eng Regen Med. doi: 10.1002/term1464 [Epub ahead of print]

Cook SD, Baffes GC, Wolfe MW, Sampath TK, Rueger DC (1994) Recombinant human bone morphogenic protein-7 induces healing in a canine long-bone segmental defect model. Clin Orthop (301):302–312

Patel ZS, Young S, Tabata Y, Jansen JA, Wong ME, Mikos AG (2008) Dual delivery of an angiogenic and an osteogenic growth factor for bone regeneration in a critical size defect model. Bone 43(5):931–940

Giannoudis PV, Einhorn TA, Marsh D (2007) Fracture healing: the diamond concept. Injury (38S):3–6

Tsiridis E, Upadhyay N, Giannoudis P (2007) Molecular aspects of fracture healing: which are the important molecules? Injury (38S):11–25

Keramaris NC, Calori GM, Nikolaou VS, Schemitsch EH, Giannoudis PV (2008) Fracture vascularity and bone healing: a systematic review of the role of VEGF. Injury (39S):45–57

Beamer B, Hettrich C, Lane J (2009) Vascular endothelial growth factor: an essential component of angiogenesis and fracture healing. HSS J (9) [Epub ahead of print]

Augustin G, Antabak A, Davila S (2007) The periosteum. Part 1: anatomy, histology and molecular biology. Injury 38(10):1115–1130

Gerber HP, Vu TH, Ryan AM (1999) VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med 5(6):623–628

Dimitriou R, Tsiridis E, Carr I, Simpson H, Giannoudis PV (2006) The role of inhibitory molecules in fracture healing. Injury (37S):20–29

Kleinheinz J, Stratmann U, Joos U, Wiessman HP (2005) VEGF-activated angiogenesis during bone regeneration. J Oral Maxillofac Surg 63(9):1310–1316

Tripathi A, Kumar A (2011) Multi-featured macroporous agarose-alginate cryogel: synthesis and characterization for bioengineering applications. Macromol Biosci 11(1):22–35

Liu Y, Lu Y, Tian X, Cui G, Zhao Y, Yang Q et al (2009) Segmental bone regeneration using an rhBMP-2-loaded gelatin/nanohydroxyapatite/fibrin scaffold in a rabbit model. Biomaterials 30(31):6276–6285

Ichinohe N, Kuboki Y, Tabata Y (2008) Bone regeneration using titanium nonwoven fabrics combined with fgf-2 release from gelatin hydrogel microspheres in rabbit skull defects. Tissue Eng Part A 14(10):1663–1671