The translational regulator eIF3a: The tricky eIF3 subunit!

Pardee, 1989, G1 events and regulation of cell proliferation, Science, 246, 603, 10.1126/science.2683075 Maitra, 1982, Initiation factors in protein biosynthesis, Annu. Rev. Biochem., 51, 869, 10.1146/annurev.bi.51.070182.004253 Dong, 2006, Initiation factor eIF3 and regulation of mRNA translation, cell growth, and cancer, Crit. Rev. Oncol. Hematol., 59, 169, 10.1016/j.critrevonc.2006.03.005 Damoc, 2007, Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry, Mol. Cell. Proteomics, 6, 1135, 10.1074/mcp.M600399-MCP200 Algire, 2002, Development and characterization of a reconstituted yeast translation initiation system, RNA, 8, 382, 10.1017/S1355838202029527 Lee, 2002, Initiation factor eIF5B catalyzes second GTP-dependent step in eukaryotic translation initiation, Proc. Natl. Acad. Sci. U. S. A., 99, 16689, 10.1073/pnas.262569399 Pestova, 2002, The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection, Genes Dev., 16, 2906, 10.1101/gad.1020902 Hinnebusch, 2006, eIF3: a versatile scaffold for translation initiation complexes, Trends Biochem. Sci., 31, 553, 10.1016/j.tibs.2006.08.005 Masutani, 2007, Reconstitution reveals the functional core of mammalian eIF3, EMBO J., 26, 3373, 10.1038/sj.emboj.7601765 Siridechadilok, 2005, Structural roles for human translation factor eIF3 in initiation of protein synthesis, Science, 310, 1513, 10.1126/science.1118977 Zhang, 2007, Individual overexpression of five subunits of human translation initiation factor eIF3 promotes malignant transformation of immortal fibroblast cells, J. Biol. Chem., 282, 5790, 10.1074/jbc.M606284200 Srivastava, 1992, Eukaryotic initiation factor 3 does not prevent association through physical blockage of the ribosomal subunit-subunit interface, J. Mol. Biol., 226, 301, 10.1016/0022-2836(92)90946-H Benne, 1976, Purification and characterization of initiation factor IF-E3 from rabbit reticulocytes, Proc. Natl. Acad. Sci. U. S. A., 73, 3005, 10.1073/pnas.73.9.3005 Bjorklund, 1990, S-phase-specific expression of mammalian ribonucleotide reductase R1 and R2 subunit mRNAs, Biochemistry, 29, 5452, 10.1021/bi00475a007 Sizova, 1998, Specific interaction of eukaryotic translation initiation factor 3 with the 5′ nontranslated regions of hepatitis C virus and classical swine fever virus RNAs, J. Virol., 72, 4775, 10.1128/JVI.72.6.4775-4782.1998 Hershey, 1989, Protein phosphorylation controls translation rates, J. Biol. Chem., 264, 20823, 10.1016/S0021-9258(19)30005-5 Dever, 2002, Gene-specific regulation by general translation factors, Cell, 108, 545, 10.1016/S0092-8674(02)00642-6 Bachmann, 1997, Cloning of a novel protein overexpressed in human mammary carcinoma, Cancer Res., 57, 988 Pincheira, 2001, Identification of a 170-kDa protein over-expressed in lung cancers, Br. J. Cancer, 84, 1520, 10.1054/bjoc.2001.1828 Couch, 2010, Association of mitotic regulation pathway polymorphisms with pancreatic cancer risk and outcome, Cancer Epidemiol. Biomarkers Prev., 19, 251, 10.1158/1055-9965.EPI-09-0629 Olson, 2010, Variation in genes required for normal mitosis and risk of breast cancer, Breast Cancer Res. Treat., 119, 423, 10.1007/s10549-009-0386-1 Chen, 1999, p150 expression and its prognostic value in squamous-cell carcinoma of the esophagus, Int. J. Cancer, 84, 95, 10.1002/(SICI)1097-0215(19990420)84:2<95::AID-IJC1>3.0.CO;2-N Chen, 2004, p150 overexpression in gastric carcinoma: the association with p53, apoptosis and cell proliferation, Int. J. Cancer, 112, 393, 10.1002/ijc.20443 Dellas, 1998, Expression of p150 in cervical neoplasia and its potential value in predicting survival, Cancer, 83, 1376, 10.1002/(SICI)1097-0142(19981001)83:7<1376::AID-CNCR15>3.0.CO;2-1 Yu, 2007, Tuning cell cycle regulation with an iron key, Cell Cycle, 6, 1982, 10.4161/cc.6.16.4603 Ensinger, 1998, Assignment1 of the p150 subunit of the eukaryotic initiation factor 3A gene (EIF3A) to human chromosome band 10q26 by in situ hybridisation, Cytogenet Cell Genet., 83, 74, 10.1159/000015130 Asano, 1997, Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly, J. Biol. Chem., 272, 27042, 10.1074/jbc.272.43.27042 Johnson, 1997, Identification of cDNA clones for the large subunit of eukaryotic translation initiation factor 3. Comparison of homologues from human, Nicotiana tabacum, Caenorhabditis elegans, and Saccharomyces cerevisiae, J. Biol. Chem., 272, 7106, 10.1074/jbc.272.11.7106 Vornlocher, 1999, A 110-kilodalton subunit of translation initiation factor eIF3 and an associated 135-kilodalton protein are encoded by the Saccharomyces cerevisiae TIF32 and TIF31 genes, J. Biol. Chem., 274, 16802, 10.1074/jbc.274.24.16802 Hofmann, 1998, The PCI domain: a common theme in three multiprotein complexes, Trends Biochem. Sci., 23, 204, 10.1016/S0968-0004(98)01217-1 Zhou, 2005, PCI proteins eIF3e and eIF3m define distinct translation initiation factor 3 complexes, BMC Biol., 3, 14, 10.1186/1741-7007-3-14 Dessau, 2008, The Arabidopsis COP9 signalosome subunit 7 is a model PCI domain protein with subdomains involved in COP9 signalosome assembly, Plant Cell, 20, 2815, 10.1105/tpc.107.053801 Pascual, 1997, Solution structure of the spectrin repeat: a left-handed antiparallel triple-helical coiled-coil, J. Mol. Biol., 273, 740, 10.1006/jmbi.1997.1344 Pincheira, 2001, Two subcellular localizations of eIF3 p170 and its interaction with membrane-bound microfilaments: implications for alternative functions of p170, Eur. J. Cell Biol., 80, 410, 10.1078/0171-9335-00176 T. Nagase, N. Seki, A. Tanaka, K. Ishikawa, N. Nomura, Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. DNA Res. 2 (1995) 167–174, 199–210. Methot, 1997, The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170, J. Biol. Chem., 272, 1110, 10.1074/jbc.272.2.1110 Asano, 1998, Complex formation by all five homologues of mammalian translation initiation factor 3 subunits from yeast Saccharomyces cerevisiae, J. Biol. Chem., 273, 18573, 10.1074/jbc.273.29.18573 Block, 1998, Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3, J. Biol. Chem., 273, 31901, 10.1074/jbc.273.48.31901 Valasek, 2001, Related eIF3 subunits TIF32 and HCR1 interact with an RNA recognition motif in PRT1 required for eIF3 integrity and ribosome binding, EMBO J., 20, 891, 10.1093/emboj/20.4.891 Valasek, 2002, Direct eIF2–eIF3 contact in the multifactor complex is important for translation initiation in vivo, EMBO J., 21, 5886, 10.1093/emboj/cdf563 Valasek, 1999, The Saccharomyces cerevisiae HCR1 gene encoding a homologue of the p35 subunit of human translation initiation factor 3 (eIF3) is a high copy suppressor of a temperature-sensitive mutation in the Rpg1p subunit of yeast eIF3, J. Biol. Chem., 274, 27567, 10.1074/jbc.274.39.27567 Mayeur, 2003, Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3, Eur. J. Biochem., 270, 4133, 10.1046/j.1432-1033.2003.03807.x Valasek, 2003, The yeast eIF3 subunits TIF32/a, NIP1/c, and eIF5 make critical connections with the 40S ribosome in vivo, Genes Dev., 17, 786, 10.1101/gad.1065403 Szamecz, 2008, eIF3a cooperates with sequences 5′ of uORF1 to promote resumption of scanning by post-termination ribosomes for reinitiation on GCN4 mRNA, Genes Dev., 22, 2414, 10.1101/gad.480508 Asano, 2000, A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo, Genes Dev., 14, 2534, 10.1101/gad.831800 Phan, 2001, A subcomplex of three eIF3 subunits binds eIF1 and eIF5 and stimulates ribosome binding of mRNA and tRNA(i)Met, EMBO J., 20, 2954, 10.1093/emboj/20.11.2954 Gradi, 1998, A novel functional human eukaryotic translation initiation factor 4G, Mol. Cell. Biol., 18, 334, 10.1128/MCB.18.1.334 Methot, 1996, A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3, Mol. Cell. Biol., 16, 5328, 10.1128/MCB.16.10.5328 Kroczynska, 2009, Interferon-dependent engagement of eukaryotic initiation factor 4B via S6 kinase (S6K)- and ribosomal protein S6K-mediated signals, Mol. Cell. Biol., 29, 2865, 10.1128/MCB.01537-08 Asp, 2008, Fission yeast mitogen-activated protein kinase Sty1 interacts with translation factors, Eukaryot. Cell, 7, 328, 10.1128/EC.00358-07 Lin, 2001, Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7, J. Cell. Biochem., 80, 483, 10.1002/1097-4644(20010315)80:4<483::AID-JCB1002>3.0.CO;2-B Scholler, 1997, The human p167 gene encodes a unique structural protein that contains centrosomin A homology and associates with a multicomponent complex, DNA Cell Biol., 16, 515, 10.1089/dna.1997.16.515 MacDonald, 1999, Activity-dependent interaction of the intracellular domain of rat trkA with intermediate filament proteins, the beta-6 proteasomal subunit, Ras-GRF1, and the p162 subunit of eIF3, J. Mol. Neurosci., 13, 141, 10.1385/JMN:13:1-2:141 Buratti, 1998, Functional analysis of the interaction between HCV 5′UTR and putative subunits of eukaryotic translation initiation factor eIF3, Nucleic Acids Res., 26, 3179, 10.1093/nar/26.13.3179 Kuramochi-Miyagawa, 2004, Mili, a mammalian member of piwi family gene, is essential for spermatogenesis, Development, 131, 839, 10.1242/dev.00973 Unhavaithaya, 2009, MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation, J. Biol. Chem., 284, 6507, 10.1074/jbc.M809104200 Liu, 2007, Role of eIF3a (eIF3 p170) in intestinal cell differentiation and its association with early development, Differentiation, 75, 652, 10.1111/j.1432-0436.2007.00165.x Severin, 1997, A major 170kDa protein associated with bovine adrenal medulla microtubules: a member of the centrosomin family?, FEBS Lett., 420, 125, 10.1016/S0014-5793(97)01501-9 Adelman, 1973, Ribosome-membrane interaction. Nondestructive disassembly of rat liver rough microsomes into ribosomal and membranous components, J. Cell Biol., 56, 206, 10.1083/jcb.56.1.206 Shi, 1996, The subcellular distribution of eukaryotic translation initiation factor, eIF-5A, in cultured cells, Exp. Cell Res., 225, 348, 10.1006/excr.1996.0185 Hasek, 2000, Rpg1p, the subunit of the Saccharomyces cerevisiae eIF3 core complex, is a microtubule-interacting protein, Cell Motil. Cytoskeleton, 45, 235, 10.1002/(SICI)1097-0169(200003)45:3<235::AID-CM6>3.0.CO;2-I Hall, 1998, Rho GTPases and the actin cytoskeleton, Science, 279, 509, 10.1126/science.279.5350.509 Shanina, 2001, Translation initiation factor eIF3 is able to bind with microtubules in mammalian cells, Mol. Biol. (Mosk), 35, 638, 10.1023/A:1010518925622 Petzelt, 1997, The centrosomal protein centrosomin A and the nuclear protein centrosomin B derive from one gene by post-transcriptional processes involving RNA editing, J. Cell Sci., 110, 2573, 10.1242/jcs.110.20.2573 Chudinova, 2004, Large subunit of translation initiation factor-3 p170 contains potentially functional nuclear localization signals, Mol. Biol. (Mosk), 38, 684, 10.1023/B:MBIL.0000037010.48936.af Strudwick, 2002, The emerging roles of translation factor eIF4E in the nucleus, Differentiation, 70, 10, 10.1046/j.1432-0436.2002.700102.x Nakai, 2005, Externalization and recognition by macrophages of large subunit of eukaryotic translation initiation factor 3 in apoptotic cells, Exp. Cell Res., 309, 137, 10.1016/j.yexcr.2005.05.006 Chaudhuri, 1997, Biochemical characterization of mammalian translation initiation factor 3 (eIF3). Molecular cloning reveals that p110 subunit is the mammalian homologue of Saccharomyces cerevisiae protein Prt1, J. Biol. Chem., 272, 30975, 10.1074/jbc.272.49.30975 Dong, 2003, EIF3 p170, a mediator of mimosine effect on protein synthesis and cell cycle progression, Mol. Biol. Cell, 14, 3942, 10.1091/mbc.E02-12-0784 Dong, 2004, Role of eIF3 p170 in controlling synthesis of ribonucleotide reductase M2 and cell growth, Oncogene, 23, 3790, 10.1038/sj.onc.1207465 Dong, 2009, Role of eIF3a in regulating cell cycle progression, Exp. Cell Res., 315, 1889, 10.1016/j.yexcr.2009.03.009 Kittler, 2004, An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division, Nature, 432, 1036, 10.1038/nature03159 Kozak, 1992, Regulation of translation in eukaryotic systems, Annu. Rev. Cell Biol., 8, 197, 10.1146/annurev.cb.08.110192.001213 Etchison, 1990, Variations in cap-binding complexes from uninfected and poliovirus-infected HeLa cells, J. Biol. Chem., 265, 7492, 10.1016/S0021-9258(19)39140-9 Smith, 1975, Binding of Met-tRNA-f to native and derived 40S ribosomal subunits, Biochemistry, 14, 1060, 10.1021/bi00676a028 Thompson, 1977, Studies on native ribosomal subunits from rat liver. Purification and characterization of a ribosome dissociation factor, Biochemistry, 16, 2221, 10.1021/bi00629a028 Chaudhuri, 1999, Distinct functions of eukaryotic translation initiation factors eIF1A and eIF3 in the formation of the 40S ribosomal preinitiation complex, J. Biol. Chem., 274, 17975, 10.1074/jbc.274.25.17975 Goss, 1988, Effects of eucaryotic initiation factor 3 on eucaryotic ribosomal subunit equilibrium and kinetics, Biochemistry, 27, 1489, 10.1021/bi00405a014 Trachsel, 1979, Initiation of mammalian protein synthesis. The multiple functions of the initiation factor eIF-3, Biochim. Biophys. Acta, 565, 305, 10.1016/0005-2787(79)90207-7 Henshaw, 1973, The ribosome cycle in mammalian protein synthesis. I. The place of monomeric ribosomes and ribosomal subunits in the cycle, J. Biol. Chem., 248, 4367, 10.1016/S0021-9258(19)43780-0 Checkley, 1981, Characterization of initiation factor eIF-3 from wheat germ, J. Biol. Chem., 256, 1582, 10.1016/S0021-9258(19)69844-3 Baugh, 2004, 20S proteasome differentially alters translation of different mRNAs via the cleavage of eIF4F and eIF3, Mol. Cell, 16, 575, 10.1016/j.molcel.2004.10.017 Fraser, 2004, The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40S ribosomal subunits in vitro, J. Biol. Chem., 279, 8946, 10.1074/jbc.M312745200 Valasek, 1998, Rpg1, the Saccharomyces cerevisiae homologue of the largest subunit of mammalian translation initiation factor 3, is required for translational activity, J. Biol. Chem., 273, 21253, 10.1074/jbc.273.33.21253 Kovarik, 1998, RPG1: an essential gene of Saccharomyces cerevisiae encoding a 110-kDa protein required for passage through the G1 phase, Curr. Genet., 33, 100, 10.1007/s002940050314 Grousl, 2009, Robust heat shock induces eIF2alpha-phosphorylation-independent assembly of stress granules containing eIF3 and 40S ribosomal subunits in budding yeast. Saccharomyces cerevisiae, J. Cell Sci., 122, 2078, 10.1242/jcs.045104 Kedersha, 2002, Evidence that ternary complex (eIF2-GTP-tRNA(i)(Met))-deficient preinitiation complexes are core constituents of mammalian stress granules, Mol. Biol. Cell, 13, 195, 10.1091/mbc.01-05-0221 Ivanov, 2003, Disruption of microtubules inhibits cytoplasmic ribonucleoprotein stress granule formation, Exp. Cell Res., 290, 227, 10.1016/S0014-4827(03)00290-8 Lalande, 1990, A reversible arrest point in the late G1 phase of the mammalian cell cycle, Exp. Cell Res., 186, 332, 10.1016/0014-4827(90)90313-Y Mosca, 1992, The plant amino acid mimosine may inhibit initiation at origins of replication in Chinese hamster cells, Mol. Cell. Biol., 12, 4375, 10.1128/MCB.12.10.4375 Kang, 1994, Effect of initiation factor eIF-5A depletion on protein synthesis and proliferation of Saccharomyces cerevisiae, J. Biol. Chem., 269, 3934, 10.1016/S0021-9258(17)41723-6 Yoon, 2002, Iron chelation-induced senescence-like growth arrest in hepatocyte cell lines: association of transforming growth factor beta1 (TGF-beta1)-mediated p27Kip1 expression, Biochem. J., 366, 613, 10.1042/bj20011445 Richardson, 1994, The effect of the iron(III) chelator, desferrioxamine, on iron and transferrin uptake by the human malignant melanoma cell, Cancer Res., 54, 685 Richardson, 1992, Intermediate steps in cellular iron uptake from transferrin. Detection of a cytoplasmic pool of iron, free of transferrin, J. Biol. Chem., 267, 21384, 10.1016/S0021-9258(19)36621-9 Toyoshima, 1994, p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21, Cell, 78, 67, 10.1016/0092-8674(94)90573-8 Nogales, 2000, Structural insights into microtubule function, Annu. Rev. Biochem., 69, 277, 10.1146/annurev.biochem.69.1.277 Wright, 1990, Regulation and drug resistance mechanisms of mammalian ribonucleotide reductase, and the significance to DNA synthesis, Biochem. Cell Biol., 68, 1364, 10.1139/o90-199 Gonzalez-Garay, 1996, alpha-Tubulin limits its own synthesis: evidence for a mechanism involving translational repression, J. Cell Biol., 135, 1525, 10.1083/jcb.135.6.1525 Eriksson, 1984, Cell cycle-dependent regulation of mammalian ribonucleotide reductase. The S phase-correlated increase in subunit M2 is regulated by de novo protein synthesis, J. Biol. Chem., 259, 11695, 10.1016/S0021-9258(20)71265-2 Fey, 1986, The morphological oncogenic signature. Reorganization of epithelial cytoarchitecture and metabolic regulation by tumor promoters and by transformation, Dev. Biol. (N. Y. 1985), 3, 81 Hwang, 2007, Benzo(a)pyrene inhibits growth and functional differentiation of mouse bone marrow-derived dendritic cells. Downregulation of RelB and eIF3 p170 by benzo(a)pyrene, Toxicol. Lett., 169, 82, 10.1016/j.toxlet.2007.01.001 Dong, 2005, Modulation of differentiation-related gene 1 expression by cell cycle blocker mimosine, revealed by proteomic analysis, Mol. Cell. Proteomics, 4, 993, 10.1074/mcp.M500044-MCP200 Ellen, 2008, NDRG1, a growth and cancer related gene: regulation of gene expression and function in normal and disease states, Carcinogenesis, 29, 2, 10.1093/carcin/bgm200 Kovacevic, 2008, The iron-regulated metastasis suppressor, Ndrg-1: identification of novel molecular targets, Biochim. Biophys. Acta, 1783, 1981, 10.1016/j.bbamcr.2008.05.016 van Belzen, 1997, A novel gene which is up-regulated during colon epithelial cell differentiation and down-regulated in colorectal neoplasms, Lab. Invest., 77, 85 Kokame, 1996, Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes, J. Biol. Chem., 271, 29659, 10.1074/jbc.271.47.29659 Le, 2004, Iron chelators with high antiproliferative activity up-regulate the expression of a growth inhibitory and metastasis suppressor gene: a link between iron metabolism and proliferation, Blood, 104, 2967, 10.1182/blood-2004-05-1866 Salnikow, 2002, The regulation of hypoxic genes by calcium involves c-Jun/AP-1, which cooperates with hypoxia-inducible factor 1 in response to hypoxia, Mol. Cell. Biol., 22, 1734, 10.1128/MCB.22.6.1734-1741.2002 Ulrix, 1999, The differentiation-related gene 1, Drg1, is markedly upregulated by androgens in LNCaP prostatic adenocarcinoma cells, FEBS Lett., 455, 23, 10.1016/S0014-5793(99)00845-5 Zhou, 1998, Cap43, a novel gene specifically induced by Ni2+ compounds, Cancer Res., 58, 2182 Kurdistani, 1998, Inhibition of tumor cell growth by RTP/rit42 and its responsiveness to p53 and DNA damage, Cancer Res., 58, 4439 Pierce, 1988, Tumors as caricatures of the process of tissue renewal: prospects for therapy by directing differentiation, Cancer Res., 48, 1996 Amara, 1994, Phorbol ester modulation of a novel cytoplasmic protein binding activity at the 3′-untranslated region of mammalian ribonucleotide reductase R2 mRNA and role in message stability, J. Biol. Chem., 269, 6709, 10.1016/S0021-9258(17)37433-1 Chen, 2000, Inhibition of human cancer cell growth by inducible expression of human ribonucleotide reductase antisense cDNA, Antisense Nucleic Acid Drug Dev., 10, 111, 10.1089/oli.1.2000.10.111 Fan, 1996, Ribonucleotide reductase R2 component is a novel malignancy determinant that cooperates with activated oncogenes to determine transformation and malignant potential, Proc. Natl. Acad. Sci. U. S. A., 93, 14036, 10.1073/pnas.93.24.14036 Hurta, 1995, Malignant transformation by H-ras results in aberrant regulation of ribonucleotide reductase gene expression by transforming growth factor-beta 1, J. Cell. Biochem., 57, 543, 10.1002/jcb.240570319 Lee, 2003, GTI-2040, an antisense agent targeting the small subunit component (R2) of human ribonucleotide reductase, shows potent antitumor activity against a variety of tumors, Cancer Res., 63, 2802 Zhou, 1998, Overexpression of transfected human ribonucleotide reductase M2 subunit in human cancer cells enhances their invasive potential, Clin. Exp. Metastasis, 16, 43, 10.1023/A:1006559901771 Kalinowski, 2005, The evolution of iron chelators for the treatment of iron overload disease and cancer, Pharmacol. Rev., 57, 547, 10.1124/pr.57.4.2 Whitnall, 2006, A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics, Proc. Natl. Acad. Sci. U. S. A., 103, 14901, 10.1073/pnas.0604979103 Yuan, 2004, Novel di-2-pyridyl-derived iron chelators with marked and selective antitumor activity: in vitro and in vivo assessment, Blood, 104, 1450, 10.1182/blood-2004-03-0868 Platanias, 2005, Mechanisms of type-I- and type-II-interferon-mediated signalling, Nat. Rev. Immunol., 5, 375, 10.1038/nri1604 Saramaki, 2001, Amplification of EIF3S3 gene is associated with advanced stage in prostate cancer, Am. J. Pathol., 159, 2089, 10.1016/S0002-9440(10)63060-X Buttitta, 2005, Int6 expression can predict survival in early-stage non-small cell lung cancer patients, Clin. Cancer Res., 11, 3198, 10.1158/1078-0432.CCR-04-2308 Mayeur, 2002, Malignant transformation by the eukaryotic translation initiation factor 3 subunit p48 (eIF3e), FEBS Lett., 514, 49, 10.1016/S0014-5793(02)02307-4 Lazaris-Karatzas, 1990, Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5′ cap, Nature, 345, 544, 10.1038/345544a0 Fukuchi-Shimogori, 1997, Malignant transformation by overproduction of translation initiation factor eIF4G, Cancer Res., 57, 5041 Donze, 1995, Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells, EMBO J., 14, 3828, 10.1002/j.1460-2075.1995.tb00052.x