The toxicogenomics of nuclear receptor agonists

Francis, 2003, Nuclear receptors and the control of metabolism, Annu Rev Physiol, 65, 261, 10.1146/annurev.physiol.65.092101.142528 Chiang, 2002, Bile acid regulation of gene expression: roles of nuclear hormone receptors, Endocr Rev, 23, 443, 10.1210/er.2000-0035 Chiang, 2003, Bile acid regulation of hepatic physiology III. Bile acids and nuclear receptors, Am J Physiol Gastrointest Liver Physiol, 284, G349, 10.1152/ajpgi.00417.2002 Willson, 2002, PXR, CAR and drug metabolism, Nat Rev Drug Discov, 1, 259, 10.1038/nrd753 Sonoda, 2002, Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR), Proc Natl Acad Sci USA, 99, 13801, 10.1073/pnas.212494599 Xie, 2003, Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor, Proc Natl Acad Sci USA, 100, 4150, 10.1073/pnas.0438010100 Staudinger, 2003, Regulation of drug transporter gene expression by nuclear receptors, Drug Metab Dispos, 31, 523, 10.1124/dmd.31.5.523 Fuhr, 2000, Induction of drug metabolising enzymes: pharmacokinetic and toxicological consequences in humans, Clin Pharmacokinet, 38, 493, 10.2165/00003088-200038060-00003 He, 2001, Troglitazone quinone formation catalyzed by human and rat CYP3A: an analytical CYP oxidation reaction, Biochem Pharmacol, 62, 191, 10.1016/S0006-2952(01)00653-0 Kassahun, 2001, Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission, Chem Res Toxicol, 14, 62, 10.1021/tx000180q Jones, 2000, The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution, Mol Endocrinol, 14, 27, 10.1210/me.14.1.27 Sahi, 2000, Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes, Xenobiotica, 30, 273, 10.1080/004982500237668 Zhang, 2002, Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR, Science, 298, 422, 10.1126/science.1073502 Staudinger, 2001, The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity, Proc Natl Acad Sci USA, 98, 3369, 10.1073/pnas.051551698 Coumoul, 2002, PXR-dependent induction of human CYP3A4 gene expression by organochlorine pesticides, Biochem Pharmacol, 64, 1513, 10.1016/S0006-2952(02)01298-4 Sonoda, 2003, A nuclear receptor-mediated xenobiotic response and its implication in drug metabolism and host protection, Current Drug Metabolism, 4, 59, 10.2174/1389200033336739 Ueda, 2002, Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital, Mol Pharmacol, 61, 1, 10.1124/mol.61.1.1 Maglich, 2002, Nuclear pregnane X receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification, Mol Pharmacol, 62, 638, 10.1124/mol.62.3.638 Rosenfeld JM, Vargas RJ, Xie W, Evans RM: Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor PXR. Mol Endocrinol 2003, in press. [epub ahead of print: doi 10.1210/me.2002-0421.] Tugwood, 2002, Biology and toxicology of PPARγ ligands, Hum Exp Toxicol, 21, 429, 10.1191/0960327102ht282oa Nakajima, 2002, Functional activation of peroxisome proliferator-activated receptor alpha (PPARalpha) by environmental chemicals in relation to their toxicities, Nagoya J Med Sci, 65, 85 Boitier E, Gautier J-C, Roberts R: Advances in understanding the regulation of apoptosis and mitosis by peroxisome-proliferator activated receptors in pre-clinical models: relevance for human health and disease. Comparative Hepatology 2003, 2 in press. Roberts, 2002, PPARα and the regulation of cell division and apoptosis, Toxicology, 181-182, 167, 10.1016/S0300-483X(02)00275-5 Hamadeh, 2002, Gene expression analysis reveals chemical-specific profiles, Toxicol Sci, 67, 219, 10.1093/toxsci/67.2.219 Yamazaki, 2002, Microarray analysis of gene expression changes in mouse liver induced by peroxisome proliferator-activated receptor α agonists, Biochem Biophys Res Commun, 290, 1114, 10.1006/bbrc.2001.6319 Cherkaoui-Malki, 2001, Identification of novel peroxisome proliferator-activated receptor alpha (PPARalpha) target genes in mouse liver using cDNA microarray analysis, Gene Expr, 9, 291, 10.3727/000000001783992533 Cai, 2002, The role of hepatocyte RXRα in xenobiotic-sensing nuclear receptor-mediated pathways, Eur J Pharm Sci, 15, 89, 10.1016/S0928-0987(01)00211-1 Mimura, 2003, Functional role of AhR in the expression of toxic effects by TCDD, Biochim Biophys Acta, 1619, 263, 10.1016/S0304-4165(02)00485-3 Nebert, 2000, Role of aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control and apoptosis, Biochem Pharmacol, 59, 65, 10.1016/S0006-2952(99)00310-X Frueh, 2001, Identification of dioxin-responsive genes in Hep G2 cells using differential mRNA display RT-PCR, Toxicol Lett, 122, 189, 10.1016/S0378-4274(01)00364-2 Waring, 2001, Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles, Toxicol Appl Pharmacol, 175, 28, 10.1006/taap.2001.9243 Waring, 2002, Identifying toxic mechanisms using DNA microarrays: evidence that an experimental inhibitor of cell adhesion molecule expression signals through the aryl hydrocarbon nuclear receptor, Toxicology, 181-182, 537, 10.1016/S0300-483X(02)00477-8 Martinez, 2002, Differential toxicogenomic responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin in malignant and nonmalignant human airway epithelial cells, Toxicol Sci, 69, 409, 10.1093/toxsci/69.2.409 Waters, 2001, Differential gene expression in response to methoxychlor and estradiol through ERα, ERβ, and AR in reproductive tissues of female mice, Toxicol Sci, 63, 47, 10.1093/toxsci/63.1.47 Crump, 2002, Exposure to the herbicide acetochlor alters thyroid hormone-dependent gene expression and metamorphosis in Xenopus laevis, Environ Health Perspect, 110, 1199, 10.1289/ehp.021101199