The tolerogenic role of IFN-γ

Cytokine & Growth Factor Reviews - Tập 41 - Trang 40-53 - 2018
Primož Rožman1, Urban Švajger1
1Blood Transfusion Centre of Slovenia, Department for Diagnostic Services, Šlajmerjeva 6, 1000, Ljubljana, Slovenia

Tài liệu tham khảo

Wheelock, 1965, Interferon-Like Virus-Inhibitor Induced in Human Leukocytes by Phytohemagglutinin, Science, 149, 310, 10.1126/science.149.3681.310 Eberl, 2015, Innate lymphoid cells., Innate lymphoid cells: a new paradigm in immunology, Science, 348, aaa6566 Schroder, 2004, Interferon-gamma: an overview of signals, mechanisms and functions, J Leukoc Biol, 75, 163, 10.1189/jlb.0603252 Frucht, 2001, IFN-gamma production by antigen-presenting cells: mechanisms emerge, Trends Immunol, 22, 556, 10.1016/S1471-4906(01)02005-1 Nathan, 1983, Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity, J Exp Med, 158, 670, 10.1084/jem.158.3.670 Young, 1995, Role of interferon-gamma in immune cell regulation, J Leukoc Biol, 58, 373, 10.1002/jlb.58.4.373 Murray, 1985, Activation of mouse peritoneal macrophages in vitro and in vivo by interferon-gamma, J Immunol, 134, 1619, 10.4049/jimmunol.134.3.1619 Flynn, 1993, An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection, J Exp Med, 178, 2249, 10.1084/jem.178.6.2249 Suzuki, 1988, Interferon-gamma: the major mediator of resistance against Toxoplasma gondii, Science, 240, 516, 10.1126/science.3128869 Dunn, 2006, Interferons, immunity and cancer immunoediting, Nat Rev Immunol, 6, 836, 10.1038/nri1961 Steinman, 2003, Tolerogenic dendritic cells, Annu Rev Immunol, 21, 685, 10.1146/annurev.immunol.21.120601.141040 Matzinger, 2002, The danger model: a renewed sense of self, Science, 296, 301, 10.1126/science.1071059 Takenaka, 2017, Tolerogenic dendritic cells, Semin Immunopathol, 39, 113, 10.1007/s00281-016-0587-8 Svajger, 2014, Tolerogenic dendritic cells: molecular and cellular mechanisms in transplantation, J Leukoc Biol, 95, 53, 10.1189/jlb.0613336 Wieckowski, 2011, Type-1 polarized dendritic cells loaded with apoptotic prostate cancer cells are potent inducers of CD8(+) T cells against prostate cancer cells and defined prostate cancer-specific epitopes, Prostate, 71, 125, 10.1002/pros.21228 Vieira, 2000, Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction, J Immunol, 164, 4507, 10.4049/jimmunol.164.9.4507 Munn, 2005, GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase, Immunity, 22, 633, 10.1016/j.immuni.2005.03.013 Cobbold, 2009, Infectious tolerance via the consumption of essential amino acids and mTOR signaling, Proc Natl Acad Sci U S A, 106, 12055, 10.1073/pnas.0903919106 Munn, 2013, Indoleamine 2,3 dioxygenase and metabolic control of immune responses, Trends Immunol, 34, 137, 10.1016/j.it.2012.10.001 Jurgens, 2009, Interferon-gamma-triggered indoleamine 2,3-dioxygenase competence in human monocyte-derived dendritic cells induces regulatory activity in allogeneic T cells, Blood, 114, 3235, 10.1182/blood-2008-12-195073 Li, 2016, Tolerogenic Phenotype of IFN-gamma-Induced IDO+ Dendritic Cells Is Maintained via an Autocrine IDO-Kynurenine/AhR-IDO Loop, J Immunol, 197, 962, 10.4049/jimmunol.1502615 Nguyen, 2010, Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism, Proc Natl Acad Sci U S A, 107, 19961, 10.1073/pnas.1014465107 Xiao, 2004, Therapeutic potential of IFN-gamma-modified dendritic cells in acute and chronic experimental allergic encephalomyelitis, Int Immunol, 16, 13, 10.1093/intimm/dxh003 Svajger, 2014, IFN-gamma-rich environment programs dendritic cells toward silencing of cytotoxic immune responses, J Leukoc Biol, 95, 33, 10.1189/jlb.1112589 Contini, 2003, Soluble HLA-A,-B,-C and -G molecules induce apoptosis in T and NK CD8+ cells and inhibit cytotoxic T cell activity through CD8 ligation, Eur J Immunol, 33, 125, 10.1002/immu.200390015 Vignali, 2008, How regulatory T cells work, Nat Rev Immunol, 8, 523, 10.1038/nri2343 Koch, 2009, The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation, Nat Immunol, 10, 595, 10.1038/ni.1731 Liston, 2014, Homeostatic control of regulatory T cell diversity, Nat Rev Immunol, 14, 154, 10.1038/nri3605 Zheng, 2011, Generation of human Th1-like regulatory CD4+ T cells by an intrinsic IFN-gamma- and T-bet-dependent pathway, Eur J Immunol, 41, 128, 10.1002/eji.201040724 Feng, 2008, Exogenous IFN-gamma ex vivo shapes the alloreactive T-cell repertoire by inhibition of Th17 responses and generation of functional Foxp3+ regulatory T cells, Eur J Immunol, 38, 2512, 10.1002/eji.200838411 Komatsu, 2014, Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis, Nat Med, 20, 62, 10.1038/nm.3432 Takahashi, 2011, SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-{gamma} and IL-17A production, J Exp Med, 208, 2055, 10.1084/jem.20110428 Sawitzki, 2005, IFN-gamma production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo, J Exp Med, 201, 1925, 10.1084/jem.20050419 Daniel, 2008, Observational support for an immunoregulatory role of CD3+CD4+CD25+IFN-gamma+ blood lymphocytes in kidney transplant recipients with good long-term graft outcome, Transpl Int, 21, 646, 10.1111/j.1432-2277.2008.00662.x Jiang, 2011, Transplant long-surviving induced by CD40-CD40 ligand costimulation blockade is dependent on IFN-gamma through its effect on CD4(+)CD25(+) regulatory T cells, Transpl Immunol, 24, 113, 10.1016/j.trim.2010.10.005 Koenecke, 2012, IFN-gamma production by allogeneic Foxp3+ regulatory T cells is essential for preventing experimental graft-versus-host disease, J Immunol, 189, 2890, 10.4049/jimmunol.1200413 Naves, 2013, The interdependent, overlapping, and differential roles of type I and II IFNs in the pathogenesis of experimental autoimmune encephalomyelitis, J Immunol, 191, 2967, 10.4049/jimmunol.1300419 Tanuma, 1999, Differential role of TNF-alpha and IFN-gamma in the brain of rats with chronic relapsing autoimmune encephalomyelitis, J Neuroimmunol, 96, 73, 10.1016/S0165-5728(99)00018-1 Furlan, 2001, Intrathecal delivery of IFN-gamma protects C57BL/6 mice from chronic-progressive experimental autoimmune encephalomyelitis by increasing apoptosis of central nervous system-infiltrating lymphocytes, J Immunol, 167, 1821, 10.4049/jimmunol.167.3.1821 Olsson, 1992, Cytokines in neuroinflammatory disease: role of myelin autoreactive T cell production of interferon-gamma, J Neuroimmunol, 40, 211, 10.1016/0165-5728(92)90135-8 Fletcher, 2010, T cells in multiple sclerosis and experimental autoimmune encephalomyelitis, Clin Exp Immunol, 162, 1, 10.1111/j.1365-2249.2010.04143.x Aranami, 2008, Th17 Cells and autoimmune encephalomyelitis (EAE/MS),, Allergol Int, 57, 115, 10.2332/allergolint.R-07-159 Noack, 2014, Th17 and regulatory T cell balance in autoimmune and inflammatory diseases, Autoimmun Rev, 13, 668, 10.1016/j.autrev.2013.12.004 Berghmans, 2011, Interferon-gamma orchestrates the number and function of Th17 cells in experimental autoimmune encephalomyelitis, J Interferon Cytokine Res, 31, 575, 10.1089/jir.2010.0137 Billiau, 1988, Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-gamma, J Immunol, 140, 1506, 10.4049/jimmunol.140.5.1506 Heremans, 1996, Chronic relapsing experimental autoimmune encephalomyelitis (CREAE) in mice: enhancement by monoclonal antibodies against interferon-gamma, Eur J Immunol, 26, 2393, 10.1002/eji.1830261019 Rajaiah, 2011, Interleukin-27 and interferon-gamma are involved in regulation of autoimmune arthritis, J Biol Chem, 286, 2817, 10.1074/jbc.M110.187013 Murugaiyan, 2010, Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation, Proc Natl Acad Sci U S A, 107, 11495, 10.1073/pnas.1002099107 Chong, 2015, NK-DC crosstalk controls the autopathogenic Th17 response through an innate IFN-gamma-IL-27 axis, J Exp Med, 212, 1739, 10.1084/jem.20141678 Kaplan, 2013, Th9 cells: differentiation and disease, Immunol Rev, 252, 104, 10.1111/imr.12028 Elyaman, 2017, Th9 cells in the pathogenesis of EAE and multiple sclerosis, Semin Immunopathol, 39, 79, 10.1007/s00281-016-0604-y Murugaiyan, 2012, IFN-gamma limits Th9-mediated autoimmune inflammation through dendritic cell modulation of IL-27, J Immunol, 189, 5277, 10.4049/jimmunol.1200808 Vermeire, 1997, Accelerated collagen-induced arthritis in IFN-gamma receptor-deficient mice, J Immunol, 158, 5507, 10.4049/jimmunol.158.11.5507 Kelchtermans, 2005, Defective CD4+CD25+ regulatory T cell functioning in collagen-induced arthritis: an important factor in pathogenesis, counter-regulated by endogenous IFN-gamma, Arthritis Res Ther, 7, R402, 10.1186/ar1500 De Klerck, 2004, Enhanced osteoclast development in collagen-induced arthritis in interferon-gamma receptor knock-out mice as related to increased splenic CD11b+ myelopoiesis, Arthritis Res Ther, 6, R220, 10.1186/ar1167 Kelchtermans, 2007, Protective role of IFN-γ in collagen-induced arthritis conferred by inhibition of mycobacteria-induced granulocyte chemotactic protein-2 production, Journal of Leukocyte Biology, 81, 1044, 10.1189/jlb.0806486 Kageyama, 1998, Reduced susceptibility to collagen-induced arthritis in mice deficient in IFN-gamma receptor, J Immunol, 161, 1542, 10.4049/jimmunol.161.3.1542 Kim, 2008, Regulation of autoimmune arthritis by the pro-inflammatory cytokine interferon-gamma, Clin Immunol, 127, 98, 10.1016/j.clim.2008.01.003 Satpute, 2009, Tolerization with Hsp65 induces protection against adjuvant-induced arthritis by modulating the antigen-directed interferon-gamma, interleukin-17, and antibody responses, Arthritis Rheum, 60, 103, 10.1002/art.24139 Chabaud, 1999, Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium, Arthritis Rheum, 42, 963, 10.1002/1529-0131(199905)42:5<963::AID-ANR15>3.0.CO;2-E Raza, 2006, Synovial fluid leukocyte apoptosis is inhibited in patients with very early rheumatoid arthritis, Arthritis Res Ther, 8, R120, 10.1186/ar2009 Nakae, 2003, Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice, J Immunol, 171, 6173, 10.4049/jimmunol.171.11.6173 Kolls, 2004, Interleukin-17 family members and inflammation, Immunity, 21, 467, 10.1016/j.immuni.2004.08.018 Harrington, 2005, Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages, Nat Immunol, 6, 1123, 10.1038/ni1254 Park, 2005, A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17, Nat Immunol, 6, 1133, 10.1038/ni1261 Kelchtermans, 2009, Effector mechanisms of interleukin-17 in collagen-induced arthritis in the absence of interferon-gamma and counteraction by interferon-gamma, Arthritis Res Ther, 11, R122, 10.1186/ar2787 Sarkar, 2013, Interleukin-22 reduces the severity of collagen-induced arthritis in association with increased levels of interleukin-10, Arthritis Rheum, 65, 960, 10.1002/art.37849 Obermeier, 1999, Interferon-gamma (IFN-gamma)- and tumour necrosis factor (TNF)-induced nitric oxide as toxic effector molecule in chronic dextran sulphate sodium (DSS)-induced colitis in mice, Clin Exp Immunol, 116, 238, 10.1046/j.1365-2249.1999.00878.x Ito, 2006, Interferon-gamma is causatively involved in experimental inflammatory bowel disease in mice, Clin Exp Immunol, 146, 330, 10.1111/j.1365-2249.2006.03214.x Singh, 2003, Inhibition of IFN-gamma-inducible protein-10 abrogates colitis in IL-10-/- mice,, J Immunol, 171, 1401, 10.4049/jimmunol.171.3.1401 Singh, 2003, IFN-gamma-inducible chemokines enhance adaptive immunity and colitis, J Interferon Cytokine Res, 23, 591, 10.1089/107999003322485099 Harbour, 2015, Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis, Proceedings of the National Academy of Sciences, 112, 7061, 10.1073/pnas.1415675112 Kamada, 2008, Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis, J Clin Invest, 118, 2269 Davidson, 1998, IL-12, but not IFN-gamma, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice, J Immunol, 161, 3143, 10.4049/jimmunol.161.6.3143 Yen, 2006, IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6, J Clin Invest, 116, 1310, 10.1172/JCI21404 Cho, 2008, The genetics and immunopathogenesis of inflammatory bowel disease, Nat Rev Immunol, 8, 458, 10.1038/nri2340 Sheikh, 2010, Cutting edge: IFN-gamma is a negative regulator of IL-23 in murine macrophages and experimental colitis, J Immunol, 184, 4069, 10.4049/jimmunol.0903600 Cerovic, 2014, Intestinal macrophages and dendritic cells: what’s the difference?, Trends Immunol, 35, 270, 10.1016/j.it.2014.04.003 Muzaki, 2016, Intestinal CD103(+)CD11b(-) dendritic cells restrain colitis via IFN-gamma-induced anti-inflammatory response in epithelial cells, Mucosal Immunol, 9, 336, 10.1038/mi.2015.64 Siegmund, 2001, Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production, Am J Physiol Regul Integr Comp Physiol, 281, R1264, 10.1152/ajpregu.2001.281.4.R1264 Thelemann, 2014, Interferon-gamma induces expression of MHC class II on intestinal epithelial cells and protects mice from colitis, PLoS One, 9, e86844, 10.1371/journal.pone.0086844 Kambayashi, 2014, Atypical MHC class II-expressing antigen-presenting cells: can anything replace a dendritic cell?, Nat Rev Immunol, 14, 719, 10.1038/nri3754 Jagasia, 2012, Risk factors for acute GVHD and survival after hematopoietic cell transplantation, Blood, 119, 296, 10.1182/blood-2011-06-364265 Sung, 2013, Concise review: acute graft-versus-host disease: immunobiology, prevention, and treatment, Stem Cells Transl Med, 2, 25, 10.5966/sctm.2012-0115 Shlomchik, 1999, Prevention of graft versus host disease by inactivation of host antigen-presenting cells, Science, 285, 412, 10.1126/science.285.5426.412 Matte, 2004, Donor APCs are required for maximal GVHD but not for GVL, Nat Med, 10, 987, 10.1038/nm1089 Lu, 2009, Dichotomous role of interferon-gamma in allogeneic bone marrow transplant, Biol Blood Marrow Transplant, 15, 1347, 10.1016/j.bbmt.2009.07.015 Ghimire, 2017, Pathophysiology of GvHD and Other HSCT-Related Major Complications, Front Immunol, 8, 79, 10.3389/fimmu.2017.00079 Hill, 2000, The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation, Blood, 95, 2754, 10.1182/blood.V95.9.2754.009k25_2754_2759 Snijders, 1998, High-level IL-12 production by human dendritic cells requires two signals, Int Immunol, 10, 1593, 10.1093/intimm/10.11.1593 Wang, 2014, The complex and central role of interferon-gamma in graft-versus-host disease and graft-versus-tumor activity, Immunol Rev, 258, 30, 10.1111/imr.12151 Shlomchik, 2007, Transplantation’s greatest challenges: advances in chronic graft-versus-host disease, Biol Blood Marrow Transplant, 13, 2, 10.1016/j.bbmt.2006.10.020 Coghill, 2011, Effector CD4+ T cells, the cytokines they generate, and GVHD: something old and something new, Blood, 117, 3268, 10.1182/blood-2010-12-290403 Lamarthee, 2016, Donor interleukin-22 and host type I interferon signaling pathway participate in intestinal graft-versus-host disease via STAT1 activation and CXCL10, Mucosal Immunol, 9, 309, 10.1038/mi.2015.61 MacDonald, 2017, Chronic graft-versus-host disease: biological insights from preclinical and clinical studies, Blood, 129, 13, 10.1182/blood-2016-06-686618 Nava, 2010, Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways, Immunity, 32, 392, 10.1016/j.immuni.2010.03.001 Ellison, 2003, The role of interferon-gamma, nitric oxide and lipopolysaccharide in intestinal graft-versus-host disease developing in F1-hybrid mice, Immunology, 109, 440, 10.1046/j.1365-2567.2003.01663.x Wei, 2010, IFN-gamma triggered STAT1-PKB/AKT signalling pathway influences the function of alloantigen reactive regulatory T cells, Am J Transplant, 10, 69, 10.1111/j.1600-6143.2009.02858.x Lu, 2012, IFN-gamma and indoleamine 2,3-dioxygenase signaling between donor dendritic cells and T cells regulates graft versus host and graft versus leukemia activity, Blood, 119, 1075, 10.1182/blood-2010-12-322891 Kaminski, 1989, Prediction of graft versus host disease by frequency analysis of cytotoxic T cells after unrelated donor bone marrow transplantation, Transplantation, 48, 608 Valujskikh, 2002, Cross-primed CD8(+) T cells mediate graft rejection via a distinct effector pathway, Nat Immunol, 3, 844, 10.1038/ni831 Asavaroengchai, 2007, An essential role for IFN-gamma in regulation of alloreactive CD8 T cells following allogeneic hematopoietic cell transplantation, Biol Blood Marrow Transplant, 13, 46, 10.1016/j.bbmt.2006.09.014 Hill, 2011, Cell therapy with autologous tolerogenic dendritic cells induces allograft tolerance through interferon-gamma and epstein-barr virus-induced gene 3, Am J Transplant, 11, 2036, 10.1111/j.1600-6143.2011.03651.x Yang, 2002, Donor-derived interferon gamma separates graft-versus-leukemia effects and graft-versus-host disease induced by donor CD8 T cells, Blood, 99, 4207, 10.1182/blood.V99.11.4207 Chu, 2000, Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis, J Exp Med, 192, 123, 10.1084/jem.192.1.123 Dalton, 2000, Interferon gamma eliminates responding CD4 T cells during mycobacterial infection by inducing apoptosis of activated CD4 T cells, J Exp Med, 192, 117, 10.1084/jem.192.1.117 Badovinac, 2000, Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma, Science, 290, 1354, 10.1126/science.290.5495.1354 Novelli, 1997, Expression and role in apoptosis of the alpha- and beta-chains of the IFN-gamma receptor on human Th1 and Th2 clones, J Immunol, 159, 206, 10.4049/jimmunol.159.1.206 Refaeli, 2002, Interferon gamma is required for activation-induced death of T lymphocytes, J Exp Med, 196, 999, 10.1084/jem.20020666 Konieczny, 1998, IFN-gamma is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways, J Immunol, 160, 2059, 10.4049/jimmunol.160.5.2059 Keir, 2006, Tissue expression of PD-L1 mediates peripheral T cell tolerance, J Exp Med, 203, 883, 10.1084/jem.20051776 Schoop, 2004, Suppressed T-cell activation by IFN-gamma-induced expression of PD-L1 on renal tubular epithelial cells, Nephrol Dial Transplant, 19, 2713, 10.1093/ndt/gfh423 Yi, 2009, Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease, Blood, 114, 3101, 10.1182/blood-2009-05-219402 Blazar, 2003, Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism, J Immunol, 171, 1272, 10.4049/jimmunol.171.3.1272 Hommes, 2006, Fontolizumab, a humanised anti-interferon gamma antibody, demonstrates safety and clinical activity in patients with moderate to severe Crohn’s disease, Gut, 55, 1131, 10.1136/gut.2005.079392 Reinisch, 2006, A dose escalating, placebo controlled, double blind, single dose and multidose, safety and tolerability study of fontolizumab, a humanised anti-interferon gamma antibody, in patients with moderate to severe Crohn’s disease, Gut, 55, 1138, 10.1136/gut.2005.079434 Sigidin, 2001, Randomized, double-blind trial of anti-interferon-gamma antibodies in rheumatoid arthritis, Scand J Rheumatol, 30, 203, 10.1080/030097401316909530 Jang, 2000, Clinical improvement and immunohistochemical findings in severe atopic dermatitis treated with interferon gamma, J Am Acad Dermatol, 42, 1033, 10.1067/mjd.2000.104793 Machold, 1992, Recombinant human interferon gamma in the treatment of rheumatoid arthritis: double blind placebo controlled study, Ann Rheum Dis, 51, 1039, 10.1136/ard.51.9.1039 Hofschneider, 1992, Double blind controlled phase III multicenter clinical trial with interferon gamma in rheumatoid arthritis, Rheumatology International, 12, 175, 10.1007/BF00302149 Lemmel, 1988, Results of a multicenter placebo-controlled double-blind randomized phase III clinical study of treatment of rheumatoid arthritis with recombinant interferon-gamma, Rheumatol Int, 8, 87, 10.1007/BF00271840 Leipe, 2010, Role of Th17 cells in human autoimmune arthritis, Arthritis Rheum, 62, 2876, 10.1002/art.27622 Pope, 2013, Possible roles of IL-12-family cytokines in rheumatoid arthritis, Nat Rev Rheumatol, 9, 252, 10.1038/nrrheum.2012.170 Tsuchiya, 2005, Expression of mouse HtrA1 serine protease in normal bone and cartilage and its upregulation in joint cartilage damaged by experimental arthritis, Bone, 37, 323, 10.1016/j.bone.2005.03.015 Polur, 2010, Role of HTRA1, a serine protease, in the progression of articular cartilage degeneration, Histol Histopathol, 25, 599 Grau, 2006, The role of human HtrA1 in arthritic disease, J Biol Chem, 281, 6124, 10.1074/jbc.M500361200 Hu, 1998, Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage, J Biol Chem, 273, 34406, 10.1074/jbc.273.51.34406 Hou, 2014, The inhibitory effect of IFN-gamma on protease HTRA1 expression in rheumatoid arthritis, J Immunol, 193, 130, 10.4049/jimmunol.1302700 Wright, 2015, Interferon gene expression signature in rheumatoid arthritis neutrophils correlates with a good response to TNFi therapy, Rheumatology (Oxford), 54, 188, 10.1093/rheumatology/keu299 Panitch, 1987, Exacerbations of multiple sclerosis in patients treated with gamma interferon, Lancet, 1, 893, 10.1016/S0140-6736(87)92863-7 Miller, 2015, Anti-inflammatory mechanisms of IFN-gamma studied in experimental autoimmune encephalomyelitis reveal neutrophils as a potential target in multiple sclerosis, Front Neurosci, 9, 287, 10.3389/fnins.2015.00287 Bever, 1991, Gamma-interferon induction in patients with chronic progressive MS, Neurology, 41, 1124, 10.1212/WNL.41.7.1124 Jagessar, 2012, Discrepant effects of human interferon-gamma on clinical and immunological disease parameters in a novel marmoset model for multiple sclerosis, J Neuroimmune Pharmacol, 7, 253, 10.1007/s11481-011-9320-5 Young, 2006, Current concepts in the pathophysiology and treatment of aplastic anemia, Blood, 108, 2509, 10.1182/blood-2006-03-010777 Kordasti, 2012, Functional characterization of CD4+ T cells in aplastic anemia, Blood, 119, 2033, 10.1182/blood-2011-08-368308 Shi, 2012, Intrinsic impairment of CD4(+)CD25(+) regulatory T cells in acquired aplastic anemia, Blood, 120, 1624, 10.1182/blood-2011-11-390708 Frickhofen, 2003, Aplastic Anemia Study, Antithymocyte globulin with or without cyclosporin A: 11-year follow-up of a randomized trial comparing treatments of aplastic anemia, Blood, 101, 1236, 10.1182/blood-2002-04-1134 Maciejewski, 1995, Fas antigen expression on CD34+ human marrow cells is induced by interferon gamma and tumor necrosis factor alpha and potentiates cytokine-mediated hematopoietic suppression in vitro, Blood, 85, 3183, 10.1182/blood.V85.11.3183.bloodjournal85113183 Klimpel, 1982, Gamma interferon (IFN gamma) and IFN alpha/beta suppress murine myeloid colony formation (CFU-C)N: magnitude of suppression is dependent upon level of colony-stimulating factor (CSF), J Immunol, 129, 76, 10.4049/jimmunol.129.1.76 Zoumbos, 1984, Interferon is the suppressor of hematopoiesis generated by stimulated lymphocytes in vitro, J Immunol, 133, 769, 10.4049/jimmunol.133.2.769 Snoeck, 1994, Interferon gamma selectively inhibits very primitive CD342+CD38- and not more mature CD34+CD38+ human hematopoietic progenitor cells, J Exp Med, 180, 1177, 10.1084/jem.180.3.1177 Selleri, 1996, Interferon-gamma constitutively expressed in the stromal microenvironment of human marrow cultures mediates potent hematopoietic inhibition, Blood, 87, 4149, 10.1182/blood.V87.10.4149.bloodjournal87104149 de Bruin, 2014, Impact of interferon-gamma on hematopoiesis, Blood, 124, 2479, 10.1182/blood-2014-04-568451 Li, 2011, Interleukin-27 enhances the production of tumour necrosis factor-alpha and interferon-gamma by bone marrow T lymphocytes in aplastic anaemia, Br J Haematol, 153, 764, 10.1111/j.1365-2141.2010.08431.x Du, 2013, Expression of IL-27, Th1 and Th17 in patients with aplastic anemia, J Clin Immunol, 33, 436, 10.1007/s10875-012-9810-0 Silva-Santos, 2015, gammadelta T cells in cancer, Nat Rev Immunol, 15, 683, 10.1038/nri3904 Morvan, 2016, NK cells and cancer: you can teach innate cells new tricks, Nat Rev Cancer, 16, 7, 10.1038/nrc.2015.5 Vivier, 2012, Targeting natural killer cells and natural killer T cells in cancer, Nat Rev Immunol, 12, 239, 10.1038/nri3174 Glasner, 2018, NKp46 Receptor-Mediated Interferon-gamma Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis, Immunity, 48, 107, 10.1016/j.immuni.2017.12.007 Zaidi, 2011, The two faces of interferon-gamma in cancer, Clin Cancer Res, 17, 6118, 10.1158/1078-0432.CCR-11-0482 Abiko, 2015, IFN-gamma from lymphocytes induces PD-L1 expression and promotes progression of ovarian cancer, Br J Cancer, 112, 1501, 10.1038/bjc.2015.101 Chen, 2015, Anti-PD-1/PD-L1 therapy of human cancer: past, present, and future, J Clin Invest, 125, 3384, 10.1172/JCI80011 Ayers, 2017, IFN-gamma-related mRNA profile predicts clinical response to PD-1 blockade, J Clin Invest, 127, 2930, 10.1172/JCI91190 Zhang, 2017, PD-L1 induced by IFN-gamma from tumor-associated macrophages via the JAK/STAT3 and PI3K/AKT signaling pathways promoted progression of lung cancer, Int J Clin Oncol, 22, 1026, 10.1007/s10147-017-1161-7 Platten, 2012, Tryptophan catabolism in cancer: beyond IDO and tryptophan depletion, Cancer Res, 72, 5435, 10.1158/0008-5472.CAN-12-0569 Sikalidis, 2015, Amino acids and immune response: a role for cysteine, glutamine, phenylalanine, tryptophan and arginine in T-cell function and cancer?, Pathol Oncol Res, 21, 9, 10.1007/s12253-014-9860-0 Sosa, 2014, Mechanisms of disseminated cancer cell dormancy: an awakening field, Nat Rev Cancer, 14, 611, 10.1038/nrc3793 Liu, 2017, Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells, Nature Communications, 8, 15207, 10.1038/ncomms15207 Rouas-Freiss, 2003, HLA-G in cancer: a way to turn off the immune system, Seminars in Cancer Biology, 13, 325, 10.1016/S1044-579X(03)00023-3 de Kruijf, 2010, HLA-E and HLA-G expression in classical HLA class I-negative tumors is of prognostic value for clinical outcome of early breast cancer patients, J Immunol, 185, 7452, 10.4049/jimmunol.1002629 LeMaoult, 2004, HLA-G1-expressing antigen-presenting cells induce immunosuppressive CD4+ T cells, Proc Natl Acad Sci U S A, 101, 7064, 10.1073/pnas.0401922101 Le Friec, 2003, Soluble HLA-G inhibits human dendritic cell-triggered allogeneic T-cell proliferation without altering dendritic differentiation and maturation processes, Hum Immunol, 64, 752, 10.1016/S0198-8859(03)00091-0 Loumagne, 2014, In vivo evidence that secretion of HLA-G by immunogenic tumor cells allows their evasion from immunosurveillance, Int J Cancer, 135, 2107, 10.1002/ijc.28845 Ristich, 2005, Tolerization of dendritic cells by HLA-G, Eur J Immunol, 35, 1133, 10.1002/eji.200425741 Sun, 2014, The roles of mesenchymal stem cells in tumor inflammatory microenvironment, J Hematol Oncol, 7, 14, 10.1186/1756-8722-7-14 Liotta, 2015, Mesenchymal stem cells are enriched in head neck squamous cell carcinoma, correlates with tumour size and inhibit T-cell proliferation, Br J Cancer, 112, 745, 10.1038/bjc.2015.15 Ling, 2014, Mesenchymal stem cells use IDO to regulate immunity in tumor microenvironment, Cancer Res, 74, 1576, 10.1158/0008-5472.CAN-13-1656 Huang, 2006, Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host, Cancer Res, 66, 1123, 10.1158/0008-5472.CAN-05-1299 Medina-Echeverz, 2014, IFN-gamma regulates survival and function of tumor-induced CD11b+ Gr-1high myeloid derived suppressor cells by modulating the anti-apoptotic molecule Bcl2a1, Eur J Immunol, 44, 2457, 10.1002/eji.201444497