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Liệu pháp kháng insulin trong các bệnh khác ngoài tiểu đường loại 2
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity - Tập 19 - Trang 275-283 - 2014
Tóm tắt
Kháng insulin là một tình trạng lâm sàng được chia sẻ bởi nhiều bệnh ngoài tiểu đường loại 2 (T2DM) như béo phì, hội chứng buồng trứng đa nang (PCOS) và bệnh gan nhiễm mỡ không do rượu (NAFLD). Bằng chứng thực nghiệm được sản xuất qua nhiều năm cho thấy metformin có nhiều lợi ích trong điều trị các bệnh này. Metformin là thuốc điều trị hàng đầu cho bệnh nhân tiểu đường loại 2 thừa cân và béo phì, mang lại một phương pháp tiếp cận sinh lý bệnh chọn lọc thông qua tác động của nó lên sự kháng insulin. Hơn nữa, một số nghiên cứu đã xác lập tác động tích cực của metformin lên cân nặng cơ thể, không chỉ khi đánh giá chỉ số khối cơ thể (BMI), mà còn khi xem xét thành phần khối lượng cơ thể, thông qua việc giảm khối lượng mỡ. Ngoài ra, nó còn làm giảm kháng insulin, hyperinsulinemia, các thông số lipid, huyết áp động mạch và rối loạn chức năng nội mạch. Đặc biệt, một chế phẩm metformin giải phóng kéo dài (ER) mới hiện đã có mặt với các chế phẩm khác nhau ở các quốc gia khác nhau. Metformin ER truyền thuốc hoạt động qua các polymer hydrat hóa, mở rộng khả năng tiếp nhận chất lỏng an toàn, kéo dài thời gian di chuyển trong dạ dày và làm chậm quá trình hấp thụ thuốc trong ống tiêu hóa trên. Thêm vào đó, Metformin ER gây ra một sự giảm nhỏ nhưng có ý nghĩa thống kê trong BMI khi được thêm vào chương trình can thiệp lối sống ở thanh thiếu niên béo phì. Bởi vì những lợi ích được gợi ý trong điều trị kháng insulin ở nhiều tình trạng lâm sàng, ngoài tiểu đường loại 2, khả năng đưa ra nhiều chỉ định điều trị metformin đang trở thành hiện thực.
Từ khóa
#Metformin #kháng insulin #tiểu đường loại 2 #béo phì #hội chứng buồng trứng đa nang #bệnh gan nhiễm mỡ không do rượu #chỉ số khối cơ thể #điều trị.Tài liệu tham khảo
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