The target tissue in autoimmunity – an influential niche

European Journal of Immunology - Tập 37 Số 3 - Trang 589-597 - 2007
Natasha Hill1, Monica Hultcrantz2, Nora Sarvetnick3, Malin Flodström‐Tullberg2
1Centre for Diabetes and Metabolic Medicine, Institute of Cell and Molecular Sciences, Barts and the London Queen Mary's School of Medicine and Dentistry, London, UK
2Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
3The Department of Immunology, The Scripps Research Institute, La Jolla, CA, USA

Tóm tắt

AbstractCentral and peripheral tolerance mechanisms were for a long time the only regulatory circuits known in autoimmunity. It is now becoming clear that the target tissue itself may have the capacity to control its own destiny. Here we review mechanisms by which the target tissue regulates local inflammation, and the way this could influence progression to overt autoimmunity. Moreover, we discuss recent data showing that physiological properties of the target tissue can determine the organ specificity of autoimmune disease. These recent discoveries and ideas concerning the regulatory potential of the target tissue may, in the future, add a new dimension to our concept of regulatory circuits in autoimmunity.

Từ khóa


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Thông tin xuất bản

European Journal of Immunology

Tập 37 Số 3

589-597

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