The suprachiasmatic nucleus: age-related decline in biological rhythms

Takahiro J. Nakamura1, Nobuo Takasu2, Wataru Nakamura2
1Department of Life Sciences, School of Agriculture, Meiji University, Kawasaki, Japan
2Laboratory of Oral Chronobiology, Graduate School of Dentistry, Osaka University, Suita, Japan

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Nakamura TJ, Nakamura W, Yamazaki S, Kudo T, Cutler T, Colwell CS, Block GD (2011) Age-related decline in circadian output. J Neurosci 31:10201–10205

Kawakami F, Okamura H, Tamada Y, Maebayashi Y, Fukui K, Ibata Y (1997) Loss of day–night differences in VIP mRNA levels in the suprachiasmatic nucleus of aged rats. Neurosci Lett 222:99–102

Wise PM, Cohen IR, Weiland NG, London ED (1988) Aging alters the circadian rhythm of glucose utilization in the suprachiasmatic nucleus. Proc Natl Acad Sci USA 85:5305–5309

Cai A, Scarbrough K, Hinkle DA, Wise PM (1997) Fetal grafts containing suprachiasmatic nuclei restore the diurnal rhythm of CRH and POMC mRNA in aging rats. Am J Physiol 273:R1764–R1770

Li H, Satinoff E (1998) Fetal tissue containing the suprachiasmatic nucleus restores multiple circadian rhythms in old rats. Am J Physiol 275:R1735–R1744

Van Reeth O, Zhang Y, Zee PC, Turek FW (1994) Grafting fetal suprachiasmatic nuclei in the hypothalamus of old hamsters restores responsiveness of the circadian clock to a phase shifting stimulus. Brain Res 643:338–342

Viswanathan N, Davis FC (1995) Suprachiasmatic nucleus grafts restore circadian function in aged hamsters. Brain Res 686:10–16

Munetomo A, Hojo Y, Higo S, Kato A, Yoshida K, Shirasawa T, Shimizu T, Barron A, Kimoto T, Kawato S (2015) Aging-induced changes in sex-steroidogenic enzymes and sex-steroid receptors in the cortex, hypothalamus and cerebellum. J Physiol Sci 65:253–263

Everett JW, Sawyer CH (1950) A 24-hour periodicity in the “LH-release apparatus” of female rats, disclosed by barbiturate sedation. Endocrinology 47:198–218

Takasu NN, Nakamura TJ, Tokuda IT, Todo T, Block GD, Nakamura W (2015) Recovery from age-related infertility under environmental light-dark adjusted to the intrinsic circadian period. Cell Rep 12:1407–1413

Meyer-Bernstein EL, Jetton AE, Matsumoto SI, Markuns JF, Lehman MN, Bittman EL (1999) Effects of suprachiasmatic transplants on circadian rhythms of neuroendocrine function in golden hamsters. Endocrinology 140:207–218

Pittendrigh C, Daan S (1976) A functional analysis of circadian pacemakers in nocturnal rodents. J Comp Physiol 106:223–252

Refinetti R (2015) Comparison of light, food, and temperature as environmental synchronizers of the circadian rhythm of activity in mice. J Physiol Sci 65:359–366

Daan S, Pittendrigh C (1976) A Functional analysis of circadian pacemakers in nocturnal rodents. J Comp Physiol 106:253–266

Honma K, Honma S, Hiroshige T (1985) Response curve, free-running period, and activity time in circadian locomotor rhythm of rats. Jpn J Physiol 35:643–658

Honma K, Honma S (1988) A human phase response curve for bright light pulses. Jpn J Psychiatr Neurol 42:167–168

Minors DS, Waterhouse JM, Wirz-Justice A (1991) A human phase-response curve to light. Neurosci Lett 133:36–40

Bliwise DL (1993) Sleep apnea and cognitive function: where do we stand now? Sleep 16:S72–S73

Turek FW, Penev P, Zhang Y, van Reeth O, Zee P (1995) Effects of age on the circadian system. Neurosci Biobehav Rev 19:53–58

Van Someren EJ (2000) Circadian and sleep disturbances in the elderly. Exp Gerontol 35:1229–1237

Pittendrigh CS, Daan S (1974) Circadian oscillations in rodents: a systematic increase of their frequency with age. Science 186:548–550

Scarbrough K, Losee-Olson S, Wallen EP, Turek FW (1997) Aging and photoperiod affect entrainment and quantitative aspects of locomotor behavior in Syrian hamsters. Am J Physiol 272:R1219–R1225

Valentinuzzi VS, Scarbrough K, Takahashi JS, Turek FW (1997) Effects of aging on the circadian rhythm of wheel-running activity in C57BL/6 mice. Am J Physiol 273:R1957–R1964

Zhang Y, Kornhauser JM, Zee PC, Mayo KE, Takahashi JS, Turek FW (1996) Effects of aging on light-induced phase-shifting of circadian behavioral rhythms, fos expression and CREB phosphorylation in the hamster suprachiasmatic nucleus. Neuroscience 70:951–961

Stephan FK, Zucker I (1972) Circadian rhythms in drinking behavior and locomotor activity of rats are eliminated by hypothalamic lesions. Proc Natl Acad Sci USA 69:1583–1586

Drucker-Colín R, Aguilar-Roblero R, García-Hernández F, Fernández-Cancino F, Rattoni FB (1984) Fetal suprachiasmatic nucleus transplants: diurnal rhythm recovery of lesioned rats. Brain Res 311:353–357

Sawaki Y, Nihonmatsu I, Kawamura H (1984) Transplantation of the neonatal suprachiasmatic nuclei into rats with complete bilateral suprachiasmatic lesions. Neurosci Res 1:67–72

Sujino M, Masumoto KH, Yamaguchi S, van der Horst GT, Okamura H, Inouye ST (2003) Suprachiasmatic nucleus grafts restore circadian behavioral rhythms of genetically arrhythmic mice. Curr Biol 13:664–668

Ralph MR, Menaker M (1988) A mutation of the circadian system in golden hamsters. Science 241:1225–1227

Ralph MR, Foster RG, Davis FC, Menaker M (1990) Transplanted suprachiasmatic nucleus determines circadian period. Science 247:975–978

Silver R, LeSauter J, Tresco PA, Lehman MN (1996) A diffusible coupling signal from the transplanted suprachiasmatic nucleus controlling circadian locomotor rhythms. Nature 382:810–813

Vogelbaum MA, Menaker M (1992) Temporal chimeras produced by hypothalamic transplants. J Neurosci 12:3619–3627

King DP, Zhao Y, Sangoram AM, Wilsbacher LD, Tanaka M, Antoch MP, Steeves TD, Vitaterna MH, Kornhauser JM, Lowrey PL et al (1997) Positional cloning of the mouse circadian clock gene. Cell 89:641–653

Tei H, Okamura H, Shigeyoshi Y, Fukuhara C, Ozawa R, Hirose M, Sakaki Y (1997) Circadian oscillation of a mammalian homologue of the Drosophila period gene. Nature 389:512–516

Welsh DK, Logothetis DE, Meister M, Reppert SM (1995) Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms. Neuron 14:697–706

Honma S, Nakamura W, Shirakawa T, Honma K (2004) Diversity in the circadian periods of single neurons of the rat suprachiasmatic nucleus depends on nuclear structure and intrinsic period. Neurosci Lett 358:173–176

Honma S, Shirakawa T, Nakamura W, Honma K (2000) Synaptic communication of cellular oscillations in the rat suprachiasmatic neurons. Neurosci Lett 294:113–116

Nakamura W, Honma S, Shirakawa T, Honma K (2001) Regional pacemakers composed of multiple oscillator neurons in the rat suprachiasmatic nucleus. Eur J Neurosci 14:666–674

Nakamura W, Honma S, Shirakawa T, Honma K (2002) Clock mutation lengthens the circadian period without damping rhythms in individual SCN neurons. Nat Neurosci 5:399–400

Schwartz WJ, Gross RA, Morton MT (1987) The suprachiasmatic nuclei contain a tetrodotoxin-resistant circadian pacemaker. Proc Natl Acad Sci USA 84:1694–1698

Nakamura W, Yamazaki S, Nakamura TJ, Shirakawa T, Block GD, Takumi T (2008) In vivo monitoring of circadian timing in freely moving mice. Curr Biol 18:381–385

Cheng MY, Bullock CM, Li C, Lee AG, Bermak JC, Belluzzi J, Weaver DR, Leslie FM, Zhou QY (2002) Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. Nature 417:405–410

Kramer A, Yang FC, Snodgrass P, Li X, Scammell TE, Davis FC, Weitz CJ (2001) Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signaling. Science 294:2511–2515

Kraves S, Weitz CJ (2006) A role for cardiotrophin-like cytokine in the circadian control of mammalian locomotor activity. Nat Neurosci 9:212–219

Vujovic N, Gooley JJ, Jhou TC, Saper CB (2015) Projections from the subparaventricular zone define four channels of output from the circadian timing system. J Comp Neurol 523:2714–2737

Saper CB, Scammell TE, Lu J (2005) Hypothalamic regulation of sleep and circadian rhythms. Nature 437:1257–1263

Lu J, Zhang YH, Chou TC, Gaus SE, Elmquist JK, Shiromani P, Saper CB (2001) Contrasting effects of ibotenate lesions of the paraventricular nucleus and subparaventricular zone on sleep-wake cycle and temperature regulation. J Neurosci 21:4864–4874

Nakamura TJ, Nakamura W, Tokuda IT, Ishikawa T, Kudo T, Colwell CS, Block GD (2015) Age-related changes in the circadian system unmasked by constant conditions. eNeuro. doi: 10.1523/ENEURO.0064-15.2015

Tanaka M, Yamaguchi E, Takahashi M, Hashimura K, Shibata T, Nakamura W, Nakamura TJ (2012) Effects of age-related dopaminergic neuron loss in the substantia nigra on the circadian rhythms of locomotor activity in mice. Neurosci Res 74:210–215

Butcher RL, Collins WE, Fugo NW (1974) Plasma concentration of LH, FSH, prolactin, progesterone and estradiol-17beta throughout the 4-day estrous cycle of the rat. Endocrinology 94:1704–1708

Wollnik F, Turek FW (1988) Estrous correlated modulations of circadian and ultradian wheel-running activity rhythms in LEW/Ztm rats. Physiol Behav 43:389–396

Yamazaki S, Numano R, Abe M, Hida A, Takahashi R, Ueda M, Block GD, Sakaki Y, Menaker M, Tei H (2000) Resetting central and peripheral circadian oscillators in transgenic rats. Science 288:682–685

Yoo SH, Yamazaki S, Lowrey PL, Shimomura K, Ko CH, Buhr ED, Siepka SM, Hong HK, Oh WJ, Yoo OJ et al (2004) PERIOD2:LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues USA. Proc Natl Acad Sci USA 101:5339–5346

Chappell PE, White RS, Mellon PL (2003) Circadian gene expression regulates pulsatile gonadotropin-releasing hormone (GnRH) secretory patterns in the hypothalamic GnRH-secreting GT1-7 cell line. J Neurosci 23:11202–11213

Sellix MT, Menaker M (2010) Circadian clocks in the ovary. Trends Endocrinol Metab 21:628–636

Nakamura TJ, Sellix MT, Kudo T, Nakao N, Yoshimura T, Ebihara S, Colwell CS, Block GD (2010) Influence of the estrous cycle on clock gene expression in reproductive tissues: effects of fluctuating ovarian steroid hormone levels. Steroids 75:203–212

Nakamura TJ, Moriya T, Inoue S, Shimazoe T, Watanabe S, Ebihara S, Shinohara K (2005) Estrogen differentially regulates expression of Per1 and Per2 genes between central and peripheral clocks and between reproductive and nonreproductive tissues in female rats. J Neurosci Res 82:622–630

Nakamura TJ, Sellix MT, Menaker M, Block GD (2008) Estrogen directly modulates circadian rhythms of PER2 expression in the uterus. Am J Physiol Endocrinol Metab 295:E1025–E1031

Mishima K, Okawa M, Shimizu T, Hishikawa Y (2001) Diminished melatonin secretion in the elderly caused by insufficient environmental illumination. J Clin Endocrinol Metab 86:129–134

Takasu N, Nigi H, Tokura H (2002) Effects of diurnal bright/dim light intensity on circadian core temperature and activity rhythms in the Japanese macaque. Jpn J Physiol 52:573–578