The superoxide anion donor, potassium superoxide, induces pain and inflammation in mice through production of reactive oxygen species and cyclooxygenase-2

Verri Jr WA, 2012, Flavonoids as anti-inflammatory and analgesic drugs: mechanisms of action and perspectives in the development of pharmaceutical forms, 297, 10.1016/B978-0-444-53836-9.00026-8

Valerio DA, 2009, Quercetin reduces inflammatory pain: inhibition of oxidative stress and cytokine production, J Nat Prod, 72, 1975, 10.1021/np900259y

Souto FO, 2011, Quercetin reduces neutrophil recruitment induced by CXCL8, LTB4, and fMLP: inhibition of actin polymerization, J Nat Prod, 74, 113, 10.1021/np1003017

Guazelli CF, 2013, Quercetin-loaded microcapsules ameliorate experimental colitis in mice by anti-inflammatory and antioxidant mechanisms, J Nat Prod, 76, 200, 10.1021/np300670w

Borghi SM, 2013, Vitexin inhibits inflammatory pain in mice by targeting TRPV1, oxidative stress, and cytokines, J Nat Prod, 76, 1141, 10.1021/np400222v

Navarro SA, 2013, Analgesic activity of piracetam: effect on cytokine production and oxidative stress, Pharmacol Biochem Behav, 105, 183, 10.1016/j.pbb.2013.02.018

Wang ZQ, 2004, A newly identified role for superoxide in inflammatory pain, J Pharmacol Exp Ther, 309, 869, 10.1124/jpet.103.064154

Khattab MM, 2006, TEMPOL, a membrane-permeable radical scavenger, attenuates peroxynitrite- and superoxide anion-enhanced carrageenan-induced paw edema and hyperalgesia: a key role for superoxide anion, Eur J Pharmacol, 548, 167, 10.1016/j.ejphar.2006.08.007

Salvemini D, 2011, Roles of reactive oxygen and nitrogen species in pain, Free Radic Biol Med, 51, 951, 10.1016/j.freeradbiomed.2011.01.026

Ndengele MM, 2008, Cyclooxygenases 1 and 2 contribute to peroxynitrite-mediated inflammatory pain hypersensitivity, FASEB J, 22, 3154, 10.1096/fj.08-108159

Casagrande R, 2006, Protective effect of topical formulations containing quercetin against UVB-induced oxidative stress in hairless mice, J Photochem Photobiol B, 84, 21, 10.1016/j.jphotobiol.2006.01.006

Verri Jr WA, 2010, IL-33 induces neutrophil migration in rheumatoid arthritis and is a target of anti-TNF therapy, Ann Rheum Dis, 69, 1697, 10.1136/ard.2009.122655

Katalinic V, 2005, Gender differences in antioxidant capacity of rat tissues determined by 2,2′-azinobis (3-ethylbenzothiazoline 6-sulfonate; ABTS) and ferric reducing antioxidant power (FRAP) assays, Comp Biochem Physiol C Toxicol Pharmacol, 140, 47, 10.1016/j.cca.2005.01.005

Sedlak J, 1968, Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent, Anal Biochem, 25, 192, 10.1016/0003-2697(68)90092-4

Wang HD, 1998, Superoxide anion from the adventitia of the rat thoracic aorta inactivates nitric oxide, Circ Res, 82, 810, 10.1161/01.RES.82.7.810

Verri Jr WA, 2007, IL-15 mediates antigen-induced neutrophil migration by triggering IL-18 production, Eur J Immunol, 37, 3373, 10.1002/eji.200737488

Sun YH, 2013, Synergistic analgesia of duloxetine and celecoxib in the mouse formalin test: a combination analysis, PLoS One, 8

Carvalho TT, 2011, Granulocyte-colony stimulating factor (G-CSF) induces mechanical hyperalgesia via spinal activation of MAP kinases and PI3K in mice, Pharmacol Biochem Behav, 98, 188, 10.1016/j.pbb.2010.12.027

Rezende RM, 2010, Celecoxib induces tolerance in a model of peripheral inflammatory pain in rats, Neuropharmacology, 59, 551, 10.1016/j.neuropharm.2010.07.022

Fridovich I, 1978, The biology of oxygen radicals, Science, 201, 875, 10.1126/science.210504

Hattori H, 2010, Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis, Proc Natl Acad Sci U S A, 107, 3546, 10.1073/pnas.0914351107

Taubert D, 2003, Reaction rate constants of superoxide scavenging by plant antioxidants, Free Radic Biol Med, 35, 1599, 10.1016/j.freeradbiomed.2003.09.005

Choi DC, 2012, Inhibition of ROS-induced p38MAPK and ERK activation in microglia by acupuncture relieves neuropathic pain after spinal cord injury in rats, Exp Neurol, 236, 268, 10.1016/j.expneurol.2012.05.014

Alves-Filho JC, 2010, Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection, Nat Med, 16, 708, 10.1038/nm.2156

Guerrero AT, 2008, Involvement of LTB4 in zymosan-induced joint nociception in mice: participation of neutrophils and PGE2, J Leukoc Biol, 83, 122, 10.1189/jlb.0207123

Zarpelon AC, 2013, IL-33/ST2 signalling contributes to carrageenin-induced innate inflammation and inflammatory pain: role of cytokines, endothelin-1 and prostaglandin E2, Br J Pharmacol, 169, 90, 10.1111/bph.12110

Verri Jr WA, 2009, Targeting endothelin ETA and ETB receptors inhibits antigen-induced neutrophil migration and mechanical hypernociception in mice, Naunyn Schmiedebergs Arch Pharmacol, 379, 271, 10.1007/s00210-008-0360-1

Kim HY, 2008, Increased production of mitochondrial superoxide in the spinal cord induces pain behaviors in mice: the effect of mitochondrial electron transport complex inhibitors, Neurosci Lett, 447, 87, 10.1016/j.neulet.2008.09.041

Nishio N, 2013, Reactive oxygen species enhance excitatory synaptic transmission in rat spinal dorsal horn neurons by activating TRPA1 and TRPV1 channels, Neuroscience, 247, 201, 10.1016/j.neuroscience.2013.05.023

Muscoli C, 2004, Superoxide-mediated nitration of spinal manganese superoxide dismutase: a novel pathway in N-methyl-D-aspartate-mediated hyperalgesia, Pain, 111, 96, 10.1016/j.pain.2004.06.004

Ko YK, 2012, Antinociceptive effect of phenyl N-tert-butylnitrone, a free radical scavenger, on the rat formalin test, Korean J Anesthesiol, 62, 558, 10.4097/kjae.2012.62.6.558

Robak J, 1988, Flavonoids are scavengers of superoxide anions, Biochem Pharmacol, 37, 837, 10.1016/0006-2952(88)90169-4

Morikawa K, 2003, Inhibitory effect of quercetin on carrageenan-induced inflammation in rats, Life Sci, 74, 709, 10.1016/j.lfs.2003.06.036

Kim HY, 2009, Superoxide signaling in pain is independent of nitric oxide signaling, Neuroreport, 20, 1424, 10.1097/WNR.0b013e328330f68b

Kress M, 1995, Effects of oxygen radicals on nociceptive afferents in the rat skin in vitro, Pain, 62, 87, 10.1016/0304-3959(94)00254-C