The structure–activity relationship review of the main bioactive constituents of Morus genus plants
Tóm tắt
Morus genus plants are mainly distributed in the temperate to tropical areas over the world and include 17 species and two subspecies. Due to their excellent pharmacological activity, security in food additives and high value in the national economy, Morus genus plants have drawn more and more attention in recent years. In the light of the references published over the last few decades, flavonoids, benzofurans, stilbenes, and Diels–Alder adducts have been reported to be the main bioactive constituents of Morus genus plants. This review summarizes the compounds with excellent bioactivities isolated from Morus genus plants as well as their structure–activity relationships (SARs), which might be useful for the further research and development of Morus genus plants.
The aromatic heterocycles with excellent bioactivities isolated from Morus genus plants as well as their structure–activity relationships (SARs) were summarized.
Tài liệu tham khảo
Yang Y, Tan YX, Chen RY, Kang J (2014) The latest review on the polyphenols and their bioactivities of Chinese Morus plants. J Asian Nat Prod Res 16(6):690–702
Chan EW, Lye PY, Wong SK (2016) Phytochemistry, pharmacology, and clinical trials of Morus alba. Chin J Nat Med 14(1):17–30
Thaipitakwong T, Numhom S, Aramwit P (2018) Mulberry leaves and their potential effects against cardiometabolic risks: a review of chemical compositions, biological properties and clinical efficacy. Pharm Biol 56(1):109–118
Chaita E, Lambrinidis G, Cheimonidi C, Agalou A, Beis D, Trougakos I, Mikros E, Skaltsounis AL, Aligiannis N (2017) Anti-melanogenic properties of Greek plants. A novel depigmenting agent from Morus alba wood. Molecules 22(4):E514
Kuk EB, Jo AR, Oh SI, Sohn HS, Seong SH, Roy A, Choi JS, Jung HA (2017) Anti-Alzheimer’s disease activity of compounds from the root bark of Morus alba L. Arch Pharm Res 40(3):338–349
Mudra M, Ercan-Fang N, Zhong L, Furne J, Levitt M (2007) Influence of mulberry leaf extract on the blood glucose and breath hydrogen response to ingestion of 75 g sucrose by type 2 diabetic and control subjects. Diabetes Care 30(5):1272–1274
Kimura T, Nakagawa K, Kubota H, Kojima Y, Goto Y, Yamagishi K, Oita S, Oikawa S, Miyazawa T (2007) Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans. J Agric Food Chem 55(14):5869–5874
Kojima Y, Kimura T, Nakagawa K, Asai A, Hasumi K, Oikawa S, Miyazawa T (2010) Effects of mulberry leaf extract rich in 1-deoxynojirimycin on blood lipid profiles in humans. J Clin Biochem Nutr 47(2):155–161
Andallu B, Suryakantham V, Srikanthi BL, Reddy GK (2001) Effect of mulberry Morus indica L. therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes. Clin Chim Acta 314(1–2):47–53
Li XH, Xu LX, Wu P, Xie HH, Huang ZL, Ye WH, Wei XY (2009) Prenylflavonols from the leaves of Macaranga sampsonii. Chem Pharm Bull 57(5):495–498
Hu X, Wu JW, Wang M, Yu MH, Zhao QS, Wang HY, Hou AJ (2012) 2-Arylbenzofuran, flavonoid, and tyrosinase inhibitory constituents of Morus yunnanensis. J Nat Prod 75(1):82–87
Ha MT, Seong SH, Nguyen TD, Cho WK, Ah KJ, Ma JY, Woo MH, Choi JS, Min BS (2018) Chalcone derivatives from the root bark of Morus alba L. act as inhibitors of PTP1B and α-glucosidase. Phytochemistry 155:114–125
Ni G (2010) Studies on the chemical constituents and bioactivities of Acorus tatarinowii Schott and Morus cathayana. Graduation thesis of Ph.D. degree, Chinese Academy of Medical Sciences and Peking Union Medieal College, Beijing, China
Ahn E, Lee J, Jeon YH, Choi SW, Kim E (2017) Anti-diabetic effects of mulberry (Morus alba L.) branches and oxyresveratrol in streptozotocin-induced diabetic mice. Food Sci Biotechnol 26(6):1693–1702
Zhang YL, Luo JG, Wan CX, Zhou ZB, Kong LY (2015) Four new flavonoids with α-glucosidase inhibitory activities from Morus alba var. tatarica. Chem Biodivers 12(11):1768–1776
Yang ZZ, Wang YC, Wang Y, Zhang YF (2012) Bioassay-guided screening and isolation of α-glucosidase and tyrosinase inhibitors from leaves of Morus alba. Food Chem 131:617–625
Zhang YL, Luo JG, Wan CX, Zhou ZB, Kong LY (2014) Geranylated 2–arylbenzofurans from Morus alba var. tatarica and their α-glucosidase and protein tyrosine phosphatase 1B inhibitory activities. Fitoterapia 92:116–126
Zeni ALB, Moreira TD, Dalmagro AP, Camargo A, Bini LA, Simionatto EL, Scharf DR (2017) Evaluation of phenolic compounds and lipid-lowering effect of Morus nigra leaves extract. An Acad Bras Cienc 89(4):2805–2815
Li HX, Jo E, Myung CS, Kim YH, Yang SY (2018) Lipolytic effect of compounds isolated from leaves of mulberry (Morus alba L.) in 3T3-L1 adipocytes. Nat Prod Res 32(16):1963–1966
Jeong JY, Jo YH, Kim SB, Liu Q, Lee JW, Mo EJ, Lee KYB, Hwang Y, Lee MK (2015) Pancreatic lipase inhibitory constituents from Morus alba leaves and optimization for extraction conditions. Bioorg Med Chem Lett 25(11):2269–2274
Ha MTL, Tran MH, Ah KJ, Jo KJ, Kim J, Kim WD, Cheon WJ, Woo MH, Ryu SH, Min BS (2016) Potential pancreatic lipase inhibitory activity of phenolic constituents from the root bark of Morus alba. Bioorg Med Chem Lett 26(12):2788–2794
Li HX, Park JU, Su XD, Kim KT, Kang JS, Kim YR, Kim YH, Yang SY (2018) Identification of anti-melanogenesis constituents from Morus alba L. leaves. Molecules 23(10):E2559
Koirala P, Seong SH, Zhou Y, Shrestha S, Jung HA, Choi JS (2018) Structure-activity relationship of the tyrosinase inhibitors kuwanon G, mulberrofuran G, and albanol B from Morus species: a kinetics and molecular docking study. Molecules 23(6):E1413
Shin NH, Ryu SY, Choi EJ, Kang SH, Chang IM, Min KR, Kim Y (1998) Oxyresveratrol as the potent inhibitor on dopa oxidase activity of mushroom tyrosinase. Biochem Biophs Res Commun 243(3):801–803
Zheng ZP, Cheng KW, Zhu Q, Wang XC, Lin ZX, Wang MF (2010) Tyrosinase inhibitory constituents from the roots of Morus nigra: a structure-activity relationship study. J Agric Food Chem 58(9):5368–5373
Ryu YB, Ha TJ, Curtis-Long MJ, Ryu HW, Gal SW, Park KH (2008) Inhibitory effects on mushroom tyrosinase by flavones from the stem barks of Morus lhou (S.) Koidz. J Enzyme Inhib Med Chem 23(6):922–930
Zheng ZP, Tan HY, Wang M (2012) Tyrosinase inhibition constituents from the roots of Morus australis. Fitoterapia 83(6):1008–1013
Xia CL, Tang GH, Guo YQ, Xu YK, Huang ZS, Yin S (2019) Mulberry Diels-Alder-type adducts from Morus alba as multi-targeted agents for Alzheimer’s disease. Phytochemistry 157:82–91
Cho JK, Ryu YB, Curtis-Long MJ, Kim JY, Kim D, Lee S, Lee WS, Park KH (2011) Inhibition and structural reliability of prenylated flavones from the stem bark of Morus lhou on β-secretase (BACE–1). Bioorg Med Chem Lett 21(10):2945–2948
Kim JY, Lee WS, Kim YS, Curtis-Long MJ, Lee BW, Ryu YB, Park KH (2011) Isolation of cholinesterase–inhibiting flavonoids from Morus lhou. J Agric Food Chem 59(9):4589–4596
Seo KH, Lee DY, Jeong RH, Lee DS, Kim YE, Hong EK, Kim YC, Baek NI (2015) Neuroprotective effect of prenylated arylbenzofuran and flavonoids from Morus alba fruits on glutamate-induced oxidative injury in HT22 hippocampal cells. J Med Food 18(4):403–408
Ferlinahayati SYM, Juliawaty LD, Achmad SA, Hakim EH, Takayama H, Said IM, Latip J (2008) Phenolic constituents from the wood of Morus australis with cytotoxic activity. Z Naturforsch C 63(1–2):35–39
Ni G, Zhang QJ, Wang YH, Chen RY, Zheng ZF, Yu DQ (2010) Chemical constituents of the stem bark of Morus cathayana. J Asian Nat Prod Res 12(6):505–515