The sterol-sensing domain: multiple families, a unique role?
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Liscum, 1999, Intracellular cholesterol transport, Biochim. Biophys. Acta Mol. Cell Res., 1438, 19, 10.1016/S1388-1981(99)00043-8
Simons, 2000, Lipid rafts and signal transduction, Nat. Rev. Mol. Cell Biol., 1, 31, 10.1038/35036052
Brown, 1999, A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood, Proc. Natl. Acad. Sci. U. S. A., 96, 11041, 10.1073/pnas.96.20.11041
Carstea, 1997, Niemann–Pick C1 disease gene: homology to mediators of cholesterol homeostasis, Science, 277, 228, 10.1126/science.277.5323.228
Loftus, 1997, Murine model of Niemann–Pick C disease: mutation in a cholesterol homeostasis gene, Science, 277, 232, 10.1126/science.277.5323.232
Ingham, 2001, Hedgehog signaling in animal development: paradigms and principles, Genes Dev., 15, 3059, 10.1101/gad.938601
Burke, 1999, Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells, Cell, 99, 803, 10.1016/S0092-8674(00)81677-3
Kuwabara, 2000, A C. elegans patched gene, ptc-1, functions in germ-line cytokinesis, Genes Dev., 14, 1933, 10.1101/gad.14.15.1933
Pentchev, 1995, Type C Niemann–Pick disease: a cellular cholesterol lipidosis, 2625
Gil, 1985, Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme, Cell, 41, 249, 10.1016/0092-8674(85)90078-9
Sato, 1994, Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1), J. Biol. Chem., 269, 17267, 10.1016/S0021-9258(17)32550-4
DeBose-Boyd, 1999, Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi, Cell, 99, 703, 10.1016/S0092-8674(00)81668-2
Nohturfft, 1999, Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi, Proc. Natl. Acad. Sci. U. S. A., 96, 11235, 10.1073/pnas.96.20.11235
Hua, 1996, Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein, Cell, 87, 415, 10.1016/S0092-8674(00)81362-8
Wang, 1994, SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis, Cell, 77, 53, 10.1016/0092-8674(94)90234-8
Sakai, 1996, Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment, Cell, 85, 1037, 10.1016/S0092-8674(00)81304-5
Hua, 1996, Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane, J. Biol. Chem., 271, 10379, 10.1074/jbc.271.17.10379
Yang, 2000, Overexpression of membrane domain of SCAP prevents sterols from inhibiting SCAP–SREBP exit from endoplasmic reticulum, J. Biol. Chem., 275, 29881, 10.1074/jbc.M005439200
Nohturfft, 2000, Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes, Cell, 102, 315, 10.1016/S0092-8674(00)00037-4
Neufeld, 1999, The Niemann–Pick C1 protein resides in a vesicular compartment linked to retrograde transport of multiple lysosomal cargo, J. Biol. Chem., 274, 9627, 10.1074/jbc.274.14.9627
Kobayashi, 1999, Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport, Nat. Cell Biol., 1, 113, 10.1038/15666
Blanchette-Mackie, 1988, Type-C Niemann–Pick disease: low density lipoprotein uptake is associated with premature cholesterol accumulation in the Golgi complex and excessive cholesterol storage in lysosomes, Proc. Natl. Acad. Sci. U. S. A., 85, 8022, 10.1073/pnas.85.21.8022
Cruz, 2000, Role of Niemann–Pick type C1 protein in intracellular trafficking of low density lipoprotein-derived cholesterol, J. Biol. Chem., 275, 4013, 10.1074/jbc.275.6.4013
Millat, 2001, Niemann–Pick C1 disease: correlations between NPC1 mutations, levels of NPC1 protein, and phenotypes emphasize the functional significance of the putative sterol-sensing domain and of the cysteine-rich luminal loop, Am. J. Hum. Genet., 68, 1373, 10.1086/320606
Higgins, 1999, Niemann–Pick C1 is a late endosome-resident protein that transiently associates with lysosomes and the trans-Golgi network, Mol. Genet. Metab., 68, 1, 10.1006/mgme.1999.2882
Zhang, 2001, Cessation of rapid late endosomal tubulovesicular trafficking in Niemann–Pick type C1 disease, Proc. Natl. Acad. Sci. U. S. A., 98, 4466, 10.1073/pnas.081070898
Ko, 2001, Dynamic movements of organelles containing Niemann–Pick C1 protein: NPC1 involvement in late endocytic events, Mol. Biol. Cell, 12, 601, 10.1091/mbc.12.3.601
Lange, 2000, Cholesterol movement in Niemann–Pick type C cells and in cells treated with amphiphiles, J. Biol. Chem., 275, 17468, 10.1074/jbc.M000875200
Ioannou, 2001, Multidrug permeases and subcellular cholesterol transport, Nat. Rev. Mol. Cell Biol., 2, 657, 10.1038/35089558
Davies, 2000, Transmembrane molecular pump activity of Niemann–Pick C1 protein, Science, 290, 2295, 10.1126/science.290.5500.2295
Sym, 2000, A model for Niemann–Pick type C disease in the nematode Caenorhabditis elegans, Curr. Biol., 10, 527, 10.1016/S0960-9822(00)00468-1
Chen, 1996, Dual roles for patched in sequestering and transducing Hedgehog, Cell, 87, 553, 10.1016/S0092-8674(00)81374-4
Briscoe, 2001, A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube, Mol. Cell, 7, 1279, 10.1016/S1097-2765(01)00271-4
Porter, 1996, Cholesterol modification of hedgehog signaling proteins in animal development, Science, 274, 255, 10.1126/science.274.5285.255
Pepinsky, 1998, Identification of a palmitic acid-modified form of human Sonic hedgehog, J. Biol. Chem., 273, 14037, 10.1074/jbc.273.22.14037
Chamoun, 2001, Skinny Hedgehog, an acyltransferase required for palmitoylation and activity of the Hedgehog signal, Science, 293, 2080, 10.1126/science.1064437
The, 1999, Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan, Mol. Cell, 4, 633, 10.1016/S1097-2765(00)80214-2
Zeng, 2001, A freely diffusible form of Sonic hedgehog mediates long-range signalling, Nature, 411, 716, 10.1038/35079648
Martin, 2001, The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking, Curr. Biol., 11, 601, 10.1016/S0960-9822(01)00178-6
Strutt, 2001, Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation, Curr. Biol., 11, 608, 10.1016/S0960-9822(01)00179-8
Marigo, 1996, Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb, Development, 122, 1225, 10.1242/dev.122.4.1225
Stone, 1996, The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog, Nature, 384, 129, 10.1038/384129a0
Lewis, 2001, Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1, Cell, 105, 599, 10.1016/S0092-8674(01)00369-5
Capdevila, 1994, Subcellular localization of the segment polarity protein patched suggests an interaction with the wingless reception complex in Drosophila embryos, Development, 120, 987, 10.1242/dev.120.4.987
Bellaiche, 1998, Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion, Nature, 394, 85, 10.1038/27932
Incardona, 2000, Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1, Proc. Natl. Acad. Sci. U. S. A., 97, 12044, 10.1073/pnas.220251997
Johnson, 2000, In vivo functions of the patched protein: requirement of the C terminus for target gene inactivation but not Hedgehog sequestration, Mol. Cell, 6, 467, 10.1016/S1097-2765(00)00045-9
Denef, 2000, Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened, Cell, 102, 521, 10.1016/S0092-8674(00)00056-8
Alcedo, 2000, Posttranscriptional regulation of smoothened is part of a self-correcting mechanism in the Hedgehog signaling system, Mol. Cell, 6, 457, 10.1016/S1097-2765(00)00044-7
Ingham, 2000, Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein, Curr. Biol., 10, 1315, 10.1016/S0960-9822(00)00755-7
Barnes, 2001, Patched1 interacts with cyclin B1 to regulate cell cycle progression, EMBO J., 20, 2214, 10.1093/emboj/20.9.2214
Rietveld, 1999, Association of sterol- and glycosylphosphatidylinositol-linked proteins with Drosophila raft lipid microdomains, J. Biol. Chem., 274, 12049, 10.1074/jbc.274.17.12049
Karpen, 2001, The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane, J. Biol. Chem., 276, 19503, 10.1074/jbc.M010832200
Cooper, 1998, Teratogen-mediated inhibition of target tissue response to Shh signaling, Science, 280, 1603, 10.1126/science.280.5369.1603
Incardona, 1998, The teratogenic veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction, Development, 125, 3553, 10.1242/dev.125.18.3553
Taipale, 2000, Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine, Nature, 406, 1005, 10.1038/35023008
Incardona, 2000, Cyclopamine inhibition of Sonic hedgehog signal transduction is not mediated through effects on cholesterol transport, Dev. Biol., 224, 440, 10.1006/dbio.2000.9775
Aspock, 1999, Caenorhabditis elegans has scores of hedgehog-related genes: sequence and expression analysis, Genome Res., 9, 909, 10.1101/gr.9.10.909
Skop, 2001, Completion of cytokinesis in C. elegans requires a brefeldin A-sensitive membrane accumulation at the cleavage furrow apex, Curr. Biol., 11, 735, 10.1016/S0960-9822(01)00231-7
Sisson, 2000, Lava lamp, a novel peripheral golgi protein, is required for Drosophila melanogaster cellularization, J. Cell Biol., 151, 905, 10.1083/jcb.151.4.905
Michaux, 2000, CHE-14, a protein with a sterol-sensing domain, is required for apical sorting in C. elegans ectodermal epithelial cells, Curr. Biol., 10, 1098, 10.1016/S0960-9822(00)00695-3
The Caenorhabditis elegans Sequencing Consortium (1998) Genome sequence of the nematode C. elegans: a platform for investigating biology. Science 282, 2012–2018.
Yochem, 1999, A gp330/megalin-related protein is required in the major epidermis of Caenorhabditis elegans for completion of molting, Development, 126, 597, 10.1242/dev.126.3.597
Thiele, 2000, Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesicles, Nat. Cell Biol., 2, 42, 10.1038/71366
Holtta-Vuori, 2000, Mobilization of late-endosomal cholesterol is inhibited by Rab guanine nucleotide dissociation inhibitor, Curr. Biol., 10, 95, 10.1016/S0960-9822(99)99991-8
Eggenschwiler, 2001, Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway, Nature, 412, 194, 10.1038/35084089
Thompson, 1994, CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice, Nucleic Acids Res., 22, 4673, 10.1093/nar/22.22.4673