The small subunit of geranyl diphosphate synthase: a tool to improve aroma and flavour by metabolic engineering

Aharoni A, Giri A P, Verstappen F W, Bertea C M, Sevenier R, Sun Z, Jongsma M A, Schwab W and Bouwmeester H J 2004 Gain and loss of fruit flavor compounds produced by wild and cultivated strawberry species; Plant Cell 16 3110–3131 Burke C C, Wildung M R and Croteau R 1999 Geranyl diphosphate synthase: Cloning, expression, and characterization of this prenyltransferase as a heterodimer; Proc. Natl. Acad. Sci. USA 96 13062–13067 Cseke L, Dudareva N and Pichersky E 1998 Structure and evolution of linalool synthase; Mol. Biol. Evol. 15 1491–1498 Dudareva N, Negre F, Nagegowda D A and Orlova I 2006 Plant volatiles: recent advances and future perspectives; Crit. Rev. Plant Sci. 25 417–440 Nagegowda D A, Gutensohn M, Wilkerson C G and Dudareva N 2008 Two nearly identical terpene synthases catalyze the formation of nerolidol and linalool in snapdragon flowers; Plant J. 55 224–239 Ogura K and Koyama T 1998 Enzymatic aspects of isoprenoid chain elongation; Chem. Rev. 98 1263–1276 Orlova I, Nagegowda D A, Kish C M, Gutensohn M, Maeda H, Varbanova M, Fridman E, Yamaguchi S, et al. 2009 The small subunit of snapdragon geranyl diphosphate synthase modifies the chain length specificity of tobacco geranylgeranyl diphosphate synthase in planta; Plant Cell 21 4002–4017 Tholl D, Kish C M, Orlova I, Sherman D, Gershenzon J, Pichersky E and Dudareva N 2004 Formation of monoterpenes in Antirrhinum majus and Clarkia breweri flowers involves heterodimeric geranyl diphosphate synthases; Plant Cell 16 977–992 Wagner K H and Elmadfa I 2003 Biological relevance of terpenoids: Overview focusing on mono-, di and tetraterpenes; Ann. Nutr. Met. 47 95–106 Wang G and Dixon R A 2009 Heterodimeric geranyl(geranyl)diphosphate synthase from hop (Humulus lupulus) and the evolution of monoterpene biosynthesis; Proc. Natl. Acad. Sci. USA 106 9914–9919