The sirtuins, oxidative stress and aging: an emerging link
Tóm tắt
Từ khóa
Tài liệu tham khảo
Murphy, 2009, How mitochondria produce reactive oxygen species, Biochem J, 41, 1, 10.1042/BJ20081386
Winterbourn, 2008, Reconciling the chemistry and biology of reactive oxygen species, Nat Chem Biol, 4, 278, 10.1038/nchembio.85
Turrens, 2003, Mitochondrial formation of reactive oxygen species, J Physiol, 55, 335, 10.1113/jphysiol.2003.049478
Toledano, 2007, ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis, Nat Rev Mol Cell Biol, 8, 813, 10.1038/nrm2256
Weindruch, 1996, Oxidative stress, caloric restriction, and aging, Science, 27, 59
Guarente, 2004, The Sir2 family of protein deacetylases, Annu Rev Biochem, 7, 417
Haigis, 2010, Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling, Trends Biochem Sci, 3, 669
Zhang, 2011, Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase, Science, 33, 806
Ho, 2011, The first identification of lysine malonylation substrates and its regulatory enzyme, Mol Cell Proteomics, 1, M111
Guarente, 1999, The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms, Genes Dev, 1, 2570
Guarente, 2001, Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans, Nature, 41, 227
Helfand, 2004, Sir2 mediates longevity in the fly through a pathway related to calorie restriction, Proc Natl Acad Sci U S A, 10, 15998
Guarente, 2000, Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae, Science, 28, 2126
Bonni, 2008, SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging, Cell, 13, 907
Nystrom, 2003, Asymmetric inheritance of oxidatively damaged proteins during cytokinesis, Science, 29, 1751
Ackerman, 2011, Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila, Nature, 47, 482
Jedrychowski, 2004, Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase, Science, 30, 2011
Guarente, 2004, Mammalian SIRT1 represses forkhead transcription factors, Cell, 11, 551
Burgering, 2004, FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1), J Biol Chem, 27, 28873
Boriek, 2012, An autoregulatory loop reverts the mechanosensitive Sirt1 induction by EGR1 in skeletal muscle cells, Aging (Albany NY), 4, 456
Boriek, 2011, Induction of Sirt1 by mechanical stretch of skeletal muscle through the early response factor EGR1 triggers an antioxidative response, J Biol Chem, 28, 2559
Puigserver, 2005, Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1, Nature, 43, 113
Spiegelman, 2006, Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators, Cell, 12, 397
Park, 2009, Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathway, Diabetes, 5, 344
Harper, 2008, SirT1 regulates energy metabolism and response to caloric restriction in mice, PLoS One, 3, e1759, 10.1371/journal.pone.0001759
Guarente, 2005, Increase in activity during calorie restriction requires Sirt1, Science, 31, 1641
Guarente, 2007, SIRT1 transgenic mice show phenotypes resembling calorie restriction, Aging Cell, 6, 759, 10.1111/j.1474-9726.2007.00335.x
Tucci, 2012, Caloric restriction: is mammalian life extension linked to p53?, Aging (Albany NY), 4, 525, 10.18632/aging.100481
Chen, 2010, Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation, Cell Metab, 1, 662
Prolla, 2010, Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction, Cell, 14, 802
Chen, 2011, SIRT-ain relief from age-inducing stress, Aging (Albany NY), 3158
Park, 2010, SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress, Cancer Cell, 1, 41
Guarente, 2011, SirT3 suppresses hypoxia inducible factor 1alpha and tumor growth by inhibiting mitochondrial ROS production, Oncogene, 3, 2986
Haigis, 2011, SIRT3 opposes reprogramming of cancer cell metabolism through HIF1alpha destabilization, Cancer Cell, 1, 416
Tong, 2007, SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction, Aging Cell, 6, 505, 10.1111/j.1474-9726.2007.00304.x
Hsu, 2006, Genomic instability and aging-like phenotype in the absence of mammalian SIRT6, Cell, 12, 315
Cohen, 2012, The sirtuin SIRT6 regulates lifespan in male mice, Nature, 48, 218
Gorbunova, 2011, SIRT6 promotes DNA repair under stress by activating PARP1, Science, 33, 1443
Seluanov, 2011, Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair, Aging (Albany NY), 3, 829
Jeggo, 2006, The role of double-strand break repair - insights from human genetics, Nat Rev Genet, 7, 45, 10.1038/nrg1746
Bober, 2008, Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice, Circ Res, 10, 703
Harman, 1956, Aging: a theory based on free radical and radiation chemistry, J Gerontol, 1, 298, 10.1093/geronj/11.3.298
Richardson, 2009, The overexpression of major antioxidant enzymes does not extend the lifespan of mice, Aging Cell, 8, 73, 10.1111/j.1474-9726.2008.00449.x
Zarse, 2010, How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis), Exp Gerontol, 45410
Hekimi, 2010, A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans, PLoS Biol, 8, e1000556, 10.1371/journal.pbio.1000556
Suzuki, 1990, A methyl viologen-sensitive mutant of the nematode Caenorhabditis elegans, Mutat Res, 23, 165
Guarente, 2002, Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration, Nature, 41, 344
Carruba, 2005, Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS, Science, 31, 314
Ristow, 2007, Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress, Cell Metab, 6, 280, 10.1016/j.cmet.2007.08.011
Sinclair, 2005, Toward a unified theory of caloric restriction and longevity regulation, Mech Ageing Dev, 12, 987, 10.1016/j.mad.2005.03.019
Lombard, 2009, Calorie restriction alters mitochondrial protein acetylation, Aging Cell, 8, 604, 10.1111/j.1474-9726.2009.00503.x
Saha, 2010, SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation, Nature, 46, 121
Kakar, 2011, SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome, Mol Cell, 4, 177
Denu, 2012, SIRT3 protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status, J Biol Chem, 28, 14078
Gius, 2011, Acetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative stress, Aging (Albany NY), 3, 102
Friedman, 2011, Reduced mitochondrial function in obesity-associated fatty liver: SIRT3 takes on the fat, Aging (Albany NY), 3, 175