The sensitivity of the human thirst response to changes in plasma osmolality: a systematic review

Fintan Hughes1, Monty Mythen1, Hugh Montgomery1
1Institute for Sport, Exercise and Health, University College London, 170 Tottenham Court Road, London, W1T 7HA, UK

Tóm tắt

Từ khóa


Tài liệu tham khảo

Andersson B, Rundgren M. Thirst and its disorders. Annu Rev Med. 1982;33:231–9.

Argent NB, Burrell LM, Goodship TH, Wilkinson R, Baylis PH. Osmoregulation of thirst and vasopressin release in severe chronic renal failure. Kidney Int. 1991;39:295–300.

Armstrong LE. Assessing hydration status: the elusive gold standard. J Am Coll Nutr. 2007;26:575S–84S.

Arnaud MJ. Mild dehydration: a risk factor of constipation? Eur J Clin Nutr. 2003;57(Suppl 2):S88–95.

Association HP: Listen to patients, speak up for change. 2010.

Baylis PH, Thompson CJ. Osmoregulation of vasopressin secretion and thirst in health and disease. Clin Endocrinol. 1988;29:549–76.

Becker BJ, Wu M-J. The synthesis of regression slopes in meta-analysis; 2007. p. 414–29.

Boettger S, Jenewein J, Breitbart W. Delirium and severe illness: etiologies, severity of delirium and phenomenological differences. Palliat Support Care. 2015;13:1087–92.

Calzone WL, Silva C, Keefe DL, Stachenfeld NS. Progesterone does not alter osmotic regulation of AVP. Am J Physiol Regul Integr Comp Physiol. 2001;281:R2011–20.

Comission NuTCQ. Dignity and nutrition inspection program: national overview. Commission CQ. 2011;

Davies I, O'Neill PA, McLean KA, Catania J, Bennett D. Age-associated alterations in thirst and arginine vasopressin in response to a water or sodium load. Age Ageing. 1995;24:151–9.

Davison JM, Shiells EA, Philips PR, Lindheimer MD. Serial evaluation of vasopressin release and thirst in human pregnancy. Role of human chorionic gonadotrophin in the osmoregulatory changes of gestation. J Clin Invest. 1988;81:798–806.

El-Sharkawy AM, Watson P, Neal KR, Ljungqvist O, Maughan RJ, Sahota O, Lobo DN. Hydration and outcome in older patients admitted to hospital (the HOOP prospective cohort study). Age Ageing. 2015;44:943–7.

Evbuomwan IO, Davison JM, Baylis PH, Murdoch AP. Altered osmotic thresholds for arginine vasopressin secretion and thirst during superovulation and in the ovarian hyperstimulation syndrome (OHSS): relevance to the pathophysiology of OHSS. Fertil Steril. 2001;75:933–41.

Farrell MJ, Egan GF, Zamarripa F, Shade R, Blair-West J, Fox P, Denton DA. Unique, common, and interacting cortical correlates of thirst and pain. Proc Natl Acad Sci U S A. 2006;103:2416–21.

Feehally J, Khosravi M. Effects of acute and chronic hypohydration on kidney health and function. Nutr Rev. 2015;73(Suppl 2):110–9.

Figaro MK, Mack GW. Regulation of fluid intake in dehydrated humans: role of oropharyngeal stimulation. Am J Phys. 1997;272:R1740–6.

Fortes MB, Owen JA, Raymond-Barker P, Bishop C, Elghenzai S, Oliver SJ, Walsh NP. Is this elderly patient dehydrated? Diagnostic accuracy of hydration assessment using physical signs, urine, and saliva markers. J Am Med Dir Assoc. 2015;16:221–8.

Frangeskou M, Lopez-Valcarcel B, Serra-Majem L. Dehydration in the elderly: a review focused on economic burden. J Nutr Health Aging. 2015;19:619–27.

Gross CR, Lindquist RD, Woolley AC, Granieri R, Allard K, Webster B. Clinical indicators of dehydration severity in elderly patients. J Emerg Med. 1992;10:267–74.

Holte K, Sharrock NE, Kehlet H. Pathophysiology and clinical implications of perioperative fluid excess. Br J Anaesth. 2002;89:622–32.

Hooper L, Abdelhamid A, Ali A, Bunn DK, Jennings A, John WG, Kerry S, Lindner G, Pfortmueller CA, Sjostrand F, et al. Diagnostic accuracy of calculated serum osmolarity to predict dehydration in older people: adding value to pathology laboratory reports. BMJ Open. 2015;5:e008846.

Johnson AK. The sensory psychobiology of thirst and salt appetite. Med Sci Sports Exerc. 2007;39:1388–400.

Johnson AK, Mann JF, Rascher W, Johnson JK, Ganten D. Plasma angiotensin II concentrations and experimentally induced thirst. Am J Phys. 1981;240:R229–34.

Kanagasundaram NS. Pathophysiology of ischaemic acute kidney injury. Ann Clin Biochem. 2015;52:193–205.

Kenney WL, Chiu P. Influence of age on thirst and fluid intake. Med Sci Sports Exerc. 2001;33:1524–32.

Kimura T, Minai K, Matsui K, Mouri T, Sato T. Effect of various states of hydration on plasma ADH and renin in man. J Clin Endocrinol Metab. 1976;42:79–87.

Kloner RA. Natural and unnatural triggers of myocardial infarction. Prog Cardiovasc Dis. 2006;48:285–300.

Koumantakis G, Wyndham LE. An evaluation of osmolality measurement by freezing point depression using micro-amounts of sample. J Automat Chem. 1989;11:80–3.

Lilot M, Ehrenfeld JM, Lee C, Harrington B, Cannesson M, Rinehart J. Variability in practice and factors predictive of total crystalloid administration during abdominal surgery: retrospective two-centre analysis. Br J Anaesth. 2015;114:767–76.

Mack GW, Weseman CA, Langhans GW, Scherzer H, Gillen CM, Nadel ER. Body fluid balance in dehydrated healthy older men: thirst and renal osmoregulation. J Appl Physiol (1985). 1994;76:1615–23.

Mackenzie A, Barnes G, Shann F. Clinical signs of dehydration in children. Lancet. 1989;2:605–7.

Martinez-Vea A, Garcia C, Gaya J, Rivera F, Oliver JA. Abnormalities of thirst regulation in patients with chronic renal failure on hemodialysis. Am J Nephrol. 1992;12:73–9.

McKenna K, Morris AD, Azam H, Newton RW, Baylis PH, Thompson CJ. Exaggerated vasopressin secretion and attenuated osmoregulated thirst in human survivors of hyperosmolar coma. Diabetologia. 1999;42:534–8.

Miescher E, Fortney SM. Responses to dehydration and rehydration during heat exposure in young and older men. Am J Phys. 1989;257:R1050–6.

Parliamentary OH: Care and compassion?: report of the Healeth service ombudsman on ten investigations into NHS Care of Older People. 2011.

Pash E, Parikh N, Hashemi L. Economic burden associated with hospital postadmission dehydration. JPEN J Parenter Enteral Nutr. 2014;38:58S–64S.

Phillips EM, Butler T, Baylis PH. Osmoregulation of vasopressin and thirst: comparison of 20% mannitol with 5% saline as osmotic stimulants in healthy man. Clin Endocrinol. 1994;41:207–12.

Phillips PA, Bretherton M, Johnston CI, Gray L. Reduced osmotic thirst in healthy elderly men. Am J Phys. 1991;261:R166–71.

Phillips PA, Rolls BJ, Ledingham JG, Forsling ML, Morton JJ, Crowe MJ, Wollner L. Reduced thirst after water deprivation in healthy elderly men. N Engl J Med. 1984;311:753–9.

Phillips PA, Rolls BJ, Ledingham JG, Morton JJ. Body fluid changes, thirst and drinking in man during free access to water. Physiol Behav. 1984;33:357–63.

Puntillo KA, Arai S, Cohen NH, Gropper MA, Neuhaus J, Paul SM, Miaskowski C. Symptoms experienced by intensive care unit patients at high risk of dying. Crit Care Med. 2010;38:2155–60.

QC RF: Mid Staffordshire NHS foundation trust public inquiry. 2013.

Robertson GL. Abnormalities of thirst regulation. Kidney Int. 1984;25:460–9.

Rowat A, Graham C, Dennis M. Dehydration in hospital-admitted stroke patients: detection, frequency, and association. Stroke. 2012;43:857–9.

Saad E, Ron H, Gleb S, Benjamin B, Yona N. Dehydration as a possible cause of monthly variation in the incidence of venous Thromboembolism. Clin Appl Thromb Hemost. 2016;22:569–74.

Satterthwaite FE. An approximate distribution of estimates of variance components. Biom Bull. 1946;2:110–4.

Siervo M, Bunn D, Prado CM, Hooper L. Accuracy of prediction equations for serum osmolarity in frail older people with and without diabetes. Am J Clin Nutr. 2014;100:867–76.

Sladek CD, Somponpun SJ. Estrogen receptors: their roles in regulation of vasopressin release for maintenance of fluid and electrolyte homeostasis. Front Neuroendocrinol. 2008;29:114–27.

Smith D, Moore K, Tormey W, Baylis PH, Thompson CJ. Downward resetting of the osmotic threshold for thirst in patients with SIADH. Am J Physiol Endocrinol Metab. 2004;287:E1019–23.

Spruce BA, Baylis PH, Burd J, Watson MJ. Variation in osmoregulation of arginine vasopressin during the human menstrual cycle. Clin Endocrinol. 1985;22:37–42.

Stachenfeld NS, DiPietro L, Nadel ER, Mack GW. Mechanism of attenuated thirst in aging: role of central volume receptors. Am J Phys Regul Integr Comp Phys. 1997;272:R148–57.

Stachenfeld NS, Keefe DL. Estrogen effects on osmotic regulation of AVP and fluid balance. Am J Physiol Endocrinol Metab. 2002;283:E711–21.

Stachenfeld NS, Silva C, Keefe DL, Kokoszka CA, Nadel ER. Effects of oral contraceptives on body fluid regulation. J Appl Physiol (1985). 1999;87:1016–25.

Stotts NA, Arai SR, Cooper BA, Nelson JE, Puntillo KA. Predictors of thirst in intensive care unit patients. J Pain Symptom Manag. 2015;49:530–8.

Takamata A, Ito T, Yaegashi K, Takamiya H, Maegawa Y, Itoh T, Greenleaf JE, Morimoto T. Effect of an exercise-heat acclimation program on body fluid regulatory responses to dehydration in older men. Am J Phys. 1999;277:R1041–50.

Thomas DR, Tariq SH, Makhdomm S, Haddad R, Moinuddin A. Physician misdiagnosis of dehydration in older adults. J Am Med Dir Assoc. 2004;5:S30–4.

Thompson CJ, Baylis PH. Thirst in diabetes insipidus: clinical relevance of quantitative assessment. Q J Med. 1987;65:853–62.

Thompson CJ, Bland J, Burd J, Baylis PH. The osmotic thresholds for thirst and vasopressin release are similar in healthy man. Clin Sci (Lond). 1986;71:651–6.

Thompson CJ, Burd JM, Baylis PH. Osmoregulation of vasopressin secretion and thirst in cyclical oedema. Clin Endocrinol. 1988;28:629–35.

Thompson CJ, Davis SN, Butler PC, Charlton JA, Baylis PH. Osmoregulation of thirst and vasopressin secretion in insulin-dependent diabetes mellitus. Clin Sci (Lond). 1988;74:599–606.

Thompson CJ, Edwards CR, Baylis PH. Osmotic and non-osmotic regulation of thirst and vasopressin secretion in patients with compulsive water drinking. Clin Endocrinol. 1991;35:221–8.

Thompson CJ, Selby P, Baylis PH. Reproducibility of osmotic and nonosmotic tests of vasopressin secretion in men. Am J Phys. 1991;260:R533–9.

Vokes T. Water homeostasis. Annu Rev Nutr. 1987;7:383–406.

Wiffen PJ, Derry S, Moore RA. Impact of morphine, fentanyl, oxycodone or codeine on patient consciousness, appetite and thirst when used to treat cancer pain. Cochrane Database Syst Rev. 2014:CD011056.

Wilson J, Woods I, Fawcett J, Whall R, Dibb W, Morris C, McManus E. Reducing the risk of major elective surgery: randomised controlled trial of preoperative optimisation of oxygen delivery. BMJ. 1999;318:1099–103.