The role of mitochondria in NLRP3 inflammasome activation

Molecular Immunology - Tập 103 - Trang 115-124 - 2018
Qiuyun Liu1, Danyan Zhang1, Diyu Hu1, Xiangmei Zhou2, Yang Zhou1
1College of Animal Science, Southwest University, Chongqing 402460, China
2State Key Laboratories for Agrobiotechnology, Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China

Tóm tắt

Từ khóa


Tài liệu tham khảo

Abais, 2015, Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?, Antioxid. Redox Signal., 22, 1111, 10.1089/ars.2014.5994

Afonina, 2017, Limiting inflammation-the negative regulation of NF-kappa B and the NLRP3 inflammasome, Nat. Immunol., 18, 861, 10.1038/ni.3772

Alfonso-Loeches, 2014, Role of mitochondria ROS generation in ethanol-induced NLRP3 inflammasome activation and cell death in astroglial cells, Front. Cell. Neurosci., 8, 1, 10.3389/fncel.2014.00216

Alfonso-Loeches, 2016, Ethanol-induced TLR4/NLRP3 neuroinflammatory response in microglial cells promotes leukocyte infiltration across the BBB, Neurochem. Res., 41, 193, 10.1007/s11064-015-1760-5

Allen, 2009, The NLRP3 inflammasome mediates in vivo innate immunity to influenza a virus through recognition of viral RNA, Immunity, 30, 556, 10.1016/j.immuni.2009.02.005

Anderson, 2009, SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis, PLoS One, 4, 10.1371/journal.pone.0005839

Bach, 2003, Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism–a novel regulatory mechanism altered in obesity, J. Biol. Chem., 278, 17190, 10.1074/jbc.M212754200

Bauernfeind, 2009, Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression, J. Immunol., 183, 787, 10.4049/jimmunol.0901363

Bauernfeind, 2011, Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome, J. Immunol., 187, 613, 10.4049/jimmunol.1100613

Boya, 2003, Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine, Oncogene, 22, 3927, 10.1038/sj.onc.1206622

Bronner, 2015, Endoplasmic reticulum stress activates the inflammasome via NLRP3-and caspase-2-driven mitochondrial damage, Immunity, 43, 451, 10.1016/j.immuni.2015.08.008

Brown, 2012, There is no evidence that mitochondria are the main source of reactive oxygen species in mammalian cells, Mitochondrion, 12, 1, 10.1016/j.mito.2011.02.001

Bruchard, 2013, Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth, Nat. Med., 19, 57, 10.1038/nm.2999

Buskiewicz, 2016, Reactive oxygen species induce virus-independent MAVS oligomerization in systemic lupus erythematosus, Sci. Signal., 9, ra115, 10.1126/scisignal.aaf1933

Carneiro, 2009, Shigella induces mitochondrial dysfunction and cell death in nonmyleoid cells, Cell Host Microbe, 5, 123, 10.1016/j.chom.2008.12.011

Chan, 2006, Mitochondrial fusion and fission in mammals, Annu. Rev. Cell Dev. Biol., 22, 79, 10.1146/annurev.cellbio.22.010305.104638

Chen, 2005, Emerging functions of mammalian mitochondrial fusion and fission, Hum. Mol. Genet., 14, R283, 10.1093/hmg/ddi270

Chin, 2017, The regulation of NLRP3 inflammasome expression during the development of cardiac contractile dysfunction in chronic kidney disease, Oncotarget, 8, 113303, 10.18632/oncotarget.22964

Chomyn, 2003, MtDNA mutations in aging and apoptosis, Biochem. Biophys. Res. Commun., 304, 519, 10.1016/S0006-291X(03)00625-9

Chu, 2014, LC3 binds externalized cardiolipin on injured mitochondria to signal mitophagy in neurons implications for Parkinson disease, Autophagy, 10, 376, 10.4161/auto.27191

Chuang, 2011, Tumor suppressor death-associated protein kinase is required for full IL-1 beta production, Blood, 117, 960, 10.1182/blood-2010-08-303115

Chuang, 2013, TLR-induced PAI-2 expression suppresses IL-1 beta processing via increasing autophagy and NLRP3 degradation, Proc. Natl. Acad. Sci. U. S. A., 110, 16079, 10.1073/pnas.1306556110

Cruz, 2007, ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages, J. Biol. Chem., 282, 2871, 10.1074/jbc.M608083200

Csordas, 2006, Structural and functional features and significance of the physical linkage between ER and mitochondria, J. Cell Biol., 174, 915, 10.1083/jcb.200604016

Dai, 2017, ROS-activated NLRP3 inflammasome initiates inflammation in delayed wound healing in diabetic rats, Int. J. Clin. Exp. Pathol., 10, 9902

Dashdorj, 2013, Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines, BMC Med., 11, 178, 10.1186/1741-7015-11-178

de Brito, 2008, Mitofusin 2 tethers endoplasmic reticulum to mitochondria, Nature, 456, 605, 10.1038/nature07534

Dostert, 2008, Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica, Science, 320, 674, 10.1126/science.1156995

Dostert, 2009, Malarial hemozoin is a Nalp3 inflammasome activating danger signal, PLoS One, 4, e6510, 10.1371/journal.pone.0006510

Duong, 2015, A20 restricts ubiquitination of pro-interleukin-1beta protein complexes and suppresses NLRP3 inflammasome activity, Immunity, 42, 55, 10.1016/j.immuni.2014.12.031

Elliott, 2015, Initiation and perpetuation of NLRP3 inflammasome activation and assembly, Immunol. Rev., 265, 35, 10.1111/imr.12286

Feng, 2010, The Lys(63)-specific deubiquitinating enzyme BRCC36 is regulated by two scaffold proteins localizing in different subcellular compartments, J. Biol. Chem., 285, 30982, 10.1074/jbc.M110.135392

Frank, 2001, The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis, Dev. Cell, 1, 515, 10.1016/S1534-5807(01)00055-7

Garcia, 2007, Mitochondrial DNA fragments released through the permeability transition pore correspond to specific gene size, Life Sci., 81, 1160, 10.1016/j.lfs.2007.08.019

Garrido, 2006, Mechanisms of cytochrome c release from mitochondria, Cell Death Differ., 13, 1423, 10.1038/sj.cdd.4401950

Ghonime, 2014, Inflammasome priming by lipopolysaccharide is dependent upon ERK signaling and proteasome function, J. Immunol., 192, 3881, 10.4049/jimmunol.1301974

Giorgi, 2010, PML regulates apoptosis at endoplasmic reticulum by modulating calcium release, Science, 330, 1247, 10.1126/science.1189157

Guo, 2016, Bile acids control inflammation and metabolic disorder through Inhibition of NLRP3 inflammasome, Immunity, 45, 802, 10.1016/j.immuni.2016.09.008

Gupta, 2017, Putative roles of mitochondrial voltage-dependent anion channel, Bcl-2 family proteins and c-Jun N-terminal kinases in ischemic stroke associated apoptosis, Biochim. Open, 4, 47, 10.1016/j.biopen.2017.02.002

Gurcel, 2006, Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival, Cell, 126, 1135, 10.1016/j.cell.2006.07.033

Gurung, 2015, Cutting edge: SHARPIN is required for optimal NLRP3 inflammasome activation, J. Immunol., 194, 2064, 10.4049/jimmunol.1402951

Gurung, 2015, Mitochondria: diversity in the regulation of the NLRP3 inflammasome, Trends Mol. Med., 21, 193, 10.1016/j.molmed.2014.11.008

Hayashi, 2009, MAM: more than just a housekeeper, Trends Cell Biol., 19, 81, 10.1016/j.tcb.2008.12.002

He, 2016, Mechanism and regulation of NLRP3 inflammasome activation, Trends Biochem. Sci., 41, 1012, 10.1016/j.tibs.2016.09.002

He, 2016, Dengue virus subverts host innate immunity by targeting adaptor protein MAVS, J. Virol., 90, 7219, 10.1128/JVI.00221-16

Hee, 2017, Viperin interaction with mitochondrial antiviral signaling protein (MAVS) limits viperin-mediated inhibition of the interferon response in macrophages, PLoS One, 12, 10.1371/journal.pone.0172236

Heid, 2013, Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation, J. Immunol., 191, 5230, 10.4049/jimmunol.1301490

Hise, 2009, An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans, Cell Host Microbe, 5, 487, 10.1016/j.chom.2009.05.002

Horner, 2011, Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus, Proc. Natl. Acad. Sci. U. S. A., 108, 14590, 10.1073/pnas.1110133108

Horng, 2014, Calcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome, Trends Immunol., 35, 253, 10.1016/j.it.2014.02.007

Hornung, 2008, Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization, Nat. Immunol., 9, 847, 10.1038/ni.1631

Hornung, 2009, AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC, Nature, 458, U514, 10.1038/nature07725

Hou, 2011, MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response, Cell, 146, 448, 10.1016/j.cell.2011.06.041

Ichinohe, 2013, Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection, Proc. Natl. Acad. Sci. U. S. A., 110, 17963, 10.1073/pnas.1312571110

Iyer, 2013, Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation, Immunity, 39, 311, 10.1016/j.immuni.2013.08.001

Jacobson, 1993, Bcl-2 blocks apoptosis in cells lacking mitochondrial-DNA, Nature, 361, 365, 10.1038/361365a0

Juliana, 2012, Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation, J. Biol. Chem., 287, 36617, 10.1074/jbc.M112.407130

Kanneganti, 2007, Intracellular NOD-like receptors in host defense and disease, Immunity, 27, 549, 10.1016/j.immuni.2007.10.002

Khan, 2016, Hepatitis B virus-induced Parkin-dependent recruitment of linear ubiquitin assembly complex (LUBAC) to mitochondria and attenuation of innate immunity, PLoS Pathog., 12, 10.1371/journal.ppat.1005693

Kwon, 2017, Stimulator of IFN genes-mediated DNA-sensing pathway is suppressed by NLRP3 agonists and regulated by mitofusin 1 and TBC1D15, mitochondrial dynamics mediators, FASEB J., 31, 4866, 10.1096/fj.201700328R

Lamkanfi, 2014, Mechanisms and functions of inflammasomes, Cell, 157, 1013, 10.1016/j.cell.2014.04.007

Lawlor, 2013, Bcl-2 overexpression ameliorates immune complex-mediated arthritis by altering Fc gamma RIIb expression and monocyte homeostasis, J. Leukoc. Biol., 94, 585, 10.1189/jlb.0412190

Lawlor, 2014, Ambiguities in NLRP3 inflammasome regulation: Is there a role for mitochondria?, BBA-Gen. Subj., 1840, 1433, 10.1016/j.bbagen.2013.08.014

Lee, 2002, Control of mitochondrial membrane potential and ROS formation by reversible phosphorylation of cytochrome c oxidase, Mol. Cell. Biochem, 234, 63, 10.1023/A:1015921513720

Lee, 2012, The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP, Nature, 492, 123, 10.1038/nature11588

Lee, 2016, A translocator protein 18 kDa ligand, Ro5-4864, inhibits ATP-induced NLRP3 inflammasome activation, Biochem. Biophys. Res. Commun., 474, 587, 10.1016/j.bbrc.2016.04.080

Lerner, 2012, IRE1alpha induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress, Cell Metab., 16, 250, 10.1016/j.cmet.2012.07.007

Li, 2016, Acute exercise-induced mitochondrial stress triggers an inflammatory response in the myocardium via NLRP3 inflammasome activation with mitophagy, Oxid. Med. Cell. Longev., 2016

Lin, 2014, IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation, Proc. Natl. Acad. Sci. U. S. A., 111, 775, 10.1073/pnas.1320294111

Liu, 2013, Research progress on the NLRP3 inflammasome and its role in the central nervous system, Neurosci. Bull., 29, 779, 10.1007/s12264-013-1328-9

Liu, 2014, Activation of the Nlrp3 inflammasome by mitochondrial reactive oxygen species: a novel mechanism of albumin-induced tubulointerstitial inflammation, Int. J. Biochem. Cell Biol., 57, 7, 10.1016/j.biocel.2014.09.018

Liu, 2016, Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores, Nature, 535, 153, 10.1038/nature18629

Lopez, 2009, Melatonin protects the mitochondria from oxidative damage reducing oxygen consumption, membrane potential, and superoxide anion production, J. Pineal Res., 46, 188, 10.1111/j.1600-079X.2008.00647.x

Ma, 2014, NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage, Ann. Neurol., 75, 209, 10.1002/ana.24070

Mannam, 2014, MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury, Am. J. Physiol.-Lung C, 306, L604, 10.1152/ajplung.00272.2013

Marchetti, 1996, Apoptosis-associated derangement of mitochondrial function in cells lacking mitochondrial DNA, Cancer Res., 56, 2033

Martinez-Reyes, 2016, TCA cycle and mitochondrial membrane potential are necessary for diverse biological functions, Mol. Cell, 61, 199, 10.1016/j.molcel.2015.12.002

Martinon, 2006, Gout-associated uric acid crystals activate the NALP3 inflammasome, Nature, 440, 237, 10.1038/nature04516

Mastrocola, 2016, Pharmacological inhibition of NLRP3 inflammasome attenuates myocardial Ischemia/Reperfusion injury by activation of RISK and mitochondrial pathways, Oxid. Med. Cell. Longev., 2016, 10.1155/2016/5271251

Matsuzawa, 2015, TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy, Autophagy, 11, 1052, 10.1080/15548627.2015.1055439

Meng, 2017, shRNA interference of NLRP3 inflammasome alleviate ischemia reperfusion-induced myocardial damage through autophagy activation, Biochem. Biophys. Res. Commun., 494, 728, 10.1016/j.bbrc.2017.10.111

Menu, 2012, ER stress activates the NLRP3 inflammasome via an UPR-independent pathway, Cell Death Dis., 3, 10.1038/cddis.2011.132

Mills, 2017, Mitochondria are the powerhouses of immunity, Nat. Immunol., 18, 488, 10.1038/ni.3704

Misawa, 2013, Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome, Nat. Immunol., 14, 454, 10.1038/ni.2550

Misawa, 2017, Mitochondria-endoplasmic reticulum contact sites mediate innate immune responses, Adv. Exp. Med. Biol., 997, 187, 10.1007/978-981-10-4567-7_14

Montesinos, 2016, Impact of the innate immune response in the actions of ethanol on the central nervous system, Alcohol. Clin. Exp. Res., 40, 2260, 10.1111/acer.13208

Muller-Rischart, 2013, The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO, Mol. Cell, 49, 908, 10.1016/j.molcel.2013.01.036

Munoz-Planillo, 2013, K+ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter, Immunity, 38, 1142, 10.1016/j.immuni.2013.05.016

Murakami, 2012, Critical role for calcium mobilization in activation of the NLRP3 inflammasome, Proc. Natl. Acad. Sci. U. S. A., 109, 11282, 10.1073/pnas.1117765109

Nakahira, 2011, Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome, Nat. Immunol., 12, 222, 10.1038/ni.1980

Nazir, 2017, Cytoprotective activated protein C averts Nlrp3 inflammasome-induced ischemia-reperfusion injury via mTORC1 inhibition, Blood, 130, 2664, 10.1182/blood-2017-05-782102

O’Neill, 2013, Cardiolipin and the Nlrp3 inflammasome, Cell Metab., 18, 610, 10.1016/j.cmet.2013.10.013

Park, 2013, The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity, J. Immunol., 191, 4358, 10.4049/jimmunol.1301170

Park, 2015, Defective mitochondrial fission augments NLRP3 inflammasome activation, Sci. Rep., 5, 15489, 10.1038/srep15489

Patrushev, 2004, Mitochondrial permeability transition triggers the release of mtDNA fragments, Cell. Mol. Life Sci., 61, 3100, 10.1007/s00018-004-4424-1

Pelegrin, 2006, Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor, EMBO J., 25, 5071, 10.1038/sj.emboj.7601378

Pelegrin, 2007, Pannexin-1 couples to maitotoxin- and nigericin-induced interleukin-1 beta release through a dye uptake-independent pathway, J. Biol. Chem., 282, 2386, 10.1074/jbc.M610351200

Petrilli, 2007, Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration, Cell Death Differ., 14, 1583, 10.1038/sj.cdd.4402195

Prochnicki, 2017, Inflammasomes on the crossroads of innate immune recognition and metabolic control, Cell Metab., 26, 71, 10.1016/j.cmet.2017.06.018

Py, 2013, Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity, Mol. Cell, 49, 331, 10.1016/j.molcel.2012.11.009

Ra, 2016, TRIM31 promotes Atg5/Atg7-independent autophagy in intestinal cells, Nat. Commun., 7, 11726, 10.1038/ncomms11726

Reth, 2002, Hydrogen peroxide as second messenger in lymphocyte activation, Nat. Immunol., 3, 1129, 10.1038/ni1202-1129

Rimessi, 2016, Mitochondrial reactive oxygen species and inflammation: molecular mechanisms, diseases and promising therapies, Int. J. Biochem. Cell Biol., 81, 281, 10.1016/j.biocel.2016.06.015

Rintahaka, 2011, Recognition of cytoplasmic RNA results in cathepsin-dependent inflammasome activation and apoptosis in human macrophages, J. Immunol., 186, 3085, 10.4049/jimmunol.1002051

Rodgers, 2014, The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation, J. Exp. Med., 211, 1333, 10.1084/jem.20132486

Sagulenko, 2013, AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC, Cell Death Differ., 20, 1149, 10.1038/cdd.2013.37

Scheibel, 2010, I kappa B beta is an essential co-activator for LPS-induced IL-1 beta transcription in vivo, J. Exp. Med., 207, 2621, 10.1084/jem.20100864

Schinzel, 2005, Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia, Proc. Natl. Acad. Sci. U. S. A., 102, 12005, 10.1073/pnas.0505294102

Schroder, 2010, The inflammasomes, Cell, 140, 821, 10.1016/j.cell.2010.01.040

Schroder, 2010, The NLRP3 inflammasome: a sensor for metabolic danger?, Science, 327, 296, 10.1126/science.1184003

Schug, 2009, Cardiolipin acts as a mitochondrial signalling platform to launch apoptosis, BBA-Biomembranes, 1788, 2022, 10.1016/j.bbamem.2009.05.004

Schug, 2011, BID is cleaved by caspase-8 within a native complex on the mitochondrial membrane, Cell Death Differ., 18, 538, 10.1038/cdd.2010.135

Seth, 2005, Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappa B and IRF3, Cell, 122, 669, 10.1016/j.cell.2005.08.012

Shimada, 2012, Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis, Immunity, 36, 401, 10.1016/j.immuni.2012.01.009

Sollberger, 2015, Caspase-1 activity Is required for UVB-induced apoptosis of human keratinocytes, J. Invest. Dermatol., 135, 1395, 10.1038/jid.2014.551

Song, 2016, The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3, Nat. Commun., 7, 13727, 10.1038/ncomms13727

Sterky, 2011, Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo, Proc. Natl. Acad. Sci. U. S. A., 108, 12937, 10.1073/pnas.1103295108

Subramanian, 2013, The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation, Cell, 153, 348, 10.1016/j.cell.2013.02.054

Sutterwala, 2014, Mechanism of NLRP3 inflammasome activation, Ann. N. Y. Acad. Sci., 1319, 82, 10.1111/nyas.12458

Szabadkai, 2004, Drp-1-dependent division of the mitochondrial network blocks intraorganellar Ca2+ waves and protects against Ca2+-mediated apoptosis, Mol. Cell, 16, 59, 10.1016/j.molcel.2004.09.026

Tenno, 2004, Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains, Genes Cells, 9, 865, 10.1111/j.1365-2443.2004.00780.x

Triantafilou, 2013, The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation, J. Cell Sci., 126, 2903, 10.1242/jcs.124388

van Bruggen, 2010, Human NLRP3 inflammasome activation is Nox1-4 independent, Blood, 115, 5398, 10.1182/blood-2009-10-250803

Vander, 1997, Bcl-x(L) regulates the membrane potential and volume homeostasis of mitochondria, Cell, 91, 627, 10.1016/S0092-8674(00)80450-X

Wawrzyniak, 2016, Idiopathic chronic fatigue in older adults is linked to impaired mitochondrial content and biogenesis signaling in skeletal muscle, Oncotarget, 7, 52695, 10.18632/oncotarget.10685

West, 2011, Mitochondria in innate immune responses, Nat. Rev. Immunol., 11, 389, 10.1038/nri2975

Wolf, 2016, Hexokinase is an innate immune receptor for the detection of bacterial peptidoglycan, Cell, 166, 624, 10.1016/j.cell.2016.05.076

Yan, 2015, Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome, Cell, 160, 62, 10.1016/j.cell.2014.11.047

Yen, 2015, Enteropathogenic Escherichia coli uses NleA to inhibit NLRP3 inflammasome activation, PLoS Pathog., 11, 10.1371/journal.ppat.1005121

Yu, 2016, Mitochondria and the NLRP3 inflammasome: physiological and pathological relevance, Arch. Pharm. Res., 39, 1503, 10.1007/s12272-016-0827-4

Yu, 2014, Inflammasome activation leads to caspase-1-dependent mitochondrial damage and block of mitophagy, Proc. Natl. Acad. Sci. U. S. A., 111, 15514, 10.1073/pnas.1414859111

Yuan, 2018, Differential effects of short chain fatty acids on endothelial Nlrp3 inflammasome activation and neointima formation: antioxidant action of butyrate, Redox Biol., 16, 21, 10.1016/j.redox.2018.02.007

Zanoni, 2016, An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells, Science, 352, 1232, 10.1126/science.aaf3036

Zhang, 2017, Protein kinase D at the Golgi controls NLRP3 inflammasome activation, J. Exp. Med., 214, 2671, 10.1084/jem.20162040

Zheng, 2013, A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses, Cell Rep., 5, 180, 10.1016/j.celrep.2013.08.025

Zhong, 2016, NF-kappa B restricts inflammasome activation via elimination of damaged mitochondria, Cell, 164, 896, 10.1016/j.cell.2015.12.057

Zhou, 2011, A role for mitochondria in NLRP3 inflammasome activation, Nature, 469, 221, 10.1038/nature09663

Zhou, 2016, Virulent mycobacterium bovis Beijing strain activates the NLRP7 inflammasome in THP-1 macrophages, PLoS One, 11

Zhuang, 2014, NLRP3 inflammasome mediates albumin-induced renal tubular injury through impaired mitochondrial function, J. Biol. Chem., 289, 25101, 10.1074/jbc.M114.578260

Zhuang, 2015, Mitochondrial dysfunction confers albumin-induced NLRP3 inflammasome activation and renal tubular injury, Am. J. Physiol.-Ren., 308, F857, 10.1152/ajprenal.00203.2014

Zorova, 2017, Mitochondrial membrane potential, Anal. Biochem., 1