The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis
Tài liệu tham khảo
Abramson, 2008, Osteoarthritis and nitric oxide, Osteoarthr. Cartil., 16, S15, 10.1016/S1063-4584(08)60008-4
Adam-Vizi, 2006, Bioenergetics and the formation of mitochondrial reactive oxygen species, Trends Pharmacol. Sci., 27, 639, 10.1016/j.tips.2006.10.005
Adatia, 2012, Osteoarthritis of the knee and hip. Part I: aetiology and pathogenesis as a basis for pharmacotherapy, J. Pharm. Pharmacol., 64, 617, 10.1111/j.2042-7158.2012.01458.x
Aigner, 2006, Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis, Arthritis Rheum., 54, 3533, 10.1002/art.22174
Akhbari, 2019, Differences in the composition of hip and knee synovial fluid in osteoarthritis: a nuclear magnetic resonance (NMR) spectroscopy study of metabolic profiles, Osteoarthr. Cartil., 27, 1768, 10.1016/j.joca.2019.07.017
Akram, 2014, Citric acid cycle and role of its intermediates in metabolism, Cell Biochem. Biophys., 68, 475, 10.1007/s12013-013-9750-1
Ali, 2016, Regulation of cholesterol homeostasis by hedgehog signaling in osteoarthritic cartilage, ., 68, 127
Allen, 2012, Nitrite and nitric oxide metabolism in peripheral artery disease, Nitric Oxide, 26, 217, 10.1016/j.niox.2012.03.003
Alquraishi, 2019, Pyruvate kinase M2: a simple molecule with complex functions, Free Radic. Biol. Med., 143, 176, 10.1016/j.freeradbiomed.2019.08.007
Alvarez-Garcia, 2014, Palmitate has proapoptotic and proinflammatory effects on articular cartilage and synergizes with interleukin-1, ., 66, 1779
Anderson, 2020, Ex Vivo Equine Cartilage Explant Osteoarthritis Model: A Metabolomics and Proteomics Study, J. Proteome Res., 19, 3652, 10.1021/acs.jproteome.0c00143
Ansari, 2017, Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease, Aging Cell, 16, 4, 10.1111/acel.12538
Ansari, 2018, Butein activates autophagy through AMPK/TSC2/ULK1/mTOR pathway to inhibit IL-6 expression in IL-1β stimulated human chondrocytes, Cell. Physiol. Biochem., 49, 932, 10.1159/000493225
Arra, 2020, LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis, Nat. Commun., 11, 3427, 10.1038/s41467-020-17242-0
Astudillo, 2012, Dynamics of arachidonic acid mobilization by inflammatory cells, Biochim. Biophys. Acta, 1821, 249, 10.1016/j.bbalip.2011.11.006
Bai, 2019, Redox control of chondrocyte differentiation and chondrogenesis, Free Radic. Biol. Med., 132, 83, 10.1016/j.freeradbiomed.2018.10.443
Baker, 2012, Association of plasma n-6 and n-3 polyunsaturated fatty acids with synovitis in the knee: the MOST study, Osteoarthr. Cartil., 20, 382, 10.1016/j.joca.2012.01.021
Bao, 2020, Rapamycin protects chondrocytes against IL-18-induced apoptosis and ameliorates rat osteoarthritis, Aging (Albany NY), 12, 5152, 10.18632/aging.102937
Baudart, 2017, Association between osteoarthritis and dyslipidaemia: a systematic literature review and meta-analysis, RMD Open, 3, 10.1136/rmdopen-2017-000442
Baumann, 2014, Regulation of human trophoblast GLUT1 glucose transporter by insulin-like growth factor I (IGF-I), PLoS One, 9, 10.1371/journal.pone.0106037
Benabdoune, 2016, The role of resolvin D1 in the regulation of inflammatory and catabolic mediators in osteoarthritis, Inflamm. Res., 65, 635, 10.1007/s00011-016-0946-x
Bermúdez-Cardona, 2016, Profile of free fatty acids and fractions of phospholipids, cholesterol esters and triglycerides in serum of obese youth with and without metabolic syndrome, Nutrients, 8, 54, 10.3390/nu8020054
Bierma-Zeinstra, 2017, Osteoarthritis: in search of phenotypes, Nat. Rev. Rheumatol., 13, 705, 10.1038/nrrheum.2017.181
Blanco, 1998, Osteoarthritis chondrocytes die by apoptosis. A possible pathway for osteoarthritis pathology, Arthritis Rheum., 41, 284, 10.1002/1529-0131(199802)41:2<284::AID-ART12>3.0.CO;2-T
Blanco, 2004, Mitochondrial dysfunction in osteoarthritis, Mitochondrion, 4, 715, 10.1016/j.mito.2004.07.022
Blanco, 2011, The role of mitochondria in osteoarthritis, Nat. Rev. Rheumatol., 7, 161, 10.1038/nrrheum.2010.213
Blanco, 2018, Mitochondrial DNA variation and the pathogenesis of osteoarthritis phenotypes, Nat. Rev. Rheumatol., 14, 327, 10.1038/s41584-018-0001-0
Bolduc, 2019, Reactive oxygen species, aging and articular cartilage homeostasis, Free Radic. Biol. Med., 132, 73, 10.1016/j.freeradbiomed.2018.08.038
Bora, 1987, Joint physiology, cartilage metabolism, and the etiology of osteoarthritis, Hand Clin., 3, 325, 10.1016/S0749-0712(21)00667-3
Brandt, 2006, Yet more evidence that osteoarthritis is not a cartilage disease, Ann. Rheum. Dis., 65, 1261, 10.1136/ard.2006.058347
Brookheart, 2009, As a matter of fat, Cell Metab., 10, 9, 10.1016/j.cmet.2009.03.011
Brouwers, 2015, Lipid mediators of inflammation in rheumatoid arthritis and osteoarthritis, Best Pract. Res. Clin. Rheumatol., 29, 741, 10.1016/j.berh.2016.02.003
Bustamante, 2018, Hexokinase 2 as a novel selective metabolic target for rheumatoid arthritis, Ann. Rheum. Dis., 77, 1636, 10.1136/annrheumdis-2018-213103
Cai, 2019, MiR-27a promotes the autophagy and apoptosis of IL-1β treated-articular chondrocytes in osteoarthritis through PI3K/AKT/mTOR signaling, Aging (Albany NY), 11, 6371, 10.18632/aging.102194
Cairns, 2011, Regulation of cancer cell metabolism, Nat. Rev. Cancer, 11, 85, 10.1038/nrc2981
Calders, 2018, Presence of comorbidities and prognosis of clinical symptoms in knee and/or hip osteoarthritis: a systematic review and meta-analysis, Semin. Arthritis Rheum., 47, 805, 10.1016/j.semarthrit.2017.10.016
Cantó, 2009, PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure, Curr. Opin. Lipidol., 20, 98, 10.1097/MOL.0b013e328328d0a4
Caramés, 2012, Autophagy activation by rapamycin reduces severity of experimental osteoarthritis, Ann. Rheum. Dis., 71, 575, 10.1136/annrheumdis-2011-200557
Catterall, 2009, Post-translational aging of proteins in osteoarthritic cartilage and synovial fluid as measured by isomerized aspartate, Arthritis Res. Ther., 11, R55, 10.1186/ar2675
Chen, 2018, Activation of AMPK-SIRT3 signaling is chondroprotective by preserving mitochondrial DNA integrity and function, Osteoarthr. Cartil., 26, 1539, 10.1016/j.joca.2018.07.004
Chocron, 2019, Cause or casualty: the role of mitochondrial DNA in aging and age-associated disease, Biochim Biophys Acta Mol Basis Dis, 1865, 285, 10.1016/j.bbadis.2018.09.035
Choi, 2019, The CH25H-CYP7B1-RORα axis of cholesterol metabolism regulates osteoarthritis, Nature, 566, 254, 10.1038/s41586-019-0920-1
Choi, 2019, Critical role for arginase II in osteoarthritis pathogenesis, Ann. Rheum. Dis., 78, 421, 10.1136/annrheumdis-2018-214282
Choudhry, 2018, Advances in Hypoxia-Inducible factor biology, Cell Metab., 27, 281, 10.1016/j.cmet.2017.10.005
Cillero-Pastor, 2008, Mitochondrial dysfunction activates cyclooxygenase 2 expression in cultured normal human chondrocytes, Arthritis Rheum., 58, 2409, 10.1002/art.23644
Coimbra, 2004, Hypoxia inducible factor-1 alpha expression in human normal and osteoarthritic chondrocytes, Osteoarthr. Cartil., 12, 336, 10.1016/j.joca.2003.12.005
Courties, 2017, Metabolic syndrome-associated osteoarthritis, Curr. Opin. Rheumatol., 29, 214, 10.1097/BOR.0000000000000373
Crivelli, 2019, Silk fibroin nanoparticles for celecoxib and curcumin delivery: ROS-scavenging and anti-inflammatory activities in an in vitro model of osteoarthritis, Eur. J. Pharm. Biopharm., 137, 37, 10.1016/j.ejpb.2019.02.008
Cucchiarini, 2009, Remodelling of human osteoarthritic cartilage by FGF-2, alone or combined with Sox9 via rAAV gene transfer, J. Cell. Mol. Med., 13, 2476, 10.1111/j.1582-4934.2008.00474.x
de Munter, 2013, Cholesterol accumulation caused by low density lipoprotein receptor deficiency or a cholesterol-rich diet results in ectopic bone formation during experimental osteoarthritis, Arthritis Res. Ther., 15, 10.1186/ar4367
Dell’Isola, 2016, Identification of clinical phenotypes in knee osteoarthritis: a systematic review of the literature, BMC Musculoskelet. Disord., 17, 10.1186/s12891-016-1286-2
Dennis, 2015, Eicosanoid storm in infection and inflammation, Nat. Rev. Immunol., 15, 511, 10.1038/nri3859
Dickson, 2019, The burden of metabolic syndrome on osteoarthritic joints, Arthritis Res. Ther., 21, 10.1186/s13075-019-2081-x
Dröge, 2002, Free radicals in the physiological control of cell function, Physiol. Rev., 82, 47, 10.1152/physrev.00018.2001
Fang, 2014, Role of mtDNA haplogroups in the prevalence of knee osteoarthritis in a southern Chinese population, Int. J. Mol. Sci., 15, 2646, 10.3390/ijms15022646
Farnaghi, 2017, Cholesterol metabolism in pathogenesis of osteoarthritis disease, Int. J. Rheum. Dis., 20, 131, 10.1111/1756-185X.13061
Feng, 2019, Quercetin attenuates oxidative stress-induced apoptosis via SIRT1/AMPK-mediated inhibition of ER stress in rat chondrocytes and prevents the progression of osteoarthritis in a rat model, J. Cell. Physiol., 234, 18192, 10.1002/jcp.28452
Fernández-Torres, 2017, Hypoxia-Inducible Factors (HIFs) in the articular cartilage: a systematic review, Eur. Rev. Med. Pharmacol. Sci., 21, 2800
Fitzpatrick, 2019, Immunometabolism and Sepsis: a role for HIF?, Front. Mol. Biosci., 6, 85, 10.3389/fmolb.2019.00085
Forrester, 2018, Reactive oxygen species in metabolic and inflammatory signaling, Circ. Res., 122, 877, 10.1161/CIRCRESAHA.117.311401
Frey, 2017, Hyperlipidaemia and incident osteoarthritis of the hand: a population-based case-control study, Osteoarthr. Cartil., 25, 1040, 10.1016/j.joca.2017.01.014
Fu, 2016, Oleic/Palmitate induces apoptosis in human articular chondrocytes via upregulation of NOX4 expression and ROS production, Ann. Clin. Lab. Sci., 46, 353
Fu, 2016, Aging promotes sirtuin 3-Dependent cartilage superoxide dismutase 2 acetylation and osteoarthritis, ., 68, 1887
Geltink, 2018, Unraveling the complex interplay between t cell metabolism and function, Annu. Rev. Immunol., 36, 461, 10.1146/annurev-immunol-042617-053019
Gierman, 2014, Osteoarthritis development is induced by increased dietary cholesterol and can be inhibited by atorvastatin in APOE*3Leiden.CETP mice--a translational model for atherosclerosis, Ann. Rheum. Dis., 73, 921, 10.1136/annrheumdis-2013-203248
Gkretsi, 2011, Lipid metabolism and osteoarthritis: lessons from atherosclerosis, Prog. Lipid Res., 50, 133, 10.1016/j.plipres.2010.11.001
Goldring, 2011, Inflammation in osteoarthritis, Curr. Opin. Rheumatol., 23, 471, 10.1097/BOR.0b013e328349c2b1
Goldring, 2011, Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis, Eur. Cell. Mater., 21, 202, 10.22203/eCM.v021a16
Gorman, 2015, Prevalence of nuclear and mitochondrial DNA mutations related to adult mitochondrial disease, Ann. Neurol., 77, 753, 10.1002/ana.24362
Grimmer, 2007, Hypoxia-inducible factor 1alpha is involved in the prostaglandin metabolism of osteoarthritic cartilage through up-regulation of microsomal prostaglandin E synthase 1 in articular chondrocytes, Arthritis Rheum., 56, 4084, 10.1002/art.23136
Grishko, 2009, Diminished mitochondrial DNA integrity and repair capacity in OA chondrocytes, Osteoarthr. Cartil., 17, 107, 10.1016/j.joca.2008.05.009
Guilak, 2018, Osteoarthritis as a disease of the cartilage pericellular matrix, Matrix Biol., 71-72, 40, 10.1016/j.matbio.2018.05.008
Han, 2016, Regulation of glucose metabolism from a liver-centric perspective, Exp. Mol. Med., 48, 10.1038/emm.2015.122
Hashimoto, 1998, Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis, Arthritis Rheum., 41, 1632, 10.1002/1529-0131(199809)41:9<1632::AID-ART14>3.0.CO;2-A
Hashimoto, 1998, Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis, Arthritis Rheum., 41, 1266, 10.1002/1529-0131(199807)41:7<1266::AID-ART18>3.0.CO;2-Y
Hayflick, 1961, The serial cultivation of human diploid cell strains, Exp. Cell Res., 25, 585, 10.1016/0014-4827(61)90192-6
He, 2017, Antioxidants maintain cellular redox homeostasis by elimination of reactive oxygen species, Cell. Physiol. Biochem., 44, 532, 10.1159/000485089
Henrotin, 2007, Antioxidant to treat osteoarthritis: dream or reality?, Curr. Drug Targets, 8, 347, 10.2174/138945007779940151
Henze, 2003, Evolutionary biology: essence of mitochondria, Nature, 426, 127, 10.1038/426127a
Heras-Sandoval, 2014, The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration, Cell. Signal., 26, 2694, 10.1016/j.cellsig.2014.08.019
High, 2019, In vivo assessment of extracellular pH of joint tissues using acidoCEST-UTE MRI, Quant. Imaging Med. Surg., 9, 1664, 10.21037/qims.2019.08.11
Hirata, 2012, C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes, Hum. Mol. Genet., 21, 1111, 10.1093/hmg/ddr540
Hu, 2020, Stabilization of HIF-1α alleviates osteoarthritis via enhancing mitophagy, Cell Death Dis., 11, 481, 10.1038/s41419-020-2680-0
Huang, 2014, Enhancement of the synthesis of n-3 PUFAs in fat-1 transgenic mice inhibits mTORC1 signalling and delays surgically induced osteoarthritis in comparison with wild-type mice, Ann. Rheum. Dis., 73, 1719, 10.1136/annrheumdis-2013-203231
Huang, 2017, Targeting the d series resolvin receptor system for the treatment of osteoarthritis pain, ., 69, 996
Huang, 2020, Zinc protects chondrocytes from monosodium iodoacetate-induced damage by enhancing ATP and mitophagy, Biochem. Biophys. Res. Commun., 521, 50, 10.1016/j.bbrc.2019.10.066
Huh, 2015, Crosstalk between FLS and chondrocytes is regulated by HIF-2α-mediated cytokines in arthritis, Exp. Mol. Med., 47, e197, 10.1038/emm.2015.88
Hunter, 2019, Osteoarthritis, Lancet, 393, 1745, 10.1016/S0140-6736(19)30417-9
Hunter, 2014, The individual and socioeconomic impact of osteoarthritis, Nat. Rev. Rheumatol., 10, 437, 10.1038/nrrheum.2014.44
Hwang, 2015, Chondrocyte apoptosis in the pathogenesis of osteoarthritis, Int. J. Mol. Sci., 16, 26035, 10.3390/ijms161125943
Ioan-Facsinay, 2018, Bioactive lipids in osteoarthritis: risk or benefit?, Curr. Opin. Rheumatol., 30, 108, 10.1097/BOR.0000000000000463
Jeon, 2017, Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment, Nat. Med., 23, 775, 10.1038/nm.4324
Jiang, 2018, Gas chromatography-time of flight/mass spectrometry-based metabonomics of changes in the urinary metabolic profile in osteoarthritic rats, Exp. Ther. Med., 15, 2777
Jørgensen, 2017, The effect of aging and mechanical loading on the metabolism of articular cartilage, J. Rheumatol., 44, 410, 10.3899/jrheum.160226
Johnson, 2004, Mediation of spontaneous knee osteoarthritis by progressive chondrocyte ATP depletion in Hartley guinea pigs, Arthritis Rheum., 50, 1216, 10.1002/art.20149
Johnson, 2008, Hypoxia induces a novel signature of chromatin modifications and global repression of transcription, Mutat. Res., 640, 174, 10.1016/j.mrfmmm.2008.01.001
Jónasdóttir, 2017, Targeted lipidomics reveals activation of resolution pathways in knee osteoarthritis in humans, Osteoarthr. Cartil., 25, 1150, 10.1016/j.joca.2017.01.018
June, 2016, Emerging role of metabolic signaling in synovial joint remodeling and osteoarthritis, J. Orthop. Res., 34, 2048, 10.1002/jor.23420
Jutila, 2014, Candidate mediators of chondrocyte mechanotransduction via targeted and untargeted metabolomic measurements, Arch. Biochem. Biophys., 545, 116, 10.1016/j.abb.2014.01.011
Kalev-Zylinska, 2018, Altered N-methyl D-aspartate receptor subunit expression causes changes to the circadian clock and cell phenotype in osteoarthritic chondrocytes, Osteoarthr. Cartil., 26, 1518, 10.1016/j.joca.2018.06.015
Kaneko, 2019, Oral administration of N-acetyl cysteine prevents osteoarthritis development and progression in a rat model, Sci. Rep., 9, 10.1038/s41598-019-55297-2
Kapoor, 2011, Role of proinflammatory cytokines in the pathophysiology of osteoarthritis, Nat. Rev. Rheumatol., 7, 33, 10.1038/nrrheum.2010.196
Karonitsch, 2018, mTOR senses environmental cues to shape the fibroblast-like synoviocyte response to inflammation, Cell Rep., 23, 2157, 10.1016/j.celrep.2018.04.044
Kelly, 2015, Metabolic reprogramming in macrophages and dendritic cells in innate immunity, Cell Res., 25, 771, 10.1038/cr.2015.68
Kim, 2010, Mitochondrial DNA damage is involved in apoptosis caused by pro-inflammatory cytokines in human OA chondrocytes, Osteoarthr. Cartil., 18, 424, 10.1016/j.joca.2009.09.008
Kohlwein, 2010, Triacylglycerol homeostasis: insights from yeast, J. Biol. Chem., 285, 15663, 10.1074/jbc.R110.118356
Koike, 2015, Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration, Sci. Rep., 5, 10.1038/srep11722
Kong, 2020, Active vitamin D activates chondrocyte autophagy to reduce osteoarthritis via mediating the AMPK-mTOR signaling pathway, Biochem. Cell Biol., 98, 434, 10.1139/bcb-2019-0333
Konttinen, 2002, Acidic cysteine endoproteinase cathepsin K in the degeneration of the superficial articular hyaline cartilage in osteoarthritis, Arthritis Rheum., 46, 953, 10.1002/art.10185
Koo, 2019, Association of Asian mitochondrial DNA haplogroup B with new development of knee osteoarthritis in Koreans, Int. J. Rheum. Dis., 22, 411, 10.1111/1756-185X.13453
Kosai, 2019, Changes in acetyl-CoA mediate Sik3-induced maturation of chondrocytes in endochondral bone formation, Biochem. Biophys. Res. Commun., 516, 1097, 10.1016/j.bbrc.2019.06.139
Koskinen, 2011, Leptin enhances MMP-1, MMP-3 and MMP-13 production in human osteoarthritic cartilage and correlates with MMP-1 and MMP-3 in synovial fluid from OA patients, Clin. Exp. Rheumatol., 29, 57
Lancaster, 2018, Evidence that TLR4 is not a receptor for saturated fatty acids but mediates lipid-induced inflammation by reprogramming macrophage metabolism, Cell Metab., 27, 10.1016/j.cmet.2018.03.014
Lane, 1977, Anaerobic and aerobic metabolism in articular cartilage, J. Rheumatol., 4, 334
Lauber, 2003, Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal, Cell, 113, 717, 10.1016/S0092-8674(03)00422-7
Lee, 1997, Evidence for a negative Pasteur effect in articular cartilage, Biochem. J., 321, 95, 10.1042/bj3210095
Leistad, 2011, Multiple phospholipase A2 enzymes participate in the inflammatory process in osteoarthritic cartilage, Scand. J. Rheumatol., 40, 308, 10.3109/03009742.2010.547872
Li, 2015, A review on phospholipids and their main applications in drug delivery systems, Asian J. Pharm. Sci., 10, 81, 10.1016/j.ajps.2014.09.004
Li, 2016, Alterations of amino acid metabolism in osteoarthritis: its implications for nutrition and health, Amino Acids, 48, 907, 10.1007/s00726-015-2168-x
Li, 2019, PI3K/Akt and caspase pathways mediate oxidative stress-induced chondrocyte apoptosis, Cell Stress Chaperones, 24, 195, 10.1007/s12192-018-0956-4
Li, 2020, Exploration of metformin as novel therapy for osteoarthritis: preventing cartilage degeneration and reducing pain behavior, Arthritis Res. Ther., 22, 34, 10.1186/s13075-020-2129-y
Li, 2020, Metformin limits osteoarthritis development and progression through activation of AMPK signalling, Ann. Rheum. Dis., 79, 635, 10.1136/annrheumdis-2019-216713
Liu, 2020, Asiatic acid attenuates hypertrophic and fibrotic differentiation of articular chondrocytes via AMPK/PI3K/AKT signaling pathway, Arthritis Res. Ther., 22, 112, 10.1186/s13075-020-02193-0
Liu, 2020, High-spatial-Resolution multi-omics sequencing via Deterministic Barcoding in tissue, Cell, 183, 10.1016/j.cell.2020.10.026
Liu, 2020, Magnolol alleviates IL-1β-Induced dysfunction of chondrocytes through repression of SIRT1/AMPK/PGC-1α signaling pathway, J. Interferon Cytokine Res., 40, 145, 10.1089/jir.2019.0139
Loef, 2019, The association of plasma fatty acids with hand and knee osteoarthritis: the NEO study, Osteoarthr. Cartil., 10.1016/j.joca.2019.02.636
Loef, 2019, Fatty acids and osteoarthritis: different types, different effects, Joint Bone Spine, 86, 451, 10.1016/j.jbspin.2018.07.005
Loeser, 2009, Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix, Osteoarthr. Cartil., 17, 971, 10.1016/j.joca.2009.03.002
Loeser, 2011, Aging and osteoarthritis, Curr. Opin. Rheumatol., 23, 492, 10.1097/BOR.0b013e3283494005
Loeser, 2012, Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice, Arthritis Rheum., 64, 705, 10.1002/art.33388
Loeser, 2016, Ageing and the pathogenesis of osteoarthritis, Nat. Rev. Rheumatol., 12, 412, 10.1038/nrrheum.2016.65
Loeser, 2016, Association of urinary metabolites with radiographic progression of knee osteoarthritis in overweight and obese adults: an exploratory study, Osteoarthr. Cartil., 24, 1479, 10.1016/j.joca.2016.03.011
Luo, 2020, Mechanisms and regulation of cholesterol homeostasis, Nat. Rev. Mol. Cell Biol., 21, 225, 10.1038/s41580-019-0190-7
Mahon, 2019, Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism and promote M1 macrophage polarization, Osteoarthr. Cartil.
Mahon, 2020, Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism and promote M1 macrophage polarization, Osteoarthr. Cartil., 28, 603, 10.1016/j.joca.2019.10.010
Maneiro, 2003, Mitochondrial respiratory activity is altered in osteoarthritic human articular chondrocytes, Arthritis Rheum., 48, 700, 10.1002/art.10837
Mariani, 2014, Signaling pathways in cartilage repair, Int. J. Mol. Sci., 15, 8667, 10.3390/ijms15058667
Martel-Pelletier, 2016, Osteoarthritis, Nat. Rev. Dis. Primers, 2, 16072, 10.1038/nrdp.2016.72
Martin, 2002, Aging, articular cartilage chondrocyte senescence and osteoarthritis, Biogerontology, 3, 257, 10.1023/A:1020185404126
Martínez-Reyes, 2020, Mitochondrial TCA cycle metabolites control physiology and disease, Nat. Commun., 11, 102, 10.1038/s41467-019-13668-3
Mathieu, 2019, Cardiovascular profile in osteoarthritis: a meta-analysis of cardiovascular events and risk factors, Joint Bone Spine, 86, 679, 10.1016/j.jbspin.2019.06.013
Maxfield, 2005, Role of cholesterol and lipid organization in disease, Nature, 438, 612, 10.1038/nature04399
Miao, 2015, Stearic acid induces proinflammatory cytokine production partly through activation of lactate-HIF1α pathway in chondrocytes, Sci. Rep., 5, 10.1038/srep13092
Mickiewicz, 2015, Metabolic profiling of synovial fluid in a unilateral ovine model of anterior cruciate ligament reconstruction of the knee suggests biomarkers for early osteoarthritis, J. Orthop. Res., 33, 71, 10.1002/jor.22743
Mickiewicz, 2015, Metabolic analysis of knee synovial fluid as a potential diagnostic approach for osteoarthritis, J. Orthop. Res., 33, 1631, 10.1002/jor.22949
Misko, 2013, Characterization of nitrotyrosine as a biomarker for arthritis and joint injury, Osteoarthr. Cartil., 21, 151, 10.1016/j.joca.2012.09.005
Mobasheri, 2012, Glucose: an energy currency and structural precursor in articular cartilage and bone with emerging roles as an extracellular signaling molecule and metabolic regulator, Front. Endocrinol. (Lausanne), 3, 153, 10.3389/fendo.2012.00153
Mobasheri, 2012, Glucose: an energy currency and structural precursor in articular cartilage and bone with emerging roles as an extracellular signaling molecule and metabolic regulator, Front. Endocrinol. (Lausanne), 3, 10.3389/fendo.2012.00153
Mobasheri, 2016, An update on the pathophysiology of osteoarthritis, Ann. Phys. Rehabil. Med., 59, 333, 10.1016/j.rehab.2016.07.004
Mobasheri, 2005, Expression of the GLUT1 and GLUT9 facilitative glucose transporters in embryonic chondroblasts and mature chondrocytes in ovine articular cartilage, Cell Biol. Int., 29, 249, 10.1016/j.cellbi.2004.11.024
Mobasheri, 2015, Chondrosenescence: definition, hallmarks and potential role in the pathogenesis of osteoarthritis, Maturitas, 80, 237, 10.1016/j.maturitas.2014.12.003
Mobasheri, 2017, The role of metabolism in the pathogenesis of osteoarthritis, Nat. Rev. Rheumatol., 13, 302, 10.1038/nrrheum.2017.50
Mookerjee, 2015, The contributions of respiration and glycolysis to extracellular acid production, Biochim. Biophys. Acta, 1847, 171, 10.1016/j.bbabio.2014.10.005
Murahashi, 2018, Intra-articular administration of IκBα kinase inhibitor suppresses mouse knee osteoarthritis via downregulation of the NF-κB/HIF-2α axis, Sci. Rep., 8, 16475, 10.1038/s41598-018-34830-9
Mustonen, 2019, Anterior cruciate ligament transection alters the n-3/n-6 fatty acid balance in the lapine infrapatellar fat pad, Lipids Health Dis., 18, 10.1186/s12944-019-1008-5
Nahir, 1987, Aerobic glycolysis: a study of human articular cartilage, Cell Biochem. Funct., 5, 109, 10.1002/cbf.290050205
Nissanka, 2018, Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease, FEBS Lett., 592, 728, 10.1002/1873-3468.12956
O’Neill, 2013, Metabolism of inflammation limited by AMPK and pseudo-starvation, Nature, 493, 346, 10.1038/nature11862
O’Neill, 2016, A guide to immunometabolism for immunologists, Nat. Rev. Immunol., 16, 553, 10.1038/nri.2016.70
Okada, 2020, Hypoxia-inducible factor-1 alpha maintains mouse articular cartilage through suppression of NF-κB signaling, Sci. Rep., 10, 5425, 10.1038/s41598-020-62463-4
Oren, 2011, Arthroplasty in veterans: analysis of cartilage, bone, serum, and synovial fluid reveals differences and similarities in osteoarthritis with and without comorbid diabetes, J. Rehabil. Res. Dev., 48, 1195, 10.1682/JRRD.2010.09.0186
Pal, 2015, mTOR: a potential therapeutic target in osteoarthritis?, Drugs R., 15, 27, 10.1007/s40268-015-0082-z
Pallu, 2010, Obesity affects the chondrocyte responsiveness to leptin in patients with osteoarthritis, Arthritis Res. Ther., 12, 10.1186/ar3048
Pascale, 2013, L-arginine, asymmetric dimethylarginine, and symmetric dimethylarginine in plasma and synovial fluid of patients with knee osteoarthritis, Med. Sci. Monit., 19, 1057, 10.12659/MSM.889275
Passarino, 2010, Mitochondrial function, mitochondrial DNA and ageing: a reappraisal, Biogerontology, 11, 575, 10.1007/s10522-010-9294-3
Peansukmanee, 2009, Effects of hypoxia on glucose transport in primary equine chondrocytes in vitro and evidence of reduced GLUT1 gene expression in pathologic cartilage in vivo, J. Orthop. Res., 27, 529, 10.1002/jor.20772
Pereira, 2011, The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review, Osteoarthr. Cartil., 19, 1270, 10.1016/j.joca.2011.08.009
Petursson, 2013, Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes, Arthritis Res. Ther., 15, 10.1186/ar4254
Pfander, 2003, HIF-1alpha controls extracellular matrix synthesis by epiphyseal chondrocytes, J. Cell. Sci., 116, 1819, 10.1242/jcs.00385
Piao, 2020, Protectin DX attenuates IL-1β-induced inflammation via the AMPK/NF-κB pathway in chondrocytes and ameliorates osteoarthritis progression in a rat model, Int. Immunopharmacol., 78, 10.1016/j.intimp.2019.106043
Piepoli, 2009, Glutamate signaling in chondrocytes and the potential involvement of NMDA receptors in cell proliferation and inflammatory gene expression, Osteoarthr. Cartil., 17, 1076, 10.1016/j.joca.2009.02.002
Pruzanski, 1991, Enzymatic activity and distribution of phospholipase A2 in human cartilage, Life Sci., 48, 2457, 10.1016/0024-3205(91)90381-K
Qing-Xian, 2020, Programming changes in GLUT1 mediated the accumulation of AGEs and matrix degradation in the articular cartilage of female adult rats after prenatal caffeine exposure, Pharmacol. Res., 151, 10.1016/j.phrs.2019.104555
Qu, 2016, PFKFB3 modulates glycolytic metabolism and alleviates endoplasmic reticulum stress in human osteoarthritis cartilage, Clin. Exp. Pharmacol. Physiol., 43, 312, 10.1111/1440-1681.12537
Rahmati, 2016, Inflammatory mediators in osteoarthritis: a critical review of the state-of-the-art, current prospects, and future challenges, Bone, 85, 81, 10.1016/j.bone.2016.01.019
Rasheed, 2011, Advanced glycation end products induce the expression of interleukin-6 and interleukin-8 by receptor for advanced glycation end product-mediated activation of mitogen-activated protein kinases and nuclear factor-κB in human osteoarthritis chondrocytes, Rheumatology Oxford (Oxford), 50, 838, 10.1093/rheumatology/keq380
Rego, 2010, Role of European mitochondrial DNA haplogroups in the prevalence of hip osteoarthritis in Galicia, Northern Spain, Ann. Rheum. Dis., 69, 210, 10.1136/ard.2008.105254
Rego-Perez, 2013, Mitochondrial genetics and osteoarthritis, Front. Biosci. Schol. Ed. (Schol Ed), 5, 360, 10.2741/S377
Richardson, 2003, Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation, Osteoarthr. Cartil., 11, 92, 10.1053/joca.2002.0858
Richardson, 2010, Mesenchymal stem cells in regenerative medicine: opportunities and challenges for articular cartilage and intervertebral disc tissue engineering, J. Cell. Physiol., 222, 23, 10.1002/jcp.21915
Rieder, 2018, Hydrostatic pressure-generated reactive oxygen species induce osteoarthritic conditions in cartilage pellet cultures, Sci. Rep., 8, 10.1038/s41598-018-34718-8
Rockel, 2018, The metabolome and osteoarthritis: possible contributions to symptoms and pathology, Metabolites, 8
Rolland, 2001, Glucose-sensing mechanisms in eukaryotic cells, Trends Biochem. Sci., 26, 310, 10.1016/S0968-0004(01)01805-9
Ruiz-Romero, 2009, Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics: a decrease in mitochondrial superoxide dismutase points to a redox imbalance, Mol. Cell Proteomics, 8, 172, 10.1074/mcp.M800292-MCP200
Runhaar, 2014, Malalignment: a possible target for prevention of incident knee osteoarthritis in overweight and obese women, Rheumatology Oxford (Oxford), 53, 1618, 10.1093/rheumatology/keu141
Ryu, 2011, Interleukin-6 plays an essential role in hypoxia-inducible factor 2α-induced experimental osteoarthritic cartilage destruction in mice, Arthritis Rheum., 63, 2732, 10.1002/art.30451
Ryu, 2012, Hypoxia-inducible factor-2α regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction, Cell Death Differ., 19, 440, 10.1038/cdd.2011.111
Saito, 2010, Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development, Nat. Med., 16, 678, 10.1038/nm.2146
Salinas, 2017, Combining Targeted Metabolomic Data with a Model of Glucose Metabolism: Toward Progress in Chondrocyte Mechanotransduction, PLoS One, 12, 10.1371/journal.pone.0168326
Salinas, 2019, Physiological dynamic compression regulates central energy metabolism in primary human chondrocytes, Biomech. Model. Mechanobiol., 18, 69, 10.1007/s10237-018-1068-x
Salminen, 2012, Inflammaging: disturbed interplay between autophagy and inflammasomes, Aging (Albany NY), 4, 166, 10.18632/aging.100444
Saudek, 2003, Advanced glycation endproducts and osteoarthritis, Curr. Rheumatol. Rep., 5, 33, 10.1007/s11926-003-0081-x
Scanzello, 2017, Role of low-grade inflammation in osteoarthritis, Curr. Opin. Rheumatol., 29, 79, 10.1097/BOR.0000000000000353
Schofield, 2004, Oxygen sensing by HIF hydroxylases, Nat. Rev. Mol. Cell Biol., 5, 343, 10.1038/nrm1366
Scott, 2010, Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease, Ann. Rheum. Dis., 69, 1502, 10.1136/ard.2009.119966
Serhan, 2014, Pro-resolving lipid mediators are leads for resolution physiology, Nature, 510, 92, 10.1038/nature13479
Serhan, 2015, The resolution code of acute inflammation: novel pro-resolving lipid mediators in resolution, Semin. Immunol., 27, 200, 10.1016/j.smim.2015.03.004
Shambaugh, 1977, Urea biosynthesis I. The urea cycle and relationships to the citric acid cycle, Am. J. Clin. Nutr., 30, 2083, 10.1093/ajcn/30.12.2083
Shen, 2014, Role of mtDNA haplogroups in the prevalence of osteoarthritis in different geographic populations: a meta-analysis, PLoS One, 9, 10.1371/journal.pone.0108896
Shet, 2012, High-resolution magic angle spinning NMR spectroscopy of human osteoarthritic cartilage, NMR Biomed., 25, 538, 10.1002/nbm.1769
Shet, 2012, High-resolution magic angle spinning NMR spectroscopy of human osteoarthritic cartilage, NMR Biomed., 25, 538, 10.1002/nbm.1769
Shi, 2019, A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development, Nat. Commun., 10, 1914, 10.1038/s41467-019-09839-x
Shirai, 2016, The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease, J. Exp. Med., 213, 337, 10.1084/jem.20150900
Showiheen, 2019, Application of metabolomics to osteoarthritis: from basic science to the clinical approach, Curr. Rheumatol. Rep., 21, 10.1007/s11926-019-0827-8
Sibille, 2018, Omega-6: Omega-3 PUFA ratio, pain, functioning, and distress in adults with knee pain, Clin. J. Pain, 34, 182, 10.1097/AJP.0000000000000517
Silver, 1975, Measurement of pH and ionic composition of pericellular sites, Philos. Trans. R. Soc. Lond., B, Biol. Sci., 271, 261, 10.1098/rstb.1975.0050
Silverwood, 2015, Current evidence on risk factors for knee osteoarthritis in older adults: a systematic review and meta-analysis, Osteoarthr. Cartil., 23, 507, 10.1016/j.joca.2014.11.019
Soto-Hermida, 2014, mtDNA haplogroups and osteoarthritis in different geographic populations, Mitochondrion, 15, 18, 10.1016/j.mito.2014.03.001
Stegen, 2019, HIF-1α metabolically controls collagen synthesis and modification in chondrocytes, Nature, 565, 511, 10.1038/s41586-019-0874-3
Stoppoloni, 2013, L-carnitine enhances extracellular matrix synthesis in human primary chondrocytes, Rheumatol. Int., 33, 2399, 10.1007/s00296-012-2373-9
Stürmer, 1998, Serum cholesterol and osteoarthritis. The baseline examination of the Ulm Osteoarthritis Study, J. Rheumatol., 25, 1827
Sun, 2018, miR-4262 regulates chondrocyte viability, apoptosis, autophagy by targeting SIRT1 and activating PI3K/AKT/mTOR signaling pathway in rats with osteoarthritis, Exp. Ther. Med., 15, 1119
Tanner, 2018, Four key steps control glycolytic flux in mammalian cells, Cell Syst., 7
Terkeltaub, 2002, Invited review: the mitochondrion in osteoarthritis, Mitochondrion, 1, 301, 10.1016/S1567-7249(01)00037-X
Terkeltaub, 2011, Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α, Arthritis Rheum., 63, 1928, 10.1002/art.30333
Thoms, 2013, Hypoxia promotes the production and inhibits the destruction of human articular cartilage, Arthritis Rheum., 65, 1302, 10.1002/art.37867
Tsikas, 2015, Homoarginine, arginine, and relatives: analysis, metabolism, transport, physiology, and pathology, Amino Acids, 47, 1697, 10.1007/s00726-015-2055-5
Tvrzicka, 2011, Fatty acids as biocompounds: their role in human metabolism, health and disease--a review. Part 1: classification, dietary sources and biological functions, Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech., 155, 117, 10.5507/bp.2011.038
Vaamonde-García, 2012, Mitochondrial dysfunction increases inflammatory responsiveness to cytokines in normal human chondrocytes, Arthritis Rheum., 64, 2927, 10.1002/art.34508
van der Bliek, 2017, Cell biology of the mitochondrion, Genetics, 207, 843, 10.1534/genetics.117.300262
Vander Heiden, 2009, Understanding the Warburg effect: the metabolic requirements of cell proliferation, Science, 324, 1029, 10.1126/science.1160809
Varela-Eirin, 2018, Cartilage regeneration and ageing: targeting cellular plasticity in osteoarthritis, Ageing Res. Rev., 42, 56, 10.1016/j.arr.2017.12.006
Vettore, 2020, New aspects of amino acid metabolism in cancer, Br. J. Cancer, 122, 150, 10.1038/s41416-019-0620-5
Wang, 2018, Pro-inflammatory cytokines: the link between obesity and osteoarthritis, Cytokine Growth Factor Rev., 44, 38, 10.1016/j.cytogfr.2018.10.002
Wang, 2015, Mitochondrial biogenesis is impaired in osteoarthritis chondrocytes but reversible via peroxisome proliferator-activated receptor γ coactivator 1α, ., 67, 2141
Wang, 2017, Identification of functional hypoxia inducible factor response elements in the human lysyl oxidase gene promoter, Biochem. Biophys. Res. Commun., 490, 480, 10.1016/j.bbrc.2017.06.066
Wang, 2018, Distinct metabolic programs induced by TGF-β1 and BMP2 in human articular chondrocytes with osteoarthritis, J. Orthop. Translat., 12, 66, 10.1016/j.jot.2017.12.004
Wang, 2018, Puerarin attenuates osteoarthritis via upregulating AMP-Activated protein Kinase/Proliferator-Activated Receptor-γ Coactivator-1 signaling pathway in osteoarthritis rats, Pharmacology, 102, 117, 10.1159/000490418
Wang, 2019, Icariin increases chondrocyte vitality by promoting hypoxia-inducible factor-1α expression and anaerobic glycolysis, Knee
Warburg, 1956, On the origin of cancer cells, Science, 123, 309, 10.1126/science.123.3191.309
Wen, 2015, Excitatory amino acid glutamate: role in peripheral nociceptive transduction and inflammation in experimental and clinical osteoarthritis, Osteoarthr. Cartil., 23, 2009, 10.1016/j.joca.2015.03.017
Weng, 2014, Loss of Vhl in cartilage accelerated the progression of age-associated and surgically induced murine osteoarthritis, Osteoarthr. Cartil., 22, 1197, 10.1016/j.joca.2014.06.031
Wiley, 2016, From ancient pathways to aging cells-connecting metabolism and cellular senescence, Cell Metab., 23, 1013, 10.1016/j.cmet.2016.05.010
Wilkins, 1995, Control of matrix synthesis in isolated bovine chondrocytes by extracellular and intracellular pH, J. Cell. Physiol., 164, 474, 10.1002/jcp.1041640305
Wu, 2009, Amino acids: metabolism, functions, and nutrition, Amino Acids, 37, 1, 10.1007/s00726-009-0269-0
Wu, 2009, Arginine metabolism and nutrition in growth, health and disease, Amino Acids, 37, 153, 10.1007/s00726-008-0210-y
Xu, 2019, PKM2: a potential regulator of rheumatoid arthritis via glycolytic and non-glycolytic pathways, Front. Immunol., 10, 10.3389/fimmu.2019.02919
Xue, 2017, Inhibition of PI3K/AKT/mTOR signaling pathway promotes autophagy of articular chondrocytes and attenuates inflammatory response in rats with osteoarthritis, Biomed. Pharmacother., 89, 1252, 10.1016/j.biopha.2017.01.130
Yang, 2010, Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction, Nat. Med., 16, 687, 10.1038/nm.2153
Yang, 2015, Advanced glycation end products-induced chondrocyte apoptosis through mitochondrial dysfunction in cultured rabbit chondrocyte, Fundam. Clin. Pharmacol., 29, 54, 10.1111/fcp.12094
Yang, 2018, Pyruvate kinase M2 modulates the glycolysis of chondrocyte and extracellular matrix in osteoarthritis, DNA Cell Biol., 37, 271, 10.1089/dna.2017.4048
Yang, 2019, Effects of AURKA-mediated degradation of SOD2 on mitochondrial dysfunction and cartilage homeostasis in osteoarthritis, J. Cell. Physiol., 234, 17727, 10.1002/jcp.28398
Ye, 2016, Advanced oxidation protein products induce catabolic effect through oxidant-dependent activation of NF-κ B pathway in human chondrocyte, Int. Immunopharmacol., 39, 149, 10.1016/j.intimp.2016.07.018
Yudoh, 2005, Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1 alpha in articular chondrocytes: involvement of HIF-1 alpha in the pathogenesis of osteoarthritis, Arthritis Res. Ther., 7, R904, 10.1186/ar1765
Zainal, 2009, Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis, Osteoarthr. Cartil., 17, 896, 10.1016/j.joca.2008.12.009
Zandalinas, 2018, ROS-induced ROS release in plant and animal cells, Free Radic. Biol. Med., 122, 21, 10.1016/j.freeradbiomed.2017.11.028
Zhai, 2010, Serum branched-chain amino acid to histidine ratio: a novel metabolomic biomarker of knee osteoarthritis, Ann. Rheum. Dis., 69, 1227, 10.1136/ard.2009.120857
Zhai, 2019, Activation of the phosphatidylcholine to lysophosphatidylcholine pathway is associated with osteoarthritis knee cartilage volume loss over time, Sci. Rep., 9, 9648, 10.1038/s41598-019-46185-w
Zhang, 2008, Epidemiology of osteoarthritis, Rheum. Dis. Clin. North Am., 34, 515, 10.1016/j.rdc.2008.05.007
Zhang, 2010, Circulating mitochondrial DAMPs cause inflammatory responses to injury, Nature, 464, 104, 10.1038/nature08780
Zhang, 2015, Serum metabolites as potential biomarkers for diagnosis of knee osteoarthritis, Dis. Markers, 2015, 10.1155/2015/684794
Zhang, 2015, Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis, Ann. Rheum. Dis., 74, 1432, 10.1136/annrheumdis-2013-204599
Zhang, 2016, Lysophosphatidylcholines to phosphatidylcholines ratio predicts advanced knee osteoarthritis, Rheumatology Oxford (Oxford), 55, 1566, 10.1093/rheumatology/kew207
Zhang, 2016, Metabolomic analysis of human synovial fluid and plasma reveals that phosphatidylcholine metabolism is associated with both osteoarthritis and diabetes mellitus, Metabolomics, 12, 24, 10.1007/s11306-015-0937-x
Zhang, 2016, Metabolomic analysis of human plasma reveals that arginine is depleted in knee osteoarthritis patients, Osteoarthr. Cartil., 24, 827, 10.1016/j.joca.2015.12.004
Zhang, 2016, Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model, Arthritis Res. Ther., 18, 128, 10.1186/s13075-016-1025-y
Zhang, 2018, Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2, Ann. Rheum. Dis., 77, 1524, 10.1136/annrheumdis-2018-213450
Zheng, 2017, Global and targeted metabolomics of synovial fluid discovers special osteoarthritis metabolites, J. Orthop. Res., 35, 1973, 10.1002/jor.23482
Zhou, 2004, Factors influencing the oxygen concentration gradient from the synovial surface of articular cartilage to the cartilage-bone interface: a modeling study, Arthritis Rheum., 50, 3915, 10.1002/art.20675
Zhou, 2017, The cross-sectional and longitudinal effect of hyperlipidemia on knee osteoarthritis: results from the Dongfeng-Tongji cohort in China, Sci. Rep., 7
Zhou, 2017, AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice, Sci. Rep., 7
Zhou, 2020, Chemically modified curcumin (CMC2.24) alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis, J. Mol. Med., 98, 1479, 10.1007/s00109-020-01972-1
Zignego, 2015, Mechanotransduction in primary human osteoarthritic chondrocytes is mediated by metabolism of energy, lipids, and amino acids, J. Biomech., 48, 4253, 10.1016/j.jbiomech.2015.10.038