The role of long non-coding RNAs in the pathogenesis of head and neck squamous cell carcinoma

Bray, 2018, Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, CA Cancer J. Clin., 68, 394, 10.3322/caac.21492 Wyss, 2013, Cigarette, cigar, and pipe smoking and the risk of head and neck cancers: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium, Am. J. Epidemiol., 178, 679, 10.1093/aje/kwt029 Maier, 1992, Tobacco and alcohol and the risk of head and neck cancer, Clin. Invest., 70, 320 Chaturvedi, 2011, Human papillomavirus and rising oropharyngeal cancer incidence in the United States, J. Clin. Oncol., 29, 4294, 10.1200/JCO.2011.36.4596 Gatta, 2015, Prognoses and improvement for head and neck cancers diagnosed in Europe in early 2000s: the EUROCARE-5 population-based study, Eur. J. Cancer, 51, 2130, 10.1016/j.ejca.2015.07.043 Budach, 2019, Novel prognostic clinical factors and biomarkers for outcome prediction in head and neck cancer: a systematic review, Lancet Oncol., 20, e313, 10.1016/S1470-2045(19)30177-9 Schmitt, 2016, Long noncoding RNAs in cancer pathways, Cancer Cell, 29, 452, 10.1016/j.ccell.2016.03.010 Wong, 2018, Non-coding RNAs in hepatocellular carcinoma: molecular functions and pathological implications, Nat. Rev. Gastroenterol. Hepatol., 15, 137, 10.1038/nrgastro.2017.169 Cabili, 2011, Integrative annotation of human large intergenic non-coding RNAs reveals global properties and specific subclasses, Genes Dev., 25, 1915, 10.1101/gad.17446611 Hezroni, 2015, Principles of long non-coding RNA evolution derived from direct comparison of transcriptomes in 17 species, Cell Rep., 11, 1110, 10.1016/j.celrep.2015.04.023 Quinn, 2016, Unique features of long non-coding RNA biogenesis and function, Nat. Rev. Genet., 17, 47, 10.1038/nrg.2015.10 Ulitsky, 2011, Conserved function of lincRNAs in vertebrate embryonic development despite rapid sequence evolution, Cell, 147, 1537, 10.1016/j.cell.2011.11.055 Guttman, 2009, Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals, Nature, 458, 223, 10.1038/nature07672 Huarte, 2010, A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response, Cell, 142, 409, 10.1016/j.cell.2010.06.040 Zheng, 2014, Dicer-microRNA-Myc circuit promotes transcription of hundreds of long non-coding RNAs, Nat. Struct. Mol. Biol., 21, 585, 10.1038/nsmb.2842 de Lena, 2017, Clusterization in head and neck squamous carcinomas based on lncRNA expression: molecular and clinical correlates, Clin. Epigenetics, 9, 36, 10.1186/s13148-017-0334-6 Wang, 2021, Integrative analysis of DNA methylation data and transcriptome data identified a DNA methylation-dysregulated four-lncRNA signature for predicting prognosis in head and neck squamous cell carcinoma, Front. Cell. Dev. Biol., 9, 666349, 10.3389/fcell.2021.666349 Lee, 2021, Hypomethylation of lncRNA H19 as a potential prognostic biomarker for oral squamous cell carcinoma, Arch. Oral Biol., 129, 105214, 10.1016/j.archoralbio.2021.105214 Shi, 2020, Aberrant methylation-mediated decrease of lncRNA HNF1A-AS1 contributes to malignant progression of laryngeal squamous cell carcinoma via EMT, Oncol. Rep., 44, 2503, 10.3892/or.2020.7823 Nohata, 2016, Unraveling the oral cancer lncRNAome: identification of novel lncRNAs associated with malignant progression and HPV infection, Oral Oncol., 59, 58, 10.1016/j.oraloncology.2016.05.014 Ma, 2017, LncRNAs as an intermediate in HPV16 promoting myeloid-derived suppressor cell recruitment of head and neck squamous cell carcinoma, Oncotarget, 8, 42061, 10.18632/oncotarget.14939 Song, 2019, Association of lnc-IL17RA-11 with increased radiation sensitivity and improved prognosis of HPV-positive HNSCC, J. Cell. Biochem., 120, 17438, 10.1002/jcb.29008 Di Agostino, 2018, Long non-coding MIR205HG depletes hsa-miR-590-3p leading to unrestrained proliferation in head and neck squamous cell carcinoma, Theranostics, 8, 1850, 10.7150/thno.22167 Chaudhary, 2020, Long non-coding RNA, LINC00460, as a prognostic biomarker in head and neck squamous cell carcinoma (HNSCC), Am. J. Transl. Res., 12, 684 Jin, 2019, p53-targeted lincRNA-p21 acts as a tumor suppressor by inhibiting JAK2/STAT3 signaling pathways in head and neck squamous cell carcinoma, Mol. Cancer, 18, 38, 10.1186/s12943-019-0993-3 Yu, 2016, RNA-seq analysis identifies key long non-coding RNAs connected to the pathogenesis of alcohol-associated head and neck squamous cell carcinoma, Oncol. Lett., 12, 2846, 10.3892/ol.2016.4972 Arunkumar, 2017, Expression profiling of long non-coding RNA identifies linc-RoR as a prognostic biomarker in oral cancer, Tumour Biol., 39, 10.1177/1010428317698366 Li, 2013, Long intergenic non-coding RNA HOTAIR is overexpressed and regulates PTEN methylation in laryngeal squamous cell carcinoma, Am. J. Pathol., 182, 64, 10.1016/j.ajpath.2012.08.042 Wu, 2015, Long non-coding RNA HOTAIR promotes tumor cell invasion and metastasis by recruiting EZH2 and repressing E-cadherin in oral squamous cell carcinoma, Int. J. Oncol., 46, 2586, 10.3892/ijo.2015.2976 Sun, 2018, STAT3/HOTAIR signaling axis regulates HNSCC growth in an EZH2-dependent manner, Clin. Cancer Res., 24, 2665, 10.1158/1078-0432.CCR-16-2248 Kong, 2015, Targeting HOTAIR induces mitochondria related apoptosis and inhibits tumor growth in head and neck squamous cell carcinoma in vitro and in vivo, Curr. Mol. Med., 15, 952, 10.2174/1566524016666151123112716 Li, 2019, Long non-coding RNA HOTAIR/microRNA-206 sponge regulates STC2 and further influences cell biological functions in head and neck squamous cell carcinoma, Cell Prolif., 52, e12651, 10.1111/cpr.12651 Wang, 2016, A novel cell cycle-associated lncRNA, HOXA11-AS, is transcribed from the 5-prime end of the HOXA transcript and is a biomarker of progression in glioma, Cancer Lett., 373, 251, 10.1016/j.canlet.2016.01.039 Qu, 2018, Expression of long non-coding RNA HOXA11-AS is correlated with progression of laryngeal squamous cell carcinoma, Am. J. Transl. Res., 10, 573 Xu, 2020, lncRNA HOXA11-AS promotes proliferation and migration via sponging miR-155 in hypopharyngeal squamous cell carcinoma, Oncol. Res., 28, 311, 10.3727/096504020X15801233454611 Li, 2019, HOXA11-AS promotes the progression of oral squamous cell carcinoma by targeting the miR-518a-3p/PDK1 axis, Cancer Cell Int., 19, 140, 10.1186/s12935-019-0838-6 Wang, 2018, TGF-β-induced STAT3 overexpression promotes human head and neck squamous cell carcinoma invasion and metastasis through malat1/miR-30a interactions, Cancer Lett., 436, 52, 10.1016/j.canlet.2018.08.009 Zhu, 2019, lncRNA MALAT1 potentiates the progression of tongue squamous cell carcinoma through regulating miR-140-5p-PAK1 pathway, Onco Targets Ther., 12, 1365, 10.2147/OTT.S192069 Xu, 2020, Blocking long non-coding RNA MALAT1 restrained the development of laryngeal and hypopharyngeal carcinoma, Eur. Arch. Otorhinolaryngol., 277, 611, 10.1007/s00405-019-05732-x Zhang, 2018, Long non-coding RNA ANRIL promotes tumorgenesis through regulation of FGFR1 expression by sponging miR-125a-3p in head and neck squamous cell carcinoma, Am. J. Cancer Res., 8, 2296 Hao, 2019, Long non-coding RNA ANRIL promotes proliferation, clonogenicity, invasion and migration of laryngeal squamous cell carcinoma by regulating miR-181a/Snai2 axis, Regen. Ther., 11, 282, 10.1016/j.reth.2019.07.007 Liu, 2019, Effects of lncRNA ANRIL on proliferation and apoptosis of oral squamous cell carcinoma cells by regulating TGF-β/Smad pathway, Eur. Rev. Med. Pharmacol. Sci., 23, 6194 Guan, 2016, Overexpression of lncRNA H19/miR-675 promotes tumorigenesis in head and neck squamous cell carcinoma, Int. J. Med. Sci., 13, 914, 10.7150/ijms.16571 Kou, 2019, H19 facilitates tongue squamous cell carcinoma migration and invasion via sponging miR-let-7, Oncol. Res., 27, 173, 10.3727/096504018X15202945197589 Wu, 2016, Regulation of laryngeal squamous cell cancer progression by the lncRNA H19/miR-148a-3p/DNMT1 axis, Oncotarget, 7, 11553, 10.18632/oncotarget.7270 Li, 2019, Small nucleolar RNA host gene 12 (SNHG12) promotes proliferation and invasion of laryngeal cancer cells via sponging miR-129-5p and potentiating WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) expression, Med. Sci. Monit., 25, 5552, 10.12659/MSM.917088 Wu, 2019, Long non-coding RNA SNHG20 promotes the tumorigenesis of oral squamous cell carcinoma via targeting miR-197/LIN28 axis, J. Cell. Mol. Med., 23, 680, 10.1111/jcmm.13987 Diao, 2019, Overexpression of ZEB2-AS1 promotes epithelial-to-mesenchymal transition and metastasis by stabilizing ZEB2 mRNA in head neck squamous cell carcinoma, J. Cell. Mol. Med., 23, 4269, 10.1111/jcmm.14318 Wen, 2018, Long non-coding RNA DANCR stabilizes HIF-1α and promotes metastasis by interacting with NF90/NF45 complex in nasopharyngeal carcinoma, Theranostics, 8, 5676, 10.7150/thno.28538 Kolenda, 2019, Oncogenic role of ZFAS1 lncRNA in head and neck squamous cell carcinomas, Cells, 8, 366, 10.3390/cells8040366 Sun, 2020, Long non-coding RNA KCNQ1OT1 promotes proliferation, migration, and invasion in maxillary sinus squamous cell carcinoma by regulating miR-204/EphA7 axis, J. Cell. Biochem., 121, 2962, 10.1002/jcb.29548 Zhang, 2018, Low expression of lncRNA MEG3 promotes the progression of oral squamous cell carcinoma by targeting miR-21, Eur. Rev. Med. Pharmacol. Sci., 22, 8315 Dong, 2019, Downregulation of lncRNA CASC2 promotes the postoperative local recurrence of early oral squamous cell carcinoma, Eur. Arch. Otorhinolaryngol., 276, 605, 10.1007/s00405-018-5209-8 Zhuang, 2016, CCAT1 promotes laryngeal squamous cell carcinoma cell proliferation and invasion, Am. J. Transl. Res., 8, 4338 Gao, 2018, A positive feedback regulation between long non-coding RNA SNHG1 and YAP1 modulates growth and metastasis in laryngeal squamous cell carcinoma, Am. J. Cancer Res., 8, 1712 Li, 2019, Overexpression of lncRNA WWTR1-AS1 associates with tumor aggressiveness and unfavorable survival in head-neck squamous cell carcinoma, J. Cell. Biochem., 120, 18266, 10.1002/jcb.29132 Leng, 2021, A micro-peptide encoded by HOXB-AS3 promotes the proliferation and viability of oral squamous cell carcinoma cell lines by directly binding with IGF2BP2 to stabilize c-Myc, Oncol. Lett., 22, 697, 10.3892/ol.2021.12958 Ma, 2021, FOXD1-AS1 upregulates FOXD1 to promote oral squamous cell carcinoma progression, Oral Dis., 10.1111/odi.14002 Li, 2020, Long noncoding RNA DANCR regulates cell proliferation by stabilizing SOX2 mRNA in nasopharyngeal carcinoma, Am. J. Pathol., 190, 2343, 10.1016/j.ajpath.2020.09.005 Ma, 2020, A novel IFNα-induced long non-coding RNA negatively regulates immunosuppression by interrupting H3K27 acetylation in head and neck squamous cell carcinoma, Mol. Cancer, 19, 4, 10.1186/s12943-019-1123-y Wang, 2016, Long non-coding RNA NEAT1 promotes laryngeal squamous cell cancer through regulating miR-107/CDK6 pathway, J. Exp. Clin. Cancer Res., 35, 22, 10.1186/s13046-016-0297-z Shen, 2018, Long non-coding RNA AC026166.2-001 inhibits cell proliferation and migration in laryngeal squamous cell carcinoma by regulating the miR-24-3p/p27 axis, Sci. Rep., 8, 3375, 10.1038/s41598-018-21659-5 Ouyang, 2019, Long non-coding RNA LINC00052 regulates miR-608/EGFR axis to promote progression of head and neck squamous cell carcinoma, Exp. Mol. Pathol., 111, 104321, 10.1016/j.yexmp.2019.104321 Chen, 2020, LINC00467 enhances head and neck squamous cell carcinoma progression and the epithelial-mesenchymal transition process via miR-299-5p/ubiquitin specific protease-48 axis, J. Gene Med., 22, e3184, 10.1002/jgm.3184 Bao, 2019, KCNQ1OT1 promotes migration and inhibits apoptosis by modulating miR-185-5p/Rab14 axis in oral squamous cell carcinoma, Dev. Growth Differ, 61, 466, 10.1111/dgd.12638 Qiao, 2020, LncRNA KCNQ1OT1 contributes to the cisplatin resistance of tongue cancer through the KCNQ1OT1/miR-124-3p/TRIM14 axis, Eur. Rev. Med. Pharmacol. Sci., 24, 200 Liu, C., Lu, Z., Liu, H., Zhuang, S., Guo, P.. LncRNA XIST promotes the progression of laryngeal squamous cell carcinoma via sponging miR-125b-5p to modulate TRIB2. Biosci. Rep. 40, BSR20193172. Cui, 2020, lncRNA XIST promotes the progression of laryngeal squamous cell carcinoma by sponging miR-144 to regulate IRS1 expression, Oncol. Rep., 43, 525 Zheng, 2019, Long noncoding RNA FAM225A promotes nasopharyngeal carcinoma tumorigenesis and metastasis by acting as ceRNA to sponge miR-590-3p/miR-1275 and upregulate ITGB3, Cancer Res., 79, 4612, 10.1158/0008-5472.CAN-19-0799 Xue, 2019, Downregulation of LINC00460 decreases STC2 and promotes autophagy of head and neck squamous cell carcinoma by upregulating microRNA-206, Life Sci., 231, 116459, 10.1016/j.lfs.2019.05.015 Xie, 2019, Long non-coding RNA LINC00460 promotes head and neck squamous cell carcinoma cell progression by sponging miR-612 to upregulate AKT2, Am. J. Transl. Res., 11, 6326 Gao, 2019, Long non-coding RNA HOXC13-AS positively affects cell proliferation and invasion in nasopharyngeal carcinoma via modulating miR-383-3p/HMGA2 axis, J. Cell. Physiol., 234, 12809, 10.1002/jcp.27915 Jiang, 2019, LncRNA LINC00460 promotes EMT in head and neck squamous cell carcinoma by facilitating peroxiredoxin-1 into the nucleus, J. Exp. Clin. Cancer Res., 38, 365, 10.1186/s13046-019-1364-z Yu, 2020, A novel lncRNA, AC091729.7 promotes sinonasal squamous cell carcinomas proliferation and invasion through binding SRSF2, Front. Oncol., 9, 1575, 10.3389/fonc.2019.01575 Wang, 2018, LncRNA MIR31HG targets HIF1A and P21 to facilitate head and neck cancer cell proliferation and tumorigenesis by promoting cell-cycle progression, Mol. Cancer, 17, 162, 10.1186/s12943-018-0916-8 Qin, 2019, The long non-coding RNA ST7-AS1 promotes laryngeal squamous cell carcinoma by stabilizing CARM1, Biochem. Biophys. Res. Commun., 512, 34, 10.1016/j.bbrc.2019.02.057 Guo, 2018, Long non-coding RNA CEBPA-AS1 correlates with poor prognosis and promotes tumorigenesis via CEBPA/Bcl2 in oral squamous cell carcinoma, Cancer Biol. Ther., 19, 205, 10.1080/15384047.2017.1416276 Yang, 2019, Genome-wide identification of a novel eight-lncRNA signature to improve prognostic prediction in head and neck squamous cell carcinoma, Front. Oncol., 9, 898, 10.3389/fonc.2019.00898 Li, 2020, Long non-coding RNA FOXD2-AS1 enhances chemotherapeutic resistance of laryngeal squamous cell carcinoma via STAT3 activation, Cell Death Dis., 11, 41, 10.1038/s41419-020-2232-7 Cantelli, 2017, TGFΒ-induced transcription in cancer, Semin. Cancer Biol., 42, 60, 10.1016/j.semcancer.2016.08.009 Huang, 2018, Identification and validation a TGF-β-associated long non-coding RNA of head and neck squamous cell carcinoma by bioinformatics method, J. Transl. Med., 16, 46, 10.1186/s12967-018-1418-6 Liu, 2018, Increased expression of lncRNA FTH1P3 promotes oral squamous cell carcinoma cells migration and invasion by enhancing PI3K/Akt/GSK3b/Wnt/β-catenin signaling, Eur. Rev. Med. Pharmacol. Sci., 22, 8306 Sun, 2019, LncRNA UCA1 promotes cell proliferation, invasion and migration of laryngeal squamous cell carcinoma cells by activating Wnt/β-catenin signaling pathway, Exp. Ther. Med., 17, 1182 Liang, 2017, LncRNA, TUG1 regulates the oral squamous cell carcinoma progression possibly via interacting with Wnt/β-catenin signaling, Gene, 608, 49, 10.1016/j.gene.2017.01.024 Cui, 2019, Long non-coding RNA NEF inhibits proliferation and promotes apoptosis of laryngeal squamous cell carcinoma cells by inhibiting Wnt/β-catenin signaling, Oncol. Lett., 17, 4928 Han, 2018, Upregulation of lncRNA LINC00473 promotes radioresistance of HNSCC cells through activating Wnt/β-catenin signaling pathway, Eur. Rev. Med. Pharmacol. Sci., 22, 7305 Wang, 2021, Identification of immune-related LncRNA pairs for predicting prognosis and immunotherapeutic response in head and neck squamous cell carcinoma, Front. Immunol., 12, 658631, 10.3389/fimmu.2021.658631 Yin, 2021, Immune-related lncRNA signature for predicting the immune landscape of head and neck squamous cell carcinoma, Front. Mol. Biosci., 8, 689224, 10.3389/fmolb.2021.689224 Feng, 2021, Immune infiltrates of m6A RNA methylation-related lncRNAs and identification of PD-L1 in patients with primary head and neck squamous cell carcinoma, Front. Cell. Dev. Biol., 9, 672248, 10.3389/fcell.2021.672248 Ai, 2021, lncRNA DCST1-AS1 facilitates oral squamous cell carcinoma by promoting M2 macrophage polarization through activating NF-κB signaling, J. Immunol. Res., 2021, 5524231 Li, 2020, Long non-coding RNA LINC02195 as a regulator of MHC I molecules and favorable prognostic marker for head and neck squamous cell carcinoma, Front. Oncol., 10, 615, 10.3389/fonc.2020.00615 Chen, 2021, An immune-related seven-lncRNA signature for head and neck squamous cell carcinoma, Cancer Med., 10, 2268, 10.1002/cam4.3756 Zhong, 2020, Transcriptome analysis reveals the link between lncRNA-mRNA co-expression network and tumor immune microenvironment and overall survival in head and neck squamous cell carcinoma, BMC Med. Genomics, 13, 57, 10.1186/s12920-020-0707-0 Ren, 2021, PDGFBB regulates the transformation of fibroblasts into cancer-associated fibroblasts via the lncRNA LURAP1L-AS1/LURAP1L/IKK/IκB/NFκB signaling pathway, Oncol. Lett., 22, 537, 10.3892/ol.2021.12798 Wang, 2018, LncRNA-p23154 promotes the invasion-metastasis potential of oral squamous cell carcinoma by regulating Glut1-mediated glycolysis, Cancer Lett., 434, 172, 10.1016/j.canlet.2018.07.016 Li, 2020, Long non-coding RNA PVT1 promotes tumor cell proliferation, invasion, migration and inhibits apoptosis in oral squamous cell carcinoma by regulating miR-150-5p/GLUT-1, Oncol. Rep., 44, 1524 Yang, 2021, Glycolysis reprogramming in cancer-associated fibroblasts promotes the growth of oral cancer through the lncRNA H19/miR-675-5p/PFKFB3 signaling pathway, Int. J. Oral Sci., 13, 12, 10.1038/s41368-021-00115-7 Ørom, 2010, Long non-coding RNAs with enhancer-like function in human cells, Cell, 143, 46, 10.1016/j.cell.2010.09.001 Zhang, 2018, Shedding light on the dark cancer genomes: long noncoding RNAs as novel biomarkers and potential therapeutic targets for cancer, Mol. Cancer Ther., 17, 1816, 10.1158/1535-7163.MCT-18-0124 Gu, 2019, AP001056.1, a prognosis-related enhancer RNA in squamous cell carcinoma of the head and neck, Cancers (Basel), 11, 347, 10.3390/cancers11030347 Yin, 2019, HOTTIP functions as a key candidate biomarker in head and neck squamous cell carcinoma by integrated bioinformatic analysis, Biomed. Res. Int., 2019, 5450617, 10.1155/2019/5450617 Qian, 2017, Upregulation of the long non-coding RNA UCA1 affects the proliferation, invasion, and survival of hypopharyngeal carcinoma, Mol. Cancer, 16, 68, 10.1186/s12943-017-0635-6 Cao, 2017, A three-lncRNA signature derived from The Atlas of ncRNA in Cancer (TANRIC) database predicts the survival of patients with head and neck squamous cell carcinoma, Oral Oncol., 65, 94, 10.1016/j.oraloncology.2016.12.017 Wang, 2018, A three-lncRNA expression signature predicts survival in head and neck squamous cell carcinoma (HNSCC), Biosci. Rep., 38, 10.1042/BSR20181528 Zhang, 2019, Prediction of head and neck squamous cell carcinoma survival based on the expression of 15 lncRNAs, J. Cell. Physiol., 234, 18781, 10.1002/jcp.28517 Liu, 2018, A prognostic 5-lncRNA expression signature for head and neck squamous cell carcinoma, Sci. Rep., 8, 15250, 10.1038/s41598-018-33642-1 Diao, 2018, Identification of 4-lncRNA prognostic signature in head and neck squamous cell carcinoma, J. Cell. Biochem., 120, 10010, 10.1002/jcb.28284 Pan, 2019, Analysis of lncRNA-mediated ceRNA crosstalk and identification of prognostic signature in head and neck squamous cell carcinoma, Front. Pharmacol., 10, 150, 10.3389/fphar.2019.00150 Fang, 2018, Comprehensive analysis of competitive endogenous RNAs network associated with head and neck squamous cell carcinoma, Sci. Rep., 8, 10544, 10.1038/s41598-018-28957-y Zhang, 2017, Seven LncRNA-mRNA based risk score predicts the survival of head and neck squamous cell carcinoma, Sci. Rep., 7, 309, 10.1038/s41598-017-00252-2 Fang, 2017, LncRNA UCA1 promotes proliferation and cisplatin resistance of oral squamous cell carcinoma by suppressing miR-184 expression, Cancer Med., 6, 2897, 10.1002/cam4.1253 Jiang, 2020, The implication of LncRNA MALAT1 in promoting chemo-resistance of laryngeal squamous cell carcinoma cells, J. Clin. Lab. Anal., 34, e23116, 10.1002/jcla.23116 Huang, 2019, LINC00958-MYC positive feedback loop modulates resistance of head and neck squamous cell carcinoma cells to chemo- and radiotherapy in vitro, Onco Targets Ther., 12, 5989, 10.2147/OTT.S208318 Ding, 2017, The TLR3 agonist inhibit drug efflux and sequentially consolidates low-dose cisplatin-based chemoimmunotherapy while reducing side effects, Mol. Cancer Ther., 16, 1068, 10.1158/1535-7163.MCT-16-0454 Gou, 2020, Knockdown of lncRNA BLACAT1 enhances radiosensitivity of head and neck squamous cell carcinoma cells by regulating PSEN1, Br. J. Radiol., 93, 20190154, 10.1259/bjr.20190154 Cramer, 2019, The changing therapeutic landscape of head and neck cancer, Nat. Rev. Clin. Oncol., 16, 669, 10.1038/s41571-019-0227-z Tan, 2017, Long non-coding RNA EGFR-AS1 mediates epidermal growth factor receptor addiction and modulates treatment response in squamous cell carcinoma, Nat. Med., 23, 1167, 10.1038/nm.4401 Adams, 2017, Targeting non-coding RNAs in disease, J. Clin. Invest., 127, 761, 10.1172/JCI84424