The role of interleukin-17A in the pathogenesis of kidney diseases

Jin, 2013, IL-17 cytokines in immunity and inflammation, Emerg Microbes Infect, 2, e60, 10.1038/emi.2013.58 Gaffen, 2009, Structure and signalling in the IL-17 receptor family, Nat Rev Immunol, 9, 556, 10.1038/nri2586 Korn, 2009, IL-17 and Th17 cells, Annu Rev Immunol, 27, 485, 10.1146/annurev.immunol.021908.132710 Cua, 2010, Innate IL-17-producing cells: the sentinels of the immune system, Nat Rev Immunol, 10, 479, 10.1038/nri2800 Song, 2013, The activation and regulation of IL-17 receptor mediated signaling, Cytokine, 62, 175, 10.1016/j.cyto.2013.03.014 Chen, 2012, The potential role of Th17 cells and Th17-related cytokines in the pathogenesis of lupus nephritis, Lupus, 21, 1385, 10.1177/0961203312457718 Kitching, 2011, The emergence of TH17 cells as effectors of renal injury, J Am Soc Nephrol, 22, 235, 10.1681/ASN.2010050536 DuPage, 2016, Harnessing the plasticity of CD4(+) T cells to treat immune-mediated disease, Nat Rev Immunol, 16, 149, 10.1038/nri.2015.18 Rodrigues-Díez, 2013, The C-terminal module IV of connective tissue growth factor is a novel immune modulator of the Th17 response, Lab Invest, 93, 812, 10.1038/labinvest.2013.67 McGeachy, 2008, Th17 cell differentiation: the long and winding road, Immunity, 28, 445, 10.1016/j.immuni.2008.03.001 Zhu, 2012, IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential, Clin Sci (Lond), 122, 487, 10.1042/CS20110496 Mills, 2013, The role of inflammasome-derived IL-1 in driving IL-17 responses, J Leukoc Biol, 93, 489, 10.1189/jlb.1012543 Reynolds, 2010, Toll-like receptor 2 signaling in CD4(+) T lymphocytes promotes T helper 17 responses and regulates the pathogenesis of autoimmune disease, Immunity, 32, 692, 10.1016/j.immuni.2010.04.010 O'Quinn, 2008, Emergence of the Th17 pathway and its role in host defense, Adv Immunol, 99, 115, 10.1016/S0065-2776(08)00605-6 Lai Kwan Lam, 2008, Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis, Proc Natl Acad Sci USA, 105, 14993, 10.1073/pnas.0806044105 Maloy, 2008, The Interleukin-23 / Interleukin-17 axis in intestinal inflammation, J Intern Med, 263, 584, 10.1111/j.1365-2796.2008.01950.x Ogura, 2008, Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction, Immunity, 29, 628, 10.1016/j.immuni.2008.07.018 Stark, 2005, Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17, Immunity, 22, 285, 10.1016/j.immuni.2005.01.011 Ley, 2006, IL-17A-producing neutrophil-regulatory Tn lymphocytes, Immunol Res, 34, 229, 10.1385/IR:34:3:229 von Vietinghoff, 2008, Homeostatic regulation of blood neutrophil counts, J Immunol, 181, 5183, 10.4049/jimmunol.181.8.5183 Chan, 2014, Innate IL-17A-producing leukocytes promote acute kidney injury via inflammasome and Toll-like receptor activation, Am J Pathol, 184, 1411, 10.1016/j.ajpath.2014.01.023 Pindjakova, 2012, Interleukin-1 accounts for intrarenal Th17 cell activation during ureteral obstruction, Kidney Int, 81, 379, 10.1038/ki.2011.348 Dong, 2008, Dendritic cells facilitate accumulation of IL-17 T cells in the kidney following acute renal obstruction, Kidney Int, 74, 1294, 10.1038/ki.2008.394 Tadagavadi, 2010, Netrin-1 regulates Th1/Th2/Th17 cytokine production and inflammation through UNC5B receptor and protects kidney against ischemia-reperfusion injury, J Immunol, 185, 3750, 10.4049/jimmunol.1000435 Xue, 2011, Detrimental functions of IL-17A in renal ischemia-reperfusion injury in mice, J Surg Res, 171, 266, 10.1016/j.jss.2009.12.031 Li, 2010, IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury, J Clin Invest, 120, 331, 10.1172/JCI38702 Lee, 2013, Critical role of interleukin-17A in murine intestinal ischemia-reperfusion injury, Am J Physiol Gastrointest Liver Physiol, 304, G12, 10.1152/ajpgi.00201.2012 Chung, 2012, Increased interleukin-17 producing effector memory T cells in the end-stage renal disease patients, Immunol Lett, 141, 181, 10.1016/j.imlet.2011.10.002 Lang, 2014, Correlation of interleukin-17-producing effector memory T cells and CD4+CD25+Foxp3 regulatory T cells with the phosphate levels in chronic hemodialysis patients, Scientific World Journal, 2014, 593170, 10.1155/2014/593170 Coto, 2015, Association between the IL17RA rs4819554 polymorphism and reduced renal filtration rate in the Spanish RENASTUR cohort, Hum Immunol, 76, 75, 10.1016/j.humimm.2015.01.027 Kim, 2012, Gene polymorphisms of interleukin-17 and interleukin-17 receptor are associated with end-stage kidney disease, Am J Nephrol, 36, 472, 10.1159/000343571 Gong, 2015, The paradoxical role of IL-17 in atherosclerosis, Cell Immunol, 297, 33, 10.1016/j.cellimm.2015.05.007 Ge, 2013, Increased atherosclerotic lesion formation and vascular leukocyte accumulation in renal impairment are mediated by interleukin-17A, Circ Res, 113, 965, 10.1161/CIRCRESAHA.113.301934 von Vietinghoff, 2011, Mycophenolate mofetil decreases atherosclerotic lesion size by depression of aortic T-lymphocyte and interleukin-17-mediated macrophage accumulation, J Am Coll Cardiol, 57, 2194, 10.1016/j.jacc.2010.12.030 Gisterå, 2013, Transforming growth factor-β signaling in T cells promotes stabilization of atherosclerotic plaques through an interleukin-17-dependent pathway, Sci Transl Med, 5, 196ra100, 10.1126/scitranslmed.3006133 Danzaki, 2012, Interleukin-17A deficiency accelerates unstable atherosclerotic plaque formation in apolipoprotein E-deficient mice, Arterioscler Thromb Vasc Biol, 32, 273, 10.1161/ATVBAHA.111.229997 Taleb, 2009, Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis, J Exp Med, 206, 2067, 10.1084/jem.20090545 Madhur, 2011, Role of interleukin 17 in inflammation, atherosclerosis, and vascular function in apolipoprotein e-deficient mice, Arterioscler Thromb Vasc Biol, 31, 1565, 10.1161/ATVBAHA.111.227629 Taleb, 2015, IL-17 and Th17 cells in atherosclerosis: subtle and contextual roles, Arterioscler Thromb Vasc Biol, 35, 258, 10.1161/ATVBAHA.114.303567 Zhang, 2015, Role of T lymphocytes in hypertension, Curr Opin Pharmacol, 21, 14, 10.1016/j.coph.2014.12.003 Norlander, 2016, Interleukin-17A regulates renal sodium transporters and renal injury in Angiotensin II-induced hypertension, Hypertension, 68, 167, 10.1161/HYPERTENSIONAHA.116.07493 Kamat, 2015, Renal transporter activation during angiotensin-II hypertension is blunted in interferon-γ-/- and interleukin-17A-/- mice, Hypertension, 65, 569, 10.1161/HYPERTENSIONAHA.114.04975 Krebs, 2014, Deficiency of the interleukin 17/23 axis accelerates renal injury in mice with deoxycorticosterone acetate+angiotensin ii-induced hypertension, Hypertension, 63, 565, 10.1161/HYPERTENSIONAHA.113.02620 Amador, 2014, Spironolactone decreases DOCA-salt-induced organ damage by blocking the activation of T helper 17 and the downregulation of regulatory T lymphocytes, Hypertension, 63, 797, 10.1161/HYPERTENSIONAHA.113.02883 Yu, 2016, The inhibitory effect of rapamycin on toll like receptor 4 and interleukin 17 in the early stage of rat diabetic nephropathy, Kidney Blood Press Res, 41, 55, 10.1159/000368547 Vasanthakumar, 2015, Serum IL-9, IL-17, and TGF-β levels in subjects with diabetic kidney disease (CURES-134), Cytokine, 72, 109, 10.1016/j.cyto.2014.10.009 Galvan, 2016, Paradoxical role of IL-17 in progression of diabetic nephropathy, J Am Soc Nephrol, 27, 657, 10.1681/ASN.2015070813 Kim, 2015, Targeting T helper 17 by mycophenolate mofetil attenuates diabetic nephropathy progression, Transl Res, 166, 375, 10.1016/j.trsl.2015.04.013 Lin, 2015, MicroRNA-155 deficiency promotes nephrin acetylation and attenuates renal damage in hyperglycemia-induced nephropathy, Inflammation, 38, 546, 10.1007/s10753-014-9961-7 Ferrantelli, 2016, The dipeptide alanyl-glutamine ameliorates peritoneal fibrosis and attenuates IL-17 dependent pathways during peritoneal dialysis, Kidney Int, 89, 625, 10.1016/j.kint.2015.12.005 Peng, 2015, IL-17A produced by both γδ T and Th17 cells promotes renal fibrosis via RANTES-mediated leukocyte infiltration after renal obstruction, J Pathol, 235, 79, 10.1002/path.4430 Rodrigues-Díez, 2014, IL-17A is a novel player in dialysis-induced peritoneal damage, Kidney Int, 86, 303, 10.1038/ki.2014.33 Qiao, 2015, A77 1726, the active metabolite of leflunomide, attenuates lupus nephritis by promoting the development of regulatory T cells and inhibiting IL-17-producing double negative T cells, Clin Immunol, 157, 166, 10.1016/j.clim.2015.01.006 Summers, 2014, Endogenous interleukin (IL)-17A promotes pristane-induced systemic autoimmunity and lupus nephritis induced by pristane, Clin Exp Immunol, 176, 341, 10.1111/cei.12287 Wen, 2013, Interleukin-17 expression positively correlates with disease severity of lupus nephritis by increasing anti-double-stranded DNA antibody production in a lupus model induced by activated lymphocyte derived DNA, PLoS One, 8, e58161, 10.1371/journal.pone.0058161 Biswas, 2012, A murine autoimmune model of rheumatoid arthritis and systemic lupus erythematosus associated with deregulated production of IL-17 and IL-21, Methods Mol Biol, 900, 233, 10.1007/978-1-60761-720-4_11 Dolff, 2010, Increased expression of costimulatory markers CD134 and CD80 on interleukin-17 producing T cells in patients with systemic lupus erythematosus, Arthritis Res Ther, 12, R150, 10.1186/ar3100 Zhang, 2009, The role of IL-23/IL-17 axis in lupus nephritis, J Immunol, 183, 3160, 10.4049/jimmunol.0900385 Zickert, 2015, IL-17 and IL-23 in lupus nephritis – association to histopathology and response to treatment, BMC Immunol, 16, 7, 10.1186/s12865-015-0070-7 Crispín, 2008, Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys, J Immunol, 181, 8761, 10.4049/jimmunol.181.12.8761 Chen, 2013, The imbalance of Th17/Treg in Chinese children with Henoch-Schonlein purpura, Int Immunopharmacol, 16, 67, 10.1016/j.intimp.2013.03.027 Li, 2012, Investigation of the change in CD4+ T cell subset in children with Henoch-Schonlein purpura, Rheumatol Int, 32, 3785, 10.1007/s00296-011-2266-3 Jen, 2011, Increased serum interleukin-17 and peripheral cells in children with acute Henoch Scholein purpura, Pediatr Allergy Immunol, 22, 862, 10.1111/j.1399-3038.2011.01198.x Hünemörder, 2015, TH1 and TH17 cells promote crescent formation in experimental autoimmune glomerulonephritis, J Pathol, 237, 62, 10.1002/path.4559 Ramani, 2014, An essential role of interleukin-17 receptor signaling in the development of autoimmune glomerulonephritis, J Leukoc Biol, 96, 463, 10.1189/jlb.3A0414-184R Turner, 2012, IL-17A production by renal γδ T cells promotes kidney injury in crescentic GN, J Am Soc Nephrol, 23, 1486, 10.1681/ASN.2012010040 Paust, 2009, The IL-23/Th17 axis contributes to renal injury in experimental glomerulonephritis, J Am Soc Nephrol, 20, 969, 10.1681/ASN.2008050556 Disteldorf, 2015, CXCL5 drives neutrophil recruitment in TH17-mediated GN, J Am Soc Nephrol, 26, 55, 10.1681/ASN.2013101061 Paust, 2012, Chemokines play a critical role in the cross-regulation of Th1 and Th17 immune responses in murine crescentic glomerulonephritis, Kidney Int, 82, 72, 10.1038/ki.2012.101 Odobasic, 2011, Interleukin-17A promotes early but attenuates established disease in crescentic glomerulonephritis in mice, Am J Pathol, 179, 1188, 10.1016/j.ajpath.2011.05.039 Nogueira, 2010, Serum IL-17 and IL-23 levels and autoantigen-specific Th17 cells are elevated in patients with ANCA-associated vasculitis, Nephrol Dial Transplant, 25, 2209, 10.1093/ndt/gfp783 Gan, 2010, Th17 cells promote autoimmune antimyeloperoxidase glomerulonephritis, J Am Soc Nephrol, 21, 925, 10.1681/ASN.2009070763 Summers, 2011, Toll-like receptor 2 induces Th17 myeloperoxidase autoimmunity while Toll-like receptor 9 drives Th1 autoimmunity in murine vasculitis, Arthritis Rheum, 63, 1124, 10.1002/art.30208 Velden, 2012, Renal IL-17 expression in human ANCA-associated glomerulonephritis, Am J Physiol Renal Physiol, 302, F1663, 10.1152/ajprenal.00683.2011 Jennette, 2011, Pathogenesis of antineutrophil cytoplasmic autoantibody vasculitis, Curr Opin Nephrol Hypertens, 20, 263, 10.1097/MNH.0b013e3283456731 Ooi, 2009, IL-23, not IL-12, directs autoimmunity to the Goodpasture antigen, J Am Soc Nephrol, 20, 980, 10.1681/ASN.2008080891 Hu, 2016, T cell infiltration is associated with kidney injury in patients with anti-glomerular basement membrane disease, Sci China Life Sci, 59, 1282, 10.1007/s11427-016-5030-9 Koga, 2016, Calcium/Calmodulin-Dependent Kinase IV facilitates the recruitment of interleukin-17-producing cells to target organs through the CCR6/CCL20 axis in Th17 cell-driven inflammatory diseases, Arthritis Rheumatol, 68, 1981, 10.1002/art.39665 Lee, 2016, Cln 3-requiring 9 is a negative regulator of Th17 pathway-driven inflammation in anti-glomerular basement membrane glomerulonephritis, Am J Physiol Renal Physiol, 311, F505, 10.1152/ajprenal.00533.2015 Shao, 2009, The prevalence of Th17 cells and FOXP3 regulate T cells (Treg) in children with primary nephrotic syndrome, Pediatr Nephrol, 24, 1683, 10.1007/s00467-009-1194-x Wang, 2013, The role of Th17/IL-17 in the pathogenesis of primary nephrotic syndrome in children, Kidney Blood Press Res, 37, 332, 10.1159/000350161 Liu, 2011, Th17/Treg imbalance in adult patients with minimal change nephrotic syndrome, Clin Immunol, 139, 314, 10.1016/j.clim.2011.02.018 Eun Kim, 2013, Could interleukin-17 be a therapeutic target of steroid-dependent minimal change disease?, Kidney Int, 84, 1049, 10.1038/ki.2013.323 Matsumoto, 2002, Increased urinary excretion of interleukin-17 in nephrotic patients, Nephron, 91, 243, 10.1159/000058399 van de Veerdonk, 2011, The anti-CD20 antibody rituximab reduces the Th17 cell response, Arthritis Rheum, 63, 1507, 10.1002/art.30314 Van Kooten, 1998, Interleukin-17 activates human renal epithelial cells in vitro and is expressed during renal allograft rejection, J Am Soc Nephrol, 9, 1526, 10.1681/ASN.V981526 Woltman, 2000, Interleukin-17 and CD40-ligand synergistically enhance cytokine and chemokine production by renal epithelial cells, J Am Soc Nephrol, 11, 2044, 10.1681/ASN.V11112044 Vondran, 2012, Decreased frequency of peripheral CD4(+) CD161(+) Th(17) -precursor cells in kidney transplant recipients on long-term therapy with Belatacept, Transpl Int, 25, 455, 10.1111/j.1432-2277.2012.01441.x Abadja, 2011, Impact of mycophenolic acid and tacrolimus on Th17-related immune response, Transplantation, 92, 396, 10.1097/TP.0b013e3182247b5f Hester, 2011, Th17 cells in alemtuzumab-treated patients: the effect of long-term maintenance immunosuppressive therapy, Transplantation, 91, 744, 10.1097/TP.0b013e31820c85dc Kwan, 2015, IL-17 deficiency attenuates allograft injury and prolongs survival in a murine model of fully MHC-mismatched renal allograft transplantation, Am J Transplant, 15, 1555, 10.1111/ajt.13140 Edozie, 2014, Regulatory T-cell therapy in the induction of transplant tolerance: the issue of subpopulations, Transplantation, 98, 370, 10.1097/TP.0000000000000243 de Menezes Neves, 2013, Distinct expression of interleukin 17, tumor necrosis factor α, transforming growth factor β, and forkhead box P3 in acute rejection after kidney transplantation, Ann Diagn Pathol, 17, 75, 10.1016/j.anndiagpath.2012.08.002 Yapici, 2011, Interleukin-17 positive cells accumulate in renal allografts during acute rejection and are independent predictors of worse graft outcome, Transpl Int, 24, 1008, 10.1111/j.1432-2277.2011.01302.x Crispim, 2009, Interleukin-17 and kidney allograft outcome, Transplant Proc, 41, 1562, 10.1016/j.transproceed.2009.01.092 Chung, 2012, Clinical significance of the ratio between FOXP3 positive regulatory T cell and interleukin-17 secreting cell in renal allograft biopsies with acute T-cell-mediated rejection, Immunology, 136, 344, 10.1111/j.1365-2567.2012.03588.x Chung, 2011, Higher infiltration by Th17 cells compared with regulatory T cells is associated with severe acute T-cell-mediated graft rejection, Exp Mol Med, 43, 630, 10.3858/emm.2011.43.11.071 San Segundo, 2008, T(H)17 versus Treg cells in renal transplant candidates: effect of a previous transplant, Transplant Proc, 40, 2885, 10.1016/j.transproceed.2008.09.043 Hsieh, 2001, IL-17 expression as a possible predictive parameter for subclinical renal allograft rejection, Transpl Int, 14, 287, 10.1111/j.1432-2277.2001.tb00062.x Millán, 2014, Should IFN-γ, IL-17 and IL-2 be considered predictive biomarkers of acute rejection in liver and kidney transplant? Results of a multicentric study, Clin Immunol, 154, 141, 10.1016/j.clim.2014.07.007 Loverre, 2011, IL-17 expression by tubular epithelial cells in renal transplant recipients with acute antibody-mediated rejection, Am J Transplant, 11, 1248, 10.1111/j.1600-6143.2011.03529.x Loverre, 2011, T helper 1, 2 and 17 cell subsets in renal transplant patients with delayed graft function, Transpl Int, 24, 233, 10.1111/j.1432-2277.2010.01157.x Deteix, 2010, Intragraft Th17 infiltrate promotes lymphoid neogenesis and hastens clinical chronic rejection, J Immunol, 184, 5344, 10.4049/jimmunol.0902999 Romanowski, 2015, Influence of the IL17A and IL17F gene polymorphisms on the long-term kidney allograft function and return to dialysis after kidney transplantation, Clin Transplant, 29, 1187, 10.1111/ctr.12649 Park, 2014, Association of IL-17F gene polymorphisms with renal transplantation outcome, Transplant Proc, 46, 121, 10.1016/j.transproceed.2013.05.015 Romanowski, 2015, Interleukin-17 gene polymorphisms in patients with post-transplant diabetes mellitus, Eur Rev Med Pharmacol Sci, 19, 3152 Spellberg, 2005, Mice with disseminated candidiasis die of progressive sepsis, J Infect Dis, 192, 336, 10.1086/430952 Mosci, 2014, Involvement of IL-17A in preventing the development of deep-seated candidiasis from oropharyngeal infection, Microbes Infect, 16, 678, 10.1016/j.micinf.2014.06.007 Huang, 2016, IL-17C is required for lethal inflammation during systemic fungal infection, Cell Mol Immunol, 13, 474, 10.1038/cmi.2015.56 Rehermann, 2000, Intrahepatic T cells in hepatitis B: viral control versus liver cell injury, J Exp Med, 191, 1263, 10.1084/jem.191.8.1263 Hejr, 2013, Association of IL-17, IL-21, and IL-23R gene polymorphisms with HBV infection in kidney transplant patients, Viral Immunol, 26, 201, 10.1089/vim.2013.0007 Miossec, 2012, Targeting IL-17 and TH17 cells in chronic inflammation, Nat Rev Drug Discov, 11, 763, 10.1038/nrd3794 Ritchlin, 2016, New therapies for psoriasis and psoriatic arthritis, Curr Opin Rheumatol, 28, 204, 10.1097/BOR.0000000000000274 Wei, 2016, Efficacy and safety of monoclonal antibodies targeting interleukin-17 pathway for inflammatory arthritis: a meta-analysis of randomized controlled clinical trials, Drug Des Devel Ther, 10, 2771, 10.2147/DDDT.S91374 Speeckaert, 2016, Secukinumab: IL-17A inhibition to treat psoriatic arthritis, Drugs Today (Barc), 52, 607, 10.1358/dot.2016.52.11.2526754 Luo, 2014, Mesenchymal stem cells ameliorate sepsis-associated acute kidney injury in mice, Shock, 41, 123, 10.1097/SHK.0000000000000080