The role of human beta defensins and cathelicidins in atopic dermatitis

Current Opinion in Allergy and Clinical Immunology - Tập 7 Số 5 - Trang 413-417 - 2007
Michael Howell1,2,3,4
1Division of Pediatric Allergy-Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado, USA
2e-mail: [email protected]
3fax: +1 303 398 1225
4to Michael D. Howell, PhD, National Jewish Medical and Research Center, 1400 Jackson Street, Room K1016, Denver, CO 80206, USA Tel: +1 303 398 1258

Tóm tắt

Từ khóa


Tài liệu tham khảo

Boguniewicz, 2006, 10. Atopic Dermatitis, J Allergy Clin Immunol, 117, S475, 10.1016/j.jaci.2005.10.018

McGirt, 2006, Innate immune defects in atopic dermatitis, J Allergy Clin Immunol, 118, 202, 10.1016/j.jaci.2006.04.033

Leung, 2004, New insights into atopic dermatitis, J Clin Invest, 113, 651, 10.1172/JCI21060

Morar, 2006, The genetics of atopic dermatitis, J Allergy Clin Immunol, 118, 24, 10.1016/j.jaci.2006.03.037

Cork, 2006, New perspectives on epidermal barrier dysfunction in atopic dermatitis: gene–environment interactions, J Allergy Clin Immunol, 118, 3, 10.1016/j.jaci.2006.04.042

Akdis, 2006, Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma, and Immunology/PRACTALL Consensus Report, J Allergy Clin Immunol, 118, 152, 10.1016/j.jaci.2006.03.045

Nomura, 2003, Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes, J Immunol, 171, 3262, 10.4049/jimmunol.171.6.3262

Harder, 2001, Isolation and characterization of human β-defensin-3, a novel human inducible peptide antibiotic, J Biol Chem, 276, 5707, 10.1074/jbc.M008557200

Harder, 1997, A peptide antibiotic from human skin, Nature, 387, 861, 10.1038/43088

Gallo, 2002, Biology and clinical relevance of naturally occurring antimicrobial peptides, J Allergy Clin Immunol, 110, 823, 10.1067/mai.2002.129801

Ali, 2001, Expression of the peptide antibiotics human β defensin-1 and human β defensin-2 in normal human skin, J Invest Dermatol, 117, 106, 10.1046/j.0022-202x.2001.01401.x

Harder, 2004, Differential gene induction of human beta-defensins (hBD-1, -2, -3, and -4) in keratinocytes is inhibited by retinoic acid, J Invest Dermatol, 123, 522, 10.1111/j.0022-202X.2004.23234.x

Frohm, 1997, The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders, J Biol Chem, 272, 15258, 10.1074/jbc.272.24.15258

Boman, 1993, Mechanisms of action on Escherichia coli of cecropin P1 and PR-39, two antibacterial peptides from pig intestine, Infect Immun, 61, 2978, 10.1128/IAI.61.7.2978-2984.1993

Nizet, 2001, Innate antimicrobial peptide protects the skin from invasive bacterial infection, Nature, 414, 454, 10.1038/35106587

Howell, 2004, Selective killing of vaccinia virus by LL-37: implications for Eczema vaccinatum, J Immunol, 172, 1763, 10.4049/jimmunol.172.3.1763

Yang, 1999, β-Defensins: linking innate and adaptive immunity through dendritic and t cell CCR6, Science, 286, 525, 10.1126/science.286.5439.525

Yang, 2000, LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells, J Exp Med, 192, 1069, 10.1084/jem.192.7.1069

Braff, 2005, Structure–function relationships among human cathelicidin peptides: dissociation of antimicrobial properties from host immunstimulatory activities, J Immunol, 174, 4271, 10.4049/jimmunol.174.7.4271

Niyonsaba, 2006, Antimicrobial peptides human β-defensins stimulate epidermal keratinocyte migration, proliferation, and production of proinflammatory cytokines and chemokines, J Invest Dermatol, 127, 594, 10.1038/sj.jid.5700599

Grice, 1975, The relationship of transepidermal water loss to skin temperature in psoriasis and eczema, J Invest Dermatol, 64, 313, 10.1111/1523-1747.ep12512258

Christophers, 1987, Contrasting disease patterns in psoriasis and atopic dermatitis, Arch Dermatol Res, 279, S48, 10.1007/BF00585919

Fulton, 1997, Expression of natural peptide antibiotics in human skin, Lancet, 350, 1750, 10.1016/S0140-6736(05)63574-X

Ong, 2002, Endogenous antimicrobial peptides and skin infections in atopic dermatitis, N Engl J Med, 347, 1151, 10.1056/NEJMoa021481

Novak, 2003, Allergic and nonallergic forms of atopic diseases, J Allergy Clin Immunol, 112, 252, 10.1067/mai.2003.1595

Howell, 2006, Mechanism of HBD-3 deficiency in atopic dermatitis, Clin Immunol, 121, 332, 10.1016/j.clim.2006.08.008

Howell, 2005, IL-10 down-regulates antimicrobial peptide expression in atopic dermatitis, J Invest Dermatol, 125, 738, 10.1111/j.0022-202X.2005.23776.x

Homey, 2006, Cytokines and chemokines orchestrate atopic skin inflammation, J Allergy Clin Immunol, 118, 178, 10.1016/j.jaci.2006.03.047

Jeong, 2003, Differential in vivo cytokine mRNA expression in lesional skin of intrinsic vs. extrinsic atopic dermatitis patients using semiquantitative RT-PCR, Clin Exp Allergy, 33, 1717, 10.1111/j.1365-2222.2003.01782.x

Grossman, 1989, Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured keratinocytes, Proc Natl Acad Sci USA, 86, 6367, 10.1073/pnas.86.16.6367

Chen, 2005, Synergistic effect of antibacterial agents human beta-defensins, cathelicidin LL-37 and lysozyme against Staphylococcus aureus and Echerichia coli, J Dermatol Sci, 40, 123, 10.1016/j.jdermsci.2005.03.014

Menzies, 2006, Signal transduction and nuclear responses in Staphylococcus aureus-induced expression of human-β-defensin 3 in skin keratinocytes, Infect Immun, 74, 6847, 10.1128/IAI.00389-06

Menzies, 2005, Staphylococcus aureus infection of epidermal keratinocytes promotes expression of innate antimicrobial peptides, Infect Immun, 73, 5241, 10.1128/IAI.73.8.5241-5244.2005

Midorikawa, 2003, Staphylococcus aureus susceptibility to innate antimicrobial peptides, B-defensins and CAP18, expressed by human keratinocytes, Infect Immun, 71, 3730, 10.1128/IAI.71.7.3730-3739.2003

Wollenberg, 2003, Predisposing factors and clinical features of eczema herpeticum: a retrospective analysis of 100 cases, J Am Acad Dermatol, 49, 198, 10.1067/S0190-9622(03)00896-X

Sanderson, 1987, Eczema herpeticum: a potentially fatal disease, BMJ, 294, 693, 10.1136/bmj.294.6573.693

Howell, 2006, Cathelicidin deficiency predisposes to eczema herpeticum, J Allergy Clin Immunol, 117, 836, 10.1016/j.jaci.2005.12.1345

Moses, 2002, Eczema vaccinatum: a timely reminder, N Engl J Med, 346, 1287, 10.1056/NEJMicm010892

Rotz, 2001, Vaccinia (smallpox) vaccine: recommendations of the Advisory Committee on Immunization Practices (ACIP), MMWR Recomm Rep, 50, 1

Howell, 2006, Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus, Immunity, 24, 341, 10.1016/j.immuni.2006.02.006

Howell, 2007, Antiviral activity of human β-defensin 3 against vaccinia virus, J Allergy Clin Immunol, 119, 1022, 10.1016/j.jaci.2007.01.044

Sandstrom, 2005, The prevalence of malassezia yeasts in patients with atopic dermatitis, seborrhoeic dermatitis, and healthy controls, Acta Derm Venerol, 85, 17, 10.1080/00015550410022276

Ramirez de Knott, 2006, Cutaneous hypersensitivity to Malassezia sympodialis and dust mite in adult atopic dermatitis with a textile pattern, Contact Dermatitis, 54, 92, 10.1111/j.0105-1873.2006.00774.x

Casagrande, 2006, Sensitization to the yeast Malassezia sympodialis is specific for extrinsic and intrinsic atopic eczema, J Invest Dermatol, 126, 2414, 10.1038/sj.jid.5700431

Lopez-Garcia, 2006, Expression and potential function of cathelicidin antimicrobial peptides in dermatophytosis and tinea versicolor, J Antimicrob Chemother, 57, 877, 10.1093/jac/dkl078

Schneider, 2005, Human defensins, J Mol Med, 83, 587, 10.1007/s00109-005-0657-1

Boguniewicz, 2006, Atopic dermatitis, J Allergy Clin Immunol, 118, 40, 10.1016/j.jaci.2006.04.044