The role of exosomes and MYC in therapy resistance of acute myeloid leukemia: Challenges and opportunities
Tài liệu tham khảo
Andreu, 2014, Tetraspanins in extracellular vesicle formation and function, Front. Immunol., 5, 442, 10.3389/fimmu.2014.00442
Anel, 2019, Role of exosomes in the regulation of T-cell mediated immune responses and in autoimmune disease, Cells, 8, 10.3390/cells8020154
Arnold, 2006, Protein phosphatase 2A regulatory subunit B56alpha associates with c-myc and negatively regulates c-myc accumulation, Mol. Cell. Biol., 26, 2832, 10.1128/MCB.26.7.2832-2844.2006
Baietti, 2012, Syndecan-syntenin-ALIX regulates the biogenesis of exosomes, Nat. Cell Biol., 14, 677, 10.1038/ncb2502
Banerji, 2012, The intersection of genetic and chemical genomic screens identifies GSK-3alpha as a target in human acute myeloid leukemia, J. Clin. Investig., 122, 935, 10.1172/JCI46465
Beals, 1997, Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3, Science, 275, 1930, 10.1126/science.275.5308.1930
Behrmann, 2018, Acute myeloid leukemia and the bone marrow niche-take a closer look, Front .Oncol., 8, 444, 10.3389/fonc.2018.00444
Bendall, 1994, Bone marrow adherent layers inhibit apoptosis of acute myeloid leukemia cells, Exp. Hematol., 22, 1252
Bhatia, 1993, Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas, Nat. Genet., 5, 56, 10.1038/ng0993-56
Biver, 2014, Crosstalk between tyrosine kinase receptors, GSK3 and BMP2 signaling during osteoblastic differentiation of human mesenchymal stem cells, Mol. Cell. Endocrinol., 382, 120, 10.1016/j.mce.2013.09.018
Bobrie, 2013, Unraveling the physiological functions of exosome secretion by tumors, OncoImmunology, 2, 10.4161/onci.22565
Buckley, 2018, Patient-reported outcomes in acute myeloid leukemia: where are we now?, Blood Rev., 32, 81, 10.1016/j.blre.2017.08.010
Burzyn, 2013, A special population of regulatory T cells potentiates muscle repair, Cell, 155, 1282, 10.1016/j.cell.2013.10.054
Chalmin, 2010, Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells, J. Clin. Investig., 120, 457
Chen, 2014, FTY720 induces apoptosis of M2 subtype acute myeloid leukemia cells by targeting sphingolipid metabolism and increasing endogenous ceramide levels, PLoS One, 9, 10.1371/journal.pone.0103033
Chen, 2019, Leukemia-derived exosomes induced IL-8 production in bone marrow stromal cells to protect the leukemia cells against chemotherapy, Life Sci., 221, 187, 10.1016/j.lfs.2019.02.003
Cheng, 2015, PKR inhibits the DNA damage response, and is associated with poor survival in AML and accelerated leukemia in NHD13 mice, Blood, 126, 1585, 10.1182/blood-2015-03-635227
Chowdhury, 2015, Cancer exosomes trigger mesenchymal stem cell differentiation into pro-angiogenic and pro-invasive myofibroblasts, Oncotarget, 6, 715, 10.18632/oncotarget.2711
Chu, 1998, Transcriptional activity of heat shock factor 1 at 37 degrees C is repressed through phosphorylation on two distinct serine residues by glycogen synthase kinase 3 and protein kinases Calpha and Czeta, J. Biol. Chem., 273, 18640, 10.1074/jbc.273.29.18640
Cohen, 2001, The renaissance of GSK3, Nat. Rev. Mol. Cell Biol., 2, 769, 10.1038/35096075
Colombo, 2014, Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles, Annu. Rev. Cell Dev. Biol., 30, 255, 10.1146/annurev-cellbio-101512-122326
Corrado, 2014, Exosome-mediated crosstalk between chronic myelogenous leukemia cells and human bone marrow stromal cells triggers an interleukin 8-dependent survival of leukemia cells, Cancer Lett., 348, 71, 10.1016/j.canlet.2014.03.009
Cristobal, 2011, PP2A impaired activity is a common event in acute myeloid leukemia and its activation by forskolin has a potent anti-leukemic effect, Leukemia, 25, 606, 10.1038/leu.2010.294
Cristobal, 2013, Downregulation of PPP2R5E is a common event in acute myeloid leukemia that affects the oncogenic potential of leukemic cells, Haematologica, 98, e103, 10.3324/haematol.2013.084731
Dahl, 2015, What causes leukemia?, Pediatr. Blood Cancer, 62, 1123, 10.1002/pbc.25526
de Groot, 1993, Negative regulation of Jun/AP-1: conserved function of glycogen synthase kinase 3 and the Drosophila kinase shaggy, Oncogene, 8, 841
De Toni, 2006, A crosstalk between the Wnt and the adhesion-dependent signaling pathways governs the chemosensitivity of acute myeloid leukemia, Oncogene, 25, 3113, 10.1038/sj.onc.1209346
Diehl, 1998, Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization, Genes Dev., 12, 3499, 10.1101/gad.12.22.3499
Disease, 2016, Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015, Lancet, 388, 1545, 10.1016/S0140-6736(16)31678-6
Dombret, 2016, An update of current treatments for adult acute myeloid leukemia, Blood, 127, 53, 10.1182/blood-2015-08-604520
Drullion, 2012, Apoptosis and autophagy have opposite roles on imatinib-induced K562 leukemia cell senescence, Cell Death Dis., 3, e373, 10.1038/cddis.2012.111
Estella-Hermoso de Mendoza, 2015, Lipid nanosystems enhance the bioavailability and the therapeutic efficacy of FTY720 in acute myeloid leukemia, J. Biomed. Nanotechnol., 11, 691, 10.1166/jbn.2015.1944
Gao, 2015, High expression of c-kit mRNA predicts unfavorable outcome in adult patients with t(8;21) acute myeloid leukemia, PLoS One, 10, 10.1371/journal.pone.0124241
Ghosh, 2010, Circulating microvesicles in B-cell chronic lymphocytic leukemia can stimulate marrow stromal cells: implications for disease progression, Blood, 115, 1755, 10.1182/blood-2009-09-242719
Gilliland, 2002, The roles of FLT3 in hematopoiesis and leukemia, Blood, 100, 1532, 10.1182/blood-2002-02-0492
Gregory, 2003, Phosphorylation by glycogen synthase kinase-3 controls c-myc proteolysis and subnuclear localization, J. Biol. Chem., 278, 51606, 10.1074/jbc.M310722200
Grindebacke, 2009, Dynamic development of homing receptor expression and memory cell differentiation of infant CD4+CD25high regulatory T cells, J. Immunol., 183, 4360, 10.4049/jimmunol.0901091
Grunwald, 2015, FLT3 tyrosine kinase inhibition as a paradigm for targeted drug development in acute myeloid leukemia, Semin. Hematol., 52, 193, 10.1053/j.seminhematol.2015.03.004
Guezguez, 2016, GSK3 deficiencies in hematopoietic stem cells initiate pre-neoplastic state that is predictive of clinical outcomes of human acute leukemia, Cancer Cell, 29, 61, 10.1016/j.ccell.2015.11.012
Haderk, 2017, Tumor-derived exosomes modulate PD-L1 expression in monocytes, Sci. Immunol., 2, 10.1126/sciimmunol.aah5509
He, 2018, Exosome theranostics: biology and translational medicine, Theranostics, 8, 237, 10.7150/thno.21945
Hernandez-Davies, 2011, The multitargeted receptor tyrosine kinase inhibitor linifanib (ABT-869) induces apoptosis through an Akt and glycogen synthase kinase 3beta-dependent pathway, Mol. Cancer Ther., 10, 949, 10.1158/1535-7163.MCT-10-0904
Holyoake, 2017, The chronic myeloid leukemia stem cell: stemming the tide of persistence, Blood, 129, 1595, 10.1182/blood-2016-09-696013
Hong, 2014, Plasma exosomes as markers of therapeutic response in patients with acute myeloid leukemia, Front. Immunol., 5, 160, 10.3389/fimmu.2014.00160
Hong, 2017, Circulating exosomes carrying an immunosuppressive cargo interfere with cellular immunotherapy in acute myeloid leukemia, Sci. Rep., 7, 14684, 10.1038/s41598-017-14661-w
Hong, 2019, Human acute myeloid leukemia blast-derived exosomes in patient-derived xenograft mice mediate immune suppression, Exp. Hematol., 76, 60, 10.1016/j.exphem.2019.07.005
Hornick, 2016, AML suppresses hematopoiesis by releasing exosomes that contain microRNAs targeting c-MYB, Sci. Signal., 9, ra88, 10.1126/scisignal.aaf2797
Hou, 2017, A genome-wide CRISPR screen identifies genes critical for resistance to FLT3 inhibitor AC220, Cancer Res., 77, 4402, 10.1158/0008-5472.CAN-16-1627
Hu, 2016, A novel glycogen synthase kinase-3 inhibitor optimized for acute myeloid leukemia differentiation activity, Mol. Cancer Ther., 15, 1485, 10.1158/1535-7163.MCT-15-0566
Huan, 2013, RNA trafficking by acute myelogenous leukemia exosomes, Cancer Res., 73, 918, 10.1158/0008-5472.CAN-12-2184
Huan, 2015, Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes, Leukemia, 29, 2285, 10.1038/leu.2015.163
Huang, 2009, Pivotal role for glycogen synthase kinase-3 in hematopoietic stem cell homeostasis in mice, J. Clin. Investig., 119, 3519
Ishikawa, 2007, Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region, Nat. Biotechnol., 25, 1315, 10.1038/nbt1350
Javidi-Sharifi, 2019, FGF2-FGFR1 signaling regulates release of Leukemia-Protective exosomes from bone marrow stromal cells, eLife, 8
Jin, 2006, Targeting of CD44 eradicates human acute myeloid leukemic stem cells, Nat. Med., 12, 1167, 10.1038/nm1483
Johnstone, 1987, Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes), J. Biol. Chem., 262, 9412, 10.1016/S0021-9258(18)48095-7
Jope, 2004, The glamour and gloom of glycogen synthase kinase-3, Trends Biochem. Sci., 29, 95, 10.1016/j.tibs.2003.12.004
Juliusson, 2016, Leukemia, Prog. Tumor. Res., 43, 87, 10.1159/000447076
Kalluri, 2016, The biology and function of exosomes in cancer, J. Clin. Investig., 126, 1208, 10.1172/JCI81135
Kandilci, 2004, Effects of SET and SET-CAN on the differentiation of the human promonocytic cell line U937, Leukemia, 18, 337, 10.1038/sj.leu.2403227
Kazi, 2018, GSK3 suppression upregulates beta-catenin and c-Myc to abrogate KRas-dependent tumors, Nat. Commun., 9, 5154, 10.1038/s41467-018-07644-6
Kode, 2014, Leukaemogenesis induced by an activating beta-catenin mutation in osteoblasts, Nature, 506, 240, 10.1038/nature12883
Kordelas, 2014, MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease, Leukemia, 28, 970, 10.1038/leu.2014.41
Kowal, 2014, Biogenesis and secretion of exosomes, Curr. Opin. Cell Biol., 29, 116, 10.1016/j.ceb.2014.05.004
Krause, 2006, Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells, Nat. Med., 12, 1175, 10.1038/nm1489
Kumar, 2018, Acute myeloid leukemia transforms the bone marrow niche into a leukemia-permissive microenvironment through exosome secretion, Leukemia, 32, 575, 10.1038/leu.2017.259
Langenau, 2003, Myc-induced T cell leukemia in transgenic zebrafish, Science, 299, 887, 10.1126/science.1080280
Le Dieu, 2009, Peripheral blood T cells in acute myeloid leukemia (AML) patients at diagnosis have abnormal phenotype and genotype and form defective immune synapses with AML blasts, Blood, 114, 3909, 10.1182/blood-2009-02-206946
Lei, 2015, Regulatory T cell-mediated anti-inflammatory effects promote successful tissue repair in both indirect and direct manners, Front. Pharmacol., 6, 184, 10.3389/fphar.2015.00184
Li, 2019, Exosomes in the tumor microenvironment as mediators of cancer therapy resistance, Mol. Cancer, 18, 32, 10.1186/s12943-019-0975-5
Li, 1996, The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A, J. Biol. Chem., 271, 11059, 10.1074/jbc.271.19.11059
Liu, 2012, Regulation of c-myc protein abundance by a protein phosphatase 2a-glycogen synthase kinase 3beta-negative feedback pathway, Genes Cancer, 3, 23, 10.1177/1947601912448067
Low, 2014, Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56delta stabilizes its antiapoptotic activity, Blood, 124, 2223, 10.1182/blood-2014-03-563296
Ludwig, 2012, Exosomes: small vesicles participating in intercellular communication, Int. J. Biochem. Cell Biol., 44, 11, 10.1016/j.biocel.2011.10.005
Luo, 2009, Glycogen synthase kinase 3beta (GSK3beta) in tumorigenesis and cancer chemotherapy, Cancer Lett., 273, 194, 10.1016/j.canlet.2008.05.045
Luo, 2005, c-Myc rapidly induces acute myeloid leukemia in mice without evidence of lymphoma-associated antiapoptotic mutations, Blood, 106, 2452, 10.1182/blood-2005-02-0734
Manabe, 1992, Bone marrow-derived stromal cells prevent apoptotic cell death in B-lineage acute lymphoblastic leukemia, Blood, 79, 2370, 10.1182/blood.V79.9.2370.2370
Matsunaga, 2003, Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia, Nat. Med., 9, 1158, 10.1038/nm909
McCubrey, 2014, Multifaceted roles of GSK-3 and Wnt/beta-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention, Leukemia, 28, 15, 10.1038/leu.2013.184
Medyouf, 2014, Myelodysplastic cells in patients reprogram mesenchymal stromal cells to establish a transplantable stem cell niche disease unit, Cell Stem Cell, 14, 824, 10.1016/j.stem.2014.02.014
Melo, 2015, Glypican-1 identifies cancer exosomes and detects early pancreatic cancer, Nature, 523, 177, 10.1038/nature14581
Mineo, 2012, Exosomes released by K562 chronic myeloid leukemia cells promote angiogenesis in a Src-dependent fashion, Angiogenesis, 15, 33, 10.1007/s10456-011-9241-1
Muller-Tidow, 2004, Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells, Mol. Cell. Biol., 24, 2890, 10.1128/MCB.24.7.2890-2904.2004
Mumby, 2007, PP2A: unveiling a reluctant tumor suppressor, Cell, 130, 21, 10.1016/j.cell.2007.06.034
Neviani, 2005, The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein, Cancer Cell, 8, 355, 10.1016/j.ccr.2005.10.015
Neviani, 2007, FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia, J. Clin. Investig., 117, 2408, 10.1172/JCI31095
Neviani, 2013, PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells, J. Clin. Investig., 123, 4144, 10.1172/JCI68951
Oaks, 2013, Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies, Blood, 122, 1923, 10.1182/blood-2013-03-492181
Ougolkov, 2006, Targeting GSK-3: a promising approach for cancer therapy?, Future Oncol., 2, 91, 10.2217/14796694.2.1.91
Paggetti, 2015, Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts, Blood, 126, 1106, 10.1182/blood-2014-12-618025
Pan, 1985, Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes, J. Cell Biol., 101, 942, 10.1083/jcb.101.3.942
Panayiotidis, 1996, Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro, Br. J. Haematol., 92, 97, 10.1046/j.1365-2141.1996.00305.x
Peinado, 2012, Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET, Nat. Med., 18, 883, 10.1038/nm.2753
Pelengaris, 2002, c-MYC: more than just a matter of life and death, Nat. Rev. Cancer, 2, 764, 10.1038/nrc904
Perrotti, 2013, Protein phosphatase 2A: a target for anticancer therapy, Lancet Oncol., 14, e229, 10.1016/S1470-2045(12)70558-2
Piper, 2007, Biogenesis and function of multivesicular bodies, Annu. Rev. Cell Dev. Biol., 23, 519, 10.1146/annurev.cellbio.23.090506.123319
Pitt, 2015, CXCL12-Producing vascular endothelial niches control acute T cell leukemia maintenance, Cancer Cell, 27, 755, 10.1016/j.ccell.2015.05.002
Raaijmakers, 2010, Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia, Nature, 464, 852, 10.1038/nature08851
Rahmani, 2013, Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism, Cancer Res., 73, 1340, 10.1158/0008-5472.CAN-12-1365
Raposo, 1996, B lymphocytes secrete antigen-presenting vesicles, J. Exp. Med., 183, 1161, 10.1084/jem.183.3.1161
Rayasam, 2009, Glycogen synthase kinase 3: more than a namesake, Br. J. Pharmacol., 156, 885, 10.1111/j.1476-5381.2008.00085.x
Reiners, 2013, Soluble ligands for NK cell receptors promote evasion of chronic lymphocytic leukemia cells from NK cell anti-tumor activity, Blood, 121, 3658, 10.1182/blood-2013-01-476606
Rice, 2007, HOX deregulation in acute myeloid leukemia, J. Clin. Investig., 117, 865, 10.1172/JCI31861
Rizzieri, 2016, An open-label phase 2 study of glycogen synthase kinase-3 inhibitor LY2090314 in patients with acute leukemia, Leuk. Lymphoma, 57, 1800, 10.3109/10428194.2015.1122781
Roberts, 2010, Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers, Cancer Res., 70, 5438, 10.1158/0008-5472.CAN-09-2544
Roccaro, 2013, BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression, J. Clin. Investig., 123, 1542, 10.1172/JCI66517
Rubinfeld, 1996, Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly, Science, 272, 1023, 10.1126/science.272.5264.1023
Ruvolo, 2011, Low expression of PP2A regulatory subunit B55alpha is associated with T308 phosphorylation of AKT and shorter complete remission duration in acute myeloid leukemia patients, Leukemia, 25, 1711, 10.1038/leu.2011.146
Ruvolo, 2015, Phosphorylation of GSK3alpha/beta correlates with activation of AKT and is prognostic for poor overall survival in acute myeloid leukemia patients, BBA Clin., 4, 59, 10.1016/j.bbacli.2015.07.001
Salvatori, 2011, Critical role of c-myc in acute myeloid leukemia involving direct regulation of miR-26a and histone methyltransferase EZH2, Genes Cancer, 2, 585, 10.1177/1947601911416357
Savina, 2003, Exosome release is regulated by a calcium-dependent mechanism in K562 cells, J. Biol. Chem., 278, 20083, 10.1074/jbc.M301642200
Schepers, 2013, Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche, Cell Stem Cell, 13, 285, 10.1016/j.stem.2013.06.009
Schroeder, 2012, Mobilization of hematopoietic stem and leukemia cells, J. Leukoc. Biol., 91, 47, 10.1189/jlb.0210085
Sears, 2000, Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability, Genes Dev., 14, 2501, 10.1101/gad.836800
Shah, 2010, The Hox genes and their roles in oncogenesis, Nat. Rev. Cancer, 10, 361, 10.1038/nrc2826
Skog, 2008, Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers, Nat. Cell Biol., 10, 1470, 10.1038/ncb1800
Song, 2010, Glycogen synthase kinase--3beta inhibitors suppress leukemia cell growth, Exp. Hematol., 38, 908, 10.1016/j.exphem.2010.06.001
Subra, 2010, Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins, J. Lipid Res., 51, 2105, 10.1194/jlr.M003657
Szczepanski, 2011, Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor-beta1, Haematologica, 96, 1302, 10.3324/haematol.2010.039743
Tajima, 1996, Natural killer cell activity and cytokine production as prognostic factors in adult acute leukemia, Leukemia, 10, 478
Taverna, 2012, Role of exosomes released by chronic myelogenous leukemia cells in angiogenesis, Int. J. Cancer, 130, 2033, 10.1002/ijc.26217
Tullai, 2007, Glycogen synthase kinase-3 represses cyclic AMP response element-binding protein (CREB)-targeted immediate early genes in quiescent cells, J. Biol. Chem., 282, 9482, 10.1074/jbc.M700067200
Umezu, 2013, Leukemia cell to endothelial cell communication via exosomal miRNAs, Oncogene, 32, 2747, 10.1038/onc.2012.295
Umezu, 2014, Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1, Blood, 124, 3748, 10.1182/blood-2014-05-576116
Vardiman, 2009, The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes, Blood, 114, 937, 10.1182/blood-2009-03-209262
Vervoorts, 2006, The ins and outs of MYC regulation by posttranslational mechanisms, J. Biol. Chem., 281, 34725, 10.1074/jbc.R600017200
Wahlgren, 2012, Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes, Nucleic Acids Res., 40, e130, 10.1093/nar/gks463
Walkley, 2007, A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency, Cell, 129, 1097, 10.1016/j.cell.2007.05.014
Wang, 2018, Roles of the bone marrow niche in hematopoiesis, leukemogenesis, and chemotherapy resistance in acute myeloid leukemia, Hematology, 23, 729, 10.1080/10245332.2018.1486064
Wang, 2008, Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy, Nature, 455, 1205, 10.1038/nature07284
Wang, 2010, GSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesis, Cancer Cell, 17, 597, 10.1016/j.ccr.2010.04.024
Wang, 2014, Bone marrow stromal cell-derived exosomes as communicators in drug resistance in multiple myeloma cells, Blood, 124, 555, 10.1182/blood-2014-03-562439
Wang, 2019, Exosomes derived from acute myeloid leukemia cells promote chemoresistance by enhancing glycolysis-mediated vascular remodeling, J. Cell. Physiol., 234, 10602, 10.1002/jcp.27735
Westermarck, 2008, Multiple pathways regulated by the tumor suppressor PP2A in transformation, Trends Mol. Med., 14, 152, 10.1016/j.molmed.2008.02.001
Whiteside, 2018, The potential of tumor-derived exosomes for noninvasive cancer monitoring: an update, Expert Rev. Mol. Diagn., 18, 1029, 10.1080/14737159.2018.1544494
Whiteside, 2019, Proteomic analysis of plasma-derived exosomes in defining their role as biomarkers of disease progression, response to therapy and outcome, Proteomes, 7, 10.3390/proteomes7030027
Wojtuszkiewicz, 2016, Exosomes secreted by apoptosis-resistant acute myeloid leukemia (AML) blasts harbor regulatory network proteins potentially involved in antagonism of apoptosis, Mol. Cell. Proteom. : MCP, 15, 1281, 10.1074/mcp.M115.052944
Wortzel, 2019, Exosome-mediated metastasis: communication from a distance, Dev. Cell, 49, 347, 10.1016/j.devcel.2019.04.011
Yeh, 2004, A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells, Nat. Cell Biol., 6, 308, 10.1038/ncb1110
Yeh, 2015, Characterization of CLL exosomes reveals a distinct microRNA signature and enhanced secretion by activation of BCR signaling, Blood, 125, 3297, 10.1182/blood-2014-12-618470
Yu, 2007, Tumor exosomes inhibit differentiation of bone marrow dendritic cells, J. Immunol., 178, 6867, 10.4049/jimmunol.178.11.6867
Zhang, 2012, Altered microenvironmental regulation of leukemic and normal stem cells in chronic myelogenous leukemia, Cancer Cell, 21, 577, 10.1016/j.ccr.2012.02.018
Zhou, 2016, Bone marrow niche-mediated survival of leukemia stem cells in acute myeloid leukemia: Yin and Yang, Cancer Biol. Med., 13, 248, 10.20892/j.issn.2095-3941.2016.0023
Zhu, 2014, BCR-ABL1-positive microvesicles transform normal hematopoietic transplants through genomic instability: implications for donor cell leukemia, Leukemia, 28, 1666, 10.1038/leu.2014.51
Zwicker, 2009, Tumor-derived tissue factor-bearing microparticles are associated with venous thromboembolic events in malignancy, Clin. Cancer Res., 15, 6830, 10.1158/1078-0432.CCR-09-0371
Zwicker, 2013, Prediction and prevention of thromboembolic events with enoxaparin in cancer patients with elevated tissue factor-bearing microparticles: a randomized-controlled phase II trial (the Microtec study), Br. J. Haematol., 160, 530, 10.1111/bjh.12163