The role of collagen in bone strength
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Myllyharju J, Kivirikko KI (2004) Collagens, modifying enzymes and their mutations in humans, flies and worms. Trends Genet 20:33–43
Dominguez LJ, Barbagallo M, Moro L (2005) Collagen overglycosylation: a biochemical feature that may contribute to bone quality. Biochem Biophys Res Commun 330:1–4
Kuznetsova N and Leikin S (1999) Does the triple helical domain of type I collagen encode molecular recognition and fiber assembly while telopeptides serve as catalytic domains? Effect of proteolytic cleavage on fibrillogenesis and on collagen-collagen interaction in fibers. J Biol Chem 274:36083–36088
Lamande SR, Bateman JF (1999) Procollagen folding and assembly: the role of endoplasmic reticulum enzymes and molecular chaperones. Semin Cell Dev Biol 10:455–464
Hendershot LM, Bulleid NJ (2000) Protein-specific chaperones: the role of HSP47 begins to gel. Curr Biol 10:912–915
Koivu J 1987 Identification of disulphides bonds in carboxy-terminal propeptides of human type I procollagen. FEBS Lett 212:229–232
Bulleid NJ, Dalley JA, Lees JF 1997 The C-propeptide domain of procollagen can be replaced with a transmembrane domain without affecting trimer formation or collagen triple helix folding during biosynthesis. EMBO J 16:6694–6701
Bachinger HP (1987) The influence of peptidyl-prolyl cis-trans isomerase on the in vitro folding of type III collagen. J Biol Chem 262:17144–17148
Kivirikko KI, Myllyharju J (1998) Prolyl 4-hydroxylases and their protein disulfide isomerase subunit. Matrix Biol 16:357–368
Myllyharju J (2003) Prolyl 4-hydroxylases, the key enzymes of collagen biosynthesis. Matrix Biol 22:15–24
Nagata K (1998) Expression and function of heat shock protein 47: a collagen-specific molecular chaperone in the endoplasmic reticulum. Matrix Biol 16:379–386
Nagata K (2003) HSP47 as a collagen-specific molecular chaperone: function and expression in normal mouse development. Semin Cell Dev Biol 14:275–14282
Engel J, Prockop DJ (1991) The zipper-like folding of collagen triple helices and the effects of mutations that disrupt the zipper. Annu Rev Biophys Biophys Chem 20:137–152
Niyibizi C, Eyre DR (1994) Structural characteristics of cross-linking sites in type V collagen of bone chain specificities and heterotypic links to type I collagen. Eur J Biochem 224:943–950
Niyibizi C, Eyre DR (1989) Bone type V collagen: chain composition and location of a trypsin cleavage site. Connect Tissue Res 20:247–250
Baum J and Brodsky B (1999) Folding of peptide models of collagen and misfolding in disease. Curr Opin Struct Biol 9:122–128
Koivu J, Myllyla R, Helaakoski T, Pihlajaniemi T, Tasanen K, Kivirikko KI (1987) A single polypeptide acts both as the beta subunit of prolyl 4-hydroxylase and as a protein disulfide-isomerase. J Biol Chem 262:6447–9
John DC, Grant ME, Bulleid NJ (1993) Cell-free synthesis and assembly of prolyl 4-hydroxylase: the role of the beta-subunit (PDI) in preventing misfolding and aggregation of the alpha-subunit. EMBO J 12:1587–1595
Privalov PL (1982) Stability of proteins. Proteins which do not present a single cooperative system. Adv Protein Chem 35:1–104
Vranka JA, Sakai LY, Bachinger HP (2004) Prolyl 3-hydroxylase 1, enzyme characterization and identification of a novel family of enzymes. J Biol Chem. 279:23615–21
Valtavaara M, Szpirer C, Szpirer J, Myllyla R (1998) Primary structure, tissue distribution, and chromosomal localization of a novel isoform of lysyl hydroxylase (lysyl hydroxylase 3). J Biol Chem 273:12881–12886
Wang C, Luosujarvi H, Heikkinen J, Risteli M, Uitto L, Myllyla R (2002) The third activity for lysyl hydroxylase 3: galactosylation of hydroxylysyl residues in collagens in vitro. Matrix Biol 21:559–566
Passoja K, Rautavuoma K, Ala-Kokko L, Kosonen T, Kivirikko KI (1998) Cloning and characterization of a third lysyl hydroxylase isoform. Proc Natl Acad Sci USA 95:10482–10486
Mercer DK, Nicol PF, Kimbembe C, Robins SP (2003) Identification, expression and tissue distribution of three rat lysyl hydroxylase isoforms. Biochem Biophys Res Commun 307:803–809
Bank RA, Robins SP, Wijmenga C, Breslau-Siderius LJ, Bardoel AF, van der Sluijs HA, Pruijs HE, TeKoppele JM (1999) Defective collagen cross-linking in bone, but not in ligament or cartilage, in Bruck syndrome: indication for a bone specific telopeptide lysyl hydroxylase on chromosome 17. Proc Natl Acad Sci USA 96:1054–1058
Ha-Vinh R, Alanay Y, Bank RA, Campos-Xavier AB, Zankl A, Superti-Furga A, Bonafe L (2004) Phenotypic and molecular characterization of Bruck syndrome (osteogenesis imperfecta with contractures of the large joints) caused by a recessive mutation in PLOD2. Am J Med Genet A 131A:115–120
Bailey AJ, Wotton SF, Sims TJ, Thompson PW (1992) Post translational modifications in the collagen of human osteoporotic femoral head. Biochem Biophys Res Commun 185:801–805
Harwood R, Grant ME, Jackson DS (1974) Collagen biosynthesis. Characterization of subcellular fractions from embyonic chick fibroblasts and the intracellular localization of protocollagen prolyl and protocollagen lysyl hydroxylases. Biochem J 144:123–130
Harwood R, Grant ME, Jackson DS (1975) Studies on the glycosylation of hydroxylysine residues during collagen biosynthesis and the subcellular localization of collagen galactosyltransferase and collagen glucosyltransferase in tendon and cartilage cells. Biochem J 152:291–302
Gineyts E, Garnero P, Delmas PD (2001) Urinary excretion of glucosyl-galactosyl pyridinoline: a specific biochemical marker of synovium degradation. Rheumatology (Oxford) 40:315–323
Segrest JP, CunninghamLW (1970) Variations in human urinary O-hydroxylysyl glycoside levels and their relationship to collagen metabolism. J Clin Invest 49:1497–1509
Pinnell SR, Fox R, Krane SM (1971) Human collagens: differences in glycosylated hydroxylysines in skin and bone. Biochim Biophys Acta 229:119–122
Smith-Mungo L, Kagan HM (1998) Lysyl oxidase: properties, regulation and multiple functions in biology. Matrix Biol 16:387–398
Maki JM, Tikkanen H, Kivirikko KI (2001) Cloning and characterization of the fifth human lysyl oxidase enzyme: the third member of the lysyl oxidase related subfamily with four scavenger repector cystein-rich domains. Matrix Biol 20:493–496
Csiszar K (2001) Lysyl oxidases: a novel multifunctional amine oxidase family. Prog Nucleic Acid Res Mol Biol 70:1–32
Atsawasuwan P, Mochida Y, Parisuthiman D, Yamauchi M (2005) Expression of lysyl oxidase isoforms in MC3T3-E1 osteoblastic cells. Biochem Biophys Res Commun 327:1042–1046
Wang SX, Mure M, Medzihradszky KF, Burlingame AL, Brown DE, Dooley DM, Smith AJ, Kagan HM, Klinman JP (1996) A crosslinked cofactor in lysyl oxidase: redox function for amino acid side chains Science 273:1078–1084
Robins SP, Shimokomaki M, Bailey AJ (1973) The chemistry of the collagen crosslinks. Age-related changes in the reducible components of intact bovine collagen fibres. Biochem J 131:771–780
Eyre DR, Paz MA, Gallop PM (1984) Cross-linking in collagen and elastin. Annu. Rev Biochem 53:717–748
Eyre DR, Dickson IR, Van Ness K (1988) Collagen cross-linking in human bone and articular cartilage. Age-related changes in the content of mature hydroxypyridinium residues. Biochem J 252:495–500
Eyre DR, Oguchi H (1980) The hydroxypyridinium crosslinks of skeletal collagen: their measurement, properties and a proposed pathway of formation. Biochem Biophys Res Commun 92:403–410
Robins SP, Ducan A (1983) Cross-linking of the collagen. Location of pyridinoline in bovine articular cartilage at two sites of the molecules. Biochem J 215:167–173
Fujimori E (1985) Ultraviolet light- and ozone-induced changes in pyridinoline, a trisubstituted 3-hydroxypyridinium crosslink of collagen. Biochim Biophys Acta 828:104–106
Colwell A, Hamer A, Blumsohn A, Eastell R (1996) To determine the effects of ultraviolet light, natural light and ionizing radiation on pyridinium cross-links in bone and urine using high-performance liquid chromatography. Eur J Clin Invest 26:1107–1114
Saito M, Marumo K, Fujii K, Ishioka N (1997) Single-column high-performance liquid chromatographic-fluorescence detection of immature, mature, and senescent cross-links of collagen. Anal Biochem 253:26–32
Moro L, Romanello M, Favia A, Lamanna MP, Lozupone E (2000) Posttranslational modifications of bone collagen type I are related to the function of rat femoral regions. Calcif Tissue Int 66:151–156
Bailey AJ, Peach CM (1968) Isolation and structural identification of a labile intermolecular crosslink in collagen Biochem Biophys Res Commun 33:812–819
Barnes MJ, Constable BJ, Morton LF, Kodicek E (1971) Hydroxylysine in the N-terminal regions of the 1- and 2-chains of various collagens. Biochem J 125:433–437
Knott L, Whitehead CC, Fleming RH, Bailey AJ (1995) Biochemical changes in the collagenous matrix of osteoporotic avian bone. Biochem J 310:1045–1051
Kuypers R, Tyler M, Kurth LB, Jenkins ID, Horgan DJ (1992) Identification of the loci of the collagen-associated Ehrlich chromogen in type I collagen confirms its role as a trivalent cross-link. Biochem J 283:129–136
Ristelli J, Eriksen H, Risteli L, Mansell JP, Bayley AJ (1994) Pyrrolic crosslinks are as abundant in human bone type I collagen as pyridinolines. J Bone Miner Res 9(Suppl 1):S186
Bailey AJ, Knott L (1999) Molecular changes in bone collagen in osteoporosis and osteoarthritis in the elderly. Exp Gerontol 1999 34:337–351
Hanson DA, Eyre DR (1996) Molecular site specificity of pyridinoline and pyrrole crosslinks in type I collagen of human bone. J Biol Chem 271:26508–26516
Knott L, Bailey AJ (1998) Collagen cross-links in mineralising tissues : a review of their chemistry, function, and clinical relevance. Bone 22:181–187
Bailey AJ, Paul RG, Knott L (1998) Mechanisms of maturation and ageing of collagen. Mech Ageing Dev 106:1–56
Eyre DR, Glimcher MJ (1973) Analysis of a crosslinked peptide from calf bone collagen: evidence that hydroxylysyl glycoside participates in the crosslink. Biochem Biophys Res Commun 52:663–671
Robins SP, Bailey AJ (1974) Isolation and characterization of glycosyl derivatives of the reducible cross-links in collagens. FEBS Lett 38:334–336
Lapolla A, Traldi P, Fedele D (2005) Importance of measuring products of non-enzymatic glycation of proteins. Clin Biochem. 2005 38:103–115
Wolff SP,Dean RT (1987) Glucose autoxidation and protein modification. The potential role of “autoxidative glycosylation” in diabetes. Biochem J 245:243–50
Sell DR, Monnier VM (1989) Structure elucidation of a senescence crosslink from human extracellular matrix: implication of pentoses in the aging process. J Biol Chem 264:21597–21602
Monnier VM, Cerami A (1983) Detection of nonenzymatic browning products in the human lens. Biochim Biophys Acta 760:97–103
Markesbery WR (1997) Oxidative stress hypothesis in Alzheimer’s disease. Free Ra Biol Med 23:134–147
Brownlee M, Cerami A, Vlassara H (1988) Advanced glycosysalation end products in tissue and the biochemical basis of diabetic complications. N Engl J Med 318:1315–1321
DeGroot J, Verzijl N, Wenting-Van Wijk MJ, Bank RA, Lafeber FP, Bijlsma JW, TeKoppele JM (2001) Age-related decrease in susceptibility of human articular cartilage to matrix metalloproteinase-mediated degradation: the role of advanced glycation end products. Arthritis Rheum 44:2562–2571
Katayama Y, Akatsu T, Yamamoto M, Kugai N, Nagata N (1996) Role of nonenzymatic glycosylation of type I collagen in diabetic osteopenia. J Bone Miner Res 11:931–937
Miyata T, Kawai R, Taketomi S, Sprague SM (1996) Possible involvement of advanced glycation end-products in bone resorption. Nephrol Dial Transplant 11:54S-57S
Verzijl N, DeGroot J, Ben ZC, Brau-Benjamin O, Maroudas A, Bank RA, Mizrahi J, Schalkwijk CG, Thorpe SR, Baynes JW, Bijlsma JW, Lafeber FP, TeKoppele JM (2002) Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: a possible mechanism through which age is a risk factor for osteoarthritis. Arthritis Rheum 46:114–123
Chen AC, Temple MM, Ng DM, Verzijl N, DeGroot J, TeKoppele JM, Sah RL (2002) Induction of advanced glycation end products and alterations of the tensile properties of articular cartilage. Arthritis Rheum 46:3212–3217
Tomasek JJ, Meyers SW, Basinger JB, Green DT, Shew RL (1994) Diabetic and age-related enhancement of collagen-linked fluorescence in cortical bone of rats. Life Sci 55:855–861
Wang X, Shen X, Li X, Agrawal CM (2002) Age-related changes in the collagen network and toughness of bone. Bone 31:1–7
Vashishth D, Gibson GJ, Khoury JI, Schaffler MB, Kimura J, Fyhrie DP (2001) Influence of nonenzymatic glycation on biomechanical properties of cortical bone. Bone 28:195–201
Clarke S (1987) Propensity for spontaneous succinimide formation from aspartyl and asparaginyl residues in cellular proteins. Int J Pept Protein Res 30:808–821
Maroudas A, Bayliss MT, Uchitel-Kaushansky N, Schneiderman R, Gilav E (1998) Aggrecan turnover in human articular cartilage: use of aspartic acid racemization as a marker of molecular age. Arch Biochem Biophys 350:61–71
Saido TC, Iwatsubo T, Mann DM, Shimada H, Ihara Y, Kawashima S. (1995) Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques. Neuron 14:457–466
Fledelius C, Johnsen AH, Cloos PA, Bonde M, Qvist P (1997) Characterisation of urinary degradation products derived from type I collagen. Identification of a beta-isomerized Asp-Gly sequence within the C-terminal telopeptide (alpha1) region. J Biol Chem 272:9755–9763
Roher AE, Lowenson JD, Clarke S, Wolkow C, Wang R, Cotter RJ, Reardon IM, Zurcher-Neely HA, Heinrikson RL, Ball MJ (1993) Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer’s disease. J Biol Chem 268:3072–3083
Geiger T and Clarke S (1987) Deamination, isomerization, and racemization at asparaginyl and aspartyl residues in peptides. Succinimide-linked reactions that contribute to protein degradation. J Biol Chem 262:785–794
Gineyts E, Cloos PA, Borel O, Grimaud L, Delmas PD, Garnero P (2000) Racemization and isomerisation of type I collagen C-telopeptides in human bone and soft tissues : assessment of tissue turnover. Biochem J 345:481–485
Tomiyama T, Asano S, Furiya Y, Shirasawa T, Endo N, Mori H (1994) Racemization of Asp23 residue affects the aggregation of Alzheimer amyloid beta protein analogues. J Biol Chem 269:10205–10208
Cloos PA, Fledelius C (2000) Collagen fragments in urine derived from bone resorption are highly racemized and isomerised: a biological clock of protein aging with clinical potential. Biochem J 345:473–480
Shimizu T, Fukuda H, Murayama S, Izumiyama N, Shirasawa T. (2002) Isoaspartate formation at position 23 of amyloid beta peptide enhanced fibril formation and deposited onto senile plaques and vascular amyloids in Alzheimer’s disease. J Neurosci Res 70:451–461
Ottani V, Raspanti M, Ruggeri A (2001) Collagen structure and functional implications. Micron 32:251–260
Fratzl P, Paris O, Klaushofer K, Landis WJ (1996) Bone mineralization in an osteogenesis imperfecta mouse model studied by small-angle x-ray scattering. J Clin Invest 97:396–402
Vetter U, Eanes ED, Kopp JB, Termine JD, Robey PG (1991) Changes in apatite crystal size in bones of patients with osteogenesis imperfecta. Calcif Tissue Int 49:248–250
Traub W, Arad T, Vetter U, Weiner S (1994) Ultrastructural studies of bones from patients with osteogenesis imperfecta. Matrix Biol 14:337–345
Marotti G, Muglia MA, Palumbo C (1994) Structure and function of lamellar bone. Clin Rheumatol 13 Suppl 1:63–68
Currey JD (1988) The effect of porosity and mineral content on the Young’s modulus of elasticity of compact bone. J Biochem 21:131–139
Currey JD, Brear K, Zioupos P (1996) The effects of aging and changes in mineral content in degrading the toughness of human femora. J Biomech 29:257–260
Wang X, Bank RA, TeKoppele JM, Agrawal CM (2001) The role of collagen in determining bone mechanical properties. J Orthop Res 19:1021–1026
Zioupos P, Currey JD, Hamer AJ (1999) The role of collagen in the declining mechanical properties of aging human cortical bone. J Biomed Mater Res 45:108–116
Thompson JB, Kindt JH, Drake B, Hansma HG, Morse DE, Hansma PK (2001) Bone indentation recovery time correlates with bond reforming time. Nature 414:773–776
Zioupos P (2001) human bone: factors affecting its biomechanical properties and the role of collagen. J Biomater Appl 15:187–229
Currey JD, Foreman J, Laketic I, Mitchell J, Pegg DE, Reilly GC (1997) Effects of ionizing radiation on the mechanical properties of human bone. J Orthop Res 15:111–117
Currey JD (2003) Role of collagen and other organics in the mechanical properties of bone. Osteoporos Int 14:S29-S36
Fantner GE, Birkedal H, Kindt JH, Hassenkam T, Weaver JC, Cutroni JA, Bosma BL, Bawazer L, Finch MM, Cidade GA, Morse DE, Stucky GD, Hansma PK (2004) Influence of the degradation of the organic matrix on the microscopic fracture behavior of trabecular bone. Bone 35:1013–1022
Hert J, Fiala P, Petrtyl M (1994) Osteon orientation of the diaphysis of the long bones in man. Bone 15:269–277
Martin RB, Burr DB, Sharkey NA (1998) Skeletal tissue mechanics. Springer, Berlin Heidelberg New York
Martin RB and Boardman DL (1993) The effects of collagen fiber orientation, porosity, density, and mineralization on bovine cortical bone bending properties. J Biomech 26:1047–1054
Puustjarvi K, Nieminen J, Rasanen T, Hyttinen M, Helminen HJ, Kroger H, Huuskonen J, Alhava E, Kovanen V (2003) Do more highly organized collagen fibrils increase bone mechanical strength in loss of mineral density after one-year running training? J Bone Miner Res 14:321–329
Oxlund H, Barckman M, Ortoft G, Andreassen TT (1995) Reduced concentrations of collagen cross-links are associated with reduced strength of bone. Bone 17:365S–371S
Lees S, Hanson D, Page E, Mook HA (1994) Comparison of dosage-dependent effects of beta-aminopropionitrile, sodium fluoride, and hydrocortisone on selected physical properties of cortical bone. J Bone Miner Res 9:1377–1389
Masse PG, Rimnac CM, Yamauchi M, Coburn SP, Rucker RB, Howell DS, Boskey AL (1996) Pyridoxine deficiency affects biomechanical properties of chick tibial bone. Bone 18:567–574
Opsahl W, Zeronian H, Ellison M, Lewis D, Rucker RB, Riggins RS (1982) Role of copper in collagen cross-linking and its influence on selected mechanical properties on selected mechanical properties of chick bone and tendon. J Nutr 112:708–716
Banse X, Devogelaer JP, Lafosse A, Sims TJ, Grynpas M, Bailey AJ (2002) Cross-link profile of bone collagen correlates with structural organization of trabeculae. Bone 31:70–76
Banse X, Sims TJ, Bailey AJ (2002) Mechanical properties of adult vertebral cancellous bone: correlation with collagen intermolecular cross-links. J Bone Miner Res 17:1621–1628
Uzawa K, Grzesik WJ, Nishiura T, Kuznetsov SA, Robey PG, Brenner DA, Yamauchi M (1999) Differential expression of human lysyl hydroxylase genes, lysine hydroxylation, and cross-linking of type I collagen during osteoblastic differentiation in vitro. J Bone Miner Res 14:1272–1280
Pornprasertsuk S, Duarte WR, Mochida Y, Yamauchi M (2004) Lysyl hydroxylase-2b directs collagen cross-linking pathways in MC3T3-E1 cells. J Bone Miner Res 19:1349–1355
Pornprasertsuk S, Duarte WR, Mochida Y, Yamauchi M (2005) Overexpression of lysyl hydroxylase-2b leads to defective collagen fibrillogenesis and matrix mineralization. J Bone Miner Res 20:81–87
Vashishth D, Wu P, Gibson GJ (2003) Age-related loss in bone toughness is explained by non-enzymatic glycation of collagen. 49th annual meeting of the Orthopaedic Research Society, New Orleans
Boxberger J, Vashishth D (2003) Nonenzymatic glycation affects bone fracture by modifying creep and inelastic properties of collagen. 49th annual meeting of the Orthopaedic Research Society, New Orleans
Wu P, Koharski C, Nonnemann H, Vashishth D (2003) Loading of non-enzymatically glycated and damaged bone results in an instantaneous fracture. 49th annual meeting of the Orthopaedic Research Society, New Orleans
Garnero P, Proust Y, Borel O, Gineyts E, Duboeuf F, Solberg H, Delmas P (2003) Collagen crosslinking modifies the mechanical properties of cortical bone. J Bone Miner Res 18(Suppl 2):S196
Garnero P, Borel O, Gineyts E, Duboeuf F, Christiansen C, Delmas P (2004) The degree of posttranslational modifications of collagen is an important determinant of the toughness of cortical bone. J Bone Miner Res 19(Suppl 1):S220
Kirsch E, Krieg T, Remberger K, Fendel H, Bruckner P, Muller PK (1981) Disorder of collagen metabolism in a patient with osteogenesis imperfecta (lethal type): increased degree of hydroxylation of lysine in collagen type I and III. Eur J Clin Invest 11:39–47
Grabner B, Landis WJ, Roschger P, Rinnerthaler S, Peterlik H, Klaushofer K, Fratzl P (2001) Age- and genotype-dependence of bone material properties in the osteogenesis imperfecta murine model (oim). Bone 29:453–457
Jepsen KJ, Schaffler MB, Kuhn JL, Goulet RW, Bonadio J, Goldstein SA (1997) Type I collagen mutation alters the strength and fatigue behavior of Mov 13 cortical tissue. J Biomech 30:1141–1147
Pereira RF, Hume EL, Halford KW, Prockop DJ (1995) Bone fragility in transgenic mice expressing a mutated gene for type I procollagen (COL1A1) parallels the age-dependent phenotype of human osteogenesis imperfecta. J Bone Miner Res 10:1837–1843
Garnero P, Fledelius C, Gineyts E, Serre CM, Vignot E, Delmas PD (1997) Decreased beta-isomerization of the C-terminal telopeptide of type I collagen alpha 1 chain in Paget’s disease of bone. J Bone Miner Res 12:1407–1415
Garnero P, Gineyts E, Schaffer AV, Seaman J, Delmas PD (1998) Measurement of urinary excretion of nonisomerized an beta-isomerized forms of type I collagen breackdown products to monitor the effects of the bisphosphonate zoledronate in Paget’s disease. Arthritis Rheum 41:354–360
Mikkonen L, Tuominen T and Kulonen E (1960) Collagen fractions in lathyritic rats. Bioch Pharma 3:181–183
Lees S, Barnard S, Mook H (1987) Neutron studies of collagen in lathyritic bone. Int J Biol Macromol 9:32–38
Grant SF, Reid DM, Blake G, Herd R, Fogelman I, Ralston SH (1996) Reduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen type I alpha 1 gene. Nature Genet 14:40–45
Mann V and Ralston SH (2003) Meta-analysis of COL1A1 Sp1 polymorphism in relation to bone mineral density and osteoporotic fracture. Bone 32:711–717
Mann V, Hobson EE, Li B, Stewart TL, Grant SF, Robins SP, Aspden RM, Ralston SH (2001) A COL1A Sp1 binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality. J Clin Invest 107:899–907
Uitterlinden AG, Burger H, Huang Q, Yue F, McGuigan FE, Grant SF, Hofman A, van Leeuwen JP, Pols HA, Ralston SH (1998) Relation of alleles of the collagen type I alpha1 gene to bone density and the risk of osteoporotic fractures in postmenopausal women. N Engl J Med 338:1016–1021
Schwartz AV, Sellmeyer DE, Ensrud KE, Cauley JA, Tabor HK, Schreiner PJ, Jamal SA, Black DM, Cummings SR (2001) Older women with diabetes have an increased risk of fractures: a prospective study. J Clin Endocrinol Metab 86:32–38
Nicodemus KK, Folsom AR (2001) Type 1 and type 2 diabetes and incident hip fractures in postmenopausal women. Diabetes Care 24:1192–1197
Keegan TH, Kelsey JL, Sidney S, Quesenberry CP Jr (2002) Foot problems as risk factors of fractures. Am J Epidemiol 155:926–931
Reddy KG, Stehno-bittel L, Hamade S, Enwemeka CS (2001) The biomechanical integrity of bone in experimemtal diabetes. Diabetes Res Cli Pract 54:1–8
Verhaeghe J, Suiker AM, Einhorn TA, Geusens P, Visser WJ, Van Herck E, Van Bree R, Magitsky S, Bouillon R (1994) Brittle bones in spontaneously diabetic female rats cannot be predicted by bone mineral measurements: studies in diabetic and ovariectomized rats. J Bone Miner Res 9:1657–1667
Paul RG, Bailey AJ (1996) Glycation of collagen: the basis of its central role in the late complications of ageing and diabetes. Int J Biochem Cell Biol 28:1297–1310
Sanada H, Shikata J, Hamamoto H, Ueba Y, Yamamuro T, Takeda T (1978) Changes in collagen cross-linking and lysyl oxidase by estrogen. Biochim Biophys Acta 541:408–413
Feres-Filho EJ, Choi YJ, Han X, Takala TE, Trackman PC (1995) Pre-translational and post-translational regulation of lysyl oxidase by transforming growth-factor-beta-1 in osteoblastic MC3T3-E1 cells. J Biol Chem 270:30797–30803
Seitzer U, Batge B, Acil Y, Muller PK (1995) Transforming growth-factor beta 1 influences lysyl hydroxylation of collagen I and reduces steady-state level of lysyl hydroxylase mRNA in human osteoblast-like cells. Eur J Clin Invest 25:959–966
Kowitz J, Knippel M, Schuhr T, Mach J (1997) Alteration in the extent of collagen I hydroxylation, isolated from femoral heads of women with a femoral neck fracture caused by osteoporosis. Calcif Tissue Int 60:501–505
Batge B, Diebold J, Stein H, Bodo M, Muller PK (1992) Compositionnal analysis of the collagenous bone matrix. A study on adult normal and osteopenic bone tissue. Eur J Clin Invest 22:805–812
Bailey AJ, Wotton SF, Sims TJ, Thompson PW (1993) Biochemical changes in the collagen of human osteoporotic bone matrix. Connect Tissue Res 29:119–132
Torre-Blanco A, Adachi E, Hojima Y, Wootton JA, Minor RR, Prockop DJ (1992) Temperature induced post-translational over-modification of type I collagen. Effects of over-modification of the protein on the rate of cleavage by procollagen N-proteinase and on self-assembly of collagen into fibrils. J Biol Chem 267:2650–2655
Oxlund H, Mosekilde L, Ortoft G (1996) Reduced concentration of collagen reducible crosslinks in human trabecular bone with respect to age and osteoporosis. Bone 19:479–484
Paschalis EP, Shane E, Lyritis G, Skarantavos G, Mendelsohn R, Boskey AL (2004) Bone fragility and collagen cross-links. J Bone Miner Res 19:2000–2004