The role of cathepsin K in oral and maxillofacial disorders

Oral Diseases - Tập 22 Số 2 - Trang 109-115 - 2016
Xiaohui Wen1, L‐z Yi2, Feng Liu3, Jianhua Wei4, Yang Xue5,2
1State Key Laboratory of Military Stomatology, Department of Prosthodontics, School of Stomatology, the Fourth Military Medical University, Xi'an, Shaanxi, China
2State Key Laboratory of Military Stomatology, Department of Oral Biology, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China
3Department of Stomatology, Northwest Women's and Children's Hospital, Xi'an, China
4State Key Laboratory of Military Stomatology, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China
5Clinic of Oral Rare and Genetic Diseases, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China

Tóm tắt

Cathepsin K (CTSK) was thought to be a collagenase, specifically expressed by osteoclasts, and played an important role in bone resorption. However, more and more research found thatCTSKwas expressed in more extensive cells, tissues, and organs. It may not only participate in regulating human physiological activity, but also be closely related to a variety of disease. In this review, we highlight the relationship betweenCTSKand oral and maxillofacial disorders on the following three aspects: oral and maxillofacial abnormities in patients with pycnodysostosis caused byCTSKmutations, oral and maxillofacial abnormities inCtsk−/−mice, and the role ofCTSKin oral and maxillofacial diseases, including periodontitis, peri‐implantitis, tooth movement, oral and maxillofacial tumor, root resorption, and periapical disease.

Từ khóa


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Oral Diseases

Tập 22 Số 2

109-115

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