The role of blood volume in cardiac dysfunction and reduced exercise tolerance in patients with diabetes

Brandenburg, 1999, Effects of exercise training on oxygen uptake kinetic responses in women with type 2 diabetes, Diabetes Care, 22, 1640, 10.2337/diacare.22.10.1640 Gusso, 2008, Impaired stroke volume and aerobic capacity in female adolescents with type 1 and type 2 diabetes mellitus, Diabetologia, 51, 1317, 10.1007/s00125-008-1012-1 Regensteiner, 1995, Effects of non-insulin-dependent diabetes on oxygen consumption during treadmill exercise, Med Sci Sports Exerc, 27, 875, 10.1249/00005768-199506000-00012 Regensteiner, 2009, Cardiac dysfunction during exercise in uncomplicated type 2 diabetes, Med Sci Sports Exerc, 41, 977, 10.1249/MSS.0b013e3181942051 Fang, 2005, Determinants of exercise capacity in patients with type 2 diabetes, Diabetes Care, 28, 1643, 10.2337/diacare.28.7.1643 Wilson, 2017, Impaired ventricular filling limits cardiac reserve during submaximal exercise in people with type 2 diabetes, Cardiovasc Diabetol, 16, 160, 10.1186/s12933-017-0644-1 Wei, 2000, Low cardiorespiratory fitness and physical inactivity as predictors of mortality in men with type 2 diabetes, Ann Intern Med, 132, 605, 10.7326/0003-4819-132-8-200004180-00002 Church, 2005, Cardiorespiratory fitness and body mass index as predictors of cardiovascular disease mortality among men with diabetes, Arch Intern Med, 165, 2114, 10.1001/archinte.165.18.2114 Boulé, 2003, Meta-analysis of the effect of structured exercise training on cardiorespiratory fitness in type 2 diabetes mellitus, Diabetologia, 46, 1071, 10.1007/s00125-003-1160-2 Nielsen, 2006, Meta-analysis of the effect of exercise interventions on fitness outcomes among adults with type 1 and type 2 diabetes, Diabetes Res Clin Pract, 74, 111, 10.1016/j.diabres.2006.03.033 Lundby, 2015, CrossTalk opposing view: diffusion limitation of O2 from microvessels into muscle does not contribute to the limitation of VO2max, J Physiol, 593, 3759, 10.1113/JP270550 Lundby, 2017, Biology of VO2max: looking under the physiology lamp, Acta Physiol (Oxf), 220, 218, 10.1111/apha.12827 Montero, 2015, Haematological rather than skeletal muscle adaptations contribute to the increase in peak oxygen uptake induced by moderate endurance training, J Physiol, 593, 4677, 10.1113/JP270250 Boushel, 2011, Muscle mitochondrial capacity exceeds maximal oxygen delivery in humans, Mitochondrion, 11, 303, 10.1016/j.mito.2010.12.006 Davies, 1982, Muscle mitochondrial bioenergetics, oxygen supply, and work capacity during dietary iron deficiency and repletion, Am J Physiol, 242, E418 Lundby, 2015, Performance enhancement: what are the physiological limits?, Physiology (Bethesda), 30, 282 Montero, 2016, Endurance training and maximal oxygen consumption with ageing: role of maximal cardiac output and oxygen extraction, Eur J Prev Cardiol, 23, 733, 10.1177/2047487315617118 Montero, 2015, Endurance training and VO2max: role of maximal cardiac output and oxygen extraction, Med Sci Sports Exerc, 47, 2024, 10.1249/MSS.0000000000000640 Covell, 1966, Comparison of the force-velocity relation and the ventricular function curve as measures of the contractile state of the intact heart, Circ Res, 19, 364, 10.1161/01.RES.19.2.364 Patterson, 1914, On the mechanical factors which determine the output of the ventricles, J Physiol, 48, 357, 10.1113/jphysiol.1914.sp001669 Bundgaard-Nielsen, 2009, Relationship between stroke volume, cardiac output and filling of the heart during tilt, Acta Anaesthesiol Scand, 53, 1324, 10.1111/j.1399-6576.2009.02062.x Yamanouchi, 1996, Changes in left ventricular volume during head-up tilt in patients with vasovagal syncope: an echocardiographic study, Am Heart J, 131, 73, 10.1016/S0002-8703(96)90053-8 Convertino, 1991, Elevated central venous pressure: a consequence of exercise training-induced hypervolemia?, Am J Physiol Regul Integr Comp Physiol, 260, R273, 10.1152/ajpregu.1991.260.2.R273 Gregersen, 1959, Blood volume, Physiol Rev, 39, 307, 10.1152/physrev.1959.39.2.307 Coyle, 1986, Effects of detraining on cardiovascular responses to exercise: role of blood volume, J Appl Physiol, 60, 95, 10.1152/jappl.1986.60.1.95 Hopper, 1988, Exercise stroke volume relative to plasma-volume expansion, J Appl Physiol, 64, 404, 10.1152/jappl.1988.64.1.404 Kanstrup, 1982, Acute hypervolemia, cardiac performance, and aerobic power during exercise, J Appl Physiol, 52, 1186, 10.1152/jappl.1982.52.5.1186 Panebianco, 1995, Effects of blood donation on exercise performance in competitive cyclists, Am Heart J, 130, 838, 10.1016/0002-8703(95)90085-3 Van Remoortel, 2017, The effect of a standard whole blood donation on oxygen uptake and exercise capacity: a systematic review and meta-analysis, Transfusion, 57, 451, 10.1111/trf.13893 Bonne, 2014, Phlebotomy eliminates the maximal cardiac output response to six weeks of exercise training, Am J Physiol Regul Integr Comp Physiol, 306, R752, 10.1152/ajpregu.00028.2014 Rissanen, 2015, Central and peripheral cardiovascular impairments limit VO2peak in type 1 diabetes, Med Sci Sport Exerc, 47, 223, 10.1249/MSS.0000000000000419 Koponen, 2013, Low total haemoglobin mass, blood volume and aerobic capacity in men with type 1 diabetes, Eur J Appl Physiol, 113, 1181, 10.1007/s00421-012-2532-4 Lalande, 2010, Effect of reduced total blood volume on left ventricular volumes and kinetics in type 2 diabetes, Acta Physiol (Oxf), 199, 23, 10.1111/j.1748-1716.2010.02081.x Ruben, 1986, Packed cell volume in diabetes mellitus, Practitioner, 230, 649 Jermendy, 1986, Circulating blood volumes in diabetic patients, Exp Clin Endocrinol, 88, 123, 10.1055/s-0029-1210587 Sugai, 1967, Total exchangeable sodium and circulating blood volume in patients with diabetes and essential hypertension, Nihon Naika Gakkai Zasshi, 56, 313, 10.2169/naika.56.313 Onoyama, 1987, Hemodynamic and volume changes by ultrafiltration in refractory edema of diabetic nephrotic syndrome with severe renal insufficiency, Clin Nephrol, 27, 21 Beretta-Piccoli, 1982, Body sodium-blood volume state in nonazotemic diabetes mellitus, Miner Electrolyte Metab, 7, 36 Weidmann, 1985, Pressor factors and responsiveness in hypertension accompanying diabetes mellitus, Hypertension, 7, 33, 10.1161/01.HYP.7.6_Pt_2.II33 Fauchald, 1985, Transcapillary colloid osmotic gradient, plasma volume and interstitial fluid volume in long-term type 1 (insulin-dependent) diabetes, Diabetologia, 28, 269, 10.1007/BF00271683 Parving, 1973, Transcapillary escape rate of albumin and plasma volume in short- and long-term juvenile diabetics, Scand J Clin Lab Invest, 32, 81, 10.3109/00365517309082454 Langer, 1971, The effect of exercise on haematocrit, plasma volume and viscosity in diabetes mellitus, Diabetologia, 7, 29, 10.1007/BF02346251 Laederach-Hofmann, 1999, Hypovolemia contributes to the pathogenesis of orthostatic hypotension in patients with diabetes mellitus, Am J Med, 106, 50, 10.1016/S0002-9343(98)00367-2 O'Hare, 1985, Exchangeable sodium and renin in hypertensive diabetic patients with and without nephropathy, Hypertension, 7, 1143, 10.1161/01.HYP.7.6_Pt_2.II43 Weidmann, 1979, Sodium-volume factor, cardiovascular reactivity and hypotensive mechanism of diuretic therapy in mild hypertension associated with diabetes mellitus, Am J Med, 67, 779, 10.1016/0002-9343(79)90734-4 de Chatel, 1977, Sodium, renin, aldosterone, catecholamines, and blood pressure in diabetes mellitus, Kidney Int, 12, 412, 10.1038/ki.1977.132 Convertino, 2007, Blood volume response to physical activity and inactivity, Am J Med Sci, 334, 72, 10.1097/MAJ.0b013e318063c6e4 Montero, 2018, Regulation of red blood cell volume with exercise training, Compr Physiol, 9, 149, 10.1002/cphy.c180004 Montero, 2017, Refuting the myth of non-response to exercise training: ‘non-responders’ do respond to higher dose of training, J Physiol, 595, 3377, 10.1113/JP273480 Vohra, 1993, Effect of diabetes mellitus on the cardiovascular responses to induction of anaesthesia and tracheal intubation, Br J Anaesth, 71, 258, 10.1093/bja/71.2.258 Burgos, 1989, Increased intraoperative cardiovascular morbidity in diabetics with autonomic neuropathy, Anesthesiology, 70, 591, 10.1097/00000542-198904000-00006 Low, 2004, Autonomic symptoms and diabetic neuropathy: a population-based study, Diabetes Care, 27, 2942, 10.2337/diacare.27.12.2942 Shideman, 1976, Hemodialysis in diabetics: complications in insulin-dependent patients accepted for renal transplantation, Arch Intern Med, 136, 1126, 10.1001/archinte.1976.03630100038011 Brunet, 1996, Tolerance of haemodialysis: a randomized cross-over trial of 5-h versus 4-h treatment time, Nephrol Dial Transplant, 11, 46, 10.1093/ndt/11.supp8.46 Huang, 2006, Pre-operative measurement of heart rate variability predicts hypotension during general anesthesia, Acta Anaesthesiol Scand, 50, 542, 10.1111/j.1399-6576.2006.001016.x Dabelea, 2017, Association of type 1 diabetes vs type 2 diabetes diagnosed during childhood and adolescence with complications during teenage years and young adulthood, JAMA, 317, 825, 10.1001/jama.2017.0686 Pantalone, 2015, Clinical characteristics, complications, comorbidities and treatment patterns among patients with type 2 diabetes mellitus in a large integrated health system, BMJ Open Diabetes Res Care, 3, 10.1136/bmjdrc-2015-000093 Stehouwer, 2018, Microvascular dysfunction and hyperglycemia: a vicious cycle with widespread consequences, Diabetes, 67, 1729, 10.2337/dbi17-0044 Montero, 2016, Reduction in central venous pressure enhances erythropoietin synthesis: role of volume-regulating hormones, Acta Physiol (Oxf), 218, 89, 10.1111/apha.12708 Gauer, 1963, Circulatory basis of fluid volume control, Physiol Rev, 43, 423, 10.1152/physrev.1963.43.3.423 Kirsch, 2005, Erythropoietin as a volume-regulating hormone: an integrated view, Semin Nephrol, 25, 388, 10.1016/j.semnephrol.2005.05.007 Miller, 1996, Effect of hyperglycaemia on arterial pressure, plasma renin activity and renal function in early diabetes, Clin Sci (Lond), 90, 189, 10.1042/cs0900189 Lim, 2004, Diabetes mellitus, the renin-angiotensin-aldosterone system, and the heart, Arch Intern Med, 164, 1737, 10.1001/archinte.164.16.1737 Montero, 2016, Arterial stiffness is strongly and negatively associated with the total volume of red blood cells, Int J Cardiol, 221, 77, 10.1016/j.ijcard.2016.06.265 Zhang, 2015, Effect of angiotensin II on voltage-gated sodium currents in aortic baroreceptor neurons and arterial baroreflex sensitivity in heart failure rats, J Hypertens, 33, 1401, 10.1097/HJH.0000000000000563 Beretta-Piccoli, 1981, Responsiveness of plasma renin and aldosterone in diabetes mellitus, Kidney Int, 20, 259, 10.1038/ki.1981.129 Christlieb, 1976, Plasma renin activity and hypertension in diabetes mellitus, Diabetes, 25, 969, 10.2337/diab.25.10.969 Kikkawa, 1986, Biphasic alteration of renin-angiotensin-aldosterone system in streptozotocin-diabetic rats, Kidney Blood Press Res, 9, 187, 10.1159/000173083 Üstündag, 1999, The study of renin-angiotensin-aldosterone in experimental diabetes mellitus, Cell Biochem Funct, 17, 193, 10.1002/(SICI)1099-0844(199909)17:3<193::AID-CBF828>3.0.CO;2-N Freudenthaler, 2000, Dose-dependent effect of angiotensin II on human erythropoietin production, Pflugers Arch, 439, 838, 10.1007/s004249900238 Kim, 2014, Mechanism of erythropoietin regulation by angiotensin II, Mol Pharmacol, 85, 898, 10.1124/mol.113.091157 Vlahakos, 1995, Renin–angiotensin system stimulates erythropoietin secretion in chronic hemodialysis patients, Clin Nephrol, 43, 53 Pratt, 1992, Effect of angiotensin converting enzyme inhibitors on erythropoietin concentrations in healthy volunteers, Br J Clin Pharmacol, 34, 363, 10.1111/j.1365-2125.1992.tb05644.x Florit, 2012, Anemia in kidney transplants without erythropoietic agents: levels of erythropoietin and iron parameters, Transplant Proc, 44, 2590, 10.1016/j.transproceed.2012.09.044 Donnelly, 1999, Erythropoietin deficiency in hyporeninemia, Am J Kidney Dis, 33, 947, 10.1016/S0272-6386(99)70431-2 Griffing, 1982, Enalapril (MK-421) and the white cell count and hematocrit, Lancet, 319, 1361, 10.1016/S0140-6736(82)92430-8 Mohanram, 2008, The effect of losartan on hemoglobin concentration and renal outcome in diabetic nephropathy of type 2 diabetes, Kidney Int, 73, 630, 10.1038/sj.ki.5002746 Montero, 2018, Arterial oxygen content regulates plasma erythropoietin independently of arterial O2 tension: a blinded crossover study, Kidney Int, 95, 173, 10.1016/j.kint.2018.09.015 Donnelly, 2001, Why is erythropoietin made in the kidney? The kidney functions as a critmeter, Am J Kidney Dis, 38, 415, 10.1053/ajkd.2001.26111 Bie, 1986, Cardiovascular and endocrine responses to head-up tilt and vasopressin infusion in humans, Am J Physiol, 251, R735 Segar, 1968, The regulation of antidiuretic hormone release in man: I. effects of change in position and ambient temperature on blood ADH levels, J Clin Invest, 47, 2143, 10.1172/JCI105900 Errington, 1972, Vasopressin clearance and secretion during haemorrhage in normal dogs and in dogs with experimental diabetes insipidus, J Physiol, 227, 395, 10.1113/jphysiol.1972.sp010039 Iwasaki, 1996, Osmoregulation of plasma vasopressin in diabetes mellitus with sustained hyperglycemia, J Neuroendocrinol, 8, 755, 10.1046/j.1365-2826.1996.05124.x Tallroth, 1992, The response of regulatory peptides to moderate hypoglycaemia of short duration in type 1 (insulin-dependent) diabetes mellitus and in normal man, Diabetes Res, 20, 73 Kamoi, 1990, Atrial natriuretic peptide in patients with the syndrome of inappropriate antidiuretic hormone secretion and with diabetes insipidus, J Clin Endocrinol Metab, 70, 1385, 10.1210/jcem-70-5-1385 Kamoi, 1991, Thirst and plasma levels of vasopressin, angiotensin II and atrial natriuretic peptide in patients with non-insulin-dependent diabetes mellitus, Diabetes Res Clin Pract, 11, 195, 10.1016/S0168-8227(05)80033-6 Walsh, 1979, Plasma arginine vasopressin in diabetic ketoacidosis, Diabetologia, 16, 93, 10.1007/BF01225456 Zerbe, 1979, Plasma vasopressin in uncontrolled diabetes mellitus, Diabetes, 28, 503, 10.2337/diab.28.5.503 Bardoux, 2003, Vasopressin increases urinary albumin excretion in rats and humans: involvement of V2 receptors and the renin–angiotensin system, Nephrol Dial Transplant, 18, 497, 10.1093/ndt/18.3.497 Bardoux, 1999, Vasopressin contributes to hyperfiltration, albuminuria, and renal hypertrophy in diabetes mellitus: study in vasopressin-deficient Brattleboro rats, Proc Natl Acad Sci USA, 96, 10397, 10.1073/pnas.96.18.10397 Bouby, 1996, Vasopressin increases glomerular filtration rate in conscious rats through its antidiuretic action, J Am Soc Nephrol, 7, 842, 10.1681/ASN.V76842 Gellai, 1984, Influence of vasopressin on renal hemodynamics in conscious Brattleboro rats, Am J Physiol, 246, F819 Bankir, 1995, Adaptation of the kidney to protein intake and to urine concentration activity: similar consequences in health and CRF, Kidney Int, 47, 7, 10.1038/ki.1995.2 Bankir, 2001, Vasopressin and diabetes mellitus, Nephron, 87, 8, 10.1159/000045879 Gozdz, 2002, Vasopressin V1a, V1b and V2 receptors mRNA in the kidney and heart of the renin transgenic TGR(mRen2)27 and Sprague Dawley rats, J Physiol Pharmacol, 53, 349 Aoyagi, 2008, Vasopressin regulates the renin-angiotensin-aldosterone system via V1a receptors in macula densa cells, Am J Physiol Renal Physiol, 295, F100, 10.1152/ajprenal.00088.2008 Engel, 1995, Increased production of erythropoietin after application of antidiuretic hormone. A consequence of renal vasoconstriction?, Exp Clin Endocrinol Diabetes, 103, 303, 10.1055/s-0029-1211370 Trevest, 2014, Prevalence and determinants of anemia in older people with diabetes attending an outpatient clinic: a cross-sectional audit, Clin Diabetes, 32, 158, 10.2337/diaclin.32.4.158 Thomas, 2005, Anemia with impaired erythropoietin response in diabetic patients, Arch Intern Med, 165, 466, 10.1001/archinte.165.4.466 Nishikawa, 1996, Arzneimittelforschung, 46, 875 Pedersen, 1992, Determinants of intra-individual variation in kidney function in normoalbuminuric insulin-dependent diabetic patients: importance of atrial natriuretic peptide and glycaemic control, Clin Sci (Lond), 83, 445, 10.1042/cs0830445 Levin, 1998, Natriuretic peptides, N Engl J Med, 339, 321, 10.1056/NEJM199807303390507 Goetz, 1988, Physiology and pathophysiology of atrial peptides, Am J Physiol, 254, E1 Jujić, 2014, Atrial natriuretic peptide and type 2 diabetes development—biomarker and genotype association study, PLoS One, 9, 10.1371/journal.pone.0089201 Magnusson, 2012, Low plasma level of atrial natriuretic peptide predicts development of diabetes: the Prospective Malmö Diet and Cancer Study, J Clin Endocrinol Metab, 97, 638, 10.1210/jc.2011-2425 Więcek, 2003, Role of angiotensin II in the progression of diabetic nephropathy—therapeutic implications, Nephrol Dial Transplant, 18, v16, 10.1093/ndt/gfg1036 Saran, 2018, US Renal Data System 2017 Annual Data Report: epidemiology of kidney disease in the United States, Am J Kidney Dis, 71, A7, 10.1053/j.ajkd.2018.01.002 Reutens, 2013, Epidemiology of diabetic kidney disease, Med Clin North Am, 97, 1, 10.1016/j.mcna.2012.10.001 Griffel, 1992, Pharmacology of colloids and crystalloids, Crit Care Clin, 8, 235, 10.1016/S0749-0704(18)30249-5 Leehey, 2005, Progression of kidney disease in type 2 diabetes—beyond blood pressure control: an observational study, BMC Nephrol, 6, 8, 10.1186/1471-2369-6-8 Hommel, 1990, Pathophysiological aspects of edema formation in diabetic nephropathy, Kidney Int, 38, 1187, 10.1038/ki.1990.332 Tessari, 2006, Diabetic nephropathy is associated with increased albumin and fibrinogen production in patients with type 2 diabetes, Diabetologia, 49, 1955, 10.1007/s00125-006-0288-2 Emanuel, 2017, Relationships between type 2 diabetes, neuropathy, and microvascular dysfunction: evidence from patients with cryptogenic axonal polyneuropathy, Diabetes Care, 40, 583, 10.2337/dc16-1690 Lindenberger, 2013, Decreased circulatory response to hypovolemic stress in young women with type 1 diabetes, Diabetes Care, 36, 4076, 10.2337/dc13-0468 Lindenberger, 2011, Impaired compensatory response to hypovolaemic circulatory stress in type 1 diabetes mellitus, Diab Vasc Dis Res, 8, 136, 10.1177/1479164111404576 Nadeau, 2009, Insulin resistance in adolescents with type 2 diabetes is associated with impaired exercise capacity, J Clin Endocrinol Metab, 94, 3687, 10.1210/jc.2008-2844 Nadeau, 2010, Insulin resistance in adolescents with type 1 diabetes and its relationship to cardiovascular function, J Clin Endocrinol Metab, 95, 513, 10.1210/jc.2009-1756 Stoddard, 1989, Influence of alteration in preload on the pattern of left ventricular diastolic filling as assessed by Doppler echocardiography in humans, Circulation, 79, 1226, 10.1161/01.CIR.79.6.1226 Prasad, 2007, The effects of aging and physical activity on Doppler measures of diastolic function, Am J Cardiol, 99, 1629, 10.1016/j.amjcard.2007.01.050 van Kraaij, 2000, Furosemide withdrawal in elderly heart failure patients with preserved left ventricular systolic function, Am J Cardiol, 85, 1461, 10.1016/S0002-9149(00)00795-5 Hensel, 2016, Subclinical alterations of cardiac mechanics present early in the course of pediatric type 1 diabetes mellitus: a prospective blinded speckle tracking stress echocardiography study, J Diabetes Res, 2016, 10.1155/2016/2583747 Suys, 2004, Female children and adolescents with type 1 diabetes have more pronounced early echocardiographic signs of diabetic cardiomyopathy, Diabetes Care, 27, 1947, 10.2337/diacare.27.8.1947 Sohn, 1997, Assessment of mitral annulus velocity by Doppler tissue imaging in the evaluation of left ventricular diastolic function, J Am Coll Cardiol, 30, 474, 10.1016/S0735-1097(97)88335-0 Huggett, 2003, Impact of type 2 diabetes mellitus on sympathetic neural mechanisms in hypertension, Circulation, 108, 3097, 10.1161/01.CIR.0000103123.66264.FE Lord, 2018, Reduced left ventricular filling following blood volume extraction does not result in compensatory augmentation of cardiac mechanics, Exp Physiol, 103, 495, 10.1113/EP086761 Boudina, 2007, Diabetic cardiomyopathy revisited, Circulation, 115, 3213, 10.1161/CIRCULATIONAHA.106.679597 Ferraro, 1993, Comparison of left ventricular function in insulin- and non-insulin-dependent diabetes mellitus, Am J Cardiol, 71, 409, 10.1016/0002-9149(93)90441-E Shimizu, 1991, Increase in left ventricular chamber stiffness in patients with non-insulin dependent diabetes mellitus, Jpn Circ J, 55, 657, 10.1253/jcj.55.657 Galderisi, 2007, Impaired inotropic response in type 2 diabetes mellitus: a strain rate imaging study, Am J Hypertens, 20, 548, 10.1016/j.amjhyper.2006.12.009 Vinereanu, 2003, Subclinical left ventricular dysfunction in asymptomatic patients with type II diabetes mellitus, related to serum lipids and glycated haemoglobin, Clin Sci (Lond), 105, 591, 10.1042/CS20030168 op den Buijs, 2005, β-Adrenergic activation reveals impaired cardiac calcium handling at early stage of diabetes, Life Sci, 76, 1083, 10.1016/j.lfs.2004.08.018 Wilson, 2017, β-Adrenergic responsiveness in the type 2 diabetic heart: effects on cardiac reserve, Med Sci Sports Exerc, 49, 907, 10.1249/MSS.0000000000001184 Lewis, 1993, The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy, N Engl J Med, 329, 1456, 10.1056/NEJM199311113292004 Parving, 2001, The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes, N Engl J Med, 345, 870, 10.1056/NEJMoa011489 Wilmer, 1999, Remission of nephrotic syndrome in type 1 diabetes: long-term follow-up of patients in the captopril study, Am J Kidney Dis, 34, 308, 10.1016/S0272-6386(99)70360-4 Whelton, 2005, Clinical outcomes in antihypertensive treatment of type 2 diabetes, impaired fasting glucose concentration, and normoglycemia: Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), Arch Intern Med, 165, 1401, 10.1001/archinte.165.12.1401 Bangalore, 2016, Diabetes mellitus as a compelling indication for use of renin angiotensin system blockers: systematic review and meta-analysis of randomized trials, BMJ, 352 Ruilope, 2011, RAS blockade for every diabetic patient: pro and con, Diabetes Care, 34, S320, 10.2337/dc11-s248 Elrggal, 2016, Renin-angiotensin-aldosterone system blockade in diabetic kidney disease: a critical and contrarian point of view, Saudi J Kidney Dis Transpl, 27, 1103, 10.4103/1319-2442.194583 Berl, 2015, Vasopressin antagonists, N Engl J Med, 372, 2207, 10.1056/NEJMra1403672 Cornelissen, 2013, Exercise training for blood pressure: a systematic review and meta-analysis, J Am Heart Assoc, 2, 10.1161/JAHA.112.004473