The role of MAPK signaling pathway in formation of EMT in oral squamous carcinoma cells induced by TNF-α

Springer Science and Business Media LLC - Tập 46 - Trang 3149-3156 - 2019
Xiao-Wei Zhao1, Jing-Ping Zhou1, Yu-Lan Bi1, Jia-Ying Wang1, Rui Yu1, Chao Deng1, Wei-Kang Wang1, Xian-Zhen Li1, Rui Huang1, Jili Zhang1, De-Tao Tao2
1Oral Diseases Research Centre, Department of Oral Medicine, College of Oral Medicine, Wannan Medical College, Wuhu, People’s Republic of China
2Department of Stomatology, Yijishan Hospital of Wannan Medical College, Wuhu, People’s Republic of China

Tóm tắt

To study the role of MAPK signaling pathway in the development of Epithelial-mesenchymal transition in oral squamous cell carcinoma induced by inflammatory factor TNF-α. After the action of TNF-α, the expression of JNK, ERK, P38 in MAPK signaling pathway increased and the expression of E-cadherin, Claudin1 decreased significantly compared to the normal control group. After the addition of corresponding inhibitor, the expression of JNK, ERK, P38 decreased and the expression of E-cadherin, Claudin1 increased compared with TNF-α group. TNF-α regulated the role of EMT in promoting the invasion and metastasis of oral squamous carcinoma cells through MAPK signaling pathway.

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