The role of B cells and autoantibodies in rheumatoid arthritis
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De Vita, 2002, Efficacy of selective B cell blockade in the treatment of rheumatoid arthritis: evidence for a pathogenetic role of B cells, Arthritis Rheum., 46, 2029, 10.1002/art.10467
Edwards, 2004, Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis, N. Engl. J. Med., 350, 2572, 10.1056/NEJMoa032534
C.A.J. Janeway, P. Travers, M. Walport, M.J. Shlomchik (Eds.), The development and survival of lymphocytes, Immunobiology, Garland Publishing, New York, 2001, pp. 221–293.
Muramatsu, 2000, Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme, Cell, 102, 553, 10.1016/S0092-8674(00)00078-7
Revy, 2000, Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2), Cell, 102, 565, 10.1016/S0092-8674(00)00079-9
Guzman-Rojas, 2002, Life and death within germinal centres: a double-edged sword, Immunology, 107, 167, 10.1046/j.1365-2567.2002.01494.x
Zhang, 2003, Contribution of Vh gene replacement to the primary B cell repertoire, Immunity, 19, 21, 10.1016/S1074-7613(03)00170-5
Zhang, 2001, Expression of recombination-activating genes and terminal deoxynucleotidyl transferase and secondary rearrangement of immunoglobulin kappa light chains in rheumatoid arthritis synovial tissue, Arthritis Rheum., 44, 2275, 10.1002/1529-0131(200110)44:10<2275::AID-ART390>3.0.CO;2-K
Wardemann, 2003, Predominant autoantibody production by early human B cell precursors, Science, 301, 1374, 10.1126/science.1086907
Nemazee, 1989, Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes, Nature, 337, 562, 10.1038/337562a0
Tiegs, 1993, Receptor editing in self-reactive bone marrow B cells, J. Exp. Med., 177, 1009, 10.1084/jem.177.4.1009
Gay, 1993, Receptor editing: an approach by autoreactive B cells to escape tolerance, J. Exp. Med., 177, 999, 10.1084/jem.177.4.999
Zemlin, 2002, Regulation and chance in the ontogeny of B and T cell antigen receptor repertoires, Immunol. Res., 26, 265, 10.1385/IR:26:1-3:265
Rahman, 2002, Systematic analysis of sequences of anti-DNA antibodies—relevance to theories of origin and pathogenicity, Lupus, 11, 807, 10.1191/0961203302lu302rr
Zvaifler, 1974, Rheumatoid synovitis. An extravascular immune complex disease, Arthritis Rheum., 17, 297, 10.1002/art.1780170315
Jasin, 1985, Autoantibody specificities of immune complexes sequestered in articular cartilage of patients with rheumatoid arthritis and osteoarthritis, Arthritis Rheum., 28, 241, 10.1002/art.1780280302
Halla, 1978, Immune complex detection and complement activity in rheumatoid arthritis: a comparative study of a radioimmunoassay using monoclonal rheumatoid factor, gel diffusion techniques and C4 activity, Clin. Exp. Immunol., 34, 226
Zvaifler, 1973, Immunopathology of joint inflammation in rheumatoid arthritis, Adv. Immunol., 16, 265, 10.1016/S0065-2776(08)60299-0
Kouskoff, 1996, Organ-specific disease provoked by systemic autoimmunity, Cell, 87, 811, 10.1016/S0092-8674(00)81989-3
2001, Basic concepts in immunology, 1
Matsumoto, 1999, Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme, Science, 286, 1732, 10.1126/science.286.5445.1732
Ditzel, 2004, The K/BxN mouse: a model of human inflammatory arthritis, Trends Mol. Med., 10, 40, 10.1016/j.molmed.2003.11.004
Dorner, 2003, The role of B cells in rheumatoid arthritis: mechanisms and therapeutic targets, Curr. Opin. Rheumatol., 15, 246, 10.1097/00002281-200305000-00011
Ji, 2002, Arthritis critically dependent on innate immune system players, Immunity, 16, 157, 10.1016/S1074-7613(02)00275-3
Bridges, 2004, Update on autoantibodies in rheumatoid arthritis, Curr. Rheumatol. Rep., 6, 343, 10.1007/s11926-004-0008-1
Leadbetter, 2002, Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors, Nature, 416, 603, 10.1038/416603a
Arend, 2001, The innate immune system in rheumatoid arthritis, Arthritis Rheum., 44, 2224, 10.1002/1529-0131(200110)44:10<2224::AID-ART384>3.0.CO;2-H
Shlomchik, 2001, From T to B and back again: positive feedback in systemic autoimmune disease, Nat. Rev. Immunol., 1, 147, 10.1038/35100573
Lanzavecchia, 1985, Antigen-specific interaction between T and B cells, Nature, 314, 537, 10.1038/314537a0
Chan, 1999, A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus, J. Exp. Med., 189, 1639, 10.1084/jem.189.10.1639
Ziff, 1974, Relation of cellular infiltration of rheumatoid synovial membrane to its immune response, Arthritis Rheum., 17, 313, 10.1002/art.1780170317
Iguchi, 1986, Electron microscopic study of rheumatoid synovial vasculature. Intimate relationship between tall endothelium and lymphoid aggregation, J. Clin. Invest., 77, 355, 10.1172/JCI112312
van Dinther-Janssen, 1990, Dendritic cells and high endothelial venules in the rheumatoid synovial membrane, J. Rheumatol., 17, 11
Randen, 1995, The identification of germinal centres and follicular dendritic networks in rheumatoid synovial tissue, Scand. J. Immunol., 41, 481, 10.1111/j.1365-3083.1995.tb03596.x
Steere, 1988, Spirochetal antigens and lymphoid cell surface markers in Lyme synovitis. Comparison with rheumatoid synovium and tonsillar lymphoid tissue, Arthritis Rheum., 31, 487, 10.1002/art.1780310405
Schröder, 1997, Antigen-dependent B cell differentiation in the synovial tissue of a patient with reactive arthritis, Mol. Med., 3, 260, 10.1007/BF03401679
Kumon, 1992, In situ characterization of mononuclear cell phenotype in intrahepatic lymphoid follicles in patients with chronic viral hepatitis, Gastroenterol. Japonica, 27, 638, 10.1007/BF02774979
Freni, 1995, Focal lymphocytic aggregates in chronic hepatitis C: occurrence, immunohistochemical characterization, and relation to markers of autoimmunity, Hepatology, 22, 389, 10.1002/hep.1840220203
Mosnier, 1993, The intraportal lymphoid nodule and its environment in chronic active hepatitis C: an immunohistochemical study, Hepatology, 17, 366, 10.1002/hep.1840170304
Armengol, 2001, Thyroid autoimmune disease: demonstration of thyroid antigen-specific B cells and recombination-activating gene expression in chemokine-containing active intrathyroidal germinal centers, Am. J. Pathol., 159, 861, 10.1016/S0002-9440(10)61762-2
Lee, 1994, Evidence of antigen receptor-influenced oligoclonal B lymphocyte expansion in the synovium of a patient with longstanding rheumatoid arthritis, J. Clin. Invest., 93, 361, 10.1172/JCI116968
Bridges, 1995, Analysis of immunoglobulin gamma heavy chains from rheumatoid arthritis synovium: evidence of antigen-driven selection, Ann. N.Y. Acad. Sci., 764, 450, 10.1111/j.1749-6632.1995.tb55862.x
Clausen, 1998, Clonally-related immunoglobulin VH domains and non-random use of DH gene segments in rheumatoid arthritis synovium, Mol. Med., 4, 240, 10.1007/BF03401921
Schröder, 1996, Differentiation of B cells in the non-lymphoid tissue of the synovial membrane of patients with rheumatoid arthritis, Proc. Natl. Acad. Sci. U.S.A., 93, 221, 10.1073/pnas.93.1.221
Itoh, 2000, Immunoglobulin heavy chain variable region gene replacement as a mechanism for receptor revision in rheumatoid arthritis synovial tissue B lymphocytes, J. Exp. Med., 192, 1151, 10.1084/jem.192.8.1151
Zhang, 1999, Expression of RAG and TdT and evidence of receptor revision in synovial B lymphocytes in rheumatoid arthritis, Scand. J. Immunol., 50, 101
Bridges, 1995, Somatic mutation and CDR3 lengths of immunoglobulin k light chains expressed in patients with rheumatoid arthritis and normal individuals, J. Clin. Invest., 96, 831, 10.1172/JCI118129
Bridges, 1998, Frequent N addition and clonal relatedness among immunoglobulin lambda light chains expressed in rheumatoid arthritis synovia and PBL, and the influence of Vlambda gene segment utilization on CDR3 length, Mol. Med., 4, 525, 10.1007/BF03401757
Wagner, 1998, The role of CD8+ CD40L+ T cells in the formation of germinal centers in rheumatoid synovitis, J. Immunol., 161, 6390, 10.4049/jimmunol.161.11.6390
Weyand, 2001, Ectopic lymphoid organogenesis: a fast track for autoimmunity, Am. J. Pathol., 159, 787, 10.1016/S0002-9440(10)61751-8
Reparon-Schuijt, 1998, Functional analysis of rheumatoid factor-producing B cells from the synovial fluid of rheumatoid arthritis patients, Arthritis Rheum., 41, 2211, 10.1002/1529-0131(199812)41:12<2211::AID-ART17>3.0.CO;2-O
Ruth, 2001, Selective lymphocyte chemokine receptor expression in the rheumatoid joint, Arthritis Rheum., 44, 2750, 10.1002/1529-0131(200112)44:12<2750::AID-ART462>3.0.CO;2-C
Weyand, 2003, Ectopic germinal center formation in rheumatoid synovitis, Ann. N.Y. Acad. Sci., 987, 140, 10.1111/j.1749-6632.2003.tb06042.x
Ansel, 2002, CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity, Immunity, 16, 67, 10.1016/S1074-7613(01)00257-6
Alimzhanov, 1997, Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice, Proc. Natl. Acad. Sci. U.S.A., 94, 9302, 10.1073/pnas.94.17.9302
Silverman, 2003, Roles of B cells in rheumatoid arthritis, Arthritis Res. Ther., 5, S1, 10.1186/ar1010
Duddy, 2004, Distinct profiles of human B cell effector cytokines: a role in immune regulation?, J. Immunol., 172, 3422, 10.4049/jimmunol.172.6.3422
Takemura, 2001, T cell activation in rheumatoid synovium is B cell dependent, J. Immunol., 167, 4710, 10.4049/jimmunol.167.8.4710
Ruddell, 2003, B lymphocyte-specific c-Myc expression stimulates early and functional expansion of the vasculature and lymphatics during lymphomagenesis, Am. J. Pathol., 163, 2233, 10.1016/S0002-9440(10)63581-X
Pap, 2004, Cooperation of Ras- and c-Myc-dependent pathways in regulating the growth and invasiveness of synovial fibroblasts in rheumatoid arthritis, Arthritis Rheum., 50, 2794, 10.1002/art.20461
Lard, 2001, Early versus delayed treatment in patients with recent-onset rheumatoid arthritis: comparison of two cohorts who received different treatment strategies, Am. J. Med., 111, 446, 10.1016/S0002-9343(01)00872-5
Moreland, 2001, Early rheumatoid arthritis: a medical emergency?, Am. J. Med., 111, 498, 10.1016/S0002-9343(01)00973-1
van Boekel, 2002, Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value, Arthritis Res., 4, 87, 10.1186/ar395
Waaler, 1940, On the occurrence of a factor in human serum activating the specific agglutination of sheep blood corpuscles, Acta Pathol. Microbiol. Scand., 17, 172, 10.1111/j.1699-0463.1940.tb01475.x
Shmerling, 1991, The rheumatoid factor: an analysis of clinical utility, Am. J. Med., 91, 528, 10.1016/0002-9343(91)90190-9
Swedler, 1997, Routine measurement of IgM, IgG, and IgA rheumatoid factors: high sensitivity, specificity, and predictive value for rheumatoid arthritis, J. Rheumatol., 4, 1037
Davidson, 2003, Autoimmunity in rheumatoid arthritis, 197
MacGregor, 2000, Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins, Arthritis Rheum., 43, 30, 10.1002/1529-0131(200001)43:1<30::AID-ANR5>3.0.CO;2-B
Jawaheer, 1994, Homozygosity” for the HLA-DR shared epitope contributes the highest risk for rheumatoid arthritis concordance in identical twins, Arthritis Rheum., 37, 681, 10.1002/art.1780370511
Alarcón, 1982, Seronegative rheumatoid arthritis. A distinct immunogenetic disease?, Arthritis Rheum., 25, 502, 10.1002/art.1780250503
Garred, 1998, CC chemokine receptor 5 polymorphism in rheumatoid arthritis, J. Rheumatol., 25, 1462
Lard, 2003, Association of the −2849 interleukin-10 promoter polymorphism with autoantibody production and joint destruction in rheumatoid arthritis, Arthritis Rheum., 48, 1841, 10.1002/art.11160
Heliovaara, 2000, Coffee consumption, rheumatoid factor, and the risk of rheumatoid arthritis, Ann. Rheum. Dis., 59, 631, 10.1136/ard.59.8.631
Saag, 1997, Cigarette smoking and rheumatoid arthritis severity, Ann. Rheum. Dis., 56, 463, 10.1136/ard.56.8.463
Jonsson, 1998, Does smoking stimulate rheumatoid factor production in non-rheumatic individuals?, APMIS, 106, 970, 10.1111/j.1699-0463.1998.tb00247.x
Bridges, 2005, Rheumatoid factor, 1227
Rantapää-Dahlqvist, 2003, Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis, Arthritis Rheum., 48, 2741, 10.1002/art.11223
Jonsson, 1998, Combined elevation of IgM and IgA rheumatoid factor has high diagnostic specificity for rheumatoid arthritis, Rheumatol. Int., 18, 119, 10.1007/s002960050069
Nienhuis, 1964, A new serum factor in patients with rheumatoid arthritis: the antiperinuclear factor, Ann. Rheum. Dis., 23, 302, 10.1136/ard.23.4.302
Young, 1979, Anti-keratin antibodies in rheumatoid arthritis, Br. Med. J., 2, 97, 10.1136/bmj.2.6182.97
Sebbag, 1995, The antiperinuclear factor and the so-called antikeratin antibodies are the same rheumatoid arthritis-specific autoantibodies, J. Clin. Invest., 95, 2672, 10.1172/JCI117969
Hoet, 1991, Antiperinuclear factor, a marker autoantibody for rheumatoid arthritis: colocalisation of the perinuclear factor and profilaggrin, Ann. Rheum. Dis., 50, 611, 10.1136/ard.50.9.611
Schellekens, 1998, Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies, J. Clin. Invest., 101, 273, 10.1172/JCI1316
Girbal-Neuhauser, 1999, The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are post-translationally generated on various sites of (pro)filaggrin by deimination of arginine residues, J. Immunol., 162, 585, 10.4049/jimmunol.162.1.585
Vossenaar, 2004, Rheumatoid arthritis specific anti-Sa antibodies target citrullinated vimentin, Arthritis Res. Ther., 6, R142, 10.1186/ar1149
Schellekens, 2000, The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide, Arthritis Rheum., 43, 155, 10.1002/1529-0131(200001)43:1<155::AID-ANR20>3.0.CO;2-3
Reparon-Schuijt, 2001, Secretion of anti-citrulline-containing peptide antibody by B lymphocytes in rheumatoid arthritis, Arthritis Rheum., 44, 41, 10.1002/1529-0131(200101)44:1<41::AID-ANR6>3.0.CO;2-0
Baeten, 2001, Specific presence of intracellular citrullinated proteins in rheumatoid arthritis synovium: relevance to antifilaggrin autoantibodies, Arthritis Rheum., 44, 2255, 10.1002/1529-0131(200110)44:10<2255::AID-ART388>3.0.CO;2-#
Vossenaar, 2004, The presence of citrullinated proteins is not specific for rheumatoid synovial tissue, Arthritis Rheum., 50, 3485, 10.1002/art.20584
Vossenaar, 2004, Citrullinated proteins: sparks that may ignite the fire in rheumatoid arthritis, Arthritis Res. Ther., 6, 107, 10.1186/ar1184
Chang, 2005, Localization of peptidylarginine deiminase 4 (PADI4) and citrullinated protein in synovial tissue of rheumatoid arthritis, Rheumatology (Oxford), 44, 40, 10.1093/rheumatology/keh414
Vossenaar, 2004, Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophages, Ann. Rheum. Dis., 63, 373, 10.1136/ard.2003.012211
Asaga, 2001, Protein deimination in the rat brain after kainate administration: citrulline-containing proteins as a novel marker of neurodegeneration, Neurosci. Lett., 299, 5, 10.1016/S0304-3940(00)01735-3
Asaga, 1998, Selective deimination of vimentin in calcium ionophore-induced apoptosis of mouse peritoneal macrophages, Biochem. Biophys. Res. Commun., 243, 641, 10.1006/bbrc.1998.8148
Suzuki, 2003, Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis, Nat. Genet., 34, 395, 10.1038/ng1206
Barton, 2004, A functional haplotype of the PADI4 gene associated with rheumatoid arthritis in a Japanese population is not associated in a United Kingdom population, Arthritis Rheum., 50, 1117, 10.1002/art.20169
Vallbracht, 2004, Diagnostic and clinical value of anti-cyclic citrullinated peptide antibodies compared with rheumatoid factor isotypes in rheumatoid arthritis, Ann. Rheum. Dis., 63, 1079, 10.1136/ard.2003.019877
Lee, 2003, Clinical utility of the anti-CCP assay in patients with rheumatic diseases, Ann. Rheum. Dis., 62, 870, 10.1136/ard.62.9.870
Pawlotsky, 1994, Immunological disorders in C virus chronic active hepatitis: a prospective case–control study, Hepatology, 19, 841, 10.1002/hep.1840190407
Bombardieri, 2004, Role of anti-cyclic citrullinated peptide antibodies in discriminating patients with rheumatoid arthritis from patients with chronic hepatitis C infection-associated polyarticular involvement, Arthritis Res. Ther., 6, R137, 10.1186/ar1041
Wener, 2004, Absence of antibodies to cyclic citrullinated peptide in sera of patients with hepatitis C virus infection and cryoglobulinemia, Arthritis Rheum., 50, 2305, 10.1002/art.20355
Berglin, 2004, A combination of autoantibodies to cyclic citrullinated peptide (CCP) and HLA-DRB1 locus antigens is strongly associated with future onset of rheumatoid arthritis, Arthritis Res. Ther., 6, R303, 10.1186/ar1187
van Gaalen, 2004, Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: a prospective cohort study, Arthritis Rheum., 50, 709, 10.1002/art.20044
Visser, 2002, How to diagnose rheumatoid arthritis early: a prediction model for persistent (erosive) arthritis, Arthritis Rheum., 46, 357, 10.1002/art.10117
Meyer, 2003, Anticitrullinated protein/peptide antibody assays in early rheumatoid arthritis for predicting five year radiographic damage, Ann. Rheum. Dis., 62, 120, 10.1136/ard.62.2.120
Forslind, 2004, Prediction of radiological outcome in early rheumatoid arthritis in clinical practice: role of antibodies to citrullinated peptides (anti-CCP), Ann. Rheum. Dis., 63, 1090, 10.1136/ard.2003.014233
Ronnelid, 1994, Local anti-type II collagen antibody production in rheumatoid arthritis synovial fluid: evidence for an HLA-DR4-restricted IgG response, Arthritis Rheum., 37, 123, 10.1002/art.1780370707
Johansen, 1993, A new biochemical marker for joint injury. Analysis of YKL-40 in serum and synovial fluid, Br. J. Rheumatol., 32, 949, 10.1093/rheumatology/32.11.949
Schaller, 2001, Autoantibodies to GPI in rheumatoid arthritis: linkage between an animal model and human disease, Nat. Immunol., 2, 746, 10.1038/90696
Jouen, 2004, Diagnostic and prognostic values of anti glucose-6-phosphate isomerase antibodies in community-recruited patients with very early arthritis, Clin. Exp. Immunol., 137, 606, 10.1111/j.1365-2249.2004.02552.x
Matsumoto, 2003, Low prevalence of antibodies to glucose-6-phosphate isomerase in patients with rheumatoid arthritis and a spectrum of other chronic autoimmune disorders, Arthritis Rheum., 48, 944, 10.1002/art.10898
van Gaalen, 2004, Association of autoantibodies to glucose-6-phosphate isomerase with extraarticular complications in rheumatoid arthritis, Arthritis Rheum., 50, 395, 10.1002/art.20028
Schubert, 2002, Autoantibodies to GPI and creatine kinase in RA, Nat. Immunol., 3, 411, 10.1038/ni0502-411a
Saulot, 2002, Presence of autoantibodies to the glycolytic enzyme alpha-enolase in sera from patients with early rheumatoid arthritis, Arthritis Rheum., 46, 1196, 10.1002/art.10252
Pratesi, 2000, Autoantibodies specific for alpha-enolase in systemic autoimmune disorders, J. Rheumatol., 27, 109
Hassfeld, 1989, Demonstration of a new antinuclear antibody (anti-RA33) that is highly specific for rheumatoid arthritis, Arthritis Rheum., 32, 1515, 10.1002/anr.1780321204
Hassfeld, 1993, Autoantibody to the nuclear antigen RA33: a marker for early rheumatoid arthritis, Br. J. Rheumatol., 32, 199, 10.1093/rheumatology/32.3.199
Yamamoto, 1992, Calcium-dependent cysteine proteinase (calpain) in human arthritic synovial joints, Arthritis Rheum., 35, 1309, 10.1002/art.1780351111
Despres, 1995, Detection and expression of a cDNA clone that encodes a polypeptide containing two inhibitory domains of human calpastatin and its recognition by rheumatoid arthritis sera, J. Clin. Invest., 95, 1891, 10.1172/JCI117870
Lackner, 1998, Autoantibodies against human calpastatin in rheumatoid arthritis: epitope mapping and analysis of patient sera, Br. J. Rheumatol., 37, 1164, 10.1093/rheumatology/37.11.1164
Martin, 2004, Pathogenic roles of B cells in human autoimmunity: insights from the clinic, Immunity, 20, 517, 10.1016/S1074-7613(04)00112-8
Leandro, 2002, Clinical outcome in 22 patients with rheumatoid arthritis treated with B lymphocyte depletion, Ann. Rheum. Dis., 61, 883, 10.1136/ard.61.10.883
Tsokos, 2004, B cells, be gone—B-cell depletion in the treatment of rheumatoid arthritis, N. Engl. J. Med., 350, 2546, 10.1056/NEJMp048114
Bridges, 2004, Genetic markers of treatment response in rheumatoid arthritis, Arthritis Rheum., 50, 1019, 10.1002/art.20152
Oligino, 2003, Targeting B cells for the treatment of rheumatoid arthritis, Arthritis Res. Ther., 5, S7, 10.1186/ar1006
Lonberg, 1995, Human antibodies from transgenic mice, Int. Rev. Immunol., 13, 65, 10.3109/08830189509061738
Carter, 2004, Signaling by the CD19/CD21 complex on B cells, Curr. Dir. Autoimmun., 7, 4, 10.1159/000075685
Loffler, 2000, A recombinant bispecific single-chain antibody, CD19×CD3, induces rapid and high lymphoma-directed cytotoxicity by unstimulated T lymphocytes, Blood, 95, 2098, 10.1182/blood.V95.6.2098
Loffler, 2003, Efficient elimination of chronic lymphocytic leukaemia B cells by autologous T cells with a bispecific anti-CD19/anti-CD3 single-chain antibody construct, Leukemia, 17, 900, 10.1038/sj.leu.2402890
Carter, 2004, B cell signalling as therapeutic target, Ann. Rheum. Dis., 63, ii65, 10.1136/ard.2004.028282
Satterthwaite, 2000, The role of Bruton's tyrosine kinase in B-cell development and function: a genetic perspective, Immunol. Rev., 175, 120, 10.1111/j.1600-065X.2000.imr017504.x
Mackay, 1999, Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations, J. Exp. Med., 190, 1697, 10.1084/jem.190.11.1697
Cheema, 2001, Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases, Arthritis Rheum., 44, 1313, 10.1002/1529-0131(200106)44:6<1313::AID-ART223>3.0.CO;2-S
Legler, 1998, B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5, J. Exp. Med., 187, 655, 10.1084/jem.187.4.655
Ansel, 2000, A chemokine-driven positive feedback loop organizes lymphoid follicles, Nature, 406, 309, 10.1038/35018581
Takemura, 2001, Lymphoid neogenesis in rheumatoid synovitis, J. Immunol., 167, 1072, 10.4049/jimmunol.167.2.1072
Ligier, 1998, A new antibody in rheumatoid arthritis targeting glycated IgG: IgM anti-IgG-AGE, Br. J. Rheumatol., 37, 1307, 10.1093/rheumatology/37.12.1307
Newkirk, 2003, Advanced glycation end-product (AGE)-damaged IgG and IgM autoantibodies to IgG-AGE in patients with early synovitis, Arthritis Res. Ther., 5, R82, 10.1186/ar622
Bas, 2003, Anti-cyclic citrullinated peptide antibodies. IgM and IgA rheumatoid factors in the diagnosis and prognosis of rheumatoid arthritis, Rheumatology (Oxford), 42, 677, 10.1093/rheumatology/keg184
Dubucquoi, 2004, Evaluation of anti-citrullinated filaggrin antibodies as hallmarks for the diagnosis of rheumatic diseases, Ann. Rheum. Dis., 63, 415, 10.1136/ard.2003.008623
Saraux, 2003, Value of antibodies to citrulline-containing peptides for diagnosing early rheumatoid arthritis, J. Rheumatol., 30, 2535
Simon, 1993, The cytokeratin filament-aggregating protein filaggrin is the target of the so-called “antikeratin antibodies”, autoantibodies specific for rheumatoid arthritis, J. Clin. Invest., 92, 1387, 10.1172/JCI116713
Despres, 1994, The Sa system: a novel antigen-antibody system specific for rheumatoid arthritis, J. Rheumatol., 21, 1027
Vossenaar, 2003, PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease, Bioessays, 25, 1106, 10.1002/bies.10357
Union, 2002, Identification of citrullinated rheumatoid arthritis-specific epitopes in natural filaggrin relevant for antifilaggrin autoantibody detection by line immunoassay, Arthritis Rheum., 46, 1185, 10.1002/art.10229
Cook, 1996, Antibodies to type II collagen in early rheumatoid arthritis. Correlation with disease progression, Arthritis Rheum., 39, 1720, 10.1002/art.1780391015
Verheijden, 1997, Human cartilage glycoprotein-39 as a candidate autoantigen in rheumatoid arthritis, Arthritis Rheum., 40, 1115, 10.1002/art.1780400616
Guerassimov, 1998, Cellular immunity to the G1 domain of cartilage proteoglycan aggrecan is enhanced in patients with rheumatoid arthritis but only after removal of keratan sulfate, Arthritis Rheum., 41, 1019, 10.1002/1529-0131(199806)41:6<1019::AID-ART8>3.0.CO;2-X
Korganow, 1999, From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins, Immunity, 10, 451, 10.1016/S1074-7613(00)80045-X
van Gaalen, 2004, Association of autoantibodies to glucose-6-phosphate isomerase with extraarticular complications in rheumatoid arthritis, Arthritis Rheum., 50, 395, 10.1002/art.20028
Steiner, 1992, Purification and partial sequencing of the nuclear autoantigen RA33 shows that it is indistinguishable from the A2 protein of the heterogeneous nuclear ribonucleoprotein complex, J. Clin. Invest., 90, 1061, 10.1172/JCI115921
Blass, 1995, Novel 68kDa autoantigen detected by rheumatoid arthritis specific antibodies, Ann. Rheum. Dis., 54, 355, 10.1136/ard.54.5.355
Atta, 1995, Investigation of the prevalence and clinical associations of antibodies to human fibronectin in systemic lupus erythematosus, Ann. Rheum. Dis., 54, 117, 10.1136/ard.54.2.117
Shrivastav, 2002, Autoantibodies against cytoskeletal proteins in rheumatoid arthritis, Clin. Rheumatol., 21, 505, 10.1007/s100670200124
Tanaka, 2003, Novel autoantibodies to pituitary gland specific factor 1a in patients with rheumatoid arthritis, Rheumatology (Oxford), 42, 353, 10.1093/rheumatology/keg088
Uesugi, 1998, Prevalence and characterization of novel pANCA, antibodies to the high mobility group non-histone chromosomal proteins HMG1 and HMG2, in systemic rheumatic diseases, J. Rheumatol., 25, 703
Mulder, 1993, Antineutrophil cytoplasmic antibodies in rheumatoid arthritis. Characterization and clinical correlations, Arthritis Rheum., 36, 1054, 10.1002/art.1780360805
Vittecoq, 2000, Prospective evaluation of the frequency and clinical significance of antineutrophil cytoplasmic and anticardiolipin antibodies in community cases of patients with rheumatoid arthritis, Rheumatology (Oxford), 39, 481, 10.1093/rheumatology/39.5.481