The role of AGEs in aging: causation or correlation

Asif, 2000, An advanced glycation endproduct cross-link breaker can reverse age-related increases in myocardial stiffness, Proc. Natl Acad. Sci., USA, 97, 2809, 10.1073/pnas.040558497

Baynes, 2000, From life to death — the struggle between chemistry and biology during aging: the Maillard reaction as an amplifier of genomic damage, Biogerontology, 1, 235, 10.1023/A:1010034213093

Baynes, 1999, Glycation and advanced glycation reactions, 337

Baynes, 1999, The role of oxidative stress in diabetic complications: a new perspective on an old paradigm, Diabetes, 48, 1, 10.2337/diabetes.48.1.1

Baynes, 2000, Glycoxidation and lipoxidation in atherogenesis, Free Radical Biol. Med., 28, 1708, 10.1016/S0891-5849(00)00228-8

Corman, 1998, Aminoguanidine prevents age-related arterial stiffening and cardiac hypertrophy, Proc. Natl Acad. Sci., USA, 95, 1301, 10.1073/pnas.95.3.1301

Garner, 2000, Non-oxidative modification of lens crystallins by kynurenine: a novel post-translational protein modification with possible relevance to ageing and cataract, Biochim. Biophys. Acta, 1476, 265, 10.1016/S0167-4838(99)00234-4

Hamada, 1996, Rapid formation of advanced glycation end products by intermediate metabolites of glycolytic pathway and polyol pathway, Biochem. Biophys. Res. Commun., 228, 539, 10.1006/bbrc.1996.1695

Horie, 1997, Immunohistochemical localization of advanced glycation end products, pentosidine and carboxymethyllysine, in lipofuscin pigments of Alzheimer's disease and aged neurons, Biochem. Biophys. Res. Commun., 236, 327, 10.1006/bbrc.1997.6944

Kislinger, 1999, Nε-(carboxymethyl)lysine (CML) adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expression, J. Biol. Chem., 274, 31740, 10.1074/jbc.274.44.31740

Lee, 1998, Oxidation–reduction properties of methylglyoxal-modified protein in relation to free radical generation, J. Biol. Chem., 273, 25272, 10.1074/jbc.273.39.25272

Li, 1996, Prevention of cardiovascular and renal pathology of aging by the advanced glycation inhibitor aminoguanidine, Proc. Natl Acad. Sci., USA, 93, 3902, 10.1073/pnas.93.9.3902

Miyata, 1997, Advanced glycation end products enhance osteoclast-induced bond resorption in cultured mouse unfractionated bone cells and in rats implanted subcutaneously with devitalized bone particles, J. Am. Soc. Nephrol., 8, 260, 10.1681/ASN.V82260

Miyata, 1998, Generation of protein carbonyls by glycoxidation and lipoxidation reactions with autoxidation products of ascorbic acid and polyunsaturated fatty acids, FEBS Lett., 437, 24, 10.1016/S0014-5793(98)01079-5

Miyata, 2000, Mechanism of the inhibitory effect of OPB-9195 ((+/−)-2-isopropylidenehydrazono-4-oxo-thiazolidin-5-yla cetanilide] on advanced glycation end product and advanced lipoxidation end product formation, J. Am. Soc. Nephrol., 11, 1719, 10.1681/ASN.V1191719

Mohamed, 1999, The role of oxidative stress and NF-κB activation in late diabetic complications, Biofactors, 10, 157, 10.1002/biof.5520100211

Munch, 1998, Advanced glycation end products in neurodegeneration: more than early markers of oxidative stress, Ann. Neurol., 44, S85, 10.1002/ana.410440713

Murtiashaw, 1983, Albumin catabolism in diabetic rats, Arch. Biochem. Biophys., 225, 256, 10.1016/0003-9861(83)90028-0

Nilsson, 1999, Biological effects of aminoguanidine: an update, Inflamm. Res., 48, 509, 10.1007/s000110050495

Ohgami, 2000, CD36, a member of class B scavenger receptor family, as a receptor for advanced glycation end products (AGE), J. Biol. Chem.

Onorato, 2000, Pyridoxamine, an inhibitor of advanced glycation reactions, also inhibits advanced lipoxidation reactions,also inhibits advanced lipooxidation reactions. Mechanism of action of pyridoxamine, J. Biol. Chem., 275, 21177, 10.1074/jbc.M003263200

Oturai, 2000, Effects of advanced glycation end-product inhibition and cross-link breakage in diabetic rats, Metabolism, 49, 996, 10.1053/meta.2000.7731

Oudes, 1998, Age-dependent accumulation of advanced glycation end-products in adult Drosophila melanogaster, Mech. Ageing Dev., 100, 221, 10.1016/S0047-6374(97)00146-2

Qian, 1998, Transition metals bind to glycated proteins forming redox active glycochelates: implications for the pathogenesis of certain diabetic complications, Biochem. Biophys. Res. Commun., 250, 385, 10.1006/bbrc.1998.9326

Raffoul, 1999, Caloric restriction and genomic stability, J. Nutr. Health Aging, 3, 102

Reckelhoff, 1999, Chronic aminoguanidine attenuates renal dysfunction and injury in aging rats, Am. J. Hypertens, 12, 492, 10.1016/S0895-7061(98)00264-7

Sano, 1999, Receptors for proteins modified by advanced glycation endproducts (AGE) — their functional role in atherosclerosis, Mech. Ageing Dev., 107, 333, 10.1016/S0047-6374(99)00011-1

Sasaki, 1998, Advanced glycation end products in Alzheimer's disease and other neurodegenerative diseases, Am. J. Pathol., 153, 1149, 10.1016/S0002-9440(10)65659-3

Saxena, 1999, Protein aging by carboxymethylation of lysines generates sites for divalent metal and redox active copper binding: relevance to diseases of glycoxidative stress, Biochem. Biophys. Res. Commun., 260, 332, 10.1006/bbrc.1999.0898

Schmidt, 2000, The biology of the receptor for advanced glycation end products and its ligands, Biochim. Biophys. Acta, 1498, 99, 10.1016/S0167-4889(00)00087-2

Sell, 1996, Longevity and the genetic determination of collagen glycoxidation kinetics in mammalian senescence, Proc. Natl Acad. Sci., USA, 93, 485, 10.1073/pnas.93.1.485

Sell, 2000, Longitudinal determination of skin collagen glycation and glycoxidation rates predicts early death in C57BL/6NNIA mice, FASEB J., 14, 145, 10.1096/fasebj.14.1.145

Shinohara, 1998, Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis, J. Clin. Invest., 101, 1142, 10.1172/JCI119885

Smith, 1997, Iron accumulation in Alzheimer disease is a source of redox-generated free radicals, Proc. Natl Acad. Sci., USA, 94, 9866, 10.1073/pnas.94.18.9866

Stadtman, 1998, Protein modification in aging, J. Gerontol., 43, B112, 10.1093/geronj/43.5.B112

Thornalley, 1998, Cell activation by glycated proteins.AGE receptors, receptor recognition factors and functional classification of AGEs, Cell. Mol. Biol., 44, 1013

Verzijl, 2000, Effect of collagen turnover on the accumulation of advanced glycation end products, J. Biol. Chem., 275, 39027, 10.1074/jbc.M006700200

Wautier, 2001, Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE, Am. J. Physiol. Endocrinol. Metab., 280, E685, 10.1152/ajpendo.2001.280.5.E685

Zhu, 2001, The role of galectin-3 in endocytosis of advanced glycation end products and modified low density lipoproteins, Biochem. Biophys. Res. Commun., 280, 1183, 10.1006/bbrc.2001.4256