The relationship of IL-4- and IFNγ-producing T cells studied by lineage ablation of IL-4-producing cells

Cell - Tập 75 Số 5 - Trang 985-995 - 1993
Yumiko Kamogawa1, Lori-ann E. Minasi1, Simon R. Carding2, Kim Bottomly3,1, R A Flavell3,1
1Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
2Department of Microbiology University of Pennsylvania School of Medicine Philadelphia, Pennsylvania 19106 USA
3Howard Hughes Medical Institute University of Pennsylvania School of Medicine Philadelphia, Pennsylvania 19106 USA

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Abehsira-Amar, 1992, IL-4 play a dominant role in the differential development of Th0 into Th1 and Th2 cells, J. Immunol., 148, 3820

Bendelac, 1992, Activation events during thymic selection, J. Exp. Med., 175, 731, 10.1084/jem.175.3.731

Betz, 1990, Regulation and development of cytochrome c-specific IL-4 producing T cells, J. Immunol., 145, 1046

Boom, 1988, Heterogeneity of helper/inducer T lymphocytes II: effects of interleukin 4- and interleukin 2-producing T cell clones on resting B lymphocytes, J. Exp. Med., 168, 1350, 10.1084/jem.167.4.1350

Borreli, 1988, Targeting of an inducible toxic phenotype in animal cells, 85, 1

Bottomly, 1989, Subsets of CD4 T cells and B cell activation, Sem. Immunol., 1, 21

Bottomly, 1989, A monoclonal antibody to murine CD45R distinguishes CD4 T cell populations that produce different cytokines, Eur. J. Immunol., 19, 617, 10.1002/eji.1830190407

Carding, 1989, Differential activation of cytokine gene in normal CD4-bearing T cells is stimulus dependent, Eur. J. Immunol., 19, 231, 10.1002/eji.1830190203

Cher, 1987, Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by Th1 clones, J. Immunol., 138, 3688

Cherwinski, 1987, Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies, J. Exp. Med., 166, 1229, 10.1084/jem.166.5.1229

Ehlers, 1991, Differentiation of T cell lymphokine gene expression: the in vitro acquisition of T cell memory, J. Exp. Med., 173, 25, 10.1084/jem.173.1.25

Finkelman, 1986, Suppression of in vivo polyclonal immunoglobulin E responses by monoclonal antibody to the lymphokine B-cell stimulatory factor 1, J. Immunol., 83, 9675

Firestein, 1989, A new murine CD4+ T cell subset with an unrestricted cytokine profile, J. Immunol., 143, 518

Heinzel, 1993, Recombinant interleukin 12 cures mice infected with Leishmania major, J. Exp. Med., 177, 1505, 10.1084/jem.177.5.1505

Henkel, 1992, A DNase I-hypersensitive site in the second intron of the murine IL-4 gene defines a mast cell-specific enhancer, J. Immunol., 149, 3239

Hsieh, 1993, Development of Th1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages, Science, 260, 547, 10.1126/science.8097338

Jones, 1983, Evidence that the Thy-1 molecule is the target for T cell mitogenic antibody against brain-associated antigens, Eur. J. Immunol., 13, 678, 10.1002/eji.1830130813

Killar, 1987, Cloned la-restricted T cells that do not produce interleukin 4 (IL-4)/B cell stimulatory factor 1 (BSF-1) fail to help antigen-specific B cells, J. Immunol., 138, 1674

Kim, 1985, Distinct functional phenotypes of clonal la-restricted helper T cells, J. Exp. Med., 162, 188, 10.1084/jem.162.1.188

Kopf, 1993, Disruption of the murine IL-4 gene blocks Th2 cytokine response, Nature, 362, 245, 10.1038/362245a0

Kühn, 1991, Generation and analysis of interleukin-4 deficient mice, Science, 254, 707, 10.1126/science.1948049

Landais, 1986, The assignment of chain specificities for anti-la monoclonal antibodies using L cell transfectants, J. Immunol., 137, 3002

Lee, 1986, Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities, 83, 2061

Le Gros, 1990, Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro; IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells, J. Exp. Med., 172, 921, 10.1084/jem.172.3.921

Maggi, 1992, Reciprocal regulatory effects of IFN-γ and IL-4 on the in vitro development of human Th1 and Th2 clones, J. Immunol., 148, 2142, 10.4049/jimmunol.148.7.2142

Manetti, 1993, Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th1 cells, J. Exp. Med., 177, 1199, 10.1084/jem.177.4.1199

Minasi, 1993, The selective ablation of interleukin-2-producing cells isolated from transgenic mice, J. Exp. Med., 177, 1451, 10.1084/jem.177.5.1451

Mosmann, 1989, Th1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties, Annu. Rev. Immunol., 7, 145, 10.1146/annurev.iy.07.040189.001045

Mosmann, 1986, Two types of murine helper T cell clone I: definition according to profiles of lymphokine activities and secreted proteins, J. Immunol., 136, 2348, 10.4049/jimmunol.136.7.2348

Murray, 1989, MHC control of CD4+ T cell subset activation, J. Exp. Med., 170, 2135, 10.1084/jem.170.6.2135

Noma, 1986, Cloning of cDNA encoding the murine immunoglobulin G1 induction factor by a novel strategy using SP6 promoter, Nature, 319, 640, 10.1038/319640a0

Ohara, 1985, Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1, Nature, 315, 333, 10.1038/315333a0

Otsuka, 1987, Structural analysis of the mouse chromosomal gene encoding interleukin 4 which expresses in the T cell and mast cell stimulating activities, Nucl. Acids Res., 15, 333, 10.1093/nar/15.1.333

Platzer, 1992, Analysis of cytokine mRNA levels in interleukin-4 transgenic mice by quantitative polymerase chain reaction, Eur. J. Immunol., 22, 1179, 10.1002/eji.1830220511

Powers, 1988, Frequencies of IL-2 and IL-4-secreting T cells in naive and antigen-stimulated lymphocyte populations, J. Immunol., 140, 3352, 10.4049/jimmunol.140.10.3352

Seder, 1992, The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice, J. Exp. Med., 176, 1091, 10.1084/jem.176.4.1091

Sideras, 1988, Analysis by in situ hybridization of cells expressing mRNA for interleukin 4 in the developing thymus and peripheral lymphocytes from mice, 85, 218

Stevens, 1988, Subsets of antigen-specific helper T cells regulate isotype secretion by antigen-specific B cells, Nature, 334, 255, 10.1038/334255a0

Stout, 1989, Antigen specific activation of effector macrophages by IFN-γ producing (Th1) T cell clones: failure of IL-4-producing (Th2) cell clones to activate effector function in macrophages, J. Immunol., 142, 760, 10.4049/jimmunol.142.3.760

Street, 1990, Heterogeneity of mouse helper T cells: evidence from bulk cultures and limiting dilution cloning for precursors of Th1 and Th2 cells, J. Immunol., 144, 1629, 10.4049/jimmunol.144.5.1629

Summers, 1977, [125I] deoxycytidine used in a rapid, sensitive, and specific assay for herpes simplex virus type 1 thymidine kinase, J. Virol., 24, 314, 10.1128/jvi.24.1.314-318.1977

Swain, 1988, Characterization of T helper 1 and 2 cell subsets in normal mice: helper T cells responsible for IL4 and IL5 production are present as precursors that require priming before they develop into lymphokine-secreting cells, J. Immunol., 141, 3445, 10.4049/jimmunol.141.10.3445

Swain, 1990, IL-4 directs the development of Th2-like helper effectors, J. Immunol., 145, 3796, 10.4049/jimmunol.145.11.3796

Swain, 1991, Transforming growth factor-β and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype, J. Immunol., 147, 2991

Sypek, 1993, Resolution of cutaneous Leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response, J. Exp. Med., 177, 1797, 10.1084/jem.177.6.1797

Tite, 1985, Protein-antigen specific la-restricted cytolytic T cells: analysis of frequency, target cell susceptibility, and mechanism of cytolysis, J. Immunol., 135, 25

Todd, 1993, Transcription of the interleukin 4 gene is regulated by multiple promoter elements, J. Exp. Med., 177, 1663, 10.1084/jem.177.6.1663

Wagner, 1981, Nucleotide sequence of the thymidine kinase gene of herpes simplex virus type 1, 78, 1441