The relationship between carbohydrate intake and glucose tolerance in pregnant women

Acta Obstetricia et Gynecologica Scandinavica - Tập 82 Số 12 - Trang 1080-1085 - 2003
Motoi Takizawa1, Takashi Kaneko2, Keiko Kohno1, Yukihito Fukada1, Kazuhiko Hoshi1
1From the Departments of Obstetrics and Gynecology and
2Environmental Health, Yamanashi Medical University, Yamanashi, Japan

Tóm tắt

Objective.  We verified whether a misdiagnosis of gestational diabetes mellitus can result in pregnant women when glucose tolerance has deteriorated after a low‐carbohydrate meal, and tried to elucidate the mechanism behind the different outcome of the test.

Study design.  Twenty‐seven pregnant women were given directions for their evening meal the day before each of two 75‐g oral glucose tolerance tests (OGTT). The evening meal was either a low‐carbohydrate meal (carbohydrate, 6.7%; Low), or a high‐carbohydrate meal (carbohydrate, 85.7%; High).

Results.  The OGTT showed that the glucose tolerance was significantly impaired after Low than after High, with a significant increase of fasting plasma non‐esterified fatty acids (NEFA) level. Moreover, the insulinogenic index (I‐I) after High significantly decreased than that after Low.

Conclusions.  The present data suggests that there is a risk of misdiagnosis of impaired glucose tolerance with only one intake of this extremely low‐carbohydrate meal on the evening before testing. The decrease of insulin secretion and the activation of glucose‐fatty acid cycle may be considered as the mechanism.

Từ khóa


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Thông tin
Thông tin xuất bản

Acta Obstetricia et Gynecologica Scandinavica

Tập 82 Số 12

1080-1085

Thông tin tác giả