The regenerative potential of Pax3/Pax7 on skeletal muscle injury
Tóm tắt
Skeletal muscle mishaps are the most well-known incidents in society, especially among athletes and the military population. From the various urgency, this accident needs to be cured more quickly. However, the current treatment still has some shortcomings and is less effective. In this case, Paired box 3 and Paired box 7 (Pax3/Pax7) proteins that induce stem cells could potentially be an alternative treatment for skeletal muscle injuries. This paper aimed to analyse the potential treatment of Pax3/Pax7 proteins inducing the stem cell for skeletal muscle injuries. We did a narrative review by gathering several scientific journals from several leading platforms like PubMed and Scopus. As common accidents, skeletal muscle disease could be due to workplace and non-workplace causes. The highest risk occurs in the athlete and military environment. The treatment of current skeletal muscle injuries is protection, rest, ice, compression, and elevation (PRICE), non-steroidal anti-inflammatory drugs (NSAIDs), and mechanical stimulation. However, it is considered less effective, especially in NSAIDs, inhibiting myogenic cell proliferation. The current finding indicates that the stem cells have markers known as Pax3/Pax7. The role of both markers in muscle injury, Pax3/Pax7, as transcription factors will induce cell division by H3K4 methylation mechanisms and chromatin modifications that stimulate gene activation. Regulation by Pax3/Pax7 factors that affect stem cells and stem cell proliferation is one of the alternative treatments. This regulation can accelerate the healing of injury victims, especially injuries to the skeletal muscles. Finally, after being compared, Pax3/Pax7 induces stem cells to have the potential to be one of the skeletal muscle injury treatments. Pax3 and Pax7, Pax3/Pax7, Skeletal muscle, Athlete, Stem cells, Cell proliferation, Injuries.
Tài liệu tham khảo
Laumonier T, Menetrey J (2016) Muscle injuries and strategies for improving their repair. J Exp Orthop 3(1):1–9. https://doi.org/10.1186/s40634-016-0051-7 (Springer Berlin Heidelberg)
Trovato FM, Imbesi R, Conway N, Castrogiovanni P (2016) Morphological and functional aspects of human skeletal muscle. J Funct Morphol. 1(3):289–302. https://doi.org/10.3390/JFMK1030289 (Multidisciplinary Digital Publishing Institute)
Dave HD, Shook M, Varacallo M (2020) Anatomy. StatPearls, StatPearls Publishing, Skeletal Muscle
Gates C, Huard J (2005) Management of skeletal muscle injuries in military personnel. Operative Techniques in Sports Medicine 13:247–256. https://doi.org/10.1053/j.otsm.2006.01.012
Owens BD, Cameron KL (2016) Musculoskeletal injuries in the military. Springer, New York. https://doi.org/10.1007/978-1-4939-2984-9
Andersen KA, Grimshaw PN, Kelso RM, Bentley DJ (2016) Musculoskeletal lower limb injury risk in army populations. Sports Med Open 2:22. https://doi.org/10.1186/s40798-016-0046-z
Baoge L, Van Den Steen E, Rimbaut S, Philips N, Witvrouw E, Almqvist KF (2012) Treatment of skeletal muscle injury: a review. ISRN ISRN Orthop 2012:1–7. https://doi.org/10.5402/2012/689012
Roy TC, Knapik JJ, Ritland BM, Murphy N, Sharp MA (2012) Risk factors for musculoskeletal injuries for soldiers deployed to Afghanistan. Aviat Space Environ Med 83:1060–1066. https://doi.org/10.3357/ASEM.3341.2012
Giacomo F, Francesco F, Alessandra Z, Francesco M, Alessia M, Francesco PB et al (2021) Musculoskeletal pain in gymnasts: a retrospective analysis on a cohort of professional athletes. Int J Environ Res Public Health 18:5460. https://doi.org/10.3390/IJERPH18105460
Laumonier T, Menetrey J (2016) Muscle injuries and strategies for improving their repair. J Exp Orthop 3(1):9. https://doi.org/10.1186/S40634-016-0051-7 (SpringerOpen)
Qazi TH, Duda GN, Ort MJ, Perka C, Geissler S, Winkler T (2019) Cell therapy to improve regeneration of skeletal muscle injuries. J Cachexia Sarcopenia Muscle 10:501–516. https://doi.org/10.1002/JCSM.12416
Garg K, Corona BT, Walters TJ (2015) Therapeutic strategies for preventing skeletal muscle fibrosis after injury. Front Pharmacol 6:87. https://doi.org/10.3389/FPHAR.2015.00087
Fernandes TL, Pedrinelli A, Hernandez AJ (2011) Muscle injury – physiopathology, diagnosis, treatment and clinical presentation. Rev Bras Ortop 46:247–255. https://doi.org/10.1016/s2255-4971(15)30190-7
Järvinen TAH, Järvinen TLN, Kääriäinen M, Kalimo H, Järvinen M (2005) Muscle injuries: biology and treatment. Am J Sports Med 33:745–764. https://doi.org/10.1177/0363546505274714
Cezar CA, Roche ET, Vandenburgh HH, Duda GN, Walsh J, Mooney DJ (2016) Biologic-free mechanically induced muscle regeneration. Proc Natl Acad Sci U S A 113(6):1534–9. https://doi.org/10.1073/pnas.1517517113
Kolios G, Moodley Y (2012) Introduction to stem cells and regenerative medicine. Respiration. 85(1):3–10. https://doi.org/10.1159/000345615
Mckinnell IW, Ishibashi J, Le Grand F, Punch VGJ, Addicks GC, Greenblatt JF (2008) Pax7 activates myogenic genes by recruitment of a histone methyltransferase complex. Nat Cell Biol 10:77–84. https://doi.org/10.1038/ncb1671
Gusetu G, Pop D, Pop-Mindru D, Zdrenghea D (2015) Exercise NT-pro-BNP and global longitudinal strain in systemic lupus erythematosus patients. Eur J Prev Cardiol 22:S135. https://doi.org/10.5281/zenodo.1069104.Funding
Molloy JM, Pendergrass TL, Lee IE, Chervak MC, Hauret KG, Rhon DI (2020) Musculoskeletal injuries and United States army readiness part I: overview of injuries and their strategic impact. Mil Med 185:E1461–E1471. https://doi.org/10.1093/milmed/usaa027
Barbe MF, Barr AE (2006) Inflammation and the pathophysiology of work-related musculoskeletal disorders. Brain Behav Immun 20(5):423–429. https://doi.org/10.1016/j.bbi.2006.03.001
Lentscher AJ, McCarthy MK, May NA, Davenport BJ, Montgomery SA, Raghunathan K (2020) Chikungunya virus replication in skeletal muscle cells is required for disease development. J Clin Invest 130:1466–1478. https://doi.org/10.1172/JCI129893
Gavino-Leopoldino D, Figueiredo CM, da Silva MOL, Barcellos LG, Neris RLS, Pinto LDM (2021) Skeletal muscle is an early site of Zika Virus replication and injury, which impairs myogenesis. J Virol 95(22):e0090421. https://doi.org/10.1128/JVI.00904-21
De Giorgio MR, Di Noia S, Morciano C, Conte D (2020) The impact of SARS-CoV-2 on skeletal muscles. Acta Myol. 39(4):307. https://doi.org/10.36185/2532-1900-034
Seixas MLGA, Mitre LP, Shams S, Lanzuolo GB, Bartolomeo CS, Silva EA (2022) Unraveling Muscle Impairment Associated With COVID-19 and the Role of 3D Culture in Its Investigation. Front Nutr. 9:115. https://doi.org/10.3389/FNUT.2022.825629/BIBTEX
Sciorati C, Rigamonti E, Manfredi AA, Rovere-Querini P (2016) Cell death, clearance and immunity in the skeletal muscle. Cell Death Differ 23:927–937. https://doi.org/10.1038/cdd.2015.171
Zúñiga-Pereira AM, Santamaría C, Gutierrez JM, Alape-Girón A, Flores-Díaz M (2019) Deficient skeletal muscle regeneration after injury induced by a clostridium perfringens strain associated with gas gangrene. Infect Immun. 87(8):e00200-19. https://doi.org/10.1128/IAI.00200-19
Jaćević V, Nepovimova E, Kuča K (2019) Toxic injury to muscle tissue of rats following acute oximes exposure. Sci Rep 9:1–13. https://doi.org/10.1038/s41598-018-37837-4
Sauers SE, Smith LB, Scofield DE, Cooper A, Warr BJ (2016) Self-management of unreported musculoskeletal injuries in a U.S Army brigade. Mil Med 181:1075–1080. https://doi.org/10.7205/MILMED-D-15-00233
Judson RN, Rossi FMV (2020) Towards stem cell therapies for skeletal muscle repair. Npj Regen Med 5:1–6. https://doi.org/10.1038/s41536-020-0094-3
Rangarajan S, Madden L, Bursac N (2014) Use of flow, electrical, and mechanical stimulation to promote engineering of striated muscles. Ann Biomed Eng 47(7):1391–405. https://doi.org/10.1007/s10439-013-0966-4
Soltow QA, Zeanah EH, Lira VA, Criswell DS (2013) Cessation of cyclic stretch induces atrophy of C2C12 myotubes. Biochem Biophys Res Commun 434:316–321. https://doi.org/10.1016/J.BBRC.2013.03.048
Niklason LE, Gao J, Abbott WM, Hirschi KK, Houser S, Marini R (1999) Functional Arteries Grown in Vitro. Science 284:489–493. https://doi.org/10.1126/SCIENCE.284.5413.489
Dahl SLM, Kypson AP, Lawson JH, Blum JL, Strader JT, Li Y (2011) Readily available tissue-engineered vascular grafts. Sci Transl Med 3(68):68ra9. https://doi.org/10.1126/SCITRANSLMED.3001426
Todros S, Spadoni S, Maghin E, Piccoli M, Pavan PG (2021) A Novel Bioreactor for the Mechanical Stimulation of Clinically Relevant Scaffolds for Muscle Tissue Engineering Purposes. Processes 2021, Vol 9, Page 474, Multidisciplinary Digital Publishing Institute. 9, 474. https://doi.org/10.3390/PR9030474
Maclean S, Khan WS, Malik AA, Anand S, Snow M (2012) The potential of stem cells in the treatment of skeletal muscle injury and disease. Stem Cells Int 2012:282348. https://doi.org/10.1155/2012/282348
Segalés J, Perdiguero E, Muñoz-Cánoves P (2015) Epigenetic control of adult skeletal muscle stem cell functions. FEBS J 282:1571–1588. https://doi.org/10.1111/febs.13065
Yin H, Price F, Rudnicki MA (2013) Satellite cells and the muscle stem cell niche. Physiol Rev 93:23–67. https://doi.org/10.1152/physrev.00043.2011
Schmidt M, Schüler SC, Hüttner SS, Von Eyss B, Von Maltzahn J (2019) Adult stem cells at work: regenerating skeletal muscle. Cell Mol Life Sci 76(13):2559–2570. https://doi.org/10.1007/s00018-019-03093-6
Gorecka A, Salemi S, Haralampieva D, Moalli F, Stroka D, Candinas D (2018) Autologous transplantation of adipose-derived stem cells improves functional recovery of skeletal muscle without direct participation in new myofiber formation. Stem Cell Res Ther 9:1–12. https://doi.org/10.1186/S13287-018-0922-1
Qazi TH, Duda GN, Ort MJ, Perka C, Geissler S, Winkler T (2019) Cell therapy to improve regeneration of skeletal muscle injuries. J Cachexia Sarcopenia Muscle 10:501–516. https://doi.org/10.1002/jcsm.12416
Relaix F, Montarras D, Zaffran S, Gayraud-Morel B, Rocancourt D, Tajbakhsh S (2006) Pax3 and Pax7 have distinct and overlapping functions in adult muscle progenitor cells. J Cell Biol 172:91–102. https://doi.org/10.1083/jcb.200508044
Buckingham M, Relaix F (2015) PAX3 and PAX7 as upstream regulators of myogenesis. Semin Cell Dev Biol 44:115–125. https://doi.org/10.1016/j.semcdb.2015.09.017
Wang M, Song W, Jin C, Huang K, Yu Q, Qi J (2021) Pax3 and Pax7 exhibit distinct and overlapping functions in marking muscle satellite cells and muscle repair in a marine teleost, sebastes schlegelii. Int J Mol Sci. 22(7):3769. https://doi.org/10.3390/IJMS22073769
Sato T, Higashioka K, Sakurai H, Yamamoto T, Goshima N, Ueno M (2019) Core transcription factors promote induction of PAX3-positive skeletal muscle stem cells. Stem Cell Reports 13:352–365. https://doi.org/10.1016/J.STEMCR.2019.06.006
Buckingham M (2007) Skeletal muscle progenitor cells and the role of Pax genes. C R Biol 330:530–533. https://doi.org/10.1016/J.CRVI.2007.03.015
Wilkinson HN, Hardman MJ (2020) Wound healing: cellular mechanisms and pathological outcomes. Open Biology, The Royal Society. 10. https://doi.org/10.1098/RSOB.200223
Collins CA, Gnocchi VF, White RB, Boldrin L, Perez-Ruiz A, Relaix F (2009) Integrated functions of Pax3 and Pax7 in the regulation of proliferation, cell size and myogenic differentiation. PLoS ONE 4:e4475. https://doi.org/10.1371/journal.pone.0004475
Soleimani VD, Punch VG, Kawabe YI, Jones AE, Palidwor GA, Porter CJ (2012) Transcriptional dominance of Pax7 in adult myogenesis is due to high-affinity recognition of homeodomain motifs. Dev Cell 22:1208–1220. https://doi.org/10.1016/j.devcel.2012.03.014
Diao Y, Guo X, Li Y, Sun K, Lu L, Jiang L (2012) Pax3/7BP is a Pax7- and Pax3-binding protein that regulates the proliferation of muscle precursor cells by an epigenetic mechanism. Cell Stem Cell 11:231–241. https://doi.org/10.1016/j.stem.2012.05.022
Pircher T, Wackerhage H, Aszodi A, Kammerlander C, Böcker W, Saller MM (2021) Hypoxic signaling in skeletal muscle maintenance and regeneration: a systematic review. Front Physiol. 12:912. https://doi.org/10.3389/FPHYS.2021.684899/BIBTEX
Zhang Z, Zhang L, Zhou Y, Li L, Zhao J, Qin W (2019) Increase in HDAC9 suppresses myoblast differentiation via epigenetic regulation of autophagy in hypoxia. cell death & disease 2019 10:8. Nat Publ Group 10:1–15. https://doi.org/10.1038/s41419-019-1763-2
Elashry MI, Kinde M, Klymiuk MC, Eldaey A, Wenisch S, Arnhold S (2022) The effect of hypoxia on myogenic differentiation and multipotency of the skeletal muscle-derived stem cells in mice. Stem Cell Res Ther 13:1–17. https://doi.org/10.1186/S13287-022-02730-5/FIGURES/5
Lilja KC, Zhang N, Magli A, Gunduz V, Bowman CJ, Arpke RW (2017) Pax7 remodels the chromatin landscape in skeletal muscle stem cells. PLoS One. 12(4):e0176190. https://doi.org/10.1371/journal.pone.0176190
Florkowska A, Meszka I, Zawada M, Legutko D, Legutko D, Proszynski TJ (2020) Pax7 as molecular switch regulating early and advanced stages of myogenic mouse ESC differentiation in teratomas. Stem Cell Res Ther 11:1–18. https://doi.org/10.1186/s13287-020-01742-3
Zalc A, Rattenbach R, Auradé F, Cadot B, Relaix F (2015) Pax3 and Pax7 play essential safeguard functions against environmental stress-induced birth defects. Dev Cell 33(1):56–66. https://doi.org/10.1016/j.devcel.2015.02.006
Kuang S, Chargé SB, Seale P, Huh M, Rudnicki MA (2006) Distinct roles for Pax7 and Pax3 in adult regenerative myogenesis. J Cell Biol 172:103–113. https://doi.org/10.1083/jcb.200508001
Crist CG, Montarras D, Pallafacchina G, Rocancourt D, Cumano A, Conway SJ (2009) Muscle stem cell behavior is modified by microRNA-27 regulation of Pax3 expression. Proc Natl Acad Sci U S A. 106(32):13383–7. https://doi.org/10.1073/pnas.0900210106
Kassar-Duchossoy L, Giacone E, Gayraud-Morel B, Jory A, Gomès D, Tajbakhsh S (2005) Pax3/Pax7 mark a novel population of primitive myogenic cells during development. Genes Dev 19:1426–1431. https://doi.org/10.1101/GAD.345505