The proteostatic network chaperome is downregulated in F508del homozygote cystic fibrosis

Journal of Cystic Fibrosis - Tập 20 - Trang 356-363 - 2021
Marc A. Sala1, Michael Alexander1, Basil Khuder1, Yuliya Politanska1, Hiam Abdala-Valencia1, G.R. Scott Budinger1, Jing Liu2, Manu Jain1, Paul A. Reyfman1
1Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
2Department of Surgery, College of Medicine, Cancer Center, University of Illinois at Chicago, Chicago, IL 60612, USA

Tài liệu tham khảo

Montoro, 2018, A revised airway epithelial hierarchy includes CFTR-expressing ionocytes, Nature, 560, 319, 10.1038/s41586-018-0393-7 Plasschaert, 2018, A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte, Nature, 560, 377, 10.1038/s41586-018-0394-6 Welsh, 1993, Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis, Cell, 73, 1251, 10.1016/0092-8674(93)90353-R Espel, 2018, The relationship between sweat chloride levels and mortality in cystic fibrosis varies by individual genotype, J Cyst Fibros, 17, 34, 10.1016/j.jcf.2017.11.002 Collaco, 2010, Quantification of the relative contribution of environmental and genetic factors to variation in cystic fibrosis lung function, J Pediatr, 157, 802, 10.1016/j.jpeds.2010.05.018 Drumm, 2005, Genetic modifiers of lung disease in cystic fibrosis, N Engl J Med, 353, 1443, 10.1056/NEJMoa051469 2017 Balchin, 2016, In vivo aspects of protein folding and quality control, Science, 353, aac4354, 10.1126/science.aac4354 Kerbiriou, 2007, Coupling cystic fibrosis to endoplasmic reticulum stress: differential role of Grp78 and ATF6, Biochim Biophys Acta, 1772, 1236, 10.1016/j.bbadis.2007.10.004 Bartoszewski, 2008, Activation of the unfolded protein response by deltaF508 CFTR, Am J Respir Cell Mol Biol, 39, 448, 10.1165/rcmb.2008-0065OC Bartoszewski, 2008, The mechanism of cystic fibrosis transmembrane conductance regulator transcriptional repression during the unfolded protein response, J Biol Chem, 283, 12154, 10.1074/jbc.M707610200 Zhang, 2010, Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium, Physiol Genomics, 41, 1, 10.1152/physiolgenomics.00167.2009 Gower, 2011, Transcriptomic studies of the airway field of injury associated with smoking-related lung disease, Proc Am Thorac Soc, 8, 173, 10.1513/pats.201011-066MS Sridhar, 2008, Smoking-induced gene expression changes in the bronchial airway are reflected in nasal and buccal epithelium, BMC Genomics, 9, 259, 10.1186/1471-2164-9-259 Ogilvie, 2011, Differential global gene expression in cystic fibrosis nasal and bronchial epithelium, Genomics, 98, 327, 10.1016/j.ygeno.2011.06.008 van Meegen, 2011, CFTR expression analysis in human nasal epithelial cells by flow cytometry, PLoS ONE, 6, e27658, 10.1371/journal.pone.0027658 van Meegen, 2013, Apical CFTR expression in human nasal epithelium correlates with lung disease in cystic fibrosis, PLoS ONE, 8, e57617, 10.1371/journal.pone.0057617 Polineni, 2018, Airway mucosal host defense is key to genomic regulation of cystic fibrosis lung disease severity, Am J Respir Crit Care Med, 197, 79, 10.1164/rccm.201701-0134OC Wright, 2006, Respiratory epithelial gene expression in patients with mild and severe cystic fibrosis lung disease, Am J Respir Cell Mol Biol, 35, 327, 10.1165/rcmb.2005-0359OC Dobin, 2013, STAR: ultrafast universal RNA-seq aligner, Bioinformatics, 29, 15, 10.1093/bioinformatics/bts635 Anders, 2015, HT-Seq - a Python framework to work with high-throughput sequencing data, Bioinformatics, 31, 166, 10.1093/bioinformatics/btu638 Robinson, 2010, edgeR: a Bioconductor package for differential expression analysis of digital gene expression data, Bioinformatics, 26, 139, 10.1093/bioinformatics/btp616 Ritchie, 2015, limma powers differential expression analyses for RNA-sequencing and microarray studies, Nucleic Acids Res, 43, e47, 10.1093/nar/gkv007 Brehme, 2014, A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease, Cell Rep, 9, 1135, 10.1016/j.celrep.2014.09.042 Plasschaert, 2018, A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte, Nature, 560, 377, 10.1038/s41586-018-0394-6 Scudieri, 2020, Ionocytes and CFTR chloride channel expression in normal and cystic fibrosis nasal and bronchial epithelial cells, Cells, 9, 10.3390/cells9092090 Clarke, 2013, Changes in transcriptome of native nasal epithelium expressing F508del-CFTR and intersecting data from comparable studies, Respir Res, 14, 38, 10.1186/1465-9921-14-38 Polineni, 2017, Airway mucosal host defense is key to genomic regulation of cystic fibrosis lung disease severity, Am J Respir Crit Care Med