The protective effects of dexmedetomidine on ischemic brain injury: A meta-analysis

Del Zoppo, 2010, Acute anti-inflammatory approaches to ischemic stroke, J Ann N Y Acad Sci, 1207, 143, 10.1111/j.1749-6632.2010.05761.x Zihl, 2015, Neuropsychology of neuroendocrine dysregulation after traumatic brain injury, J Clin Med, 4, 1051, 10.3390/jcm4051051 Zaremba, 2004, Cytokines in clinical and experimental ischemia stroke, Neurol Neurochir Pol, 38, 557 Kumar, 2014, Acute CSF interleukin-6 trajectories after tbi: associations with neuroinflammation, polytrauma, and outcome, Brain Behav Immun, 45, 253, 10.1016/j.bbi.2014.12.021 Sriram, 2007, Divergent roles for tumor necrosis factor-alpha in the brain, J NeuroImmune Pharmacol, 2, 140, 10.1007/s11481-007-9070-6 Morganti-Kossmann, 2007, Modulation of immune response by head injury, Injury, 38, 1392, 10.1016/j.injury.2007.10.005 Kennedy, 1998, Neuroendocrine and inflammatory aspects of surgery: do they affect outcome?, Eur J Anaesthesiol, 15, 736, 10.1097/00003643-199811000-00020 Westaby, 2001, Is there a relationship between cognitive dysfunction and systemic inflammatory response after cardiopulmonary bypass?, Ann Thorac Surg, 71, 667, 10.1016/S0003-4975(00)02405-X Goldfarb, 2011, Improving postoperative immune status and resistance to cancer metastasis: a combined perioperative approach of immunostimulation and prevention of excessive surgical stress responses, Ann Surg, 253, 798, 10.1097/SLA.0b013e318211d7b5 Van Munster, 2008, Time-course of cytokines during delirium in elderly patients with hip fractures, J Am Geriatr Soc, 56, 1704, 10.1111/j.1532-5415.2008.01851.x Basali, 2000, Relation between perioperative hypertension and intracranial haemorrhage after craniotomy, Anaesthesiology, 93, 48, 10.1097/00000542-200007000-00012 Baeman, 2009, Perioperative acute ischemic stroke in noncardiac and nonvascular surgery: incidence, risk factors, and outcomes, J Anesthesiol, 110, 231, 10.1097/ALN.0b013e318194b5ff Engelhard, 2002, Effect of the α2-agonist dexmedetomidine on cerebral neurotransmitter concentrations during cerebral ischemia in rats, Anesthesiology, 96, 450, 10.1097/00000542-200202000-00034 Brede, 2011, α2-Adrenoceptors do not mediate neuroprotection in acute ischemic stroke in mice, J Cereb Blood Flow Metab, 31, e1, 10.1038/jcbfm.2011.110 Karlsson, 1995, Dexmedetomidine, a potent alpha 2-agonist, does not affect neuronal damage following severe forebrain ischaemia in the rat, Eur J Anaesthesiol, 12, 281 Benggn, 2012, Effect of dexmedetomidine on brain edema and neurological outcome in surgical brain injury in rats, Anesth Analg, 115, 154, 10.1213/ANE.0b013e31824e2b86 Wang, 2014, Effects of dexmedetomidine on outcomes following craniocerebral operation, a meta-analysis, Clin Neurol Neurosurg, 125, 194 Jadad, 1996, Assessing the quality of reports of randomized clinical trials: is blinding necessary?, Control Clin Trials, 17, 1, 10.1016/0197-2456(95)00134-4 Uyar, 2008, Dexmedetomidine attenuates the hemodynamic and neuroendocrinal responses toskull-pin head-holder application during craniotomy, J Neurosurg Anesthesiol, 20, 174, 10.1097/ANA.0b013e318177e5eb Xia, 2015, Intravenous infusion of dexmedetomidine combined isoflurane inhalation reduces oxidative stress and potentiates hypoxia pulmonary vasoconstriction during one-lung ventilation in patients, Mediat Inflamm, 2015, 238041 Yang, 2014, Effect of dexmedetomidine or midazolam on postoperative S100β and mini-mental state examination under lower limbs surgery in old patients, J Int J Anesth Resus, 35, 317 Gopalakrishna, 2015, Dexmedetomidine as an anesthetic adjuvant in patients undergoing transsphenoidal resection of pituitary tumor, J Neurosurg Anesthesiol, 27, 209, 10.1097/ANA.0000000000000144 Yang, 2013, Effect of dexmedetomidine on plasma brain-derived neurotrophic factor: a double-blind, randomized and placebo-controlled study, Ups J Med Sci, 118, 235, 10.3109/03009734.2013.808295 Wang, 2014, Effects of different maintain doses of dexmedetomidine on plasma cortisol and glucose during anesthesia recovery period in patients undergoing uvulopalatopharyngoplasty under sevoflurane inhalation anesthesia, J Clin Otorhinolaryngol Head Neck Surg, 28, 1154 Tasdogan, 2009, Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis, J Clin Anesth, 21, 394, 10.1016/j.jclinane.2008.10.010 Wei, 2013, Effects ofdexraedetomidine on cerebral oxygen metabolism in elderly patients undergoing general anesthesia, J Chin Anesthesiol, 33, 1177 Chen, 2012, Protective effect of dexmedetomidine on perioperative patients with intracranial spaceoccupying lesion, J Hainan Med Univ, 18, 492 Tanskanen, 2006, Dexmedetomidine as an anaesthetic adjuvant in patients undergoing intracranial tumour surgery: a double-blind, randomized and placebo-controlled study, Br J Anaesth, 97, 658, 10.1093/bja/ael220 El Dawlatlyr, 2006, Effect of small dose intravenous dexmedetomidine and/or local anaesthetic infiltration on haemodynamic responses to skull pin placement, Pan Arab J Neurosurg, 10, 29 Wang, 2015, Effects of dexmedetomidine on patients undergoing radical gastrectomy, J Surg Res, 194, 147, 10.1016/j.jss.2014.10.008 Li, 2016, Dexmedetomidine combined with general anesthesia provides similar intraoperative stress response reduction when compared with a combined general and epidural anesthetic technique, Anesth Analg, 122, 1202, 10.1213/ANE.0000000000001165 Li, 2015, Dexmedetomidine analgesia effects in patients undergoing dental implant surgery and its impact on postoperative inflammatory and oxidative stress, Oxidative Med Cell Longev, 2015, 186736 El-Tahan, 2012, Efficacy of dexmedetomidine in suppressing cardiovascular and hormonalresponses to general anaesthesia for caesarean delivery: a dose-response study, Int J Obstet Anesth, 21, 222, 10.1016/j.ijoa.2012.04.006 Soliman, 2011, Prospective, randomized study to assess the role of dexmedetomidine in patientswith supratentorial tumors undergoing craniotomy under general anaesthesia, Middle East J Anaesthesiol, 21, 325 Bulow, 2016, Dexmedetomidine decreases the inflammatory response to myocardial surgery under mini-cardiopulmonary bypass, Braz J Med Biol Res, 49, 10.1590/1414-431X20154646 Ding, 2015, Effects of dexmedetomidine on recovery period of anesthesia and postoperative cognitive function after robot-assisted laparoscopicradical prostatectomy in the elderly people, J Cent South Univ Med Sci, 40, 129 Luo, 2016, Protective effects of dexmedetomidine on brain function of glioma patients undergoing craniotomy resection and its underlying mechanism, Clin Neurol Neurosurg, 146, 105, 10.1016/j.clineuro.2016.05.004 Bekker, 2013, The effect of intraoperative infusion of dexmedetomidine on the quality of recoveryafter major spinal surgery, J Neurosurg Anesthesiol, 25, 16, 10.1097/ANA.0b013e31826318af Sulemanji, 2007, Dexmedetomidine during coronary artery bypass grafting surgery: is it neuroprotective?-a preliminary study, Acta Anaesthesiol Scand, 51, 1093, 10.1111/j.1399-6576.2007.01377.x Peng, 2014, Dexmedetomidine as an anesthetic adjuvant for intracranial procedures: meta-analysis of randomized controlled trials, J Clin Neurosci, 21, 1951, 10.1016/j.jocn.2014.02.023 Grammas, 2011, Neurovascular dysfunction, inflammation and endothelial activation: implications for the pathogenesis of Alzheimer's disease, J Neuroinflammation, 8, 26, 10.1186/1742-2094-8-26 Kempuraj, 2016, Neuroinflammation induces neurodegeneration, J Neurol Neurosurg Spine, 1, 1003 He, 2016, Transplantation of bone marrow-derived mesenchymal stem cells (bmscs) improves brain ischemia-induced pulmonary injury in rats associated to tnf-α expression, Behav Brain Funct, 12, 1, 10.1186/s12993-016-0093-0 Cai, 2014, Molecular targets and mechanism of action of dexmedetomidine in treatment of ischemia/reperfusion injury, Mol Med Rep, 9, 1542, 10.3892/mmr.2014.2034 Korfias, 2006, Serum S100β protein as a biochemicalmarker of brain injury:a review of current concepts, Curr Med Chem, 13, 3719, 10.2174/092986706779026129 Edwards, 2006, TNF alpha affects the expression of GFAP and S100B: implications for Alzheimer's disease, J Neural Transm, 113, 1709, 10.1007/s00702-006-0479-5 Li, 1994, The influence of plasma glucose concentrations on ischemic brain damage is a threshold function, Neurosci Lett, 177, 63, 10.1016/0304-3940(94)90045-0 Li, 2015, Effect of dexmedetomidine on early postoperative cognitive dysfunction and peri-operative inflammation in elderly patients undergoing laparoscopic cholecystectomy, Exp Ther Med, 10, 1635, 10.3892/etm.2015.2726 Kang, 2012, Effects of dexmedetomidine on inflammatory responses in patients undergoing laparoscopic cholecystectomy, Acta Anaesthesiol Scand, 57, 480, 10.1111/aas.12039 Dong, 2013, Dexmedetomidine protects against ischemia-reperfusion injury in rat skeletal muscle, J Surg Res, 186, 240, 10.1016/j.jss.2013.07.052 Cosar, 2009, The neuroprotective effect of dexmedetomidine in the hippocampus of rabbits after subarachnoid hemorrhage, Surg Neurol, 71, 54, 10.1016/j.surneu.2007.08.020 Eser, 2008, The influence of dexmedetomidine on ischemic rat hippocampus, Brain Res, 1218, 250, 10.1016/j.brainres.2008.04.045