The promise of siRNAs for the treatment of influenza

Trends in Molecular Medicine - Tập 10 - Trang 571-574 - 2004
Jack R. Bennink1, Tara N. Palmore1
1National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Viral Diseases, 4 Center Drive, Bethesda, MD 20892, USA

Tài liệu tham khảo

Patriarca, 1985, Efficacy of influenza vaccine in nursing homes. Reduction in illness and complications during an influenza A (H3N2) epidemic, JAMA, 253, 1136, 10.1001/jama.253.8.1136 Palese, 2002, Influenza vaccines: present and future, J. Clin. Invest., 110, 9, 10.1172/JCI0215999 Webster, 1992, Evolution and ecology of influenza A viruses, Microbiol. Rev., 56, 152, 10.1128/MMBR.56.1.152-179.1992 Skehel, 1992, Amantadine blocks the channel, Nature, 358, 110, 10.1038/358110b0 Wang, 1993, Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block, J. Virol., 67, 5585, 10.1128/JVI.67.9.5585-5594.1993 Palese, 1976, Inhibition of influenza virus replication in tissue culture by 2-deoxy-2,3-dehydro-N-trifluoroacetylneuraminic acid (FANA): mechanism of action, J. Gen. Virol., 33, 159, 10.1099/0022-1317-33-1-159 von Itzstein, 1993, Rational design of potent sialidase-based inhibitors of influenza virus replication, Nature, 363, 418, 10.1038/363418a0 Simonsen, L. et al. (1996) Impact of influenza on mortality in the USA. In: Brown LE, Hampson AW, Webster RG, eds. Options for the control of influenza III: proceedings of the 3rd International Conference on Options for the Control of Influenza, Cairns, Australia, 4-9 May, 1996. Amsterdam, Holland: Elsevier Science, pp 26–33 Lui, 1987, Impact of influenza epidemics on mortality in the United States from October 1972 to May 1985, Am. J. Public Health, 77, 712, 10.2105/AJPH.77.6.712 World Health Organization (2004) Influenza: Report by the WHO Secretariat, World Health Assembly (WHO, Geneva), A56/23 (http://www.who.int) Ge, 2004, Inhibition of influenza virus production in virus-infected mice by RNA interference, Proc. Natl. Acad. Sci. U. S. A., 101, 8676, 10.1073/pnas.0402486101 Tompkins, 2004, Protection against lethal influenza virus challenge by RNA interference in vivo, Proc. Natl. Acad. Sci. U. S. A., 101, 8682, 10.1073/pnas.0402630101 Elbashir, 2001, Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells, Nature, 411, 494, 10.1038/35078107 Pickford, 2003, RNA-mediated gene silencing, Cell. Mol. Life Sci., 60, 871, 10.1007/s00018-003-2245-2 Nishikura, 2001, A short primer on RNAi: RNA-directed RNA polymerase acts as a key catalyst, Cell, 107, 415, 10.1016/S0092-8674(01)00581-5 Liu, 2004, Argonaute2 is the catalytic engine of mammalian RNAi, Science, 305, 1437, 10.1126/science.1102513 Joost Haasnoot, 2003, Inhibition of virus replication by RNA interference, J. Biomed. Sci., 10, 607, 10.1159/000073526 Dave, 2003, RNA interference: on the road to alternate therapeutic strategy!, Rev. Med. Virol., 13, 373, 10.1002/rmv.407 Devroe, 2004, Therapeutic potential of retroviral RNAi vectors, Expert Opin. Biol. Ther., 4, 319, 10.1517/14712598.4.3.319 Dorsett, 2004, siRNAs: Applications in functional genomics and potential as therapeutics, Nat. Rev. Drug Discov., 3, 318, 10.1038/nrd1345 Haitchi, 2004, New strategies in the treatment and prevention of allergic diseases, Expert Opin. Investig. Drugs, 13, 107, 10.1517/13543784.13.2.107 Read, 2003, RNA-based therapeutic strategies for cancer, Expert Opin. Ther. Pat., 13, 627, 10.1517/13543776.13.5.627 Ganju, 2004, Potential applications of siRNA for pain therapy, Expert Opin. Biol. Ther., 4, 531, 10.1517/14712598.4.4.531 Wood, 2003, Therapeutic gene silencing in the nervous system, Hum. Mol. Genet., 12, R279, 10.1093/hmg/ddg275 Gitlin, 2002, Short interfering RNA confers intracellular antiviral immunity in human cells, Nature, 418, 430, 10.1038/nature00873 Boden, 2003, Human immunodeficiency virus type 1 escape from RNA interference, J. Virol., 77, 11531, 10.1128/JVI.77.21.11531-11535.2003 Ge, 2003, RNA interference of influenza virus production by directly targeting rnRNA for degradation and indirectly inhibiting all viral RNA transcription, Proc. Natl. Acad. Sci. U. S. A., 100, 2718, 10.1073/pnas.0437841100 Scacheri, 2004, Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells, Proc. Natl. Acad. Sci. U. S. A., 101, 1892, 10.1073/pnas.0308698100 Snove, 2004, Many commonly used siRNAs risk off-target activity, Biochem. Biophys. Res. Commun., 319, 256, 10.1016/j.bbrc.2004.04.175