The prognostic value of p53, Ki‐67 and matrix metalloproteinases MMP‐2 and MMP‐9 in transitional cell carcinoma of the renal pelvis and ureter

International Journal of Urology - Tập 12 Số 11 - Trang 941-947 - 2005
Shuichi Kamijima1, Toyofusa Tobe1, Takahito Suyama1, Takeshi Ueda1, Tatsuo Igarashi2, Tomohiko Ichikawa1, Haruo Itô1
1Department of Urology, Graduate School of Medicine, Chiba University and
2Section for Medical Robotics and Surgical Device Creation, Research Center for Frontier Medical Engineering, Graduate School of Medicine, Chiba University, Chiba, Japan

Tóm tắt

Aim: To investigate the prognostic and predictive relevance of p53 protein, Ki‐67 antigen, MMP‐2 and MMP‐9 in patients with transitional cell carcinoma (TCC) of the upper urinary tract.Methods: The expression of p53 protein, Ki‐67 antigen, MMP‐2 and MMP‐9 was examined by immunohistochemistry in 69 patients with TCC of the upper urinary tract. Correlation of p53, Ki‐67, MMP‐2 and MMP‐9 over‐expression with conventional pathological parameters and patient survival was examined.Results: p53 over‐expression was significantly correlated with histological grade (P < 0.05), but not with pathological stage, vascular invasion, lymphatic invasion or lymph node metastasis. Ki‐67 over‐expression was significantly correlated with stage, grade, lymphatic invasion and vascular invasion (P < 0.05). In survival analyses, Ki‐67 over‐expression was a significant prognostic factor in the univariate analysis (P < 0.05), but it did not have a significant impact on survival in the multivariate analysis. Ki‐67 labeling index was a significant prognostic factor in patients with a low p53 labeling index, but not in patients with a high p53 labeling index.Conclusion: Ki‐67 over‐expression is of prognostic value in TCC of the upper urinary tract, while p53, MMP‐2 and MMP‐9 are of limited value.

Từ khóa


Tài liệu tham khảo

10.1002/1097-0142(19881101)62:9<2016::AID-CNCR2820620924>3.0.CO;2-G

10.1002/1097-0142(19870401)59:7<1369::AID-CNCR2820590724>3.0.CO;2-A

10.1016/S0022-5347(17)38059-X

10.1002/1097-0142(19901101)66:9<1919::AID-CNCR2820660911>3.0.CO;2-Z

10.1016/S0022-5347(17)40130-3

10.1016/S0090-4295(94)80253-X

10.1046/j.1464-410X.1996.00085.x

10.1093/jnci/85.1.53

10.1002/ijc.2910530304

10.1016/S0022-5347(01)67517-7

10.1046/j.1464-410X.1997.02710.x

10.1016/S0022-5347(01)66855-1

10.1016/S0046-8177(96)90347-0

10.1002/(SICI)1096-9896(199602)178:2<133::AID-PATH455>3.0.CO;2-F

10.1002/(SICI)1097-0142(19970601)79:11<2178::AID-CNCR16>3.0.CO;2-T

10.1038/bjc.1998.127

10.1159/000030239

10.1046/j.1442-2042.2000.00230.x

10.1136/jcp.46.12.1080

10.1016/0168-9525(90)90126-Q

10.1016/0092-8674(91)90642-C

10.1111/j.1349-7006.1997.tb00396.x

Kabashima A, 2000, Clinicopathological features and over‐expression of matrix metalloproteinases in intramural gastric carcinoma with lymph node metastasis, Clin. Cancer Res., 6, 3581

10.1016/S0022-5347(01)66036-1

10.1007/BF00590040

10.1200/JCO.1995.13.6.1384

Fujimoto K, 1992, Frequent association of p53 gene mutation in invasive bladder cancer, Cancer Res., 52, 1393

10.1016/S0022-5347(05)68347-4

Esrig D, 1993, p53 nuclear protein accumulation correlates with mutation in p53 gene, tumor grade, and stage in bladder cancer, Am. J. Pathol., 143, 1389

10.1007/BF02050985

10.1007/s004320050205

10.1046/j.1365-2168.1997.02468.x

10.1002/(SICI)1097-0142(19980401)82:7<1359::AID-CNCR20>3.0.CO;2-4

Bianco FJ, 1998, Matrix metalloproteinase‐9 expression in bladder washes from bladder cancer patients predicts pathological stage and grade, Clin. Cancer Res., 4, 3011

Inoue K, 2002, The prognostic value of angiogenesis and metastasis related genes for progression of transitional cell carcinoma of renal pelvis and ureter, Clin. Cancer Res., 8, 1863

10.1097/00005392-199707000-00072

Yasumitu H, 1992, Comparison of extracellular matrix‐degrading activities between 64‐kDa and 90‐kDa gelatinases purified in inhibitor‐free forms from human schwannoma cells, J. Biochem., 111, 74, 10.1093/oxfordjournals.jbchem.a123721

Thông tin
Thông tin xuất bản

International Journal of Urology

Tập 12 Số 11

941-947

Thông tin tác giả