The prognostic value of adhesion molecule CD44v6 in women with primary breast carcinoma: a clinicopathologic study

The American Cancer Society, 2003, Finding breast cancer early, CA Cancer J Clin, 53, 170, 10.3322/canjclin.53.3.170 Gunthert, 1995, Are CD44 variant isoforms involved in human tumour progression?, Cancer Surv, 24, 19 Rudzki, 1997, CD44 and the adhesion of neoplastic cells, J Clin Mol Pathol, 50, 57, 10.1136/mp.50.2.57 Cox, 2001, A biological staging model for operable non-small cell lung cancer, Thorax, 56, 561, 10.1136/thorax.56.7.561 Pastorino, 1997, Immunocytochemical markers in stage I lung cancer: relevance to prognosis, J Clin Oncol, 15, 2858, 10.1200/JCO.1997.15.8.2858 Herrera-Gayol, 1999, Adhesion proteins in the biology of breast cancer: contribution of CD44, Exp Mol Pathol, 66, 149, 10.1006/exmp.1999.2251 Lester, 1992, Tumour cell adhesion to the extracellular matrix and signal transduction mechanisms implicated in tumor cell motility, invasion and metastasis, Cancer Metastatis Rev, 11, 31, 10.1007/BF00047601 Barbour, 2003, Expression of the CD44v2-10 isoform confers a metastatic phenotype: importance of the heparan sulfate attachment site CD44v3, Cancer Res, 63, 887 Miwa, 1996, Progression in gastric carcinoma relative to the ratio of CD44 epithelial variant transcript to CD44 hematopoietic variant transcript, Cancer, 77, 25, 10.1002/(SICI)1097-0142(19960101)77:1<25::AID-CNCR6>3.0.CO;2-M Xin, 2001, CD44V6 in gastric carcinoma: a marker of tumor progression, Appl Immunohistochem Mol Morphol, 9, 138, 10.1097/00022744-200106000-00006 Shimbori, 2003, Expression of CD44 in primary lung carcinomas using histological and cytological analyses, Anticancer Res, 23, 115 Suzuki, 2002, Reduced expression of CD44 v3 and v6 is related to invasion in lung adenocarcinoma, Lung Cancer, 38, 137, 10.1016/S0169-5002(02)00176-9 Saegusa, 1999, Down-regulation of CD44 standard and variant isoforms during the development and progression of uterine cervical tumors, J Pathol, 187, 173, 10.1002/(SICI)1096-9896(199901)187:2<173::AID-PATH207>3.0.CO;2-4 Ayhan, 2001, Altered CD44 variant 6 expression in FIGO stage IB cervical carcinoma, Gynecol Oncol, 83, 569, 10.1006/gyno.2001.6406 Hoshimoto, 2003, CD44 variant 6 in endometrioid carcinoma of the uterus: its expression in the adenocarcinoma component is an independent prognostic marker, Pathol Res Pract, 199, 71, 10.1078/0344-0338-00357 Hefler, 2002, The prognostic value of immunohistochemically detected CD44v3 and CD44v6 expression in patients with surgically staged vulvar carcinoma: a multicenter study, Cancer, 94, 125, 10.1002/cncr.10206 Kan, 1995, High-level expression of the CD44 variant sharing exon v10 in renal cancer, Jpn J Cancer Res, 86, 847, 10.1111/j.1349-7006.1995.tb03095.x Heider, 1996, Expression of CD44 isoforms in human renal cell carcinomas, Virchows Arch, 428, 267, 10.1007/BF00196700 Ristamaki, 1995, CD44v6 expression in non-Hodgkin's lymphoma: an association with low histological grade and poor prognosis, J Pathol, 176, 259, 10.1002/path.1711760308 Lockhart, 1999, Evaluation of soluble CD44 in patients with breast and colorectal carcinomas and non-Hodgkin's lymphoma, Oncol Rep, 6, 1129 Kaufmann, 1995, CD44 variant exon epitopes in primary breast cancer and length of survival, Lancet, 345, 615, 10.1016/S0140-6736(95)90521-9 Ozer, 1997, The role of angiogenesis, laminin and CD44 expression in metastatic behavior of early-stage low-grade invasive breast carcinomas, Cancer Lett, 121, 119, 10.1016/S0304-3835(97)00346-7 Guriec, 1997, CD44 isoforms with exon v6 and metastasis of primary N0M0 breast carcinomas, Breast Cancer Res Treat, 44, 261, 10.1023/A:1005717519931 Tokue, 1998, CD44 variant isoform expression and breast cancer prognosis, Jpn J Cancer Res, 89, 283, 10.1111/j.1349-7006.1998.tb00560.x Morris, 2001, The prognostic significance of CD44s and CD44v6 expression in stage two breast carcinoma: an immunohistochemical study, Eur J Surg Oncol, 27, 527, 10.1053/ejso.2001.1167 Jansen, 1998, CD44v6 is not a prognostic factor in primary breast cancer, Ann Oncol, 9, 109, 10.1023/A:1008220917687 Friedrichs, 1995, CD44 isoforms correlate with cellular differentiation but not with prognosis in human breast cancer, Cancer Res, 55, 5424 Tempfer, 1996, Prognostic value of immunohistochemically detected CD44 isoforms CD44v5, CD44v6 and CD44v7-8 in human breast cancer, Eur J Cancer, 2A, 2023, 10.1016/0959-8049(96)00185-2 Aceituno, 1998, Expression of CD44 variant v6 in breast carcinoma and its relationship with other parameters of tumor biology, Med Clin (Barc), 111, 168 Hefler, 1998, Cytosol concentrations of CD44 isoforms in breast cancer tissue, Int J Cancer, 79, 541, 10.1002/(SICI)1097-0215(19981023)79:5<541::AID-IJC17>3.0.CO;2-4 American Joint Committee on Cancer, 1997 Amat, 2002, Scarff–Bloom–Richardson (SBR) grading: a pleiotropic marker of chemosensitivity in invasive ductal breast carcinomas treated by neoadjuvant chemotherapy, Int J Oncol, 20, 791 Bankfalvi, 2002, Gains and losses of adhesion molecules (CD44, E-cadherin, and beta-catenin) during oral carcinogenesis and tumour progression, J Pathol, 198, 343, 10.1002/path.1204 Auvinen, 2000, Hyaluronan in peritumoral stroma and malignant cells associates with breast cancer spreading and predicts survival, Am J Pathol, 156, 529, 10.1016/S0002-9440(10)64757-8 Bajorath, 2001, Structure and function of CD44: characteristic molecular features and analysis of the hyaluronan binding site, Results Probl Cell Differ, 33, 85, 10.1007/978-3-540-46410-5_5 Screaton, 1992, Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons, Proc Natl Acad Sci U S A, 89, 12160, 10.1073/pnas.89.24.12160 Jackson, 1992, Multiple variants of the human lymphocyte homing receptor CD44 generated by insertions at a single site in the extracellular domain, J Biol Chem, 267, 4732, 10.1016/S0021-9258(18)42893-1 Sanchez Lockhart, 2001, Splice variant expression of CD44 in patients with breast and ovarian cancer, Oncol Rep, 8, 145 Gunthert, 1991, A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells, Cell, 65, 13, 10.1016/0092-8674(91)90403-L Berner, 2003, Clinicopathological associations of CD44 mRNA and protein expression in primary breast carcinomas, Histopathology, 42, 546, 10.1046/j.1365-2559.2003.01622.x