The prevalence of co‐morbid depression in adults with Type 2 diabetes: a systematic review and meta‐analysis

Diabetic Medicine - Tập 23 Số 11 - Trang 1165-1173 - 2006
Saima Ali1, Margaret Stone2, Jaime Peters2, Melanie J. Davies2, Kamlesh Khunti2
1University of Leicester, Leicester, UK
2University of Leicester & University Hospitals of Leicester, Leicester, UK.

Tóm tắt

AbstractAim  To conduct a systematic literature review in order to estimate the prevalence and odds ratio of clinically relevant depression in adults with Type 2 diabetes compared with those without.Methods  medline, embase and psycinfo databases were searched using MeSH terms and free text to identify relevant controlled studies. Published reference lists were also examined. Study selection and appraisal were conducted independently by two reviewers and a meta‐analysis was performed to synthesize and analyse the data.Results  Ten controlled studies including a total of 51 331 people were published between January 1980 and May 2005. The prevalence of depression was significantly higher in patients with Type 2 diabetes compared with those without [17.6 vs. 9.8%, OR = 1.6, 95%, confidence interval (CI) 1.2–2.0]. However, in most studies, patients with diabetes differed from those without on variables known to be associated with an increased risk of depression. The prevalence of depression was higher in females with diabetes (23.8%) compared with males (12.8%); however, the odds ratio for depression in patients with Type 2 diabetes compared with those without was higher in males (OR = 1.9, 95% CI 1.7–2.1) than females (OR = 1.3, 95% CI 1.2–1.4). Failure to report potential confounders prevented a more rigorous meta‐analysis of risk.Conclusion  We identified raised rates of depression in people with Type 2 diabetes, however, there is a need for well‐controlled and better‐reported studies to inform the development of effective treatments for depression in these patients.

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Tài liệu tham khảo

10.1136/bmj.305.6863.1198

10.1016/0895-4356(90)90014-G

10.1001/archinte.160.21.3278

10.1016/S0163-8343(03)00055-0

Katon W, 1990, Depression and chronic medical illness, J Clin Psychiatry, 51, 12

10.1016/S0006-3223(03)00273-7

10.2337/diacare.23.7.934

10.1016/S0163-8343(98)00039-5

10.1016/S0140-6736(04)16202-8

10.2337/diacare.24.6.1069

10.2337/diacare.25.3.464

10.1016/0022-3999(89)90070-6

10.2105/AJPH.79.11.1554

10.1093/oxfordjournals.aje.a115129

10.1017/S0033291700027409

10.1136/bmj.325.7365.636

10.1093/oxfordjournals.aje.a117248

10.1001/jama.283.15.2008

10.1136/bmj.327.7414.557

10.1136/bmj.320.7249.1574

Sutton AJ, 2000, Methods for Meta‐Analysis in Medical Research, 109

10.2307/2533446

10.1136/bmj.315.7109.629

10.1016/S0033-3182(91)72066-5

10.1080/03610738708259317

10.2337/diacare.13.2.170

10.2337/diacare.22.1.56

10.1001/archinte.160.2.174

10.2337/diacare.26.3.744

10.1007/s00125-003-1124-6

10.5144/0256-4947.2003.254

10.2337/diacare.26.8.2311

10.2337/diacare.24.9.1567

Amato L, 1996, Non‐insulin dependent diabetes mellitus is associated with a greater prevalence of depression in the elderly, Diabetes Metab, 22, 314

10.2337/diacare.19.10.1097

10.1111/j.1464-5491.1991.tb01646.x

10.1111/j.1600-0447.1995.tb09602.x

10.2337/diacare.17.8.891

Mayor S., 2005, Quarter of people with diabetes in England are undiagnosed, Br Med J, 332, 656

10.1136/bmj.321.7252.24

10.1192/bjp.177.6.486

10.1001/jama.1996.03540040037030

10.1002/clc.4960200304

10.1046/j.1365-2354.1998.00100.x

10.1111/j.1600-0447.1993.tb03411.x

Lustman PJ, 1996, Practical Psychology for Diabetic Clinicians, 143

10.1016/S0006-3223(03)00569-9

KnollM TwiskJWR BeekmanAT HeineRJ SnoekFJ PouwerF.Depression as a risk factor for the onset of type 2 diabetes mellitus: a meta‐analysis.Diabetologia2006;49:837–845.

Khan KS, 2001, Undertaking Systematic Reviews of Research on Effectiveness. CRD's Guidance for Those Carrying Out or Commissioning Reviews.

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Diabetic Medicine

Tập 23 Số 11

1165-1173

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