The potential role of leptin in tumor invasion and metastasis
Tài liệu tham khảo
Ray, 2012, Adipokine leptin in obesity-related pathology of breast cancer, J. Biosci., 37, 289, 10.1007/s12038-012-9191-9
McSherry, 2007, Molecular basis of invasion in breast cancer, Cell. Mol. Life Sci., 64, 3201, 10.1007/s00018-007-7388-0
Koontongkaew, 2013, The tumor microenvironment contribution to development, growth, invasion and metastasis of head and neck squamous cell carcinomas, J. Cancer, 4, 66, 10.7150/jca.5112
Hadler-Olsen, 2013, Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets, Tumour Biol., 34, 2041, 10.1007/s13277-013-0842-8
Giordano, 2016, Activated FXR inhibits leptin signaling and counteracts tumor-promoting activities of cancer-associated fibroblasts in breast malignancy, Sci. Rep., 6, 21782, 10.1038/srep21782
Ahn, 2015, Leptin promotes human endometriotic cell migration and invasion by up-regulating MMP-2 through the JAK2/STAT3 signaling pathway, Mol. Hum. Reprod., 21, 792, 10.1093/molehr/gav039
Berg, 2014, Circulating and adipose tissue matrix metalloproteinases in cardiometabolic risk environments: pathophysiological aspects, Horm. Mol. Biol. Clin. Investig., 17, 79
Martínez-Martínez, 2014, The potential role of leptin in the vascular remodeling associated with obesity, Int. J. Obes. (Lond.), 38, 1565, 10.1038/ijo.2014.37
Cui, 2013, Thrombospondin 1 mediates renal dysfunction in a mouse model of high-fat diet-induced obesity, Am. J. Physiol. Renal Physiol., 305, F871, 10.1152/ajprenal.00209.2013
Ray, 2012, Obesity and breast cancer: a clinical biochemistry perspective, Clin. Biochem., 45, 189, 10.1016/j.clinbiochem.2011.11.016
Strong, 2015, Leptin produced by obese adipose stromal/stem cells enhances proliferation and metastasis of estrogen receptor positive breast cancers, Breast Cancer Res., 17, 112, 10.1186/s13058-015-0622-z
Choi, 2010, Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway, J. Biol. Chem., 285, 36551, 10.1074/jbc.M110.168542
Yan, 2012, Leptin-induced epithelial-mesenchymal transition in breast cancer cells requires β-catenin activation via Akt/GSK3- and MTA1/Wnt1 protein-dependent pathways, J. Biol. Chem., 287, 8598, 10.1074/jbc.M111.322800
Feng, 2013, Leptin promotes metastasis by inducing an epithelial-mesenchymal transition in A549 lung cancer cells, Oncol. Res., 21, 165, 10.3727/096504014X13887748696662
Wang, 2015, Activation of IL-8 via PI3 K/Akt-dependent pathway is involved in leptin-mediated epithelial-mesenchymal transition in human breast cancer cells, Cancer Biol. Ther., 16, 1220, 10.1080/15384047.2015.1056409
Kato, 2015, Leptin stimulates migration and invasion and maintains cancer stem-like properties in ovarian cancer cells: an explanation for poor outcomes in obese women, Oncotarget, 6, 21100, 10.18632/oncotarget.4228
Nieman, 2013, Adipose tissue and adipocytes support tumorigenesis and metastasis, Biochim. Biophys. Acta, 1831, 1533, 10.1016/j.bbalip.2013.02.010
Xiong, 2015, Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment, World J. Stem Cells, 7, 253, 10.4252/wjsc.v7.i2.253
Xiang, 2016, Omental adipocytes enhance the invasiveness of gastric cancer cells by oleic acid-induced activation of the PI3K-Akt signaling pathway, Int. J. Biochem. Cell Biol., 84, 14, 10.1016/j.biocel.2016.12.002
Wen, 2017, Adipocytes activate mitochondrial fatty acid oxidation and autophagy to promote tumor growth in colon cancer, Cell Death Dis., 8, e2593, 10.1038/cddis.2017.21
Meyer, 2016, Adipocytes promote pancreatic cancer cell proliferation via glutamine transfer, Biochem. Biophys. Rep., 7, 144
Moreira, 2015, Adipocyte secreted factors enhance aggressiveness of prostate carcinoma cells, PLoS One, 10, e0123217, 10.1371/journal.pone.0123217
Ito, 2015, Adipocyte-derived monocyte chemotactic protein-1 (MCP-1) promotes prostate cancer progression through the induction of MMP-2 activity, Prostate, 75, 1009, 10.1002/pros.22972
Ribeiro, 2012, Human periprostatic adipose tissue promotes prostate cancer aggressiveness in vitro, J. Exp. Clin. Cancer Res., 31, 32, 10.1186/1756-9966-31-32
Zhu, 2017, Invasive breast cancer preferably and predominantly occurs at the interface between fibroglandular and adipose tissue, Clin. Breast Cancer, 17, e11, 10.1016/j.clbc.2016.07.009
Fletcher, 2017, Human breast adipose tissue: characterization of factors that change during tumor progression in human breast cancer, J. Exp. Clin. Cancer Res., 36, 26, 10.1186/s13046-017-0494-4
Divella, 2016, Obesity and cancer: the role of adipose tissue and adipo-cytokines-induced chronic inflammation, J. Cancer, 7, 2346, 10.7150/jca.16884
Hefetz-Sela, 2013, Adipocytes: impact on tumor growth and potential sites for therapeutic intervention, Pharmacol. Ther., 138, 197, 10.1016/j.pharmthera.2013.01.008
Massa, 2016, Interaction between breast cancer cells and adipose tissue cells derived from fat grafting, Aesthet. Surg. J., 36, 358, 10.1093/asj/sjv194
D'Esposito, 2016, Adipose microenvironment promotes triple negative breast cancer cell invasiveness and dissemination by producing CCL5, Oncotarget, 7, 24495, 10.18632/oncotarget.8336
Lee, 2015, Adipocytes can induce epithelial-mesenchymal transition in breast cancer cells, Breast Cancer Res. Treat., 153, 323, 10.1007/s10549-015-3550-9
Yao-Borengasser, 2015, Adipocyte hypoxia promotes epithelial-mesenchymal transition-related gene expression and estrogen receptor-negative phenotype in breast cancer cells, Oncol. Rep., 33, 2689, 10.3892/or.2015.3880
Fujisaki, 2015, Cancer-mediated adipose reversion promotes cancer cell migration via IL-6 and MCP-1, Breast Cancer Res. Treat., 150, 255, 10.1007/s10549-015-3318-2
Wang, 2015, Human adipocytes stimulate invasion of breast cancer MCF-7 cells by secreting IGFBP-2, PLoS One, 10, e0119348, 10.1371/journal.pone.0119348
Park, 2011, Paracrine and endocrine effects of adipose tissue on cancer development and progression, Endocr Rev., 32, 550, 10.1210/er.2010-0030
Dirat, 2011, Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion, Cancer Res., 71, 2455, 10.1158/0008-5472.CAN-10-3323
Wolfson, 2015, Adipocyte activation of cancer stem cell signaling in breast cancer, World J. Biol Chem., 6, 39, 10.4331/wjbc.v6.i2.39
Liu, 2013, Local adipocytes enable estrogen-dependent breast cancer growth: role of leptin and aromatase, Adipocyte, 2, 165, 10.4161/adip.23645
Marwarha, 2012, Leptin signaling and Alzheimer's disease, Am. J. Neurodegener. Dis., 1, 245
Prokop, 2012, Leptin and leptin receptor: analysis of a structure to function relationship in interaction and evolution from humans to fish, Peptides, 38, 326, 10.1016/j.peptides.2012.10.002
Zhang, 2005, Leptin: structure, function and biology, Vitam. Horm., 71, 345, 10.1016/S0083-6729(05)71012-8
Chimal-Vega, 2015, Exploring the structure and conformational landscape of human leptin. A molecular dynamics approach, J. Theor. Biol., 385, 90, 10.1016/j.jtbi.2015.08.014
Peelman, 2014, 20 years of leptin: insights into signaling assemblies of the leptin receptor, J. Endocrinol., 223, 10.1530/JOE-14-0264
Dozio, 2009, Leptin, ciliary neurotrophic factor, leukemia inhibitory factor and interleukin-6: class-I cytokines involved in the neuroendocrine regulation of the reproductive function, Curr. Protein Pept. Sci., 10, 577, 10.2174/138920309789630561
Frühbeck, 2006, Intracellular signalling pathways activated by leptin, Biochem. J., 393, 7, 10.1042/BJ20051578
Han, 2015, Leptin and its receptor in hematologic malignancies, Int. J. Clin. Exp. Med., 8, 19840
Jiang, 2014, Leptin signaling molecular actions and drug target in hepatocellular carcinoma, Drug Des. Devel. Ther., 8, 2295
Siveen, 2014, Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors, Biochim. Biophys. Acta, 1845, 136
Kim, 2016, Signal transducer and activator of transcription 3 as a therapeutic target for cancer and the tumor microenvironment, Arch. Pharm. Res., 39, 1085, 10.1007/s12272-016-0795-8
Li, 2017, Regulation of EMT by STAT3 in gastrointestinal cancer (review), Int. J. Oncol., 50, 753, 10.3892/ijo.2017.3846
Yoon, 2015, Signal transducers and activators of transcription 3-induced metastatic potential in gastric cancer cells is enhanced by glycogen synthase kinase-3β, APMIS, 123, 373, 10.1111/apm.12370
Zhang, 2015, STAT3 cooperates with Twist to mediate epithelial-mesenchymal transition in human hepatocellular carcinoma cells, Oncol. Rep., 33, 1872, 10.3892/or.2015.3783
Yang, 2017, STAT3 overexpression promotes metastasis in intrahepatic cholangiocarcinoma and correlates negatively with surgical outcome, Oncotarget, 8, 7710, 10.18632/oncotarget.13846
Chen, 2015, Prognostic and clinical significance of STAT3 and MMP9 in patients with gastric cancer: a meta-analysis of a Chinese cohort, Int. J Clin. Exp. Med., 8, 546
Yu, 2016, The prognostic value of pSTAT3 in gastric cancer: a meta-analysis, J. Cancer Res Clin. Oncol., 142, 649, 10.1007/s00432-015-2023-1
Deng, 2014, STAT3 regulation the expression of VEGF-D in HGC-27 gastric cancer cell, Am. J. Transl. Res., 6, 756
Song, 2014, STAT3, p-STAT3 and HIF-1α are associated with vasculogenic mimicry and impact on survival in gastric adenocarcinoma, Oncol. Lett., 8, 431, 10.3892/ol.2014.2059
Zhong, 2014, Expressions of STAT3, p-STAT3 and E-cadherin in colorectal cancer and clinical implications, Zhonghua Wei Chang Wai Ke Za Zhi (Chinese Journal of Gastrointestinal Surgery), 17, 594
Ji, 2016, The role of p-STAT3 as a prognostic and clinicopathological marker in colorectal cancer: a systematic review and meta-analysis, PLoS One, 11, e0160125, 10.1371/journal.pone.0160125
Xu, 2014, A meta-analysis of STAT3 and phospho-STAT3 expression and survival of patients with non-small-cell lung cancer, Eur. J. Surg. Oncol., 40, 311, 10.1016/j.ejso.2013.11.012
Zhao, 2011, JAK2/STAT3 signaling pathway activation mediates tumor angiogenesis by upregulation of VEGF and bFGF in non-small-cell lung cancer, Lung Cancer, 73, 366, 10.1016/j.lungcan.2011.01.002
Yu, 2015, Activated STAT3 correlates with prognosis of non-small cell lung cancer and indicates new anticancer strategies, Cancer Chemother. Pharmacol., 75, 917, 10.1007/s00280-015-2710-2
Liu, 2014, Activation of STAT3 is involved in malignancy mediated by CXCL12-CXCR4 signaling in human breast cancer, Oncol. Rep., 32, 2760, 10.3892/or.2014.3536
Wei, 2015, Expression of signal transducer and activator of transcription 3 in breast cancer and its clinical significance, J. Cancer Res. Ther., 11, C56, 10.4103/0973-1482.163840
McDaniel, 2017, Genomic regulation of invasion by STAT3 in triple negative breast cancer, Oncotarget, 8, 8226, 10.18632/oncotarget.14153
Donato, 2010, The PI3 K signaling pathway mediates the biological effects of leptin, Arq. Bras. Endocrinol. Metabol., 54, 591, 10.1590/S0004-27302010000700002
Sheen, 2016, Constitutively activated PI3 K accelerates tumor initiation and modifies histopathology of breast cancer, Oncogenesis, 5, e267, 10.1038/oncsis.2016.65
Zardavas, 2014, PIK3CA mutations in breast cancer: reconciling findings from preclinical and clinical data, Breast Cancer Res., 16, 201, 10.1186/bcr3605
Arsenic, 2014, Analysis of PIK3CA mutations in breast cancer subtypes, Appl. Immunohistochem. Mol. Morphol., 22, 50, 10.1097/PDM.0b013e318297afea
Firoozinia, 2014, PIK3CA gene amplification and PI3 K p110α protein expression in breast carcinoma, Int. J. Med. Sci., 11, 620, 10.7150/ijms.8251
Mendelová, 2014, Correlation between the incidence of PIK3CA mutations in breast cancer and histopathological characteristics of the tumor, Ceska Gynekol., 79, 283
Tserga, 2016, Mutation of genes of the PI3 K/AKT pathway in breast cancer supports their potential importance as biomarker for breast cancer aggressiveness, Virchows Arch., 469, 35, 10.1007/s00428-016-1938-5
Harada, 2016, Prognostic and clinical impact of PIK3CA mutation in gastric cancer: pyrosequencing technology and literature review, BMC. Cancer, 16, 400, 10.1186/s12885-016-2422-y
Shi, 2012, Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer, BMC. Cancer, 12, 50, 10.1186/1471-2407-12-50
Liu, 2010, Up-regulation of PIK3CA promotes metastasis in gastric carcinoma, World J. Gastroenterol., 16, 4986, 10.3748/wjg.v16.i39.4986
Gu, 2014, Clinicopathological significance of PI3 K, Akt and survivin expression in gastric cancer, Biomed. Pharmacother., 68, 471, 10.1016/j.biopha.2014.03.010
Zhu, 2012, PI3 K expression and PIK3CA mutations are related to colorectal cancer metastases, World J. Gastroenterol., 18, 3745, 10.3748/wjg.v18.i28.3745
Dent, 2014, Crosstalk between ERK, AKT, and cell survival, Cancer Biol. Ther., 15, 245, 10.4161/cbt.27541
Dai, 2014, Interaction of mTOR and Erk1/2 signaling to regulate oligodendrocyte differentiation, Glia, 62, 2096, 10.1002/glia.22729
Ersahin, 2015, The PI3 K/AKT/mTOR interactive pathway, Mol. Biosyst., 11, 1946, 10.1039/C5MB00101C
Gungorduk, 2014, Immunolocalization of ERK1/2 and p-AKT in normal endometrium, endometrial hyperplasia, and early and advanced stage endometrioid endometrial adenocancer and their prognostic significance in malignant group, Eur. J. Obstet. Gynecol. Reprod. Biol., 179, 147, 10.1016/j.ejogrb.2014.05.040
Li, 2015, Expression of CD44 in pancreatic cancer and its significance, Int. J. Clin. Exp. Pathol., 8, 6724
Wang, 2015, High EGFR and low p-Akt expression is associated with better outcome after nimotuzumab-containing treatment in esophageal cancer patients: preliminary clinical result and testable hypothesis, Oncotarget, 6, 18674, 10.18632/oncotarget.4367
Lin, 2006, Morphoproteomic and molecular concomitants of an overexpressed and activated mTOR pathway in renal cell carcinomas, Ann. Clin. Lab. Sci., 36, 283
Aleskandarany, 2011, Clinicopathologic and molecular significance of phospho-Akt expression in early invasive breast cancer, Breast Cancer Res. Treat., 127, 407, 10.1007/s10549-010-1012-y
Yun, 2013, Clinicopathological significance of PTEN and PI3K/AKT signal transduction pathway in non-small cell lung cancer, Int. J. Clin. Exp. Pathol., 6, 2112
Chen, 2015, Expression and prognostic role of MEKK3 and pERK in patients with renal clear cell carcinoma, Asian Pac. J Cancer Prev., 16, 2495, 10.7314/APJCP.2015.16.6.2495
Holck, 2016, Localization of active, dually phosphorylated extracellular signal-regulated kinase 1 and 2 in colorectal cancer with or without activating BRAF and KRAS mutations, Hum. Pathol., 54, 37, 10.1016/j.humpath.2016.03.001
David, 2004, Phospho-Akt overexpression in non-small cell lung cancer confers significant stage-independent survival disadvantage, Clin. Cancer Res., 10, 6865, 10.1158/1078-0432.CCR-04-0174
Jia, 2014, REDD1 and p-AKT over-expression may predict poor prognosis in ovarian cancer, Int. J. Clin. Exp. Pathol., 7, 5940
Baba, 2011, Phosphorylated AKT expression is associated with PIK3CA mutation, low stage, and favorable outcome in 717 colorectal cancers, Cancer, 117, 1399, 10.1002/cncr.25630
Pantuck, 2007, Prognostic relevance of the mTOR pathway in renal cell carcinoma: implications for molecular patient selection for targeted therapy, Cancer, 109, 2257, 10.1002/cncr.22677
Yip, 2014, Phosphorylated Akt expression is a prognostic marker in early-stage non-small cell lung cancer, J. Clin. Pathol., 67, 333, 10.1136/jclinpath-2013-201870
Campbell, 2009, Activated extracellular signal-regulated kinase is an independent prognostic factor in clinically confined renal cell carcinoma, Cancer, 115, 3457, 10.1002/cncr.24389
Tsujino, 2016, Increased phosphorylation of ERK1/2 is associated with worse chemotherapeutic outcome and a poor prognosis in advanced lung adenocarcinoma, Med. Mol. Morphol., 49, 98, 10.1007/s00795-015-0130-3
Ma, 2012, Epidermal growth factor (EGF) and interleukin (IL)-1β synergistically promote ERK1/2-mediated invasive breast ductal cancer cell migration and invasion, Mol. Cancer, 11, 79, 10.1186/1476-4598-11-79
Tasioudi, 2012, pERK activation in esophageal carcinomas: clinicopathological associations, Pathol. Res. Pract., 208, 398, 10.1016/j.prp.2012.05.009
Tai, 2013, High nuclear expression of phosphorylated extracellular signal-regulated kinase in tumor cells in colorectal glands is associated with poor outcome in colorectal cancer, Ann. Diagn. Pathol., 17, 165, 10.1016/j.anndiagpath.2012.09.004
Thrift, 2016, Determination of risk for Barrett's esophagus and esophageal adenocarcinoma, Curr. Opin. Gastroenterol., 32, 319, 10.1097/MOG.0000000000000274
Tercioti-Junior, 2011, Adenocarcinoma versus squamous cell carcinoma: analysis of 306 patients in university hospital, Arq. Bras. Cir Dig., 24, 272, 10.1590/S0102-67202011000400005
Trevellin, 2015, Esophageal adenocarcinoma and obesity: peritumoral adipose tissue plays a role in lymph node invasion, Oncotarget, 6, 11203, 10.18632/oncotarget.3587
Duan, 2014, Expression of leptin and adiponectin in esophageal squamous cell carcinoma and their clinical significance, Zhonghua Zhong Liu Za Zhi (Chinese Journal of Oncology), 36, 839
Choi, 2015, Implication of leptin-signaling proteins and epstein-barr virus in gastric carcinomas, PLoS One, 10, e0130839, 10.1371/journal.pone.0130839
Espejo Romero, 2003, Classification of stomach adenocarcinomas, Rev. Gastroenterol. Peru, 23, 199
Zhao, 2007, Correlation between expression of leptin and clinicopathological features and prognosis in patients with gastric cancer, J. Gastroenterol. Hepatol, 22, 1317, 10.1111/j.1440-1746.2007.04941.x
Geng, 2012, Leptin and HER-2 are associated with gastric cancer progression and prognosis of patients, Biomed. Pharmacother., 66, 419, 10.1016/j.biopha.2012.03.002
Ishikawa, 2006, Expression pattern of leptin and leptin receptor (OB-R) in human gastric cancer, World J. Gastroenterol., 12, 5517, 10.3748/wjg.v12.i34.5517
Dong, 2013, Leptin-mediated regulation of MT1-MMP localization is KIF1 B dependent and enhances gastric cancer cell invasion, Carcinogenesis, 34, 974, 10.1093/carcin/bgt028
Dong, 2014, Leptin-mediated regulation of ICAM-1 is Rho/ROCK dependent and enhances gastric cancer cell migration, Br. J. Cancer, 110, 1801, 10.1038/bjc.2014.70
Makrilia, 2009, Cell adhesion molecules: role and clinical significance in cancer, Cancer Invest., 27, 1023, 10.3109/07357900902769749
Bain, 2014, Tumour expression of leptin is associated with chemotherapy resistance and therapy-independent prognosis in gastro-oesophageal adenocarcinomas, Br. J. Cancer, 110, 1525, 10.1038/bjc.2014.45
Catalano, 2015, A novel leptin antagonist peptide inhibits breast cancer growth in vitro and in vivo, J. Cell. Mol. Med., 19, 1122, 10.1111/jcmm.12517
Zou, 2016, Leptin promotes proliferation and metastasis of human gallbladder cancer through OB-Rb leptin receptor, Int. J. Oncol., 49, 197, 10.3892/ijo.2016.3530
Yunusova, 2015, Serum adipokines and their receptors in endometrial and colon cancer patients: relationship with tumor invasion and metastasis, Vopr. Onkol., 61, 619
Healy, 2012, Metabolic syndrome and leptin are associated with adverse pathological features in male colorectal cancer patients, Colorectal Dis., 14, 157, 10.1111/j.1463-1318.2011.02562.x
Wang, 2012, Leptin regulates proliferation and apoptosis of colorectal carcinoma through PI3 K/Akt/mTOR signalling pathway, J. Biosci., 37, 91, 10.1007/s12038-011-9172-4
Liu, 2011, Expression and biological significance of leptin, leptin receptor, VEGF, and CD34 in colorectal carcinoma, Cell Biochem. Biophys., 60, 241, 10.1007/s12013-010-9145-5
Ratke, 2010, Leptin stimulates the migration of colon carcinoma cells by multiple signaling pathways, Endocr. Relat. Cancer, 17, 179, 10.1677/ERC-09-0225
Erkasap, 2013, Leptin receptor (Ob-R) mRNA expression and serum leptin concentration in patients with colorectal and metastatic colorectal cancer, Braz. J. Med. Biol. Res., 46, 306, 10.1590/1414-431X20122559
Fan, 2015, Leptin signaling enhances cell invasion and promotes the metastasis of human pancreatic cancer via increasing MMP-13 production, Oncotarget, 6, 16120, 10.18632/oncotarget.3878
Ren, 2014, Hypoxia inducible factor (HIF)-1α directly activates leptin receptor (Ob-R) in pancreatic cancer cells, Cancer Lett., 354, 172, 10.1016/j.canlet.2014.08.001
Masoud, 2015, HIF-1α pathway: role, regulation and intervention for cancer therapy, Acta Pharm, Sin. B, 5, 378
Schmid, 2015, Adiposity and risk of thyroid cancer: a systematic review and meta-analysis, Obes. Rev., 16, 1042, 10.1111/obr.12321
Pappa, 2014, Obesity and thyroid cancer: a clinical update, Thyroid, 24, 190, 10.1089/thy.2013.0232
Fan, 2015, Expression of leptin and its receptor in thyroid carcinoma: distinctive prognostic significance in different subtypes, Clin. Endocrinol. (Oxf.), 83, 261, 10.1111/cen.12598
Zhang, 2013, Clinicopathological implications of leptin and leptin receptor expression in papillary thyroid cancer, Oncol. Lett., 5, 797, 10.3892/ol.2013.1125
Cheng, 2010, Clinicopathologic significance of leptin and leptin receptor expressions in papillary thyroid carcinoma, Surgery, 147, 847, 10.1016/j.surg.2009.11.004
Uddin, 2010, Leptin-R and its association with PI3 K/AKT signaling pathway in papillary thyroid carcinoma, Endocr. Relat. Cancer, 17, 191, 10.1677/ERC-09-0153
Cheng, 2011, Leptin enhances migration of human papillary thyroid cancer cells through the PI3 K/AKT and MEK/ERK signaling pathways, Oncol. Rep., 26, 1265
Zhang, 2014, Correlation analysis between the expressions of leptin and its receptor (ObR) and clinicopathology in endometrial cancer, Cancer Biomark., 14, 353, 10.3233/CBM-140415
Gui, 2017, The association between obesity related adipokines and risk of breast cancer: a systematic review and meta-analysis, Oncotarget, 8, 75389, 10.18632/oncotarget.17853
Engin, 2017, Obesity-associated breast cancer: analysis of risk factors, Adv. Exp. Med. Biol., 960, 571, 10.1007/978-3-319-48382-5_25
Madeddu, 2014, Role of inflammation and oxidative stress in post-menopausal oestrogen-dependent breast cancer, J. Cell. Mol. Med., 18, 2519, 10.1111/jcmm.12413
Assiri, 2015, Resistin, visfatin, adiponectin, and leptin: risk of breast cancer in pre- and postmenopausal Saudi females and their possible diagnostic and predictive implications as novel biomarkers, Dis. Markers, 2015, 253519, 10.1155/2015/253519
Hou, 2007, Adipocytokines and breast cancer risk, Chin. Med. J. (Engl.), 120, 1592, 10.1097/00029330-200709020-00009
Chen, 2006, Serum adiponectin and leptin levels in Taiwanese breast cancer patients, Cancer Lett., 237, 109, 10.1016/j.canlet.2005.05.047
Grossmann, 2010, Obesity and breast cancer: status of leptin and adiponectin in pathological processes, Cancer Metastasis Rev., 29, 641, 10.1007/s10555-010-9252-1
Ishikawa, 2004, Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer, Clin. Cancer Res., 10, 4325, 10.1158/1078-0432.CCR-03-0749
Xia, 2009, Overexpression of leptin and leptin receptors in breast cancer positively correlates with clinicopathological features, Chin. Med. J. (Engl.), 122, 3078
Alshaker, 2014, Leptin induces upregulation of sphingosine kinase 1 in oestrogen receptor-negative breast cancer via Src family kinase-mediated, janus kinase 2-independent pathway, Breast Cancer Res., 16, 426, 10.1186/s13058-014-0426-6
Park, 2010, Leptin receptor signaling supports cancer cell metabolism through suppression of mitochondrial respiration in vivo, Am. J. Pathol., 177, 3133, 10.2353/ajpath.2010.100595
Guo, 2011, Notch, IL-1 and leptin crosstalk outcome (NILCO) is critical for leptin-induced proliferation, migration and VEGF/VEGFR-2 expression in breast cancer, PLoS One, 6, e21467, 10.1371/journal.pone.0021467
McMurtry, 2009, Leptin utilizes Jun N-terminal kinases to stimulate the invasion of MCF-7 breast cancer cells, Clin. Exp. Metastasis, 26, 197, 10.1007/s10585-008-9231-x
Li, 2016, Leptin promotes breast cancer cell migration and invasion via IL-18 expression and secretion, Int. J. Oncol., 48, 2479, 10.3892/ijo.2016.3483
Zhang, 2015, Regulation of epithelial-mesenchymal transition by tumor-associated macrophages in cancer, Am. J. Transl. Res., 7, 1699
Bonde, 2012, Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors, BMC Cancer, 12, 35, 10.1186/1471-2407-12-35
Yang, 2016, Macrophage phenotypic subtypes diametrically regulate epithelial-mesenchymal plasticity in breast cancer cells, BMC Cancer, 16, 419, 10.1186/s12885-016-2411-1
Cao, 2016, Leptin promotes migration and invasion of breast cancer cells by stimulating IL-8 production in M2 macrophages, Oncotarget, 7, 65441, 10.18632/oncotarget.11761
Templeton, 2015, Breast cancer cell colonization of the human bone marrow adipose tissue niche, Neoplasia, 17, 849, 10.1016/j.neo.2015.11.005
Perera, 2008, Leptin-regulated gene expression in MCF-7 breast cancer cells: mechanistic insights into leptin-regulated mammary tumor growth and progression, J. Endocrinol., 199, 221, 10.1677/JOE-08-0215
Saxena, 2008, Bidirectional crosstalk between leptin and insulin-like growth factor-I signaling promotes invasion and migration of breast cancer cells via transactivation of epidermal growth factor receptor, Cancer Res., 68, 9712, 10.1158/0008-5472.CAN-08-1952
Huang, 2011, Leptin increases motility and integrin up-regulation in human prostate cancer cells, J. Cell. Physiol., 226, 1274, 10.1002/jcp.22455
Yang, 2009, Leptin enhances cell migration in human chondrosarcoma cells through OBRl leptin receptor, Carcinogenesis, 30, 566, 10.1093/carcin/bgp023
Liu, 2008, Integrin alpha(v)beta(3)-targeted cancer therapy, Drug Dev. Res., 69, 329, 10.1002/ddr.20265
Grossmann, 2009, Role of the adiponectin leptin ratio in prostate cancer, Oncol. Res., 18, 269, 10.3727/096504009X12596189659367
Horiguchi, 2006, Increased serum leptin levels and over expression of leptin receptors are associated with the invasion and progression of renal cell carcinoma, J. Urol., 176, 1631, 10.1016/j.juro.2006.06.039
Oba, 2016, Elevated serum leptin levels are associated with an increased risk of sentinel lymph node metastasis in cutaneous melanoma, Medicine (Baltimore), 95, e3073, 10.1097/MD.0000000000003073
Clement, 2017, Obesity and melanoma: could fat be fueling malignancy?, Pigment Cell Melanoma Res., 30, 294, 10.1111/pcmr.12584
Font-Clos, 2017, Integrative analysis of pathway deregulation in obesity, N. P. J. Syst. Biol. Appl., 3, 18, 10.1038/s41540-017-0018-z
Malvi, 2015, Obesity induced rapid melanoma progression is reversed by orlistat treatment and dietary intervention: role of adipokines, Mol. Oncol., 9, 689, 10.1016/j.molonc.2014.11.006
Qi, 2014, Type 2 diabetes mellitus and risk of malignant melanoma: a systematic review and meta-analysis of cohort studies, Iran. J. Public Health, 43, 857
Torisu-Itakura, 2007, Molecular characterization of inflammatory genes in sentinel and nonsentinel nodes in melanoma, Clin. Cancer Res., 13, 3125, 10.1158/1078-0432.CCR-06-2645
Xu, 2011, Expression and clinical significance of leptin, the functional receptor of leptin (OB-Rb) and HER-2 in non-small-cell lung cancer: a retrospective analysis, J. Cancer Res Clin. Oncol., 137, 1841, 10.1007/s00432-011-1054-5
Yan, 2010, Effects of dietary fat on spontaneous metastasis of Lewis lung carcinoma in mice, Clin. Exp. Metastasis., 27, 581, 10.1007/s10585-010-9347-7
Barrichon, 2015, Dose-dependent biphasic leptin-induced proliferation is caused by non-specific IL-6/NF-(B pathway activation in human myometrial cells, Br. J. Pharmacol., 172, 2974, 10.1111/bph.13100
Fazolini, 2015, Leptin activation of mTOR pathway in intestinal epithelial cell triggers lipid droplet formation, cytokine production and increased cell proliferation, Cell Cycle, 14, 2667, 10.1080/15384101.2015.1041684
Blanquer-Rosselló Mdel, 2016, Leptin regulates energy metabolism in MCF-7 breast cancer cells, Int. J. Biochem. Cell Biol., 72, 18, 10.1016/j.biocel.2016.01.002
Chen, 2013, Leptin stimulates ovarian cancer cell growth and inhibits apoptosis by increasing cyclin D1 and Mcl-1 expression via the activation of the MEK/ERK1/2 and PI3 K/Akt signaling pathways, Int. J. Oncol., 42, 1113, 10.3892/ijo.2013.1789
Chin, 2017, Leptin OB3 peptide suppresses leptin-induced signaling and progression in ovarian cancer cells, J. Biomed. Sci., 24, 51, 10.1186/s12929-017-0356-6
Dubois, 2014, Leptin induces a proliferative response in breast cancer cells but not in normal breast cells, Nutr. Cancer, 66, 645, 10.1080/01635581.2014.894104
Habib, 2015, Leptin influences estrogen metabolism and accelerates prostate cell proliferation, Life Sci., 121, 10, 10.1016/j.lfs.2014.11.007
Harbuzariu, 2017, Leptin-Notch signaling axis is involved in pancreatic cancer progression, Oncotarget, 8, 7740, 10.18632/oncotarget.13946
Kim, 2017, Leptin induces CREB-dependent aromatase activation through COX-2 expression in breast cancer cells, Food Chem Toxicol., 106, 232, 10.1016/j.fct.2017.05.058
Liu, 2013, Leptin promotes human endometrial carcinoma cell proliferation by enhancing aromatase (P450arom) expression and estradiol formation, Eur. J. Obstet. Gynecol. Reprod. Biol., 170, 198, 10.1016/j.ejogrb.2013.04.004
Nepal, 2015, Autophagy induction by leptin contributes to suppression of apoptosis in cancer cells and xenograft model: involvement of p53/FoxO3A axis, Oncotarget, 6, 7166, 10.18632/oncotarget.3347
Ptak, 2013, Leptin stimulation of cell cycle and inhibition of apoptosis gene and protein expression in OVCAR-3 ovarian cancer cells, Endocrine, 43, 394, 10.1007/s12020-012-9788-7
Qian, 2015, ObRb downregulation increases breast cancer cell sensitivity to tamoxifen, Tumour Biol., 36, 6813, 10.1007/s13277-015-3375-5
Shouman, 2016, Leptin influences estrogen metabolism and increases DNA adduct formation in breast cancer cells, Cancer Biol. Med., 13, 505, 10.20892/j.issn.2095-3941.2016.0079
Xu, 2013, The upregulation of signal transducer and activator of transcription 5-dependent microRNA-182 and microRNA-96 promotes ovarian cancer cell proliferation by targeting forkhead box O3 upon leptin stimulation, Int. J. Biochem. Cell Biol., 45, 536, 10.1016/j.biocel.2012.12.010
Yoon, 2014, Leptin-induced adhesion and invasion in colorectal cancer cell lines, Oncol. Rep., 31, 2493, 10.3892/or.2014.3128
Yu, 2016, Adipocytes secreted leptin is a pro-tumor factor for survival of multiple myeloma under chemotherapy, Oncotarget, 7, 86075, 10.18632/oncotarget.13342
Zhou, 2015, Leptin inhibits the apoptosis of endometrial carcinoma cells through activation of the nuclear factor κB-inducing kinase/IκB kinase pathway, Int. J. Gynecol. Cancer, 25, 770, 10.1097/IGC.0000000000000440
Valladares, 2014, Association between obesity and ovarian cancer, Rev. Med. Chil., 142, 593, 10.4067/S0034-98872014000500007
Yuan, 2013, Leptin induces cell proliferation and reduces cell apoptosis by activating c-myc in cervical cancer, Oncol. Rep., 29, 2291, 10.3892/or.2013.2390
Shen, 2009, Leptin promotes the immune escape of lung cancer by inducing proinflammatory cytokines and resistance to apoptosis, Mol. Med. Rep., 2, 295
Gonzalez-Perez, 2013, Leptin's pro-angiogenic signature in breast cancer, Cancers (Basel), 5, 1140, 10.3390/cancers5031140
Ribatti, 2008, Leptin-leptin receptor are involved in angiogenesis in human hepatocellular carcinoma, Peptides, 29, 1596, 10.1016/j.peptides.2008.05.011
Wicki, 2008, The angiogenic switch in tumorigenesis, 67
Hunter, 2008, Mechanisms of metastasis, Breast Cancer Res., 10, S2, 10.1186/bcr1988
Bloomfield, 2016, Inherent variability of cancer-specific aneuploidy generates metastases, Mol. Cytogenet., 9, 90, 10.1186/s13039-016-0297-x
Caswell, 2017, The role of tumour heterogeneity and clonal cooperativity in metastasis, immune evasion and clinical outcome, BMC. Med., 15, 133, 10.1186/s12916-017-0900-y
Yang, 2017, Intratumor heterogeneity predicts metastasis of triple-negative breast cancer, Carcinogenesis, 38, 900, 10.1093/carcin/bgx071
Werner, 2017, Epigenetics and precision oncology, Cancer J., 23, 262, 10.1097/PPO.0000000000000281
Ell, 2013, Transcriptional control of cancer metastasis, Trends Cell Biol., 23, 603, 10.1016/j.tcb.2013.06.001
Bochukova, 2010, Large, rare chromosomal deletions associated with severe early-onset obesity, Nature, 463, 666, 10.1038/nature08689
Uriarte, 2013, Shifting to a control diet after a high-fat, high-sucrose diet intake induces epigenetic changes in retroperitoneal adipocytes of Wistar rats, J. Physiol. Biochem., 69, 601, 10.1007/s13105-012-0231-6
Pokrywka, 2014, DNA methylation in obesity, Postepy Hig Med. Dosw. (Online), 68, 1383, 10.5604/17322693.1130084
Hair, 2015, Body mass index associated with genome-wide methylation in breast tissue, Breast Cancer Res. Treat., 151, 453, 10.1007/s10549-015-3401-8
Del Carmen Martínez-Jiménez, 2017, miRNAs in nutrition, obesity, and cancer: the biology of miRNAs in metabolic disorders and its relationship with cancer development, Mol. Nutr. Food Res.
Crujeiras, 2015, Leptin resistance in obesity: an epigenetic landscape, Life Sci., 140, 57, 10.1016/j.lfs.2015.05.003
Yan, 2013, Metastasis suppressor genes, Histol. Histopathol., 28, 285
Bruno, 2005, Apoptotic pathways are inhibited by leptin receptor activation in neutrophils, J. Immunol., 174, 8090, 10.4049/jimmunol.174.12.8090
Hajagos-Tóth, 2017, Obesity in pregnancy: a novel concept on the roles of adipokines in uterine contractility, Croat. Med. J., 58, 96, 10.3325/cmj.2017.58.96
Blouet, 2012, TXNIP in Agrp neurons regulates adiposity, energy expenditure, and central leptin sensitivity, J. Neurosci., 32, 9870, 10.1523/JNEUROSCI.0353-12.2012
Pachmayr, 2017, Underlying mechanisms for distant metastasis − Molecular biology, Visc. Med., 33, 11, 10.1159/000454696
Ding, 2016, APPL1-mediating leptin signaling contributes to proliferation and migration of cancer cells, PLoS One, 11, e0166172, 10.1371/journal.pone.0166172
Fava, 2008, Leptin enhances cholangiocarcinoma cell growth, Cancer Res., 68, 6752, 10.1158/0008-5472.CAN-07-6682
Frankenberry, 2004, Leptin induces cell migration and the expression of growth factors in human prostate cancer cells, Am. J. Surg., 188, 560, 10.1016/j.amjsurg.2004.07.031
Ghasemi, 2017, RhoA/ROCK pathway mediates leptin-induced uPA expression to promote cell invasion in ovarian cancer cells, Cell. Signal., 32, 104, 10.1016/j.cellsig.2017.01.020
Ghasemi, 2017, Leptin induces matrix metalloproteinase 7 expression to promote ovarian cancer cell invasion by activating ERK and JNK pathways, J. Cell Biochem
Huang, 2017, Leptin promotes the migration and invasion of breast cancer cells by upregulating ACAT2, Cell. Oncol (Dordr.), 10.1007/s13402-017-0342-8
Knight, 2011, Survivin upregulation, dependent on leptin-EGFR-Notch1 axis, is essential for leptin-induced migration of breast carcinoma cells, Endocr. Relat. Cancer, 18, 413, 10.1530/ERC-11-0075
Martín, 2017, A dangerous liaison: leptin and sPLA2-IIA join forces to induce proliferation and migration of astrocytoma cells, PLoS One, 12, e0170675, 10.1371/journal.pone.0170675
Mendonsa, 2015, Modulation of the leptin receptor mediates tumor growth and migration of pancreatic cancer cells, PLoS One, 10, e0126686, 10.1371/journal.pone.0126686
Mishra, 2017, Leptin signals via TGFB1 to promote metastatic potential and stemness in breast cancer, PLoS One, 12, e0178454, 10.1371/journal.pone.0178454
Noda, 2015, Long term exposure to leptin enhances the growth of prostate cancer cells, Int. J. Oncol., 46, 1535, 10.3892/ijo.2015.2845
Saxena, 2007, Concomitant activation of the JAK/STAT, PI3 K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells, Cancer Res., 67, 2497, 10.1158/0008-5472.CAN-06-3075
Sobrinho Santos, 2017, Leptin acts on neoplastic behavior and expression levels of genes related to hypoxia, angiogenesis, and invasiveness in oral squamous cell carcinoma, Tumor Biol., 39, 10.1177/1010428317699130
Wang, 2013, The effect of leptin and its mechanisms on the migration and invasion of human breast cancer MCF-7 cells, Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi (Chinese Journal of Cellular and Molecular Immunology), 29, 1272
Wei, 2016, Leptin promotes epithelial-mesenchymal transition of breast cancer via the upregulation of pyruvate kinase M2, J. Exp. Clin. Cancer Res., 35, 166, 10.1186/s13046-016-0446-4
Yeh, 2009, Leptin induces migration and invasion of glioma cells through MMP-13 production, Glia, 57, 454, 10.1002/glia.20773
Yuan, 2014, Leptin promotes the proliferation and migration of human breast cancer through the extracellular-signal regulated kinase pathway, Mol. Med. Rep., 9, 350, 10.3892/mmr.2013.1786
Rabold, 2017, Cellular metabolism of tumor-associated macrophages − functional impact and consequences, FEBS. Lett., 591, 3022, 10.1002/1873-3468.12771
Zhao, 2017, Prognostic significance of tumor-associated macrophages in breast cancer: a meta-analysis of the literature, Oncotarget, 8, 30576, 10.18632/oncotarget.15736
Yuan, 2017, Prognostic significance of tumor-associated macrophages in ovarian cancer: a meta-analysis, Gynecol. Oncol., 147, 181, 10.1016/j.ygyno.2017.07.007
Sousa, 2016, The role of tumour-associated macrophages in bone metastasis, J. Bone Oncol., 5, 135, 10.1016/j.jbo.2016.03.004
Rhee, 2016, Diverse macrophages polarization in tumor microenvironment, Arch. Pharm. Res., 39, 1588, 10.1007/s12272-016-0820-y
Braune, 2017, IL-6 regulates M2 polarization and local proliferation of adipose tissue macrophages in obesity, J. Immunol., 198, 2927, 10.4049/jimmunol.1600476
Jung, 2015, High-fat diet-induced obesity increases lymphangiogenesis and lymph node metastasis in the B16F10 melanoma allograft model: roles of adipocytes and M2-macrophages, Int. J. Cancer, 136, 258, 10.1002/ijc.28983
Acedo, 2013, Participation of leptin in the determination of the macrophage phenotype: an additional role in adipocyte and macrophage crosstalk, In Vitro Cell. Dev. Biol. Anim., 49, 473, 10.1007/s11626-013-9629-x
Seyfried, 2013, On the origin of cancer metastasis, Crit. Rev. Oncog., 18, 43, 10.1615/CritRevOncog.v18.i1-2.40
Clawson, 2017, Stealth dissemination of macrophage-tumor cell fusions cultured from blood of patients with pancreatic ductal adenocarcinoma, PLoS One, 12, e0184451, 10.1371/journal.pone.0184451
Ding, 2012, Tumor associated macrophage × cancer cell hybrids may acquire cancer stem cell properties in breast cancer, PLoS One, 7, e41942, 10.1371/journal.pone.0041942
Pawlina, 2016
Chapnik, 2013, A superactive leptin antagonist alters metabolism and locomotion in high-leptin mice, J. Endocrinol., 217, 283, 10.1530/JOE-13-0033
Macht, 2017, Leptin resistance elicits depressive-like behaviors in rats, Brain Behav. Immun., 60, 151, 10.1016/j.bbi.2016.10.008
Søgaard, 2013, The impact of comorbidity on cancer survival: a review, Clin. Epidemiol., 5, S3, 10.2147/CLEP.S47150
Cheung, 2014, A pegylated leptin antagonist ameliorates CKD-associated cachexia in mice, J. Am. Soc Nephrol., 25, 119, 10.1681/ASN.2013040432