The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders

Psychoneuroendocrinology - Tập 25 Số 1 - Trang 1-35 - 2000
Christine Heim1, Ulrike Ehlert2, Dirk H. Hellhammer2
1Center for Psychobiological and Psychosomatic Research, University of Trier, Germany
2Center for Psychobiological and Psychosomatic Research, Building D, University of Trier, 54286 Trier, Germany

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Ahles, 1984, Psychological factors associated with primary fibromyalgia syndrome, Arthritis Rheum., 24, 1102

Alfvén, 1994, Depressed concentrations of oxytocin and cortisol in children with recurrent abdominal pain of non-organic origin, Acta Paediatr., 83, 1076, 10.1111/j.1651-2227.1994.tb12989.x

Allen, 1995, Aspirin—now we can see it, Nat. Med., 1, 882, 10.1038/nm0995-882

Amir, 1997, Posttraumatic Stess Disorder, tenderness, and fibromyalgia, J. Psychosom. Res., 42, 607, 10.1016/S0022-3999(97)00009-3

Baker, 1982, Relationship between posttraumatic stress disorder and self-reported physical symptoms in Persian gulf war veterans, Arch. Intern. Med., 157, 2076, 10.1001/archinte.1997.00440390062009

Bateman, 1989, The immune hypothalamic pituitary adrenal axis, Endocr. Rev., 10, 92, 10.1210/edrv-10-1-92

Baum, 1993, Control and intrusive memories as possible determinants of chronic stress, Psychosom. Med., 55, 274, 10.1097/00006842-199305000-00005

Bearn, 1995, Neuroendocrine responses to d-fenfluramine and insulin-onduced hypoglycemia in chronic fatigue syndrome, Biol. Psychiatry, 37, 245, 10.1016/0006-3223(94)00121-I

Benedetto, 1989, Eicosanoids in primary dysmenorrhea, endometriosis and menstrual migraine, Gynecol. Endocrinol., 3, 71, 10.3109/09513598909152454

Blackwell, 1982, Glucocorticoids induce the formation and release of anti-inflammatory and anti-phospholipase proteins into the peritoneal cavity of the rat, Br. J. Pharmacol., 76, 185, 10.1111/j.1476-5381.1982.tb09205.x

Boisset-Pioro, 1995, Sexual and physical abuse in women with fibromyalgia syndrome, Arthritis Rheum., 38, 235, 10.1002/art.1780380212

Boscarino, 1996, Posttraumatic stress disorder, exposure to combat, and lower plasma cortisol among Vietnam veterans: Findings and clinical implications, J. Clin. Consult. Psychol., 64, 191, 10.1037/0022-006X.64.1.191

Bourne, 1968, 17 OHCS levels in combat. Special forces ‘A’ team under threat of attack, Arch. Gen. Psychiatry, 19, 135, 10.1001/archpsyc.1968.01740080007002

Bourne, 1967, Urinary 17 OHCS levels. Data on seven helicopter ambulance medics in combat, Arch. Gen. Psychiatry, 17, 104, 10.1001/archpsyc.1967.01730250106015

Boxer, 1988, Neglect contributing to tertiary hospitalization in childhood asthma, Child Abuse Negl., 12, 491, 10.1016/0145-2134(88)90066-X

Bremner, 1995, MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder, Am. J. Psychiatry, 152, 973, 10.1176/ajp.152.7.973

Bremner, 1997, Elevated CSF corticotropin-releasing factor concentrations in PTSD, Am. J. Psychiatry, 154, 624, 10.1176/ajp.154.5.624

Bremner, 1998, Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report, Biol. Psychiatry, 41, 23, 10.1016/S0006-3223(96)00162-X

Bremner, 1993, Childhood physical abuse and combat-related posttraumatic stress disorder in Vietnam veterans, Am. J. Psychiatry, 150, 235, 10.1176/ajp.150.2.235

Buchwald, 1991, Review of laboratory findings for patients with chronic fatigue syndrome, Rev. Infect. Dis., 13, 12, 10.1093/clinids/13.Supplement_1.S12

Buske-Kirschbaum, 1997, Attenuated free cortisol response to psychosocial stress in children with atopic dermatitis, Psychosom. Med., 59, 419, 10.1097/00006842-199707000-00012

Caplan, 1979, White collar work load and cortisol: disruption of a circadian rhythm by job stress?, J. Psychosom. Res., 23, 181, 10.1016/0022-3999(79)90003-5

Cash, 1992, Pituitary-adrenal axis responsiveness to ovine corticotropin releasing hormone in patients with rheumatoid arthritis treated with low dose prednisone, J. Rheumatol., 19, 1692

Catalani, 1993, Progeny of mothers drinking corticosterone during lactation has lower stress-induced corticosterone secretion and better cognitive performance, Brain Res., 624, 209, 10.1016/0006-8993(93)90079-3

Cavallo, 1986, Cortisol and immune interferon can interact in the modulation of human natural killer cell activity, Experimentia, 42, 177, 10.1007/BF01952455

Chikanza, 1992, Defective hypothalamic response to immune and inflammatory stimuli in patients with rheumatoid arthritis, Arthritis Rheum., 35, 1281, 10.1002/art.1780351107

Clark, 1985, A double blind crossover trial of prednisone versus placebo in the treatment of fibrositis, J. Rheumatol., 12, 980

Cleare, 1999, Low dose hydrocortisone in chronic fatigue syndrome: a randomized crossover trial, Lancet, 353, 455, 10.1016/S0140-6736(98)04074-4

Coplan, 1996, Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early life stressors: Implications for the pathophysiology of mood and anxiety disorders, Proc. Natl. Acad. Sci. USA, 93, 1619, 10.1073/pnas.93.4.1619

Corrigan, 1991, Glucocorticoid resistance in chronic asthma. Glucocorticoid pharmacokinetics, glucocorticoid receptor characteristics, and inhibition of peripheral blood T cell proliferation by glucocorticoids in vitro, Am. Rev. Respir. Dis., 144, 1016, 10.1164/ajrccm/144.5.1016

Cox, 1994, Alexithymia in somatoform disorder patients with chronic pain, J. Psychosom. Res., 38, 523, 10.1016/0022-3999(94)90049-3

Crofford, 1994, Hypothalamic-pituitary-adrenal axis perturbations in patients with fibromyalgia, Arthritis Rheum., 37, 1583, 10.1002/art.1780371105

Culclasure, 1993, Posttraumatic stress disorder presenting as fibromyalgia, Am. J. Med., 94, 548, 10.1016/0002-9343(93)90094-6

Davidson, 1985, A diagnostic and family study of posttraumatic stress disorder, Am. J. Psychiatry, 142, 90, 10.1176/ajp.142.1.90

Davidson, 1991, Posttraumatic stress disorder in the community: an epidemiological study, Psychol. Med., 21, 713, 10.1017/S0033291700022352

DeBellis, 1994, Hypothalamic pituitary adrenal axis dysregulation in sexually abused girls, J. Clin. Endocrinol. Metab., 78, 249

DeBellis, 1996, Antinuclaer autoantibodies and thyroid function in sexually abused girls, J. Trauma. Stress, 9, 369, 10.1002/jts.2490090218

De Castro, 1996, The non-ligand binding b-isoform of the human glucocorticoid receptor (hGRb): Tissue levels, mechanism of action, and potential physiological role, Mol. Med., 2, 597, 10.1007/BF03401643

DeGoeij, 1992, Repaeted stress enhances vasopression synthesis in corticotropin releasing factor neurons in the paraventricular nucleus, Brain Res., 577, 165, 10.1016/0006-8993(92)90552-K

Dekaris, 1993, Multiple changes of immunologic parameters in prisoners of war, J. Am. Med. Assoc., 270, 595, 10.1001/jama.1993.03510050061028

deKloet, 1991, Brain corticosteroid receptor balance and homeostatic control, Front. Neuroendocrinol., 12, 95

Delahanty, 1997, Chronic stress and natural killer cell activity after exposure to traumatic death, Psychosom. Med., 59, 467, 10.1097/00006842-199709000-00002

Demitrack, 1991, Evidence for impaired activation of the hypothalamic-pituitary-adrenal axis in patients with chronic fatigue syndrome, J. Clin. Endocrinol. Metab., 73, 1224, 10.1210/jcem-73-6-1224

Dhabhar, 1993, Stress response, adrenal steroid receptor levels and corticosteroid binding globulin levels—a comparison between Sprague-Dawley, Fischer 344 and Lewis rats, Brain Res., 616, 89, 10.1016/0006-8993(93)90196-T

Dhabhar, 1996, Stress-induced enhancement of antigen-specific cell-mediated immunity, J. Immunol., 156, 2608, 10.4049/jimmunol.156.7.2608

Dhabhar, 1997, Acute stress enhances while chronic stress suppresses immune function in vivo: a potential role for leukocyte trafficking, Brain, Behav. Immun., 11, 286, 10.1006/brbi.1997.0508

Dhabhar, 1999, Enhancing versus suppressive effects of stress hormones on skin immune function, Proc. Natl. Acad. Sci. USA, 96, 1059, 10.1073/pnas.96.3.1059

Dienstbier, 1989, Arousal and physiological toughness: implications for mental and physical health, Psycholog. Rev., 96, 84, 10.1037/0033-295X.96.1.84

Dupont, 1985, Influence of in vivo immunosuppressive drugs on production of lymphokines, Transplantation, 39, 143, 10.1097/00007890-198502000-00007

Dutton, 1978, Stress levels of ambulance paramedics and fire fighters, J. Occup. Med., 20, 111, 10.1097/00043764-197802000-00011

Ehlert, 1993, Psychoendokrinologische Untersuchungen bei Frauen mit chronischen Unterbauchbeschwerden

Elwan, 1991, Hormonal changes in headache patients, J. Neurol. Sci., 106, 75, 10.1016/0022-510X(91)90197-F

Faessler, 1986, Elevation of corticosteroid binding globulin in obese strain (OS) chickens: possible implications for the disturbed immunoregulation and the dvelopment of spontaneous autoimmune thyroiditis, J. Immunol., 136, 3657, 10.4049/jimmunol.136.10.3657

Fameli, 1994, Effects of hyperactivity of the maternal hypothalamic-pituitary-adrenal (HPA) axis during pregnancy on the development of the HPA axis and brain monoamiines in the offspring, Int. J. Dev. Neurosci., 12, 651, 10.1016/0736-5748(94)90017-5

Fauci, 1975, Mechanism of corticosteroid action on lymphocyte subpopulations. I. Redistribution of circulating T and B lymphocytes to the bone marrow, Immunology, 28, 669

Fauci, 1976, Mechanism of corticosteroid action on lymphocyte subpopulations. II. Differential effects of in vivo hydrocortisone, prednisone and dexamethasone on in vitro expression of lymphocyte function, Clin. Exp. Immunol., 24, 54

Fehm-Wolfsdorf, 1994

Ferraccioli, 1990, Neuroendocrinologic findings in primary fibromylagia and in other chronic rheumatic conditions, J. Rheumatol., 17, 869

Flower, 1979, Anti-inflammatory steroids induce biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generation, Nature, 278, 456, 10.1038/278456a0

Foy, 1987, Premilitary, military, and postmilitary factors in the development of combat-related stress disorders, Behav. Ther., 10, 3

France, 1985, The dexamethasone suppression test as a biologic marker of depression in chronic pain, Pain, 21, 49, 10.1016/0304-3959(85)90076-4

Friedman, 1963, Urinary 17-hydroxycorticosteroid levels in parents of children with neoplastic disease: a study of chronic psychological stress, Psychosom. Med., 25, 364, 10.1097/00006842-196307000-00007

Gatti, 1987, Inhibition by cortisol of human natural killer (NK) cell activity, J. Steroid Biochem., 26, 49, 10.1016/0022-4731(87)90030-6

Genazzani, 1975, Pattern of plasma ACTH, hGH, and cortisol during menstrual cycle, J. Clin. Endocrinol. Metab., 41, 431, 10.1210/jcem-41-3-431

Gerhards, 1997, Abnormal cerebral laterality in posttraumatic stress disorder, Ann. NY Acad. Sci., 821, 482, 10.1111/j.1749-6632.1997.tb48311.x

Goenjian, 1996, Basal cortisol and dexamethasone suppression oc cortisol among adolescents after the 1988 earthquake in Armenia, Am. J. Psychiatry, 153, 929, 10.1176/ajp.153.7.929

Gómez, 1996, Hypothalamic-pituitary-adrenal response to chronic stress in five inbred rat strains: differential responses are mainly located on the adrenocortical level, Neuroendocrinology, 63, 327, 10.1159/000126973

Green, 1987, Five psychosocial variables related to the existence of posttraumatic stress disorder symptoms, J. Clin. Psychol., 43, 643, 10.1002/1097-4679(198711)43:6<643::AID-JCLP2270430602>3.0.CO;2-R

Griep, 1993, Altered reactivity of the hypothalamic–pituitary–adrenal axis in the primary fibromyalgia syndrome, J. Rheumatol., 20, 469

Griep, 1998, Function of hypothalamic–pituitary–adrenal axis in patients with fibromyalgia and low back pain, J. Rheumatol., 25, 1374

Gurvits, 1996, Magnetic resonance imaging study of hippocampal volume in chronic, combat-related psottraumatic stress disorder, Biol. Psychiatry, 40, 193, 10.1016/S0006-3223(96)00229-6

Haas, 1988, Single or repeated mild stress increases synthesis and release of hypothalamic corticotropin-releasing factor, Brain Res., 461, 230, 10.1016/0006-8993(88)90254-5

Hamaty, 1989, The plasma endorphin, prostaglandin and catecholamine profile of patients with fibrositis treated with cyclobenzaprine and placebo: a 5 month study, J. Rheumatol., 19, 164

Handwerker, 1976, Influences of algogenic substances and prostaglandins on the discharges of unmyelinated cutaneous nerve fibers identified as nociceptors

Hauger, 1990, CRF receptor regulation and sensitization of ACTH responses to acute ether stress during chronic intermittent immobilization stress, Endocrinology, 123, 396, 10.1210/endo-123-1-396

Hauger, 1988, Corticotropin-releasing factor receptors and pituitary adrenal responses during immobilization stress, Endocrinology, 123, 396, 10.1210/endo-123-1-396

Hedman, 1992, Low blood and synovial fluid levels of sulpho-conjugated steroids in rheumatoid arthritis, Clin. Exp. Rheumatol., 10, 25

Heim, 1997, Psychoendocrinological observations in women with chronic pelvic pain, Ann. NY Acad. Sci., 821, 456, 10.1111/j.1749-6632.1997.tb48304.x

Heim, 1997, The role of early adverse life events in the etiology of major depression and posttraumatic stress disorder: focus on corticotropin-releasing factor, Ann. NY Acad. Sci., 821, 194, 10.1111/j.1749-6632.1997.tb48279.x

Heim, 1998, Abuse-related posttraumatic stress disorder and alterations of the hypothalamic-pituitary-adrenal axis in women with chronic pelvic pain, Psychosom. Med., 60, 309, 10.1097/00006842-199805000-00017

Heim, 1998, Discrimination of activation versus down-regulaion of the glucocortical receptor using a cytosolic binding assay combined with a whole cell Western blot, Soc. Neurosci. Abstr., 27, 4901

Heim, C., Ehlert, U., Hanker, J.P., Hellhammer, D.H., 1999. Psychological and endocrine correlates of chronic pelvic pain associated with adhesions. J. Psychosom. Obstet. Gynecol. 20, 11–20.

Hellhammer, J., 1990. Burnout bei Pflegepersonal—eine psychoendokrinologische Untersuchung. Diploma Thesis, University of Trier, Germany.

Hellhammer, 1993, Endocrine correlates of stress vulnerability, Psychother. Psychosom., 60, 8, 10.1159/000288675

Henry, 1993, Psychological and physiological responses to stress: the right hemisphere and the hypothalamo-pituitary-adrenal axis. An inquiry into problems of human bonding, Integr. Physiol. Behav. Sci., 28, 368, 10.1007/BF02690935

Henry, 1992, Shared neuroendocrine patterns of post-traumatic stress disorder and alexithymia, Psychosom. Med., 54, 407, 10.1097/00006842-199207000-00003

Hingtgen, 1994, Prostacyclin enhances the evoked release of substance P and calcitonin gene related peptide from rat sensory neurons, Brain Res., 655, 51, 10.1016/0006-8993(94)91596-2

Hirschberg, 1982, The effects of corticosteroids on the antigen presenting properties of human monocytes and endothelial cells, Clin. Immunol. Immunopathol., 23, 577, 10.1016/0090-1229(82)90320-8

Holsboer, 1985, ACTH, cortisol and corticosterone output after ovine corticotropin-releasing factor challenge during depression and after recovery, Biol. Psychiatry, 20, 276, 10.1016/0006-3223(85)90057-5

Hudson, 1994, The concept of affective spectrum disorder: releationship of fibromyalgia and other syndromes of chronic fatigue and chronic muscle pain, Bailliere’s Clin. Rheumatol., 4, 839, 10.1016/S0950-3579(05)80051-2

Hudson, 1984, The dexamethasone suppression test in fibrositis, Biol. Psychiatry, 19, 1489

Hug, 1990, Fibromyalgiesyndrom oft verkannte Realitaet, Schweiz. Med. Wochenschr., 120, 395

Imaki, 1991, Differential regulation of corticotropin-releasing factor mRNA in rat brain regions by glucocorticoids and stress, J. Neurosci., 11, 585, 10.1523/JNEUROSCI.11-03-00585.1991

Iowa Persian Gulf Study Group, 1997. Self reported illness and health status among Gulf War veterans. A population-based study. J. Am. Med. Assoc. 277, 238–245.

Johansson, 1981, Differences in serum cortisol concentrations in organic and psychogenic chronic pain syndromes, J. Psychosom. Res., 26, 351, 10.1016/0022-3999(82)90008-3

Kam, 1993, Combination of IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids, J. Immunol., 151, 3460, 10.4049/jimmunol.151.7.3460

Kaplan, 1988, The adrenal glands

Katz, 1970, Stress, distress, and ego defenses. Psychoendocrine response to impending breast tumor biopsy, Arch. Gen. Psychiatry, 23, 131, 10.1001/archpsyc.1970.01750020035005

Kaufman, 1997, The corticotropin-releasing hormone challenge in depressed abused, depressed nonabused, and normal control children, Biol. Psychiatry, 42, 669, 10.1016/S0006-3223(96)00470-2

Kelso, 1984, Glucocorticoid inhibition of lymphokine secretion by alloreactive T-lymphocyte clones, J. Immunol., 133, 784, 10.4049/jimmunol.133.2.784

Kirschbaum, 1992, Heritability of cortisol responses to hCRH, ergometry, and psychological stress in humans, J. Clin. Endocrinol. Metab., 75, 1526

Kruger, 1994, Die Diagnostik der Nebennierenrindeninsuffizienz bei steroidpflichtigem Asthma bronchiale: Der CRH-Test im Vergleich zu Kortisol Tagesprofil im Serum und Kortisol im 24h-Urin, Pneumologie, 48, 789

Ladd, 1996, Persistent changes in corticotropin-releasing factor neuronal systems induced by maternal deprivation, Endocrinology, 137, 1212, 10.1210/endo.137.4.8625891

Lentjes, 1998, Glucocorticoid receptors, fibromyalgia and low back pain, Psychoneuroendocrinology, 22, 603, 10.1016/S0306-4530(97)00061-9

Lykken, 1988, Habituation of the skin conductance in response to strong stimuli: a twin study, Psychophysiology, 25, 4, 10.1111/j.1469-8986.1988.tb00949.x

Makino, 1994, Corticosterone effects on corticotropin-releasing hormone mRNA in the central nucleus of the amygdala and the parvocellular region of the paraventricular nucleus of the hypothalamus, Brain Res., 640, 105, 10.1016/0006-8993(94)91862-7

Mason, 1968, Plasma and urinary 17-hydroxycorticosteroid responses to 72-hr. avoidance sessions in the monkey, Psychosom. Med., 30, 608, 10.1097/00006842-196809000-00021

Mason, 1988, Elevation of urinary norepinephrine/cortisol ratio in posttraumatic stress disorder, J. Nerv. Ment. Dis., 176, 498, 10.1097/00005053-198808000-00008

Mason, 1986, Urinary free-cortisol levels in post-traumatic stress disorder patients, J. Nerv. Ment. Dis., 174, 145, 10.1097/00005053-198603000-00003

McCain, 1989, Diurnal hormone variation in fibromyalgia syndrome: a comparison with rheumatoid arthritis, J. Rheumatol., 16, 154

McCranie, 1992, Negative parenting behavior. Combat exposure, and PTSD sympton severity: test of a person–event interaction model, J. Nervous Mental Dis., 180, 431, 10.1097/00005053-199207000-00005

McEwen, 1997, The role of adrenocorticoids as modulators of immune function in health and disease: neural, endocrine and immune interactions, Brain Res. Rev., 23, 79, 10.1016/S0165-0173(96)00012-4

McEwen, 1998, Protective and damaging effects of stress mediators, N. Engl. J. Med., 338, 171, 10.1056/NEJM199801153380307

McEwen, 1999, Stress and the aging hippocampus, Front. Neuroendocrinol., 20, 1, 10.1006/frne.1998.0173

McFarlane, 1988, Posttraumatic morbidity of a disaster: a study of cases presenting for psychiatric treatment, J. Nerv. Ment. Dis., 174, 4, 10.1097/00005053-198601000-00002

McKenzie, 1998, Low-dose hydrocortisone for treatment of chronic fatigue syndrome, J. Am. Med. Assoc., 280, 1061, 10.1001/jama.280.12.1061

Meaney, 1994, Early environmental programming of hypothalamic-pituitary-adrenal responses to stress, Semin. Neurosci., 6, 247, 10.1006/smns.1994.1032

Meikle, 1989, Relationship between body mass index, cigarette smoking and plasma sex steroids in normal male twins, Genetic Epidemiol., 6, 399, 10.1002/gepi.1370060303

Monjan, 1977, Stress-induced modulation of of the immune response, Science, 196, 307, 10.1126/science.557841

Morand, 1994, Impaired glucocorticoid induction of mononuclear leukocyte lipocortin-1 in rheumatoid arthritis, Arthritis Rheum., 37, 207, 10.1002/art.1780370209

Munck, 1984, Physiological functions of glucocorticoids in stress and their relation to pharmacological actions, Endocr. Rev., 5, 25, 10.1210/edrv-5-1-25

Murison, 1986, Serial stressors: prior exposure to a stressor modulates its later effectiveness on gastric ulceration and corticosterone release, Behav. Neural Biol., 45, 185, 10.1016/S0163-1047(86)90761-2

Natelson, 1988, Effect of stressor intensity on habituation of the adrenocortical stress response, Physiol. Behav., 43, 41, 10.1016/0031-9384(88)90096-0

Neeck, 1990, Adrenal secretion of cortisol in patients with rheumatoid arthritis, J. Rheumatol., 17, 24

Neeck, 1992, Adrenal secretion of cortisol in patients with rheumatoid arthritis, J. Rheumatol., 17, 24

Nemeroff, 1996, The corticotropin-releasing factor (CRF) hypothesis of depression: new findings and new directions, Mol. Psychiatry, 1, 336

Nemeroff, 1993, Adrenal gland enlargement in major depression, Arch. Gen. Psychiatry, 49, 384, 10.1001/archpsyc.1992.01820050048008

Nicol, 1992, Prostaglandin E2 increases calcium conductance and stimulates release of substance P in avian sensory neurons, J. Neurosci., 12, 1917, 10.1523/JNEUROSCI.12-05-01917.1992

Nimmagadda, 1997, Allergen exposure decreases glucocorticoid receptor binding affinity and steroid responsiveness in atopic asthmatics, Am. J. Resp. Crit. Care Med., 155, 87, 10.1164/ajrccm.155.1.9001294

Nyklı́ček, 1996, Alexithymia is associated with low tolerance to experimental painful stimulation, Psychosom. Med., 58, 66

Oakley, 1996, The human glucocorticoid receptor b isoform. Expression, biochemical properties, and putative function, J. Biol. Chem., 271, 9550, 10.1074/jbc.271.16.9550

Orr, 1990, Hyperresponsiveness of the rat neuroendocrine system due to repeated exposure to stress, Psychoneuroendocrinology, 15, 317, 10.1016/0306-4530(90)90057-G

Orth, 1992, The adrenal cortex, 489

Ottenweller, 1989, Adrenocortical and behavioral responses to repeated stressors: toward an animal model of chronic stress and stress-related mental illness, Biol. Psychiatry, 26, 829, 10.1016/0006-3223(89)90123-6

Owens, 1991, Physiology and pharmacology of corticotropin-releasing factor, Pharm. Rev., 43, 425

Pavcovich, 1997, Regulation of a putative neurotransmitter effect of corticotropin-releasing factor: effects of adrenalectomy, J. Neurosci., 17, 401, 10.1523/JNEUROSCI.17-01-00401.1997

Pariante, 1997, Steroid-independent translocation of the glucocorticoid receptor by the antidepresant desipramine, Mol. Pharmacol., 52, 571, 10.1124/mol.52.4.571

Pariante, 1997, The proinflammatory cytokine, interleukin-1 alpha, reduces glucocorticoid receptor translocation and function, Soc. Neurosci. Abstr., 24, 201.1

Piazza, 1997, Glucocorticoids as a biological substrate for reward: Physiological and pathophysiological implications, Brain Res. Rev., 25, 359, 10.1016/S0165-0173(97)00025-8

Poteliakhoff, 1981, Adrenocortical activity and some clinical findings in acute and chronic fatigue, J. Psychosom. Res., 25, 91, 10.1016/0022-3999(81)90095-7

Pruessner, 1999, Burnout, perceived stress and salivary cortisol upon awakening, Psychosom. Med., 61, 197, 10.1097/00006842-199903000-00012

Rivier, 1987, Diminished responsiveness of the hypothalamic pituitary adrenal axis of the rat during exposure to prolonged stress: a pituitary mediated-mechanism, Endocrinology, 121, 1320, 10.1210/endo-121-4-1320

Rose, 1968, Psychological state and body size as determinants of 17-OHLS excretion, Arch. Intern. Med., 121, 406, 10.1001/archinte.1968.03640050016004

Rosmond, 1998, Stress-related cortisol secretion in men: Relationships between abdominal obesity and endocrine, metabolic and hemodynamic abnormalities, J. Clin. Endocrinol. Metab., 83, 1853

Rubin, 1995, Adrenal gland volume in major depression: increase during depressive episode and decrease with successful treatment, Arch. Gen. Psychiatry, 52, 213, 10.1001/archpsyc.1995.03950150045009

Ruch, 1980, Life change and rape impact, J. Health Soc. Behav., 21, 248, 10.2307/2136619

Rupprecht, 1991, Elevated glucocorticoid receptor concentrations before and after glucocorticoid therapy in peripheral mononuclear leukocytes of patients with atopic dermatitis, Dermatologica, 183, 100, 10.1159/000247646

Sapolsky, 1985, Prolonged glucocorticoid exposure reduces hippocampal neuron number: implications for aging, J. Neurosci., 5, 1222, 10.1523/JNEUROSCI.05-05-01222.1985

Sapolsky, 1986, The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis, Endoc. Rev., 7, 284, 10.1210/edrv-7-3-284

Schaffner, 1985, Therapeutic concentrations of glucocorticoids suppress the antimicrobial activity of human macrophages without impairing their responsiveness to interferon, J. Clin. Investig., 76, 1755, 10.1172/JCI112166

Schlaghecke, 1992, Glucocorticoid receptors in rheumatoid arthritis, Arthritis Rheum., 35, 740, 10.1002/art.1780350704

Schmid-Ott, 1998, Stress-induced endocrine and immunological changes in psoriasis patients and healthy controls, Psychother. Psychosom., 67, 37, 10.1159/000012257

Scott, 1994, Post traumatic stress disorder without the trauma, Br. J. Clin. Psychol., 33, 71, 10.1111/j.2044-8260.1994.tb01095.x

Scott, 1998, Blunted adrenocorticotropin and cortisol responses to corticotropin-releasing hormone stimulation in chronic fatigue syndrome, Acta Psychiatr. Scand., 97, 450, 10.1111/j.1600-0447.1998.tb10030.x

Scott, 1998, The low dose ACTH test in chronic fatigue syndrome and in health, Clin. Endocrinol., 48, 733, 10.1046/j.1365-2265.1998.00418.x

Seligman, 1975

Selye, 1936, A syndrome produced by diverse noxious agents, Nature, 138, 32, 10.1038/138032a0

Sephton, 1998, Absence of diurnal cortisol variation predicts early breast cancer mortality, Psychoneuroendocrinology, 23, S51

Sharav, 1987, The analgesic effect of amitriptyline on chronic facial pain, Pain, 31, 199, 10.1016/0304-3959(87)90036-4

Sher, 1994, Steroid-resistant asthma. Cellular mechanisms contributing to inadequate response to glucocorticoid therapy, J. Clin. Investig., 93, 33, 10.1172/JCI116963

Sieber, 1996, Predictors of PTSD in a physically traumatized population, Psychosom. Med., 58, 95

Smith, 1989, The corticotropin-releasing hormone test in patients with posttraumatic stress disorder, Biol. Psychiatry, 26, 349, 10.1016/0006-3223(89)90050-4

Smyth, 1998, Stressors and mood measured on a momentary basis are associated with salivary cortisol secretion, Psychoneuroendocrinology, 23, 353, 10.1016/S0306-4530(98)00008-0

Spahn, 1995, Reduced glucocorticoid binding affinity in asthma is related to ongoing allergic inflammation, Am. J. Resp. Crit. Care Med., 151, 1709, 10.1164/ajrccm.151.6.7767511

Spahn, 1996, A novel action of IL-13. Induction of diminished monocyte glucocorticoid receptor-binding affinity, J. Immunol., 157, 2654, 10.4049/jimmunol.157.6.2654

Spivak, 1997, Elevated levels of serum interleukin-1β in combat-related posttraumatic stress disorder, Biol. Psychiatry, 42, 345, 10.1016/S0006-3223(96)00375-7

Stein, 1997, Enhanced dexamethasone suppression of plasma cortisol in a adult women traumatized by childhood sexual abuse, Biol. Psychiatry, 42, 680, 10.1016/S0006-3223(96)00489-1

Stein, 1997, Hippocampal volume in women victimized by childhood sexual abuse, Psychol. Med., 27, 951, 10.1017/S0033291797005242

Sternberg, 1989, Inflammatory mediator-induced hypothalamic–pituitary–adrenal axis activation is defective in streptococcal cell wall arthritis-susceptible Lewis-rats, Proc. Natl. Acad. Sci. USA, 86, 2374, 10.1073/pnas.86.7.2374

Sternberg, 1989, A central nervous system defect in biosynthesis of corticotropin releasing hormone is associated with susceptibility to streptococcal cell wall induced arthritis in Lewis rats, Proc. Natl. Acad. Sci. USA, 86, 4771, 10.1073/pnas.86.12.4771

Sternberg, 1993, Hypoimmune fatigue syndromes: diseases of the stress response?, J. Rheumatol., 20, 418

Stokes, 1984, Pretreatment DST and hypothalamic pituitary adrenocortical function in depressed patients and comparison groups. A multicenter study, Arch. Gen. Psychiatry, 41, 257, 10.1001/archpsyc.1984.01790140047006

Stone, 1998, How accurate are current coping assessments? A comparison of momentary versus end-of-day reports of coping efforts, J. Personal. Soc. Psychol., 74, 1670, 10.1037/0022-3514.74.6.1670

Stratakis, 1994, Glucocorticosteroid resistance in humans. Elucidation of the molecular mechanisms and implications for pathophysiology, Ann. NY Acad. Sci., 746, 362, 10.1111/j.1749-6632.1994.tb39257.x

Swanson, 1989, Differential steroid hormone and neural influences on peptide mRNA levels in CRH cells of the paraventricular nucleus: a hybridization histochemical study in the rat, J. Comp. Neural., 285, 413, 10.1002/cne.902850402

Takasu, 1990, Exacerbation of autoimmune thyroid dysfunction after unilateral adrenalectomy in patients with Cushing’s syndrome due to an adrenocortical adenoma, N. Engl. J. Med., 322, 1708, 10.1056/NEJM199006143222404

Tandon, 1991, Menstrual cycle effects on the dexamethasone suppression test in major depression, Biol. Psychiatry, 47, 512

Taylor, 1985, Toward the development of a new self-report alexithymia-scale, Psychother. Psychosom., 44, 191, 10.1159/000287912

Tersman, 1991, Cardiovascular responses to psychological and physiological stressors during the menstrual cycle, Psychosom. Med., 53, 185, 10.1097/00006842-199103000-00008

Thompson, 1980, Endogenous cortisol: a regulator of the number of lymphocytes in peripheral blood, Clin. Immunol. Immunopathol., 17, 506, 10.1016/0090-1229(80)90146-4

True, 1993, A twin study of genetic and environmental contributions to liability for posttraumatic stress symptoms, Arch. Gen. Psychiatry, 50, 257, 10.1001/archpsyc.1993.01820160019002

Valdés, 1989, Psychogenic pain and depressive disorders: a empirical study, J. Affect. Disord., 16, 21, 10.1016/0165-0327(89)90050-5

van Denderen, 1992, Physiological effects of exhaustive physical exercise in primary fibromyalgia syndrome (PFS), Scand. J. Rheumatol., 21, 35, 10.3109/03009749209095060

Verheggen, 1996, Modulation of glucocorticoid receptor expression in human bronchial epithelial cell lines by IL-1β, TNF-α and LPS, Eur. Resp. J., 9, 2036, 10.1183/09031936.96.09102036

von Knorring, 1989, Neuroendocrine responses to fenfluramine in patients with idiopathic pain syndromes, Nord. Psykiatr. Tidsskr., 43, 61, 10.3109/08039488909100835

Walker, 1989, Differential activation of the pituitary-adrenocortical axis after stress in the rat: use of two genetically selected lines (Roman low and high avoidance rats) as a model, J. Endocrinol., 123, 477, 10.1677/joe.0.1230477

Wallace, 1987, The role of stress and trauma in rheumatoid arthritis and systemic lupus erythematosus, Semin. Arthritis Rheum., 16, 153, 10.1016/0049-0172(87)90018-7

Wallace, 1988, Acute onset of fibromyalgia as a complication of IL-2 therapy, Arthritis Rheum., 31, S24

Wang, 1996, Stages of decompensation in combat-related post-traumatic stress disorder: a new conceptual model, Integ. Physiol. Behav. Sci., 31, 237, 10.1007/BF02691455

Waylonis, 1992, Fibromyalgia syndrome. New associations, Am. J. Phys. Med. Rehab., 71, 343, 10.1097/00002060-199212000-00006

Weiss, 1989, Behavioral and neural influences on cellular immune responses: effects of stress and interleukin-1, J. Clin. Psychiatry, 50, 43

Wiegers, 1994, Enhancement of rat splenic lymphocyte mitogenesis after short-term preexposure to corticosteroids in vitro, Endocrinology, 135, 1257, 10.1210/endo.135.6.7988417

Wolff, 1964, Relationship between psychological defenses and mean urinary 17-hydroxicorticosteroid excretion rates. Methodologic and theoretical considerations, Psychosom. Med., 26, 592, 10.1097/00006842-196409000-00003

Yehuda, 1990, Low urinary cortisol excretion in patients with post-traumatic stress disorder, J. Nerv. Ment. Dis., 178, 366, 10.1097/00005053-199006000-00004

Yehuda, 1991, Hypothalamic pituitary adrenal dysfunction in posttraumatic stress disorder, Biol. Psychiatry, 30, 1031, 10.1016/0006-3223(91)90123-4

Yehuda, 1991, Increased number of glucocorticoid receptor in posttraumatic stress disorder, Am. J. Psychiatry, 148, 499, 10.1176/ajp.148.4.499

Yehuda, 1993, Glucocorticoid receptor number and cortisol excretion in mood, anxiety, and psychotic disorders, Biol. Psychiatry, 34, 18, 10.1016/0006-3223(93)90252-9

Yehuda, 1993, Long lasting hormonal alterations to extreme stress in humans: normative or maladaptive?, Psychosom. Med., 55, 287, 10.1097/00006842-199305000-00006

Yehuda, 1993, Enhanced suppression of cortisol following dexamethasone administration in posttraumatic stress disorder, Am. J. Psychiatry, 150, 83, 10.1176/ajp.150.1.83

Yehuda, 1995, Dose-response changes in plasma cortisol and lymphocyte glucocorticoid receptors following dexamethasone administration in combat veterans with and without posttraumatic stress disorder, Arch. Gen. Psychiatry, 52, 538, 10.1001/archpsyc.1995.03950190065010

Yehuda, 1995, Low urinary cortisol excretion in Holocaust survivors with PTSD, Am. J. Psychiatry, 152, 245

Yehuda, 1995, Impact of cumulative lifetime trauma and recent stress on posttraumatic stress disorder symptoms in Holocaust survivors, Am. J. Psychiatry, 152, 1815, 10.1176/ajp.152.12.1815

Yehuda, 1996, Cortisol regulation in posttraumatic stress disorder and major depression: a chronobiological analysis, Biol. Psychiatry, 40, 79, 10.1016/0006-3223(95)00451-3

Yehuda, 1997, Sensitization of the hypothalamic-pituitary-adrenal axis in posttraumatic stress disorder, Ann. NY Acad. Sci., 821, 57, 10.1111/j.1749-6632.1997.tb48269.x

Yehuda, 1997, Increased pituitary activation following metyrapone administration in PTSD, Psychoneuroendcrinology, 21, 1

Yehuda, 1997, Alexithymia in Holocaust survivors with and without PTSD, J. Trauma. Stress, 10, 93, 10.1002/jts.2490100108

Yehuda, 1998, Predicting the development of posttraumatic stress disorder from acute response to a traumtic event, Biol. Psychiatry, 44, 1305, 10.1016/S0006-3223(98)00276-5

Yunus, 1994, Psychological aspects of fibromyalgia syndrome: a component of the dysfunctional spectrum syndrome, Bailliere’s Clin. Rheumatol., 4, 811, 10.1016/S0950-3579(05)80050-0

Zaidi, 1994, Childhood abuse experiences and combat related PTSD, J. Trauma. Stress, 7, 33, 10.1002/jts.2490070105

Zeitlin, 1993, Alexithymia in victims of sexual assault: an effect of repeated traumatization?, Am. J. Psychiatry, 150, 661, 10.1176/ajp.150.4.661