Tiềm năng ứng dụng liệu pháp gen trong điều trị chấn thương sọ não

Armstead WM, Hecker JG (2005)Heat shock protein modulation of KATP and KCa channel cerebrovasodilation after brain injury. Am J Physiol Heart Circ Physiol 289:H1184–H1190

Awasthi D, Kutz SC, Beuerman R, Nguyen D, Carey ME, Zeiller S (2003) Early gene expression in the rat cortex after experimental traumatic brain injury and hypotension. Neurosci Lett 345:29–32

Blomer U, Naldini L, Kafri T, Trono D, Verma IM, Gage FH (1997) Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector. J Virol 71:6641–6649

Carmichael ST (2003) Gene expression changes after focal stroke, traumatic brain and spinal cord injuries. Curr Opin Neurol 16:699–704

Consiglio A, Gritti A, Dolcetta D, Follenzi A, Bordignon C, Gage FH, Vescovi AL, Naldini L (2004) Robust in vivo gene transfer into adult mammalian neural stem cells by lentiviral vectors. Proc Natl Acad Sci USA 101:14835–14840

da Cruz MT, Cardoso AL, de Almeida LP, Simoes S, de Lima MC (2005) Tf-lipoplex-mediated NGF gene transfer to the CNS: neuronal protection and recovery in an excitotoxic model of brain injury. Gene Ther 12:1242–1252

de Lima MC, da Cruz MT, Cardoso AL, Simoes S, de Almeida LP (2005) Liposomal and viral vectors for gene therapy of the central nervous system. Curr Drug Targets CNS Neurol Disord 4:453–465

Demeneix B, Hassani Z, Behr JP (2004) Towards multifunctional synthetic vectors. Curr Gene Ther 4:445–455

Dietrich WD, Alonso O, Busto R, Prado R, Zhao W, Dewanjee MK, Ginsberg MD (1998) Posttraumatic cerebral ischemia after fluid percussion brain injury: an autoradiographic and histopathological study in rats. Neurosurgery 43:585–593; discussion 593–584

Dull T, Zufferey R, Kelly M, Mandel RJ, Nguyen M, Trono D, Naldini L (1998) A third-generation lentivirus vector with a conditional packaging system. J Virol 72:8463–8471

Gage FH (2000) Mammalian neural stem cells. Science 287:1433–1438

Geraerts M, Eggermont K, Hernandez-Acosta P, Garcia-Verdugo JM, Baekelandt V, Debyser Z (2006) Lentiviral vectors mediate efficient and stable gene transfer in adult neural stem cells in vivo. Hum Gene Ther 17:635–650

Gupta A, Ho DY, Brooke S, Franklin L, Roy M, McLaughlin J, Fink SL, Sapolsky RM (2001) Neuroprotective effects of an adenoviral vector expressing the glucose transporter: a detailed description of the mediating cellular events. Brain Res 908:49–57

Hannon GJ, Rossi JJ (2004) Unlocking the potential of the human genome with RNA interference. Nature 431:371–378

Hermann DM, Kilic E, Kugler S, Isenmann S, Bahr M (2001) Adenovirus-mediated glial cell line-derived neurotrophic factor (GDNF) expression protects against subsequent cortical cold injury in rats. Neurobiol Dis 8:964–973

Hovda DA, Villablanca JR, Chugani HT, Phelps ME (1996) Cerebral metabolism following neonatal or adult hemineodecortication in cats: I. Effects on glucose metabolism using [14C]2-deoxy-D-glucose autoradiography. J Cereb Blood Flow Metab 16:134–146

Kennedy PG (1997) Potential use of herpes simplex virus (HSV) vectors for gene therapy of neurological disorders. Brain 120(Pt 7):1245–1259

Kim CD, Shin HK, Lee HS, Lee JH, Lee TH, Hong KW (2002) Gene transfer of Cu/Zn SOD to cerebral vessels prevents FPI-induced CBF autoregulatory dysfunction. Am J Physiol Heart Circ Physiol 282:H1836–H1842

Klein RL, Dayton RD, Leidenheimer NJ, Jansen K, Golde TE, Zweig RM (2006) Efficient neuronal gene transfer with AAV8 leads to neurotoxic levels of tau or green fluorescent proteins. Mol Ther 13:517–527

Kochanek PM, Janesko KL, Jenkins LW, Yan HQ, Kibbe MR, Robichaud P, Wooditch AC, Clark RS, Dixon CE, Marion DW, Billiar TR (2001) Adenovirus-mediated transfer and expression of beta-gal in injured hippocampus after traumatic brain injury in mice. J Neurotrauma 18:73–82

Lawrence MS, Foellmer HG, Elsworth JD, Kim JH, Leranth C, Kozlowski DA, Bothwell AL, Davidson BL, Bohn MC, Redmond DE Jr (1999) Inflammatory responses and their impact on beta-galactosidase transgene expression following adenovirus vector delivery to the primate caudate nucleus. Gene Ther 6:1368–1379

Li HH, Lee SM, Cai Y, Sutton RL, Hovda DA (2004) Differential gene expression in hippocampus following experimental brain trauma reveals distinct features of moderate and severe injuries. J Neurotrauma 21:1141–1153

Long Y, Zou L, Liu H, Lu H, Yuan X, Robertson CS, Yang K (2003) Altered expression of randomly selected genes in mouse hippocampus after traumatic brain injury. J Neurosci Res 71:710–720

Longhi L, Watson DJ, Saatman KE, Thompson HJ, Zhang C, Fujimoto S, Royo N, Castelbuono D, Raghupathi R, Trojanowski JQ, Lee VM, Wolfe JH, Stocchetti N, McIntosh TK (2004) Ex vivo gene therapy using targeted engraftment of NGF-expressing human NT2N neurons attenuates cognitive deficits following traumatic brain injury in mice. J Neurotrauma 21:1723–1736

Lu J, Moochhala S, Kaur C, Ling E (2000) Changes in apoptosis-related protein (p53, Bax, Bcl-2 and Fos) expression with DNA fragmentation in the central nervous system in rats after closed head injury. Neurosci Lett 290:89–92

Marshall E (2002) Clinical research. Gene therapy a suspect in leukemia-like disease. Science 298:34–35

McKay R (1997) Stem cells in the central nervous system. Science 276:66–71

McMenamin MM, Byrnes AP, Charlton HM, Coffin RS, Latchman DS, Wood MJ (1998) A gamma34.5 mutant of herpes simplex 1 causes severe inflammation in the brain. Neuroscience 83:1225–1237

Michael DB, Byers DM, Irwin LN (2005) Gene expression following traumatic brain injury in humans: analysis by microarray. J Clin Neurosci 12:284–290

Miletic H, Fischer YH, Neumann H, Hans V, Stenzel W, Giroglou T, Hermann M, Deckert M, Von Laer D (2004) Selective transduction of malignant glioma by lentiviral vectors pseudotyped with lymphocytic choriomeningitis virus glycoproteins. Hum Gene Ther 15:1091–1100

Muzzin P, Cusin I, Charnay Y, Rohner-Jeanrenaud F (2000) Single intracerebroventricular bolus injection of a recombinant adenovirus expressing leptin results in reduction of food intake and body weight in both lean and obese Zucker fa/fa rats. Regul Pept 92:57–64

Naldini L, Blomer U, Gallay P, Ory D, Mulligan R, Gage FH, Verma IM, Trono D (1996) In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272:263–267

Newcomb JK, Zhao X, Pike BR, Hayes RL (1999) Temporal profile of apoptotic-like changes in neurons and astrocytes following controlled cortical impact injury in the rat. Exp Neurol 158:76–88

Ni CH, Jiang JY (1997) The research progress in the molecular biology of brain injury (in Chinese). J Int Neurol Neurosurg 24:232–234

Oyesiku NM, Evans CO, Houston S, Darrell RS, Smith JS, Fulop ZL, Dixon CE, Stein DG (1999) Regional changes in the expression of neurotrophic factors and their receptors following acute traumatic brain injury in the adult rat brain. Brain Res 833:161–172

Persson A, Fan X, Widegren B, Englund E (2006) Cell type- and region-dependent coxsackie adenovirus receptor expression in the central nervous system. J Neurooncol 78:1–6

Philips MF, Mattiasson G, Wieloch T, Bjorklund A, Johansson BB, Tomasevic G, Martinez-Serrano A, Lenzlinger PM, Sinson G, Grady MS, McIntosh TK (2001) Neuroprotective and behavioral efficacy of nerve growth factor-transfected hippocampal progenitor cell transplants after experimental traumatic brain injury. J Neurosurg 94:765–774

Phillips RG, Monje ML, Giuli LC, Meier TJ, Yenari MA, Kunis D, Sapolsky RM (2001) Gene therapy effectiveness differs for neuronal survival and behavioral performance. Gene Ther 8:579–585

Quintana A, Giralt M, Rojas S, Penkowa M, Campbell IL, Hidalgo J, Molinero A (2005) Differential role of tumor necrosis factor receptors in mouse brain inflammatory responses in cryolesion brain injury. J Neurosci Res 82:701–716

Ralph GS, Radcliffe PA, Day DM, Carthy JM, Leroux MA, Lee DC, Wong LF, Bilsland LG, Greensmith L, Kingsman SM, Mitrophanous KA, Mazarakis ND, Azzouz M (2005) Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model. Nat Med 11:429–433

Raoul C, Abbas-Terki T, Bensadoun JC, Guillot S, Haase G, Szulc J, Henderson CE, Aebischer P (2005) Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS. Nat Med 11:423–428

Ruitenberg MJ, Eggers R, Boer GJ, Verhaagen J (2002) Adeno-associated viral vectors as agents for gene delivery: application in disorders and trauma of the central nervous system. Methods 28:182–194

Shi N, Pardridge WM (2000) Noninvasive gene targeting to the brain. Proc Natl Acad Sci USA 97:7567–7572

Shi N, Zhang Y, Zhu C, Boado RJ, Pardridge WM (2001) Brain-specific expression of an exogenous gene after i.v. administration. Proc Natl Acad Sci USA 98:12754–12759

Singer O, Marr RA, Rockenstein E, Crews L, Coufal NG, Gage FH, Verma IM, Masliah E (2005) Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model. Nat Neurosci 8:1343–1349

Tuszynski MH, Gage FH (1995) Maintaining the neuronal phenotype after injury in the adult CNS. Neurotrophic factors, axonal growth substrates, and gene therapy. Mol Neurobiol 10:151–167

Van Damme A, Thorrez L, Ma L, Vandenburgh H, Eyckmans J, Dell’Accio F, De Bari C, Luyten F, Lillicrap D, Collen D, VandenDriessche T, Chuah MK (2006) Efficient lentiviral transduction and improved engraftment of human bone marrow mesenchymal cells. Stem Cells 24:896–907

Van den Haute C, Eggermont K, Nuttin B, Debyser Z, Baekelandt V (2003) Lentiviral vector-mediated delivery of short hairpin RNA results in persistent knockdown of gene expression in mouse brain. Hum Gene Ther 14:1799–1807

Vitarbo EA, Chatzipanteli K, Kinoshita K, Truettner JS, Alonso OF, Dietrich WD (2004) Tumor necrosis factor alpha expression and protein levels after fluid percussion injury in rats: the effect of injury severity and brain temperature. Neurosurgery 55:416–424; discussion 424–415

Watson DJ, Longhi L, Lee EB, Fulp CT, Fujimoto S, Royo NC, Passini MA, Trojanowski JQ, Lee VM, McIntosh TK, Wolfe JH (2003) Genetically modified NT2N human neuronal cells mediate long-term gene expression as CNS grafts in vivo and improve functional cognitive outcome following experimental traumatic brain injury. J Neuropathol Exp Neurol 62:368–380

Wennersten A, Holmin S, Mathiesen T (2003) Characterization of Bax and Bcl-2 in apoptosis after experimental traumatic brain injury in the rat. Acta Neuropathol (Berl) 105:281–288

Wiznerowicz M, Trono D (2005) Harnessing HIV for therapy, basic research and biotechnology. Trends Biotechnol 23:42–47

Wong J, Hoe NW, Zhiwei F, Ng I (2005) Apoptosis and traumatic brain injury. Neurocrit Care 3:177–182

Yang K, Clifton GL, Hayes RL (1997) Gene therapy for central nervous system injury: the use of cationic liposomes: an invited review. J Neurotrauma 14:281–297

Yang XF, Zheng XS, Liu WG, Feng JF (2006) Bcl-2 gene therapy for apoptosis following traumatic brain injury. Chin J Traumatol 9:276–281

Zou LL, Huang L, Hayes RL, Black C, Qiu YH, Perez-Polo JR, Le W, Clifton GL, Yang K (1999) Liposome-mediated NGF gene transfection following neuronal injury: potential therapeutic applications. Gene Ther 6:994–1005

Zufferey R, Nagy D, Mandel RJ, Naldini L, Trono D (1997) Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo. Nat Biotechnol 15:871–875