The polo-like kinase inhibitor BI 2536 exhibits potent activity against malignant plasma cells and represents a novel therapy in multiple myeloma
Tài liệu tham khảo
Takaki, 2008, Polo-like kinase 1 reaches beyond mitosis—cytokinesis, DNA damage response, and development, Curr Opin Cell Biol, 20, 650, 10.1016/j.ceb.2008.10.005
Ikezoe, 2009, A novel treatment strategy targeting polo-like kinase 1 in hematological malignancies, Leukemia, 23, 1564, 10.1038/leu.2009.94
Renner, 2009, Polo-like kinase 1 is overexpressed in acute myeloid leukemia and its inhibition preferentially targets the proliferation of leukemic cells, Blood, 114, 659, 10.1182/blood-2008-12-195867
Steegmaier, 2007, BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo, Curr Biol, 17, 316, 10.1016/j.cub.2006.12.037
Ramasamy K, Khatun H, Macpherson L, Mufti GJ, Schey S, Calle Y. Direct effect on the stroma by the conventional anti-multiple myeloma drug dexamethasone results in resistance of multiple myeloma plasma cells against therapy. Sensitisation to dexamethasone by the kinase inhibitor dasatinib. American Society of Haematology Annual Scientific Meeting, Abstract 193, December 2010.
Stewart, 2009, Substrate-induced phenotypical change of monocytes/macrophages into myofibroblast-like cells: a new insight into the mechanism of in-stent restenosis, J Biomed Mater Res A, 90, 465, 10.1002/jbm.a.32100
Tategu, 2008, Transcriptional regulation of human polo-like kinases and early mitotic inhibitor, J Genet Genom, 35, 215, 10.1016/S1673-8527(08)60030-2
Dezorella, 2009, Mesenchymal stromal cells revert multiple myeloma cells to less differentiated phenotype by the combined activities of adhesive interactions and interleukin-6, Exp Cell Res, 315, 1904, 10.1016/j.yexcr.2009.03.016
Poder, 2009, Bone marrow microenvironment and the identification of new targets for myeloma therapy, Leukemia, 23, 10, 10.1038/leu.2008.259
Strebhardt, 2010, Multifaceted polo-like kinases drug targets and antitargets for cancer therapy, Nat Rev Drug Discov, 9, 643, 10.1038/nrd3184
Schöffski, 2009, Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology, Oncologist, 14, 559, 10.1634/theoncologist.2009-0010
Winkless, 2005, Differential regulation of polo-like kinases 1,2,3 and 4 gene expression in mammalian cells and tissues, Oncogene, 24, 260, 10.1038/sj.onc.1208219
Zimmerman, 2007, Polo-like kinase 3 is required for entry into S phase, Proc Natl Acad Sci U S A, 104, 1847, 10.1073/pnas.0610856104
Dai, 2002, Down-regulation of PLK3 gene expression by types and amount of dietary fat in rat colon tumors, Int J Oncol, 20, 121
Habedanck, 2005, The Polo kinase Plk4 functions in centriole duplication, Nat Cell Biol, 7, 1140, 10.1038/ncb1320
Drewinko, 1981, The growth fraction of human myeloma cells, Blood, 57, 333, 10.1182/blood.V57.2.333.333
Sebastian, 2010, The efficacy and safety of BI 2536, a novel Plk-1 inhibitor, in patients with stage IIIB/IV non-small cell lung cancer who had relapsed after, or failed, chemotherapy: results from an open-label, randomized phase II clinical trial, J Thorac Oncol, 5, 1060, 10.1097/JTO.0b013e3181d95dd4
Lens, 2010, Shared and separate functions of polo-like kinases and aurora kinases in cancer, Nat Rev Cancer, 10, 825, 10.1038/nrc2964
Fulda, 2009, Caspase-8 in cancer biology and therapy, Cancer Lett, 281, 128, 10.1016/j.canlet.2008.11.023
Basak, 2009, Multiple myeloma bone marrow niche, Curr Pharm Biotechnol, 10, 345, 10.2174/138920109787847493
Meads, 2008, The bone marrow microenvironment as a tumor sanctuary and contributor to drug resistance, Clin Cancer Res, 14, 2519, 10.1158/1078-0432.CCR-07-2223
Zhang, 1989, Interleukin-6 is a potent myeloma-cell growth factor in patients with aggressive multiple myeloma, Blood, 74, 11, 10.1182/blood.V74.1.11.11
Negri, 2009, In vitro anti-myeloma activity of the aurora kinase inhibitor VE-465, Br J Haematol, 147, 672, 10.1111/j.1365-2141.2009.07891.x
Macůrek, 2008, Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery, Nature, 455, 119, 10.1038/nature07185
Shi, 2007, Targeting aurora kinases as therapy in multiple myeloma, Blood, 109, 3915, 10.1182/blood-2006-07-037671
Chng, 2008, The centrosome index is a powerful prognostic marker in myeloma and identifies a cohort of patients that might benefit from aurora kinase inhibition, Blood, 111, 1603, 10.1182/blood-2007-06-097774
Evans, 2008, The selective Aurora B kinase inhibitor AZD1152 is a potential new treatment for multiple myeloma, Br J Haematol, 140, 295, 10.1111/j.1365-2141.2007.06913.x
Hose, 2009, Inhibition of aurora kinases for tailored risk-adapted treatment of multiple myeloma, Blood, 113, 4331, 10.1182/blood-2008-09-178350
Evans, 2008, Aurora A kinase RNAi and small molecule inhibition of Aurora kinases with VE-465 induce apoptotic death in multiple myeloma cells, Leuk Lymphoma, 49, 559, 10.1080/10428190701824544
Wang, 2010, Preclinical activity of a novel multiple tyrosine kinase and aurora kinase inhibitor, ENMD-2076, against multiple myeloma, Br J Haematol, 150, 313, 10.1111/j.1365-2141.2010.08248.x
Görgün, 2010, A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma, Blood, 115, 5202, 10.1182/blood-2009-12-259523
Chopra, 2010, Polo-like kinase inhibitors: an emerging opportunity for cancer therapeutics, Exp Opin Invest Drugs, 19, 27, 10.1517/13543780903483191