The physiology of endocrine systems with ageing

Kennedy, 2014, Geroscience: linking aging to chronic disease, Cell, 159, 709, 10.1016/j.cell.2014.10.039 Cavadas, 2016, The pathophysiology of defective proteostasis in the hypothalamus—from obesity to ageing, Nat Rev Endocrinol, 12, 723, 10.1038/nrendo.2016.107 Surks, 2004, Subclinical thyroid disease: scientific review and guidelines for diagnosis and management, JAMA, 291, 228, 10.1001/jama.291.2.228 Bremner, 2012, Age-related changes in thyroid function: a longitudinal study of a community-based cohort, J Clin Endocrinol Metab, 97, 1554, 10.1210/jc.2011-3020 Waring, 2012, Longitudinal changes in thyroid function in the oldest old and survival: the cardiovascular health study all-stars study, J Clin Endocrinol Metab, 97, 3944, 10.1210/jc.2012-2481 Bjergved, 2012, Predictors of change in serum TSH after iodine fortification: an 11-year follow-up to the DanThyr study, J Clin Endocrinol Metab, 97, 4022, 10.1210/jc.2012-2508 Chaker, 2016, Thyroid function characteristics and determinants: the Rotterdam Study, Thyroid, 26, 1195, 10.1089/thy.2016.0133 Hoogendoorn, 2006, Thyroid function and prevalence of anti-thyroperoxidase antibodies in a population with borderline sufficient iodine intake: influences of age and sex, Clin Chem, 52, 104, 10.1373/clinchem.2005.055194 Mammen, 2017, Unstable thyroid function in older adults is caused by alterations in both thyroid and pituitary physiology and is associated with increased mortality, Thyroid, 27, 1370, 10.1089/thy.2017.0211 Strich, 2016, TSH enhancement of FT4 to FT3 conversion is age dependent, Eur J Endocrinol, 175, 49, 10.1530/EJE-16-0007 van den Beld, 2005, Thyroid hormone concentrations, disease, physical function, and mortality in elderly men, J Clin Endocrinol Metab, 90, 6403, 10.1210/jc.2005-0872 Burman, 1980, Nature of suppressed TSH secretion during undernutrition: effect of fasting and refeeding on TSH responses to prolonged TRH infusions, Metabolism, 29, 46, 10.1016/0026-0495(80)90097-9 Klug, 1978, Age-dependent accumulation of an immunoreactive species of thyrotropin (TSH) which inhibits production of thyroid hormones [proceedings], Adv Exp Med Biol, 97, 259 Veltri, 2017, Prevalence of thyroid dysfunction and autoimmunity in the older population and implications of age-specific reference ranges, Clin Chim Acta, 465, 34, 10.1016/j.cca.2016.12.008 Biondi, 2015, The 2015 European Thyroid Association guidelines on diagnosis and treatment of endogenous subclinical hyperthyroidism, Eur Thyroid J, 4, 149, 10.1159/000438750 Pearce, 2016, Serum thyroid function, mortality and disability in advanced old age: the Newcastle 85+ study, J Clin Endocrinol Metab, 101, 4385, 10.1210/jc.2016-1935 Selmer, 2012, The spectrum of thyroid disease and risk of new onset atrial fibrillation: a large population cohort study, BMJ, 345, e7895, 10.1136/bmj.e7895 Segna, 2018, Association between subclinical thyroid dysfunction and change in bone mineral density in prospective cohorts, J Intern Med, 283, 56, 10.1111/joim.12688 Rieben, 2016, Subclinical thyroid dysfunction and the risk of cognitive decline: a meta-analysis of prospective cohort studies, J Clin Endocrinol Metab, 101, 4945, 10.1210/jc.2016-2129 Ceresini, 2000, Evaluation of the circadian profiles of serum dehydroepiandrosterone (DHEA), cortisol, and cortisol/DHEA molar ratio after a single oral administration of DHEA in elderly subjects, Metabolism, 49, 548, 10.1016/S0026-0495(00)80024-4 Selmer, 2014, Subclinical and overt thyroid dysfunction and risk of all-cause mortality and cardiovascular events: a large population study, J Clin Endocrinol Metab, 99, 2372, 10.1210/jc.2013-4184 Atzmon, 2009, Genetic predisposition to elevated serum thyrotropin is associated with exceptional longevity, J Clin Endocrinol Metab, 94, 4768, 10.1210/jc.2009-0808 Hennessey, 2015, Diagnosis and management of subclinical hypothyroidism in elderly adults: a review of the literature, J Am Geriatr Soc, 63, 1663, 10.1111/jgs.13532 Rodondi, 2010, Subclinical hypothyroidism and the risk of coronary heart disease and mortality, JAMA, 304, 1365, 10.1001/jama.2010.1361 Chaker, 2016, Thyroid function within the reference range and the risk of stroke: an individual participant data analysis, J Clin Endocrinol Metab, 101, 4270, 10.1210/jc.2016-2255 Virgini, 2015, Subclinical thyroid dysfunction and frailty among older men, J Clin Endocrinol Metab, 100, 4524, 10.1210/jc.2015-3191 Bano, 2018, High circulating free thyroxine levels may increase the risk of frailty: the Rotterdam Study, J Clin Endocrinol Metab, 103, 328, 10.1210/jc.2017-01854 Simonsick, 2016, Free thyroxine and functional mobility, fitness, and fatigue in euthyroid older men and women in the Baltimore longitudinal study of aging, J Gerontol A Biol Sci Med Sci, 71, 961, 10.1093/gerona/glv226 Bowers, 2013, Thyroid hormone signaling and homeostasis during aging, Endocr Rev, 34, 556, 10.1210/er.2012-1056 Di Somma, 2011, Somatopause: state of the art, Minerva Endocrinol, 36, 243 Ceda, 2010, Update on new therapeutic options for the somatopause, Acta Biomed Ateneo Parmense, 81, 67 Giordano, 2008, Growth hormone treatment in human ageing: benefits and risks, Hormones (Athens), 7, 133, 10.1007/BF03401504 Nashiro, 2017, Brain structure and function associated with younger adults in growth hormone receptor-deficient humans, J Neurosci, 37, 1696, 10.1523/JNEUROSCI.1929-16.2016 Laron, 2017, IGF-I deficiency, longevity and cancer protection of patients with Laron syndrome, Mutat Res Rev Mutat Res, 772, 123, 10.1016/j.mrrev.2016.08.002 Junnila, 2013, The GH/IGF-1 axis in ageing and longevity, Nat Rev Endocrinol, 9, 366, 10.1038/nrendo.2013.67 Cruz-Jentoft, 2017, Nutrition, frailty, and sarcopenia, Aging Clin Exp Res, 29, 43, 10.1007/s40520-016-0709-0 Chapman, 2004, Endocrinology of anorexia of ageing, Best Pract Res Clin Endocrinol Metab, 18, 437, 10.1016/j.beem.2004.02.004 MacIntosh, 1999, Effects of age on concentrations of plasma cholecystokinin, glucagon-like peptide 1, and peptide YY and their relation to appetite and pyloric motility, Am J Clin Nutr, 69, 999, 10.1093/ajcn/69.5.999 Fried, 2001, Frailty in older adults: evidence for a phenotype, J Gerontol A Biol Sci Med Sci, 56, M146, 10.1093/gerona/56.3.M146 Veldhuis, 2013, Age-dependent and gender-dependent regulation of hypothalamic-adrenocorticotropic-adrenal axis, Endocrinol Metab Clin North Am, 42, 201, 10.1016/j.ecl.2013.02.002 Nater, 2013, Diurnal profiles of salivary cortisol and alpha-amylase change across the adult lifespan: evidence from repeated daily life assessments, Psychoneuroendocrinology, 38, 3167, 10.1016/j.psyneuen.2013.09.008 Almeida, 2009, Interindividual differences and intraindividual variability in the cortisol awakening response: an examination of age and gender, Psychol Aging, 24, 819, 10.1037/a0017910 Dmitrieva, 2013, A day-centered approach to modeling cortisol: diurnal cortisol profiles and their associations among U.S. adults, Psychoneuroendocrinology, 38, 2354, 10.1016/j.psyneuen.2013.05.003 Gardner, 2013, Dysregulation of the hypothalamic pituitary adrenal (HPA) axis and physical performance at older ages: an individual participant meta-analysis, Psychoneuroendocrinology, 38, 40, 10.1016/j.psyneuen.2012.04.016 Dijckmans, 2017, Does the diurnal cycle of cortisol explain the relationship between physical performance and cognitive function in older adults?, Eur Rev Aging Phys Act, 14, 6, 10.1186/s11556-017-0175-5 Ennis, 2017, Long-term cortisol measures predict Alzheimer disease risk, Neurology, 88, 371, 10.1212/WNL.0000000000003537 Schoorlemmer, 2009, Relationships between cortisol level, mortality and chronic diseases in older persons, Clin Endocrinol (Oxf), 71, 779, 10.1111/j.1365-2265.2009.03552.x Tiganescu, 2011, Localization, age- and site-dependent expression, and regulation of 11beta-hydroxysteroid dehydrogenase type 1 in skin, J Invest Dermatol, 131, 30, 10.1038/jid.2010.257 Kilgour, 2013, Increased skeletal muscle 11betaHSD1 mRNA is associated with lower muscle strength in ageing, PLoS One, 8, e84057, 10.1371/journal.pone.0084057 Herbert, 1995, The age of dehydroepiandrosterone, Lancet, 345, 1193, 10.1016/S0140-6736(95)91987-2 Ferrari, 2000, Pineal and pituitary-adrenocortical function in physiological aging and in senile dementia, Exp Gerontol, 35, 1239, 10.1016/S0531-5565(00)00160-1 Ravaglia, 1996, The relationship of dehydroepiandrosterone sulfate (DHEAS) to endocrine-metabolic parameters and functional status in the oldest-old. Results from an Italian study on healthy free-living over-ninety-year-olds, J Clin Endocrinol Metab, 81, 1173 Ohlsson, 2015, DHEA and mortality: what is the nature of the association?, J Steroid Biochem Mol Biol, 145, 248, 10.1016/j.jsbmb.2014.03.006 Baulieu, 2000, Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge Study to a sociobiomedical issue, Proc Natl Acad Sci USA, 97, 4279, 10.1073/pnas.97.8.4279 Elraiyah, 2014, The benefits and harms of systemic dehydroepiandrosterone (DHEA) in postmenopausal women with normal adrenal function: a systematic review and meta-analysis, J Clin Endocrinol Metab, 99, 3536, 10.1210/jc.2014-2261 Broekmans, 2009, Ovarian aging: mechanisms and clinical consequences, Endocr Rev, 30, 465, 10.1210/er.2009-0006 Hale, 2007, Endocrine features of menstrual cycles in middle and late reproductive age and the menopausal transition classified according to the Staging of Reproductive Aging Workshop (STRAW) staging system, J Clin Endocrinol Metab, 92, 3060, 10.1210/jc.2007-0066 Santoro, 2011, Reproductive hormones and the menopause transition, Obstet Gynecol Clin North Am, 38, 455, 10.1016/j.ogc.2011.05.004 Broer, 2011, Anti-mullerian hormone predicts menopause: a long-term follow-up study in normoovulatory women, J Clin Endocrinol Metab, 96, 2532, 10.1210/jc.2010-2776 Vanden Brink, 2015, Associations between antral ovarian follicle dynamics and hormone production throughout the menstrual cycle as women age, J Clin Endocrinol Metab, 100, 4553, 10.1210/jc.2015-2643 Shaw, 2011, Differential effects of aging on estrogen negative and positive feedback, Am J Physiol Endocrinol Metab, 301, E351, 10.1152/ajpendo.00150.2011 Davison, 2005, Androgen levels in adult females: changes with age, menopause, and oophorectomy, J Clin Endocrinol Metab, 90, 3847, 10.1210/jc.2005-0212 Fogle, 2007, Ovarian androgen production in postmenopausal women, J Clin Endocrinol Metab, 92, 3040, 10.1210/jc.2007-0581 Lonning, 2013, Aromatase inhibition 2013: clinical state of the art and questions that remain to be solved, Endocr Relat Cancer, 20, R183, 10.1530/ERC-13-0099 Stuenkel, 2015, Treatment of symptoms of the menopause: an endocrine society clinical practice guideline, J Clin Endocrinol Metab, 100, 3975, 10.1210/jc.2015-2236 Kaufman, 2005, The decline of androgen levels in elderly men and its clinical and therapeutic implications, Endocr Rev, 26, 833, 10.1210/er.2004-0013 Basaria, 2013, Reproductive aging in men, Endocrinol Metab Clin North Am, 42, 255, 10.1016/j.ecl.2013.02.012 Mahmoud, 2003, Testicular volume in relation to hormonal indices of gonadal function in community-dwelling elderly men, J Clin Endocrinol Metab, 88, 179, 10.1210/jc.2002-020408 Sartorius, 2010, Paternal age and reproduction, Hum Reprod Update, 16, 65, 10.1093/humupd/dmp027 Wu, 2008, Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study, J Clin Endocrinol Metab, 93, 2737, 10.1210/jc.2007-1972 Hsu, 2016, Temporal trend in androgen status and androgen-sensitive outcomes in older men, J Clin Endocrinol Metab, 101, 1836, 10.1210/jc.2015-3810 Araujo, 2011, Clinical review: endogenous testosterone and mortality in men: a systematic review and meta-analysis, J Clin Endocrinol Metab, 96, 3007, 10.1210/jc.2011-1137 Snyder, 2016, Effects of testosterone treatment in older men, N Engl J Med, 374, 611, 10.1056/NEJMoa1506119 Manolagas, 2013, The role of estrogen and androgen receptors in bone health and disease, Nat Rev Endocrinol, 9, 699, 10.1038/nrendo.2013.179 Orwoll, 2016, Establishing a framework—does testosterone supplementation help older men?, N Engl J Med, 374, 682, 10.1056/NEJMe1600196 Seeman, 2006, Bone quality—the material and structural basis of bone strength and fragility, N Engl J Med, 354, 2250, 10.1056/NEJMra053077 Manolagas, 2010, From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis, Endocr Rev, 31, 266, 10.1210/er.2009-0024 Onal, 2013, Suppression of autophagy in osteocytes mimics skeletal aging, J Biol Chem, 288, 17432, 10.1074/jbc.M112.444190 Kassem, 2011, Senescence-associated intrinsic mechanisms of osteoblast dysfunctions, Aging Cell, 10, 191, 10.1111/j.1474-9726.2011.00669.x Almeida, 2017, Estrogens and androgens in skeletal physiology and pathophysiology, Physiol Rev, 97, 135, 10.1152/physrev.00033.2015 Khosla, 2013, Pathogenesis of age-related bone loss in humans, J Gerontol A Biol Sci Med Sci, 68, 1226, 10.1093/gerona/gls163 Falahati-Nini, 2000, Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men, J Clin Invest, 106, 1553, 10.1172/JCI10942 Orwoll, 2017, The limited clinical utility of testosterone, estradiol, and sex hormone binding globulin measurements in the prediction of fracture risk and bone loss in older men, J Bone Miner Res, 32, 633, 10.1002/jbmr.3021 Faroqui, 2008, Estrogen downregulates the proximal tubule type IIa sodium phosphate cotransporter causing phosphate wasting and hypophosphatemia, Kidney Int, 73, 1141, 10.1038/ki.2008.33 Dick, 2005, Effects of endogenous estrogen on renal calcium and phosphate handling in elderly women, Am J Physiol Endocrinol Metab, 288, E430, 10.1152/ajpendo.00140.2004 Sato, 2017, Glucocorticoids induce bone and muscle atrophy by tissue-specific mechanisms upstream of E3 ubiquitin ligases, Endocrinology, 158, 664 Almeida, 2013, Basic biology of skeletal aging: role of stress response pathways, J Gerontol A Biol Sci Med Sci, 68, 1197, 10.1093/gerona/glt079 Weinstein, 2000, Apoptosis and osteoporosis, Am J Med, 108, 153, 10.1016/S0002-9343(99)00420-9 Fleet, 2017, The role of vitamin D in the endocrinology controlling calcium homeostasis, Mol Cell Endocrinol, 453, 36, 10.1016/j.mce.2017.04.008 Bruce, 1999, Secondary hyperparathyroidism in patients from Western Australia with hip fracture: relationship to type of hip fracture, renal function, and vitamin D deficiency, J Am Geriatr Soc, 47, 354, 10.1111/j.1532-5415.1999.tb03001.x Carrivick, 2015, Brief report: does PTH increase with age, independent of 25-hydroxyvitamin D, phosphate, renal function, and ionized calcium?, J Clin Endocrinol Metab, 100, 2131, 10.1210/jc.2014-4370 Campos-Obando, 2017, Serum phosphate is associated with fracture risk: the Rotterdam Study and MrOS, J Bone Miner Res, 32, 1182, 10.1002/jbmr.3094 Martin, 2012, Regulation and function of the FGF23/klotho endocrine pathways, Physiol Rev, 92, 131, 10.1152/physrev.00002.2011 Seck, 1998, Concentration of insulin-like growth factor (IGF)-I and -II in iliac crest bone matrix from pre- and postmenopausal women: relationship to age, menopause, bone turnover, bone volume, and circulating IGFs, J Clin Endocrinol Metab, 83, 2331 Garnero, 2000, Low serum IGF-1 and occurrence of osteoporotic fractures in postmenopausal women, Lancet, 355, 898, 10.1016/S0140-6736(99)05463-X Manson, 2017, Menopausal hormone therapy and long-term all-cause and cause-specific mortality: the Women's Health Initiative Randomized Trials, JAMA, 318, 927, 10.1001/jama.2017.11217 2017, The 2017 hormone therapy position statement of The North American Menopause Society, Menopause, 24, 728, 10.1097/GME.0000000000000921 Reaven, 1989, Effect of age on glucose tolerance and glucose uptake in healthy individuals, J Am Geriatr Soc, 37, 735, 10.1111/j.1532-5415.1989.tb02235.x Broughton, 1991, Review: deterioration of glucose tolerance with age: the role of insulin resistance, Age Ageing, 20, 221, 10.1093/ageing/20.3.221 Polonsky, 1988, Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects, J Clin Invest, 81, 442, 10.1172/JCI113339 Lang, 1979, Cyclic oscillations of basal plasma glucose and insulin concentrations in human beings, N Engl J Med, 301, 1023, 10.1056/NEJM197911083011903 Matveyenko, 2012, Pulsatile portal vein insulin delivery enhances hepatic insulin action and signaling, Diabetes, 61, 2269, 10.2337/db11-1462 Porksen, 1995, Pulsatile insulin secretion accounts for 70% of total insulin secretion during fasting, Am J Physiol, 269, E478 Lang, 1981, Brief, irregular oscillations of basal plasma insulin and glucose concentrations in diabetic man, Diabetes, 30, 435, 10.2337/diab.30.5.435 Meneilly, 1997, Increased disorderliness of basal insulin release, attenuated insulin secretory burst mass, and reduced ultradian rhythmicity of insulin secretion in older individuals, J Clin Endocrinol Metab, 82, 4088 Meneilly, 1999, Disruption of the pulsatile and entropic modes of insulin release during an unvarying glucose stimulus in elderly individuals, J Clin Endocrinol Metab, 84, 1938 Hori, 2006, Role of endosomal trafficking dynamics on the regulation of hepatic insulin receptor activity: models for Fao cells, Ann Biomed Eng, 34, 879, 10.1007/s10439-005-9065-5 Basu, 2006, Effects of age and sex on postprandial glucose metabolism: differences in glucose turnover, insulin secretion, insulin action, and hepatic insulin extraction, Diabetes, 55, 2001, 10.2337/db05-1692 Elahi, 1993, The effect of age on insulin response and glucose utilization during four hyperglycemic plateaus, Exp Gerontol, 28, 393, 10.1016/0531-5565(93)90066-M Cefalu, 1995, Contribution of visceral fat mass to the insulin resistance of aging, Metabolism, 44, 954, 10.1016/0026-0495(95)90251-1 Coon, 1992, Role of body fat distribution in the decline in insulin sensitivity and glucose tolerance with age, J Clin Endocrinol Metab, 75, 1125 Kahn, 1990, Effect of exercise on insulin action, glucose tolerance, and insulin secretion in aging, Am J Physiol, 258, E937 McBean, 2004, Differences in diabetes prevalence, incidence, and mortality among the elderly of four racial/ethnic groups: whites, blacks, hispanics, and asians, Diabetes Care, 27, 2317, 10.2337/diacare.27.10.2317 Petersen, 2003, Mitochondrial dysfunction in the elderly: possible role in insulin resistance, Science, 300, 1140, 10.1126/science.1082889 Meneilly, 2005, Metabolic alterations in middle-aged and elderly lean patients with type 2 diabetes, Diabetes Care, 28, 1498, 10.2337/diacare.28.6.1498 Diabetes Cowie, 2010, Prevalence of diabetes and high risk for diabetes using A1C criteria in the U.S. population in 1988–2006, Diabetes Care, 33, 562, 10.2337/dc09-1524 Chia, 2014, A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead, Ann Trans Med, 2, 121 2018, Classification and diagnosis of diabetes, Diabetes Care, 40, S13 2002, Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin, N Engl J Med, 346, 393, 10.1056/NEJMoa012512