The physiological effects of hypobaric hypoxia versus normobaric hypoxia: a systematic review of crossover trials

Jonny Coppel1, P. J. Hennis1, Edward Gilbert‐Kawai1, Michael P.W. Grocott2
1University College London Centre for Altitude Space and Extreme Environment Medicine, UCLH NIHR Biomedical Research Centre, Institute of Sport and Exercise Health, 170 Tottenham Court Road, London, W1T 7HA, UK
2Integrative Physiology and Critical Illness Group, Clinical and Experimental Sciences, Mailpoint 810, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton, University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton, SO16 6YD, UK

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Grocott M, Montgomery H, Vercueil A. High-altitude physiology and pathophysiology: implications and relevance for intensive care medicine. Crit Care. 2007;11:203.

Grant S, MacLeod N, Kay JW, Watt M, Patel S, Paterson A, et al. Sea level and acute responses to hypoxia: do they predict physiological responses and acute mountain sickness at altitude? Brit J Sport Med. 2002;36:141–6.

Millet GP, Faiss R, Brocherie F, Girard O. Hypoxic training and team sports: a challenge to traditional methods? Brit J Sport Med. 2013;47:6–7.

DeHart RLE. Fundamentals of aerospace medicine. 2nd ed. Baltimore: Williams and Wilkins; 1996. p. 90–1.

Conkin J, Wessel JH. Critique of the equivalent air altitude model. Aviat Space Envir Md. 2008;79:975–82.

Self DA, Mandella JG, Prinzo OV, Forster EM, Shaffstall RM. Physiological equivalence of normobaric and hypobaric exposures of humans to 25,000 feet (7620 m). Aviat Space Envir Md. 2011;82:97–103.

Debevec T, Millet GP. Discerning normobaric and hypobaric hypoxia: significance of exposure duration. J Appl Physiol. 2014;116:1255–5.

Olivier G, Koehle MS, Guenette JA, Verges S, Chapman RF, Conkin J, et al. Comments on point: counterpoint: hypobaric hypoxia induces/does not induce different responses from normobaric hypoxia. J Appl Physiol. 2012;112:1788–94.

Muza SR. Military applications of hypoxic training for high-altitude operations. Med Sci Sports Exerc. 2007;39:1625–31.

Millet GP, Faiss R, Pialoux V. Evidence for differences between hypobaric and normobaric hypoxia is conclusive. Exerc Sport Sci Rev. 2013;41:133.

Conkin J. PH2O and simulated hypobaric hypoxia. Aviat Space Envir Md. 2011;82:1157–8.

Faiss R, Pialoux V, Sartori C, Faes C, Deriaz O, Millet GP. Ventilation, oxidative stress, and nitric oxide in hypobaric versus normobaric hypoxia. Med Sci Sports Exerc. 2013;45:253–60.

Loeppky JA, Icenogle M, Scotto P, Robergs R, HinghoferSzalkay H, Roach RC. Ventilation during simulated altitude, normobaric hypoxia and normoxic hypobaria. Resp Physiol. 1997;107:231–9.

Loeppky JA, Roach RC, Maes D, Hinghofer-Szalkay H, Roessler A, Gates L, et al. Role of hypobaria in fluid balance response to hypoxia. High Alt Med Biol. 2005;6:60–71.

Miyagawa K, Kamijo Y, Ikegawa S, Goto M, Nose H. Reduced hyperthermia-induced cutaneous vasodilation and enhanced exercise-induced plasma water loss at simulated high altitude (3,200 m) in humans. J Appl Physiol. 2011;110:157–65.

Roach RC, Loeppky JA, Icenogle MV. Acute mountain sickness: increased severity during simulated altitude compared with normobaric hypoxia. J Appl Physiol. 1996;81:1908–10.

Savourey G, Launay JC, Besnard Y, Guinet A, Travers S. Normo- and hypobaric hypoxia: are there any physiological differences? Eur J Appl Physiol. 2003;89:122–6.

Savourey G, Launay JC, Besnard Y, Guinet-Lebreton A, Alonso A, Sauvet F, et al. Normo or hypobaric hypoxic tests: propositions for the determination of the individual susceptibility to altitude illnesses. Eur J Appl Physiol. 2007;100:193–205.

Hemmingsson T, Linnarsson D. Lower exhaled nitric oxide in hypobaric than in normobaric acute hypoxia. Resp Physiol Neurobi. 2009;169:74–7.

Naughton MT, Rochford PD, Pretto JJ, Pierce RJ, Cain NF, Irving LB. Is normobaric simulation of hypobaric hypoxia accurate in chronic air-flow limitation. Am J Resp Crit Care. 1995;152:1956–60.

Basualto-Alarcon C, Rodas G, et al. Cardiorespiratory parameters during submaximal exercise under acute exposure to normobaric and hypobaric hypoxia. Apunts Med Esport. 2012;47:65–72.

Tucker A, Reeves JT, Robertshaw D, Grover RF. Cardiopulmonary response to acute altitude exposure—water loading and denitrogenation. Resp Physiol. 1983;54:363–80.

Degache F, Larghi G, Faiss R, Deriaz O, Millet G. Hypobaric versus normobaric hypoxia: same effects on postural stability? High Alt Med Biol. 2012;13:40–5.

Isa KBM, Kawasaki N, Ueyama K, Sumii T, Kudo S. Effect of cold exposure and shear stree on endothelial nitric oxide synthase activation. Biochem Biophys Res Commun. 2011;412:318–22.

West JB, Milledge JS, Schoene RB, Luks A. High altitude medicine and physiology. 5th ed. Boca Raton: CRC Press/Taylor & Francis Group; 2013.

Fulco CS, Beidleman BA, Muza SR. Effectiveness of preacclimatization strategies for high-altitude exposure. Exerc Sport Sci Rev. 2013;41:55–63.