The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor
Tóm tắt
Từ khóa
Tài liệu tham khảo
Martin DS, Schwartz GK (1997) Chemotherapeutically induced DNA Damage, ATP depletion, and the apoptotic biochemical cascade. Oncol Res 9:1–5
Komatsu N, Nakagawa M, Oda T, Muramatsu T (2000) Depletion of intracellular NAD+ and ATP levels during ricin-induced apoptosis through the specific ribosomal inactivation results in the cytolysis of U937 cells. J Biochem (Tokyo) 128:463–470
Wielckens K, Schmidt A, George E, Bredehosrt R, Hilz H (1982) DNA fragmentation and NAD depletion. Their relation to the turnover of endogenous mono(ADP-ribosyl) and poly (ADP-ribosyl) proteins. J Biol Chem 257:12872–12877
Alano CC, Ying W, Swanson RA (2004) Poly(ADP-ribose) polymerase-1-mediated cell death in astrocytes requires NAD+ depletion and mitochondrial permeability transition. J Biol Chem 279:18895–18902
Du L, Zhang X, Han YY, Burke NA, Kochanek PM, Watkins SC, Graham SH, Carcillo JA, Szabo C, Clark RS (2003) Intra-mitochondrial poly(ADP-ribosylation) contributes to NAD+ depletion and cell death induced by oxidative stress. J Biol Chem 278:18426–18433
Heller B, Burkle A, Radons J, Fengler E, Muller M, Burkart V, Kolb H (1997) DNA-damage and NAD(+)-depletion are initial events in oxygen radical induced islet cell death. Adv Exp Med Biol 426:329–334
Stubberfield CR, Cohen GM (1988) NAD+ depletion and cytotoxicity in isolated hepatocytes. Biochem Pharmacol 37:3967–3974
Jacobson MK, Twehous D, Hurley LH (1986) Depletion of nicotinamide adenine dinucleotide in normal and xeroderma pigmentosum fibroblast cells by the antitumor drug CC-1065. Biochem 25:5929–5932
Alvarez-Gonzalez R, Eichenberger R, Althaus FR (1986) Poly(ADP-ribose) biosynthesis and suicidal NAD+ depletion following carcinogen exposure of mammalian cells. Molec Cell Biol Res Commun 138:1051–1057
Wosikowski K, Mattern K, Schemainda I, Hasmann M, Rattel B, Loser R (2002) WK175, a novel antitumor agent, decreases the intracellular nicotinamide adenine dinucleotide concentration and induces the apopototic cascade in human leukemia cells. Cancer Res 62:1057–1062
Hasmann M, Schemainda I (2003) FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis. Cancer Res 63:7436–7442
Drevs J, Loser R, Rattel B, Esser N (2003) Antiangiogenic potency of FK866/K22.175, a new inhibitor of intracellular NAD biosynthesis, in murine renal cell carcinoma. Anticancer Res 23:4853–4858
Miller AB, Hoogstraten B, Staquet M, Winkler A (1981) Reporting results of cancer treatment. Cancer 47:207–214