The pentavalent antimonial therapy against experimental Leishmania amazonensis infection is more effective under the inhibition of the NF-κB pathway

Almeida, 2011, Advances in the treatment of cutaneous leishmaniasis in the new world in the last ten years: a systematic literature review, An Bras Dermatol, 86, 497, 10.1590/S0365-05962011000300012 Alexander, 1992, The interaction of Leishmania species with macrophages, Adv. Parasitol., 31, 175, 10.1016/S0065-308X(08)60022-6 Basu, 2005, Macrophage and Leishmania: an unacceptable coexistence, Crit. Rev. Microbiol., 31, 145, 10.1080/10408410591005101 Nelson, 1991, Differential susceptibility of activated macrophage cytotoxic effector reactions to the suppressive effects of transforming growth factor-beta 1, J. Immunol., 146, 1849, 10.4049/jimmunol.146.6.1849 Cunha, 1992, Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-gamma in murine macrophages, Biochem. Biophys. Res. Commun., 182, 1155, 10.1016/0006-291X(92)91852-H Gazzinelli, 1992, The microbicidal activity of interferon-gamma-treated macrophages against Trypanosoma cruzi involves an l-arginine-dependent, nitrogen oxide-mediated mechanism inhibitable by interleukin-10 and transforming growth factor-beta, Eur. J. Immunol., 22, 2501, 10.1002/eji.1830221006 Green, 1991, Cytokine-induced synthesis of nitrogen oxides in macrophages: a protective host response to Leishmania and other intracellular pathogens, J. Leukoc. Biol., 50, 93, 10.1002/jlb.50.1.93 Mosser, 2008, Exploring the full spectrum of macrophage activation, Nat. Rev. Immunol., 8, 958, 10.1038/nri2448 Afonso, 1993, Immune responses associated with susceptibility of C57BL/10 mice to Leishmania amazonensis, Infect. Immun., 61, 2952, 10.1128/IAI.61.7.2952-2959.1993 Nylén, 2012, Tissue damage and immunity in cutaneous leishmaniasis, Parasite Immunol., 34, 551, 10.1111/pim.12007 Soares, 2012, Dolabelladienetriol, a compound from Dictyota pfaffii algae, inhibits the infection by Leishmania amazonensis, PLoS Negl. Trop. Dis., 6, e1787, 10.1371/journal.pntd.0001787 Lessa, 2001, Successful treatment of refractory mucosal leishmaniasis with pentoxifylline plus antimony, Am. J. Trop. Med. Hyg., 65, 87, 10.4269/ajtmh.2001.65.87 Oliveira, 2014, The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of human tegumentary leishmaniasis, Cytokine, 66, 127, 10.1016/j.cyto.2013.12.016 Barros, 2013, Liposomal-lupane system as alternative chemotherapy against cutaneous leishmaniasis: macrophage as target cell, Exp. Parasitol., 135, 337, 10.1016/j.exppara.2013.07.022 Reinhard, 2012, The role of NF-κB activation during protection against Leishmania infection, Int. J. Med. Microbiol., 302, 230, 10.1016/j.ijmm.2012.07.006 Palmer, 1988, Vascular endothelial cells synthesize nitric oxide from l-arginine, Nature, 333, 664, 10.1038/333664a0 Sakuma, 1988, Identification of arginine as a precursor of endothelium-derived relaxing factor, Proc. Natl. Acad. Sci. U. S. A., 85, 8664, 10.1073/pnas.85.22.8664 Kocyigit, 2002, Antimonial therapy induces circulating proinflammatory cytokines in patients with cutaneous Leishmaniasis, Infect. Immun., 70, 6589, 10.1128/IAI.70.12.6589-6591.2002 Berger, 1992, Interactions between immunity and chemotherapy in the treatment of the trypanosomiases and leishmaniases, Parasitology, 105, S71, 10.1017/S0031182000075375 Lima-Junior, 2013, Inflammasome-derived IL-1β production induces nitric oxide-mediated resistance to Leishmania, Nat. Med., 19, 909, 10.1038/nm.3221 De Saldanha, 2012, Meglumine antimonate treatment enhances phagocytosis and TNF-α production by monocytes in human cutaneous leishmaniasis, Trans. R. Soc. Trop. Med. Hyg., 106, 596, 10.1016/j.trstmh.2012.07.001