The p53 tumour suppressor gene: a model for molecular epidemiology of human cancer

1990, Vol. 10 Doll, 1981, The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today, J. Natl Cancer Inst., 66, 1192, 10.1093/jnci/66.6.1192 Harris, 1991, Chemical and physical carcinogenesis: advances and perspectives for the 1990s, Cancer Res., 51, 5023s Caron de Fromentel, 1992, TP53 tumour suppressor gene: a model for investigating human mutagenesis, Genes Chrom. Cancer, 4, 1, 10.1002/gcc.2870040102 Hollstein, 1991, p53 mutations in human cancers, Science, 253, 49, 10.1126/science.1905840 Soussi, 1995, The p53 tumour suppressor gene: from molecular biology to clinical investigation, 135 Kastan, 1991, Participation of p53 protein in the cellular response to DNA damage, Cancer Res., 51, 6304 Smith, 1994, Interaction of the p53-regulated protein gadd45 with proliferating cell nuclear antigen, Science, 266, 1376, 10.1126/science.7973727 Yonish-Rouach, 1991, Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6, Nature, 352, 345, 10.1038/352345a0 Lowe, 1993, p53-dependent apoptosis modulates the cytotoxicity of anticancer agents, Cell, 74, 957, 10.1016/0092-8674(93)90719-7 Pictenpol, 1994, Sequence-specific transcriptional activation is essential for growth suppression by p53, 91, 1998 Lane, 1992, p53, guardian of the genome, Nature, 358, 15, 10.1038/358015a0 Kastan, 1995, p53, cell cycle control and apoptosis: implications for cancer, Cancer Metastasis Rev., 14, 3, 10.1007/BF00690207 Jayaraman, 1995, Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus, Cell, 81, 1021, 10.1016/S0092-8674(05)80007-8 Lee, 1995, p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches, Cell, 81, 1013, 10.1016/S0092-8674(05)80006-6 Wang, 1995, p53 modulation of TFIIH-associated nucleotide excision repair activity, Nat. Genet., 10, 188, 10.1038/ng0695-188 Livingstone, 1992, Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53, Cell, 70, 923, 10.1016/0092-8674(92)90243-6 Yin, 1992, Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles, Cell, 70, 937, 10.1016/0092-8674(92)90244-7 Greenblatt, 1994, Mutations in the p53 tumour suppressor gene: clues to cancer aetiology and molecular pathogenesis, Cancer Res., 54, 4855 Parkin, 1993, Estimates of the worldwide incidence of eighteen major cancers in 1985, Int. J. Cancer, 54, 594, 10.1002/ijc.2910540413 Béroud, C., Verdier, F. and Soussi, T. p53 gene mutation: software and database.Nucleic Acids Res. (in press) Hamelin, 1994, Association of p53 mutations with short survival in colorectal cancer, Gastroenterology, 106, 42, 10.1016/S0016-5085(94)94217-X Bergh, 1995, Complete sequencing of the p53 gene provides prognostic information in breast cancer patients, particularly in relation to adjuvant systemic therapy and radiotherapy, Nat. Med., 10, 1029, 10.1038/nm1095-1029 Hollstein, 1994, Database of p53 gene somatic mutations in human tumours and cell lines, Nucleic Acids Res., 22, 3551 Cho, 1994, Crystal structure of a p53 tumour suppressor DNA complex: understanding tumorigenic mutations, Science, 265, 346, 10.1126/science.8023157 Ory, 1994, Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation, EMBO J., 13, 3496, 10.1002/j.1460-2075.1994.tb06656.x Harvey, 1995, A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53 deficient mice, Nat. Genet., 9, 305, 10.1038/ng0395-305 Dumaz, 1994, Can we predict solar UV radiation as the causal event in human tumours by analysing the mutation spectra of the p53 gene?, Mutat. Res., 307, 375, 10.1016/0027-5107(94)90311-5 Tomaletti, 1995, Complete and tissue-independent methylation of CpG sites in the p53 gene: implications for mutations in human cancers, Oncogene, 10, 1493 International Agency for Research on Cancer, 1985, Tobacco Smoking, Vol. 38 Takahashi, 1989, p53 — a frequent target for genetic abnormalities in lung cancer, Science, 246, 491, 10.1126/science.2554494 Chiba, 1990, Mutations in the p53 gene are frequent in primary, resected non-small-cell lung cancer, Oncogene, 5, 1603 Hsu, 1991, Mutational hotspot in the p53 gene in human hepato-cellular carcinomas, Nature, 350, 427, 10.1038/350427a0 Bressac, 1991, Selective G-mutation to T-mutation of p53 gene in hepatocellular carcinoma from Southern Africa, Nature, 350, 429, 10.1038/350429a0 Soussi, 1990, Structural aspects of the p53 protein in relation to gene evolution, Oncogene, 5, 945 Ozturk, 1991, p53 mutation in hepatocellular carcinoma after aflatoxin exposure, Lancet, 338, 1356, 10.1016/0140-6736(91)92236-U Aguilar, 1994, Geographic variation of p53 mutational profile in non-malignant human liver, Science, 264, 1317, 10.1126/science.8191284 Puisieux, 1991, Selective targeting of p53 gene mutational hotspots in human cancers by aetiologically defined carcinogens, Cancer Res., 51, 6185 Brash, 1991, A role for sunlight in skin cancer — UV-induced p53 mutations in squamous cell carcinoma, 88, 10124 Ziegler, 1994, Sunburn and p53 in the onset of skin cancer, Nature, 372, 773, 10.1038/372773a0 Hollstein, 1994, p53 mutations at A:T base pairs in angiosarcomas of vinyl chloride-exposed factory workers, Carcinogenesis, 15, 1, 10.1093/carcin/15.1.1 Taylor, 1994, p53 mutation hotspot in radon-associated lung cancer, Lancet, 343, 86, 10.1016/S0140-6736(94)90818-4 Takeshima, 1993, p53 mutations in lung cancers from non-smoking atomic-bomb survivors, Lancet, 342, 1520, 10.1016/S0140-6736(05)80087-X