The overall survival impact of prophylactic cranial irradiation in limited-stage small-cell lung cancer: A systematic review and meta-analysis

Sung, 2021, Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries, CA Cancer J Clin, 71, 209, 10.3322/caac.21660 Houston, 2018, Histologic Lung Cancer Incidence Rates and Trends Vary by Race/Ethnicity and Residential County, J Thorac Oncol, 13, 497, 10.1016/j.jtho.2017.12.010 Howlader, 2020, The Effect of Advances in Lung-Cancer Treatment on Population Mortality, N Engl J Med, 383, 640, 10.1056/NEJMoa1916623 Goldstraw, 2016, The IASLC Lung Cancer Staging Project: Proposals for Revision of the TNM Stage Groupings in the Forthcoming (Eighth) Edition of the TNM Classification for Lung Cancer, J Thorac Oncol, 11, 39, 10.1016/j.jtho.2015.09.009 Dingemans, 2021, Small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up☆, Ann Oncol, 32, 839, 10.1016/j.annonc.2021.03.207 Aupérin, 1999, Prophylactic Cranial Irradiation for Patients with Small-Cell Lung Cancer in Complete Remission, N Engl J Med, 341, 476, 10.1056/NEJM199908123410703 Arriagada, 1995, Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission, J Natl Cancer Inst, 87, 183, 10.1093/jnci/87.3.183 Ohonoshi, 1993, Comparative study of prophylactic cranial irradiation in patients with small cell lung cancer achieving a complete response: a long-term follow-up result, Lung Cancer, 10, 47, 10.1016/0169-5002(93)90308-K Gregor A. Prophylactic cranial irradiation in small-cell lung cancer: is it ever indicated? Oncology (Williston Park). 1998;12(1 Suppl 2):19-24. doi:176779 [pii]. Aroney, 1983, Value of prophylactic cranial irradiation given at complete remission in small cell lung carcinoma, Cancer Treat Rep, 67, 675 Laplanche, 1998, Controlled clinical trial of prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission, Lung Cancer (Amsterdam, Netherlands)., 21, 193, 10.1016/S0169-5002(98)00056-7 Tomassen, 2021, Prophylactic cranial irradiation in patients with small cell lung cancer in The Netherlands: A population-based study, Clin Transl Radiat Oncol, 27, 157, 10.1016/j.ctro.2021.02.001 Patel, 2009, Evaluation of the use of prophylactic cranial irradiation in small cell lung cancer, Cancer, 115, 842, 10.1002/cncr.24105 Farooqi, 2017, Prophylactic cranial irradiation after definitive chemoradiotherapy for limited-stage small cell lung cancer: Do all patients benefit?, Radiother Oncol, 122, 307, 10.1016/j.radonc.2016.11.012 Eaton, 2013, Effect of prophylactic cranial irradiation on survival in elderly patients with limited-stage small cell lung cancer, Cancer, 119, 3753, 10.1002/cncr.28267 Pezzi, 2020, Rates of Overall Survival and Intracranial Control in the Magnetic Resonance Imaging Era for Patients With Limited-Stage Small Cell Lung Cancer With and Without Prophylactic Cranial Irradiation, JAMA Netw Open, 3, e201929, 10.1001/jamanetworkopen.2020.1929 Mamesaya, 2018, Efficacy of prophylactic cranial irradiation in patients with limited-disease small-cell lung cancer who were confirmed to have no brain metastasis via magnetic resonance imaging after initial chemoradiotherapy, Oncotarget, 9, 17664, 10.18632/oncotarget.24830 Farris, 2019, Limited-Stage Small Cell Lung Cancer: Is Prophylactic Cranial Irradiation Necessary?, Pract Radiat Oncol, 9, e599, 10.1016/j.prro.2019.06.014 Takahashi, 2017, Prophylactic cranial irradiation versus observation in patients with extensive-disease small-cell lung cancer: a multicentre, randomised, open-label, phase 3 trial, Lancet Oncol, 18, 663, 10.1016/S1470-2045(17)30230-9 Moher, 2009, Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement, PLoS Med, 6, e1000097, 10.1371/journal.pmed.1000097 Sterne JA, Hernán MA, Reeves BC, et al. ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ. 2016;355:i4919. doi:10.1136/bmj.i4919. Higgins J, Thomas J. Cochrane Handbook for Systematic Reviews of Interventions, version 6.2 (updated February 2021). Cochrane, 2021. Available from www.training.cochrane.org/handbook. Gjyshi, 2019, Evolving Practice Patterns in the Use of Prophylactic Cranial Irradiation for Extensive-Stage Small Cell Lung Cancer, JAMA Netw Open, 2, e199135, 10.1001/jamanetworkopen.2019.9135 Giuliani, 2010, Utilization of prophylactic cranial irradiation in patients with limited stage small cell lung carcinoma, Cancer, 116, 5694, 10.1002/cncr.25341 Slotman, 2009, JCO, 27, 78, 10.1200/JCO.2008.17.0746 Wolfson, 2011, Int J Radiat Oncol Biol Phys, 81, 77, 10.1016/j.ijrobp.2010.05.013 Belderbos, 2021, Phase 3 Randomized Trial of Prophylactic Cranial Irradiation With or Without Hippocampus Avoidance in SCLC (NCT01780675), J Thorac Oncol, 16, 840, 10.1016/j.jtho.2020.12.024 Rodríguez de Dios, 2021, Randomized Phase III Trial of Prophylactic Cranial Irradiation With or Without Hippocampal Avoidance for Small-Cell Lung Cancer (PREMER): A GICOR-GOECP-SEOR Study, J Clin Oncol, 39, 3118, 10.1200/JCO.21.00639 Chad G Rusthoven. MRI Brain Surveillance Alone Versus MRI Surveillance and Prophylactic Cranial Irradiation (PCI): A Randomized Phase III Trial in Small-Cell Lung Cancer (MAVERICK). https://clinicaltrials.gov/ct2/show/NCT04155034. Updated 2021. Faivre-Finn Corinne AL. PRophylactic Cerebral Irradiation or Active MAgnetic Resonance Imaging Surveillance in Small-cell Lung Cancer Patients (PRIMALung Study). https://clinicaltrials.gov/ct2/show/NCT04790253. Ng, 2007, Tolerability of Accelerated Chest Irradiation and Impact on Survival of Prophylactic Cranial Irradiation in Patients with Limited-stage Small Cell Lung Cancer: Review of a Single Institution's Experience, J Thoracic Oncol, 2, 506, 10.1097/JTO.0b013e318060095b Bettington, 2013, A retrospective analysis of survival outcomes for two different radiotherapy fractionation schedules given in the same overall time for limited stage small cell lung cancer, J Med Imaging Radiat Oncol, 57, 105, 10.1111/j.1754-9485.2012.02470.x Zhu, 2014, Prophylactic cranial irradiation improved the overall survival of patients with surgically resected small cell lung cancer, but not for stage I disease, Lung Cancer, 86, 334, 10.1016/j.lungcan.2014.09.019 Xu, 2017, Prophylactic Cranial Irradiation for Patients with Surgically Resected Small Cell Lung Cancer, J Thoracic Oncol, 12, 347, 10.1016/j.jtho.2016.09.133 Yang, 2016, Role of Adjuvant Therapy in a Population-Based Cohort of Patients with Early-Stage Small-Cell Lung Cancer, JCO, 34, 1057, 10.1200/JCO.2015.63.8171 Eze, 2017, Treatment Response and Prophylactic Cranial Irradiation Are Prognostic Factors in a Real-life Limited-disease Small-cell Lung Cancer Patient Cohort Comprehensively Staged With Cranial Magnetic Resonance Imaging, Clin Lung Cancer, 18, e243, 10.1016/j.cllc.2016.11.005 Wu, 2017, Patterns of failure in limited-stage small cell lung cancer: Implications of TNM stage for prophylactic cranial irradiation, Radiother Oncol, 125, 130, 10.1016/j.radonc.2017.07.019 Zhang, 2017, Hypo- or conventionally fractionated radiotherapy combined with chemotherapy in patients with limited stage small cell lung cancer, Radiat Oncol, 12, 10.1186/s13014-017-0788-x Nakamura, 2018, Impact of prophylactic cranial irradiation on pattern of brain metastases as a first recurrence site for limited-disease small-cell lung cancer, J Radiat Res, 59, 767, 10.1093/jrr/rry066 Sas-Korczyńska, 2018, The retrospective evaluation of prophylactic cranial irradiation in patients treated for limited stage small-cell lung cancer -a single centre study, Nowotwory J Oncol, 68, 232 Yin, 2018, Efficacy of surgery and prophylactic cranial irradiation in stage II and III small cell lung cancer, J Cancer, 9, 3500, 10.7150/jca.26157 Chen, 2019, Comparison Of Long Term Results Between Matched Chemoradiotherapy And Surgery For Limited Stage Small Cell Lung Cancer, Cancer Manag Res, 11, 9049, 10.2147/CMAR.S222882 Kim, 2019, Role of prophylactic cranial irradiation for elderly patients with limited-disease small-cell lung cancer: inverse probability of treatment weighting using propensity score, J Radiat Res, 60, 630, 10.1093/jrr/rrz040 Kou, 2019, Application of prophylactic cranial irradiation in limited-stage small-cell lung cancer: which patients could benefit?, Future Oncol, 15, 23, 10.2217/fon-2018-0481 Resio, 2019, Prophylactic cranial irradiation is associated with improved survival following resection for limited stage small cell lung cancer, J Thorac Dis, 11, 811, 10.21037/jtd.2019.01.64 Elegbede, 2020, Real-World Adherence to Guideline-Recommended Treatment for Small Cell Lung Cancer, Am J Clin Oncol, 43, 236, 10.1097/COC.0000000000000657 Jeong, 2020, Treatment time to the end of thoracic radiotherapy has more predictive power for survival than radiation dose intensity in patients with limited-stage small-cell lung cancer receiving concurrent chemoradiation of more than 45 Gy, Oncol Lett Lou, 2020, Does surgically resected small-cell lung cancer without lymph node involvement benefit from prophylactic cranial irradiation?, Thorac Cancer, 11, 1239, 10.1111/1759-7714.13381 Ghanta, 2021, Utility of Prophylactic Cranial Irradiation for Limited Stage Small Cell Lung Cancer in the Modern Era with Magnetic Resonance Imaging Surveillance, Clin Oncol (R Coll Radiol), 33, e323, 10.1016/j.clon.2021.03.018 Li, 2021, Prophylactic cranial irradiation confers favourable prognosis for patients with limited-stage small cell lung cancer in the era of MRI: A propensity score-matched analysis, J Med Imaging Radiat Oncol, 65, 778, 10.1111/1754-9485.13269 Held, 2022, Outcomes of prophylactic cranial irradiation in patients with small cell lung cancer in the modern era of baseline magnetic resonance imaging of the brain, Acta Oncol, 61, 185, 10.1080/0284186X.2021.1974553 Yan, 2021, Limited-stage small cell lung cancer: Outcomes associated with prophylactic cranial irradiation over a 20-year period at the Princess Margaret Cancer Centre, Clin Transl Radiat Oncol, 30, 43, 10.1016/j.ctro.2021.06.009 Zhou, 2021, Predictors of survival following surgical resection of limited-stage small cell lung cancer, J Thorac Cardiovasc Surg, 161, 760, 10.1016/j.jtcvs.2020.10.148