The origin of DCs and capacity for immunologic tolerance in central and peripheral tissues
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Steinman RM, Cohn ZA (1973) Identification of a novel cell type in peripheral lymphoid organs of mice. J Exp Med 137:1142–1162
Hammer GE, Ma A (2013) Molecular control of steady-state dendritic cell maturation and immune homeostasis. Annu Rev Immunol 31:743–791
Maldonado RA, von Andrian UH (2010) How tolerogenic dendritic cells induce regulatory T cells. Adv Immunol 108:111–165
Banchereau J, Briere F, Caux C et al (2000) Immunobiology of dendritic cells. Annu Rev Immunol 18:767–811
Alvarez D, Vollmann EH, von Andrian UH (2008) Mechanisms and consequences of dendritic cell migration. Immunity 29:325–342
Forster R, Schubel A, Breitfeld D et al (1999) CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 99:23–33
Martín-Fontecha A, Sebastiani S, Höpken UE et al (2003) Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming. J Exp Med 198:615–621
Ohl L, Mohaupt M, Czeloth N et al (2004) CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions. Immunity 21:279–288
Lutz MB, Schuler G (2002) Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity? Trends Immunol 23:445–449
Baratin M, Foray C, Demaria O et al (2015) Homeostatic NF-κβ signaling in steady-state migratory dendritic cells regulates immune homeostasis and tolerance. Immunity 42:627–639
Nirschl CJ, Anandasabapathy N (2016) Duality at the gate: skin dendritic cells as mediators of vaccine immunity and tolerance. Hum Vaccines Immunother 12:104–116
Dalod M, Chelbi R, Malissen B, Lawrence T (2014) Dendritic cell maturation: functional specialization through signaling specificity and transcriptional programming. EMBO J 33:1104–1116
Cools N, Ponsaerts P, Van Tendeloo VFI, Berneman ZN (2007) Balancing between immunity and tolerance: an interplay between dendritic cells, regulatory T cells, and effector T cells. J Leukoc Biol 82:1365–1374
Hill M, Cuturi MC (2010) Negative vaccination by tolerogenic dendritic cells in organ transplantation. Curr Opin Organ Transplant 15:738–743
Steinman RM, Hawiger D, Nussenzweig MC (2003) Tolerogenic dendritic cells. Annu Rev Immunol 21:685–711
Manicassamy S, Pulendran B (2011) Dendritic cell control of tolerogenic responses. Immunol Rev 241:206–227
Morelli AE, Thomson AW (2007) Tolerogenic dendritic cells and the quest for transplant tolerance. Nat Rev Immunol 7:610–621
Mendieta-Zerón H (2011) Developing immunologic tolerance for transplantation at the fetal stage. Immunotherapy 3:1499–1512
Ezzelarab M, Thomson AW (2011) Tolerogenic dendritic cells and their role in transplantation. Semin Immunol 23:252–263
Chopin M, Nutt SL (2014) Establishing and maintaining the Langerhans cell network. Semin Cell Dev Biol 41:1–7
Chopin M, Allan RS, Belz GT (2012) Transcriptional regulation of dendritic cell diversity. Front Immunol 3:26
Tamoutounour S, Guilliams M, MontananaSanchis F et al (2013) Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin. Immunity 39:925–938
Merad M, Ginhoux F, Collin M (2008) Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells. Nat Rev Immunol 8:935–947
Shortman K, Naik SH (2007) Steady-state and inflammatory dendritic-cell development. Nat Rev Immunol 7:19–30
Cella M, Jarrossay D, Facchetti F et al (1999) Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat Med 5:919–923
Naik SH, Metcalf D, van Nieuwenhuijze A et al (2006) Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes. Nat Immunol 7:663–671
Guilliams M, Ginhoux F, Jakubzick C et al (2014) Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny. Nat Rev Immunol 14:571–578
Liu K, Victora G, Schwickert T et al (2009) In vivo analysis of dendritic cell development and homeostasis. Science 324:392–397
MartIn-Fontecha A, Sebastiani S, Höpken UE et al (2003) Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming. J Exp Med 198:615–621
Saeki H, Moore AM, Brown MJ, Hwang ST (1999) Cutting edge: secondary lymphoid-tissue chemokine (SLC) and CC chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the skin to regional lymph nodes. J Immunol 162:2472–2475
Valladeau J, Ravel O, Dezutter-Dambuyant C et al (2000) Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity 12:71–81
Kaplan DH, Igyártó BZ, Gaspari AA (2012) Early immune events in the induction of allergic contact dermatitis. Nat Rev Immunol 12:114–124
Bursch LS, Wang L, Igyarto B et al (2007) Identification of a novel population of Langerin + dendritic cells. J Exp Med 204:3147–3156
Nizza ST, Campbell JJ (2014) CD11b + Migratory dendritic cells mediate CD8 T cell cross-priming and cutaneous imprinting after topical immunization. PLoS One 9:e91054
Clausen BE, Stoitzner P (2015) Functional specialization of skin dendritic cell subsets in regulating T cell responses. Front Immunol 6:1–19
Igyártá BZ, Haley K, Ortner D et al (2011) Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper responses. Immunity 35:260–272
Hunger RE, Sieling PA, Ochoa MT et al (2004) Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells. J Clin Invest 113:701–708
De Jong A, Cheng T, Huang S et al (2014) CD1a-autoreactive T cells recognize natural skin oils that function as headless antigens. Nat Imunol 15:177–185
Anandasabapathy N, Feder R, Mollah S et al (2014) Classical Flt3L-dependent dendritic cells control immunity to protein vaccine. J Exp Med 211:1875–1891
Mollah SA, Dobrin JS, Feder RE et al (2014) Flt3L dependence helps define an uncharacterized subset of murine cutaneous dendritic cells. J Invest Dermatol 134:1265–1275
Henri S, Poulin LF, Tamoutounour S et al (2010) CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells. J Exp Med 207:189–206
Tussiwand R, Everts B, Grajales-Reyes GE et al (2015) Klf4 expression in conventional dendritic cells is required for T helper 2 cell responses. Immunity 42:916–928
Schlitzer A, McGovern N, Teo P et al (2013) IRF4 transcription factor-dependent CD11b + dendritic cells in human and mouse control mucosal IL-17 cytokine responses. Immunity 38:970–983
Nakano H, Free ME, Whitehead GS et al (2012) Pulmonary CD103+ dendritic cells prime Th2 responses to inhaled allergens. Mucosal Immunol 5:53–65
Henri S, Vremec D, Kamath A et al (2001) The dendritic cell populations of mouse lymph nodes. J Immunol 167:741–748
Borkowski TA, Nelson AJ, Farr AG, Udey MC (1996) Expression of gp40, the murine homologue of human epithelial cell adhesion molecule (ep-CAM), by murine dendritic cells. Eur J Immunol 26:110–114
Nagao K, Ginhoux F, Leitner WW et al (2009) Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions. Proc Natl Acad Sci U S A 106:3312–3317
Malissen B, Tamoutounour S, Henri S (2014) The origins and functions of dendritic cells and macrophages in the skin. Nat Rev Immunol 14:417–428
Haniffa M, Shin A, Bigley V et al (2012) Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103 + Nonlymphoid dendritic cells. Immunity 37:60–73
Nakano H, Lin KL, Yanagita M et al (2009) Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute TH1 immune responses. Nat Immunol 10:394–402
Leon B, Martinez del Hoyo G, Parrillas V et al (2004) Dendritic cell differentiation potential of mouse monocytes: monocytes represent immediate precursors of CD8- and CD8+ splenic dendritic cells. Blood 103:2668–2676
Hohl TM, Rivera A, Lipuma L et al (2009) Inflammatory monocytes facilitate adaptive CD4 T cell responses during respiratory fungal infection. Cell Host Microbe 6:470–481
Cheong C, Matos I, Choi J et al (2010) Microbial stimulation fully differentiates monocytes to DC-SIGN / CD209+ dendritic cells for immune T cell areas. Cell 143:416–429
Chicha L (2004) Clonal type I interferon-producing and dendritic cell precursors are contained in both human lymphoid and myeloid progenitor populations. J Exp Med 200:1519–1524
Manz MG, Traver D, Miyamoto T et al (2001) Dendritic cell potentials of early lymphoid and myeloid progenitors. Blood 97:3333–3341
Wu L, D’Amico A, Hochrein H et al (2001) Development of thymic and splenic dendritic cell populations from different hemopoietic precursors. Blood 98:3376–3382
Traver D, Akashi K, Manz M et al (2000) Development of CD8α-positive dendritic cells from a common myeloid progenitor. Science 290:2152–2154
Manz MG, Traver D, Akashi K et al (2001) Dendritic cell development from common myeloid progenitors. Ann N Y Acad Sci 938:167–173
Lyman SD, Jacobsen SE (1998) C-kit ligand and Flt3 ligand: stem/progenitor cell factors with overlapping yet distinct activities. Blood 91:1101–1134
Onai N, Obata-Onai A, Schmid MA et al (2007) Identification of clonogenic common Flt3 + M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow. Nat Immunol 8:1207–1216
Naik SH, Sathe P, Park H-Y et al (2007) Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo. Nat Immunol 8:1217–1226
Karsunky H, Merad M, Cozzio A et al (2003) Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells in vivo. J Exp Med 198:305–313
Waskow C, Liu K, Darrasse-jèze G et al (2008) FMS-like tyrosine kinase 3 is required for dendritic cell development in peripheral lymphoid tissues. Nat Immunol 9:676–683
McKenna HJ (2001) Role of hematopoietic growth factors/flt3 ligand in expansion and regulation of dendritic cells. Curr Opin Hematol 8:149–154
Onai N, Obata-Onai A, Tussiwand R et al (2006) Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon-producing and dendritic cell development. J Exp Med 203:227–238
Fogg DK, Sibon C, Miled C et al (2006) A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science 311:83–87
Merad M, Sathe P, Helft J et al (2013) The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. Annu Rev Immunol 31:563–604
Bruno L, Seidl T, Lanzavecchia A (2001) Mouse pre-immunocytes as non-proliferating multipotent precursors of macrophages, interferon-producing cells, CD8α + and CD8α- dendritic cells. Eur J Immunol 31:3403–3412
Ginhoux F, Liu K, Helft J et al (2009) The origin and development of nonlymphoid tissue CD103+ DCs. J Exp Med 206:3115–3130
Bogunovic M, Ginhoux F, Helft J et al (2009) Origin of the lamina propria dendritic cell network. Immunity 31:513–525
Langlet C, Tamoutounour S, Henri S et al (2012) CD64 expression distinguishes monocyte-derived and conventional dendritic cells and reveals their distinct role during intramuscular immunization. J Immunol 188:1751–1760
Lewis KL, Caton ML, Bogunovic M et al (2011) Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine. Immunity 35:780–791
Ginhoux F, Tacke F, Angeli V et al (2006) Langerhans cells arise from monocytes in vivo. Nat Immunol 7:265–273
Hoeffel G, Wang Y, Greter M et al (2012) Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages. J Exp Med 209:1167–1181
Mende I, Karsunky H, Weissman IL et al (2006) Flk2+ myeloid progenitors are the main source of Langerhans cells. Blood 107:1383–1390
Ginhoux F, Collin MP, Bogunovic M et al (2007) Blood-derived dermal langerin + dendritic cells survey the skin in the steady state. J Exp Med 204:3133–3146
Laouar Y, Welte T, Fu XY, Flavell RA (2003) STAT3 is required for Flt3L-dependent dendritic cell differentiation. Immunity 19:903–912
Lutz MB, Suri RM, Niimi M et al (2000) Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in vivo. Eur J Immunol 30:1813–1822
Vremec D, J. Lieschke G, R. Dunn A, et al. (1997) The influence of granulocyte/macrophage colony-stimulating factor on dendritic cell levels in mouse lymphoid organs. Eur J Immunol 27:40–44.
Hamilton JA (2008) Colony-stimulating factors in inflammation and autoimmunity. Nat Rev Immunol 8:533–544
Lyman SD, Jacobsen SEW (1998) C-kit ligand and Flt3 ligand: stem/progenitor cell factors with overlapping yet distinct activities. Blood 91:1101–1134
Bozzacco L, Trumpfheller C, Huang Y et al (2010) HIV gag protein is efficiently cross-presented when targeted with an antibody towards the DEC-205 receptor in Flt3 ligand-mobilized murine DC. Eur J Immunol 40:36–46
Dudziak D, Kampfhorst AO, Heidkamp G et al (2007) Differential antigen processing by dendritic cell subsets in vivo. Science 315:107–111
Tarbell KV, Petit L, Zuo X et al (2007) Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice. J Exp Med 204:191–201
Whartenby KA, Small D, Calabresi PA (2008) FLT3 inhibitors for the treatment of autoimmune disease. Expert Opin Investig drugs 17:1685–1692
Dhodapkar MV, Sznol M, Zhao B et al (2014) Induction of antigen-specific immunity with a vaccine targeting NY-ESO-1 to the dendritic cell receptor DEC-205. Sci Transl Med 6:232ra51
Spranger S, Bao R, Gajewski TF (2015) Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity. Nature 523:231–235
Salmon H, Idoyaga J, Rahman A et al (2016) Expansion and activation of CD103+ dendritic cell progenitors at the tumor site enhances tumor responses to therapeutic PD-L1 and BRAF inhibition. Immunity 44:924–938
Cisse B, Caton ML, Lehner M et al (2008) Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development. Cell 135:37–48
Wu L, D’Amico A, Winkel KD et al (1998) RelB is essential for the development of myeloid-related CD8α- dendritic cells but not of lymphoid-related CD8α + dendritic cells. Immunity 9:839–847
Hildner K, Edelson BT, Purtha WE et al (2008) Batf3 deficiency reveals a critical role for CD8α + dendritic cells in cytotoxic T cell immunity. Science 322:1097–1100
Anderson KL, Perkin H, Surh CD et al (2000) Transcription factor PU.1 is necessary for development of thymic and myeloid progenitor-derived dendritic cells. J Immunol 164:1855–1861
Spooner CJ, Cheng JX, Pujadas E et al (2009) A recurrent network involving the transcription factors PU.1 and Gfi1 orchestrates innate and adaptive immune cell fates. Immunity 31:576–586
Rathinam C, Geffers R, Yucel R et al (2005) The transcriptional repressor Gfi1 controls STAT3-dependent dendritic cell development and function. Immunity 22:717–728
Satpathy AT, Kc W, Albring JC et al (2012) Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages. J Exp Med 209:1135–1152
Meredith MM, Liu K, Darrasse-Jeze G et al (2012) Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage. J Exp Med 209:1153–1165
Ichikawa E, Hida S, Omatsu Y et al (2004) Defective development of splenic and epidermal CD4+ dendritic cells in mice deficient for IFN regulatory factor-2. Proc Natl Acad Sci U S A 101:3909–3914
Suzuki S, Honma K, Matsuyama T et al (2004) Critical roles of interferon regulatory factor 4 in CD11bhighCD8alpha- dendritic cell development. Proc Natl Acad Sci U S A 101:8981–8986
Tamura T, Tailor P, Yamaoka K et al (2005) IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity. J Immunol 174:2573–2581
Schiavoni G, Mattei F, Borghi P et al (2004) ICSBP is critically involved in the normal development and trafficking of Langerhans cells and dermal dendritic cells. Blood 103:2221–2228
Aliberti J, Schulz O, Pennington DJ et al (2003) Essential role for ICSBP in the in vivo development of murine CD8α + dendritic cells. Blood 101:305–310
Hacker C, Kirsch RD, Ju X-S et al (2003) Transcriptional profiling identifies Id2 function in dendritic cell development. Nat Immunol 4:380–386
Nagasawa M, Schmidlin H, Hazekamp MG et al (2008) Development of human plasmacytoid dendritic cells depends on the combined action of the basic helix-loop-helix factor E2-2 and the Ets factor Spi-B. Eur J Immunol 38:2389–2400
Edelson BT, Kc W, Juang R et al (2010) Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha + conventional dendritic cells. J Exp Med 207:823–836
Fainaru O, Woolf E, Lotem J et al (2004) Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammation. EMBO J 23:969–979
Esashi E, Wang YH, Perng O et al (2008) The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8. Immunity 28:509–520
Tussiwand R, Lee W-L, Murphy TL et al (2012) Compensatory dendritic cell development mediated by BATF-IRF interactions. Nature 490:502–507
Wu L, Nichogiannopoulou A, Shortman K, Georgopoulos K (1997) Cell-autonomous defects in dendritic cell populations of Ikaros mutant mice point to a developmental relationship with the lymphoid lineage. Immunity 7:483–492
Allman D, Dalod M, Asselin-Paturel C et al (2006) Ikaros is required for plasmacytoid dendritic cell differentiation. Blood 108:4025–4034
Jackson JT, Hu Y, Liu R et al (2011) Id2 expression delineates differential checkpoints in the genetic program of CD8alpha + and CD103+ dendritic cell lineages. EMBO J 30:2690–2704
Platzer B, Jörgl A, Taschner S et al (2004) RelB regulates human dendritic cell subset development by promoting monocyte intermediates. Blood 104:3655–3663
Kingston D, Schmid MA, Onai N et al (2009) The concerted action of GM-CSF and Flt3-ligand on in vivo dendritic cell homeostasis. Blood 114:835–843
Greter M, Helft J, Chow A et al (2012) GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells. Immunity 36:1031–1046
Kel JM, Girard-Madoux MJH, Reizis B, Clausen BE (2010) TGF-β is required to maintain the pool of immature langerhans cells in the epidermis. J Immunol 185:3248–3255
Wang Y-G, Kim KD, Wang J et al (2005) Stimulating lymphotoxin beta receptor on the dendritic cells is critical for their homeostasis and expansion. J Immunol 175:6997–7002
Wu Q, Wang Y, Wang J et al (1999) The requirement of membrane lymphotoxin for the presence of dendritic cells in lymphoid tissues. J Exp Med 190:629–638
Qian C, Qian L, Yu Y et al (2013) Fas signal promotes the immunosuppressive function of regulatory dendritic cells via the ERK/β-catenin pathway. J Biol Chem 288:27825–27835
Bonasio R, Scimone ML, Schaerli P et al (2006) Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus. Nat Immunol 7:1092–1100
Proietto AI, van Dommelen S, Zhou P et al (2008) Dendritic cells in the thymus contribute to T-regulatory cell induction. Proc Natl Acad Sci U S A 105:19869–19874
Watanabe N, Wang Y-H, Lee HK et al (2005) Hassall’s corpuscles instruct dendritic cells to induce CD4 + CD25+ regulatory T cells in human thymus. Nature 436:1181–1185
Besin G, Gaudreau S, Menard M et al (2008) Thymic stromal lymphopoietin and thymic stromal lymphopoietin-conditioned dendritic cells induce regulatory T-cell differentiation and protection of NOD mice against diabetes. Diabetes 57:2107–2117
Martin-Gayo E, Sierra-Filardi E, Corbi AL, Toribio ML (2010) Plasmacytoid dendritic cells resident in human thymus drive natural Treg cell development. Blood 115:5366–5375
Ziegler SF, Artis D (2010) Sensing the outside world: TSLP regulates barrier immunity. Nat Immunol 11:289–293
Ardouin L, Luche H, Chelbi R et al (2016) Broad and largely concordant molecular changes characterize tolerogenic and immunogenic dendritic cell maturation in thymus and periphery. Immunity 45:305–318
McGrath MM, Najafian N (2012) The role of coinhibitory signaling pathways in transplantation and tolerance. Front Immunol 3:1–17
Yang J, Riella LV, Chock S et al (2011) The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo. J Immunol 187:1113–1119
Li H, Shi B (2015) Tolerogenic dendritic cells and their applications in transplantation. Cell Mol Immunol 12:24–30
Morelli AE, Thomson AW (2003) Dendritic cells: regulators of alloimmunity and opportunities for tolerance induction. Immunol Rev 196:125–146
Munn DH, Sharma MD, Mellor AL (2004) Ligation of B7-1/B7-2 by human CD4+ T cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells. J Immunol 172:4100–4110
Grohmann U, Orabona C, Fallarino F et al (2002) CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat Immunol 3:1097–1101
Mellor AL, Munn DH (2004) IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nat Rev Immunol 4:762–774
Jürgens B, Hainz U, Fuchs D et al (2009) Interferon-γ-triggered indoleamine2,3-dioxygenase competence in human monocyte-derived dendritic cells induces regulatory activity in allogeneic T cells. Blood 114:3235–3243
Grohmann U, Puccetti P (2002) The immunosuppressive activity of proinflammatory cytokines in experimental models : potential for therapeutic intervention in autoimmunity. Curr Drug Targets Inflamm Allergy 1:77–87
Brenk M, Scheler M, Koch S et al (2009) Tryptophan deprivation induces inhibitory receptors ILT3 and ILT4 on dendritic cells favoring the induction of human CD4 + CD25+ Foxp3+ T regulatory cells. J Immunol 183:145–154
Chauveau C, Rémy S, Royer PJ et al (2005) Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression. Blood 106:1694–1702
Yamashita K, Ollinger R, McDaid J et al (2006) Heme oxygenase-1 is essential for and promotes tolerance to transplanted organs. FASEB J 20:776–778
Luckashenak N, Schroeder S, Endt K et al (2008) Constitutive crosspresentation of tissue antigens by dendritic cells controls CD8+ T cell tolerance in vivo. Immunity 28:521–532
Bonifaz L, Bonnyay D, Mahnke K et al (2002) Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance. J Exp Med 196:1627–1638
Belz GT, Behrens GMN, Smith CM et al (2002) The CD8 + dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens. J Exp Med 196:1099–1104
Segura E, Amigorena S (2015) Cross-Presentation in Mouse and Human Dendritic Cells, 1st ed. Adv Immunol
Bedoui S, Whitney PG, Waithman J et al (2009) Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells. Nat Immunol 10:488–495
del Rio M-L, Rodriguez-Barbosa J-I, Kremmer E, Förster R (2007) CD103− and CD103+ bronchial lymph node dendritic cells are specialized in presenting and cross-presenting innocuous antigen to CD4+ and CD8+ T cells. J Immunol 178:6861–6866
Amigorena S, Savina A (2010) Intracellular mechanisms of antigen cross presentation in dendritic cells. Curr Opin Immunol 22:109–117
Lennon-Duménil A-M, Bakker AH, Maehr R et al (2002) Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation. J Exp Med 196:529–540
Trombetta ES, Ebersold M, Garrett MP, Mellman I (2003) Activation of lysosomal function during dendritic cell maturation. Science 299:1400–1403
Savina A, Jancic C, Hugues S et al (2006) NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells. Cell 126:205–218
Lio CWJ, Hsieh CS (2008) A two-step process for thymic regulatory T cell development. Immunity 28:100–111
Kim JM, Kim JM, Rudensky A, Rudensky A (2006) The role of the transcription factor Foxp3 in the development of regulatory T cells. Immunol Rev 212:86–98
Tang Q, Bluestone JA (2008) The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat Immunol 9:239–244
Ostroukhova M, Seguin-devaux C, Oriss TB et al (2004) Tolerance induced by inhaled antigen involves CD4 + T cells expressing membrane-bound TGF-β and FOXP3. J Clin Invest 114:28–38
Tsuji NM, Kosaka A (2008) Oral tolerance: intestinal homeostasis and antigen-specific regulatory T cells. Trends Immunol 29:532–540
Cronin SJF, Penninger JM (2007) From T-cell activation signals to signaling control of anti-cancer immunity. Immunol Rev 220:151–168
Tisch R (2010) Immunogenic versus tolerogenic dendritic cells: a matter of maturation. Int Rev Immunol 29:111–118
Hintzen G, Ohl L, del Rio M-L et al (2006) Induction of tolerance to innocuous inhaled antigen relies on a CCR7-dependent dendritic cell-mediated antigen transport to the bronchial lymph node. J Immunol 177:7346–7354
Worbs T, Bode U, Yan S et al (2006) Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells. J Exp Med 203:519–527
Förster R, Davalos-Misslitz AC, Rot A (2008) CCR7 and its ligands: balancing immunity and tolerance. Nat Rev Immunol 8:362–371
Langenkamp A, Messi M, Lanzavecchia A, Sallusto F (2000) Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells. Nat Immunol 1:311–316
Langenkamp A, Casorati G, Garavaglia C et al (2002) T cell priming by dendritic cells: thresholds for proliferation, differentiation and death and intraclonal functional diversification. Eur J Immunol 32:2046–2054
Croker BA, Krebs DL, Zhang J-G et al (2003) SOCS3 negatively regulates IL-6 signaling in vivo. Nat Immunol 4:540–545
Pasare C, Medzhitov R (2003) Toll pathway-dependent blockade of CD4 + CD25+ T cell-mediated suppression by dendritic cells. Science 299:1033–1036
Dennis KL, Blatner NR, Gounari F, Khazaie K (2013) Current status of interleukin-10 and regulatory T-cells in cancer. Curr Opin Oncol 25:637–645
Ohnmacht C, Pullner A, King SBS et al (2009) Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity. J Exp Med 206:549–559
Laouar Y, Town T, Jeng D et al (2008) TGF-beta signaling in dendritic cells is a prerequisite for the control of autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 105:10865–10870
Travis MA, Reizis B, Melton AC et al (2007) Loss of integrin αvβ8 on dendritic cells causes autoimmunity and colitis in mice. Nature 449:361–365
Darrasse-Jeze G, Deroubaix S, Mouquet H et al (2009) Feedback control of regulatory T cell homeostasis by dendritic cells in vivo. J Exp Med 206:1853–1862
Volchenkov R, Karlsen M, Jonsson R, Appel S (2013) Type 1 regulatory T cells and regulatory B cells induced by tolerogenic dendritic cells. Scand J Immunol 77:246–254
Lund FE (2008) Cytokine-producing B lymphocytes - key regulators of immunity. Curr Opin Immunol 20:332–338
Qian L, Qian C, Chen Y et al (2012) Regulatory dendritic cells program B cells to differentiate into CD19hiFcγIIbhi regulatory B cells through IFN-β and CD40L. Blood 120:581–591
Obayashi K, Doi T, Koyasu S (2007) Dendritic cells suppress IgE production in B cells. Int Immunol 19:217–226
Caielli S, Conforti-Andreoni C, Di Pietro C et al (2010) On/off TLR signaling decides proinflammatory or tolerogenic dendritic cell maturation upon CD1d-mediated interaction with invariant NKT cells. J Immunol 185:7317–7329
de Vries VC, Pino-Lagos K, Nowak EC et al (2011) Mast cells condition dendritic cells to mediate allograft tolerance. Immunity 35:550–561
Leveson-Gower DB, Sega EI, Kalesnikoff J et al (2013) Mast cells suppress murine GVHD in a mechanism independent of CD4 + CD25+ regulatory T cells. Blood 122:3659–3665
Lu L-F, Lind EF, Gondek DC et al (2006) Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature 442:997–1002
Rodrigues CP, Ferreira ACF, Pinho MP et al (2016) Tolerogenic IDO(+) dendritic cells are induced by PD-1-expressing mast cells. Front Immunol 7:9
Ito K, Chung KF, Adcock IM (2006) Update on glucocorticoid action and resistance. J Allergy Clin Immunol 117:522–543
Puccetti P, Grohmann U (2007) IDO and regulatory T cells: a role for reverse signalling and non-canonical NF-kappaB activation. Nat Rev Immunol 7:817–823
Bonizzi G, Karin M (2004) The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol 25:280–288
Zhang X, Li M, Lian D et al (2008) Generation of therapeutic dendritic cells and regulatory T cells for preventing allogeneic cardiac graft rejection. Clin Immunol 127:313–321
Iruretagoyena MI, Lezana JP, Hermoso M et al (2006) Inhibition of nuclear factor-kappa B enhances the capacity of immature dendritic cells to induce antigen-specific tolerance in experimental autoimmune encephalomyelitis. J Pharmacol Exp Ther 318:59–67
Bahri R, Naji A, Menier C et al (2009) Dendritic cells secrete the immunosuppressive HLA-G molecule upon CTLA4-Ig treatment: implication in human renal transplant acceptance. J Immunol 183:7054–7062
Hu J, Wan Y (2010) Tolerogenic dendritic cells and their potential applications. Immunology 132:307–314
Anandasabapathy N, Breton G, Hurley A et al (2015) Efficacy and safety of CDX-301, recombinant human Flt3L, at expanding dendritic cells and hematopoietic stem cells in healthy human volunteers. Bone Marrow Transplant 50:924–930