The oncogenic roles of p53 mutants in mouse models

Levine, 1991, The p53 tumour suppressor gene, Nature, 351, 453, 10.1038/351453a0 Cho, 1994, Crystal structure of a p53 tumor suppressor–DNA complex: understanding tumorigenic mutations, Science, 265, 346, 10.1126/science.8023157 Dittmer, 1993, Gain of function mutations in p53, Nat Genet, 4, 42, 10.1038/ng0593-42 Ko, 1996, p53: puzzle and paradigm, Genes Dev, 10, 1054, 10.1101/gad.10.9.1054 Appella, 2001, Post-translational modifications and activation of p53 by genotoxic stresses, Eur J Biochem, 268, 2764, 10.1046/j.1432-1327.2001.02225.x Haupt, 2004, p53 regulation: a family affair, Cell Cycle, 3, 884, 10.4161/cc.3.7.995 Sigal, 2000, Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome, Cancer Res, 60, 6788 Zalcenstein, 2006, Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53, Oncogene, 25, 359, 10.1038/sj.onc.1209061 Weisz, 2004, Transactivation of the EGR1 gene contributes to mutant p53 gain of function, Cancer Res, 64, 8318, 10.1158/0008-5472.CAN-04-1145 Matas, 2001, Integrity of the N-terminal transcription domain of p53 is required for mutant p53 interference with drug-induced apoptosis, EMBO J, 20, 4163, 10.1093/emboj/20.15.4163 Moll, 2003, The role of p63 and p73 in tumor formation and progression: coming of age toward clinical usefulness, Clin Cancer Res, 9, 5437 Yang, 1998, p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant–negative activities, Mol Cell, 2, 305, 10.1016/S1097-2765(00)80275-0 Jost, 1997, p73 is a simian [correction of human] p53-related protein that can induce apoptosis, Nature, 389, 191, 10.1038/38298 Kaghad, 1997, Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers, Cell, 90, 809, 10.1016/S0092-8674(00)80540-1 Fontemaggi, 2002, Identification of direct p73 target genes combining DNA microarray and chromatin immunoprecipitation analyses, J Biol Chem, 277, 43359, 10.1074/jbc.M205573200 Flores, 2002, p63 and p73 are required for p53-dependent apoptosis in response to DNA damage, Nature, 416, 560, 10.1038/416560a Mills, 1999, p63 is a p53 homologue required for limb and epidermal morphogenesis, Nature, 398, 708, 10.1038/19531 Yang, 1999, p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development, Nature, 398, 714, 10.1038/19539 Yang, 2000, p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours, Nature, 404, 99, 10.1038/35003607 Flores, 2005, Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family, Cancer Cell, 7, 363, 10.1016/j.ccr.2005.02.019 Barbieri, 2006, Loss of p63 leads to increased cell migration and up-regulation of genes involved in invasion and metastasis, Cancer Res, 66, 7589, 10.1158/0008-5472.CAN-06-2020 Di Como, 1999, p73 function is inhibited by tumor-derived p53 mutants in mammalian cells, Mol Cell Biol, 19, 1438, 10.1128/MCB.19.2.1438 Strano, 2002, Physical interaction with human tumor-derived p53 mutants inhibits p63 activities, J Biol Chem, 277, 18817, 10.1074/jbc.M201405200 Gaiddon, 2001, A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain, Mol Cell Biol, 21, 1874, 10.1128/MCB.21.5.1874-1887.2001 Bensaad, 2003, Change of conformation of the DNA-binding domain of p53 is the only key element for binding of and interference with p73, J Biol Chem, 278, 10546, 10.1074/jbc.M208233200 Marin, 2000, A common polymorphism acts as an intragenic modifier of mutant p53 behaviour, Nat Genet, 25, 47, 10.1038/75586 Strano, 2000, Physical and functional interaction between p53 mutants and different isoforms of p73, J Biol Chem, 275, 29503, 10.1074/jbc.M003360200 Lang, 2004, Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome, Cell, 119, 861, 10.1016/j.cell.2004.11.006 Olive, 2004, Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome, Cell, 119, 847, 10.1016/j.cell.2004.11.004