The oesophagus and cough: laryngo-pharyngeal reflux, microaspiration and vagal reflexes

citation_journal_title=Am Rev Respir Dis; citation_title=Chronic persistent cough in the adult: the spectrum and frequency of causes and successful outcome of specific therapy; citation_author=RS Irwin, WM Corrao, MR Pratter; citation_volume=123; citation_publication_date=1981; citation_pages=413-417; citation_id=CR1 citation_journal_title=Am Rev Respir Dis; citation_title=Chronic cough as the sole presenting manifestation of gastroesophageal reflux; citation_author=RS Irwin, JK Zawacki, FJ Curley, CL French, PJ Hoffman; citation_volume=140; citation_publication_date=1989; citation_pages=1294-1300; citation_doi=10.1164/ajrccm/140.5.1294; citation_id=CR2 citation_journal_title=Poumon Coeur; citation_title=broncho-pulmonary manifestations and gastroesophageal reflux; citation_author=A Bel, JF Labarre, P Thivolle, E Passot; citation_volume=33; citation_publication_date=1977; citation_pages=345-350; citation_id=CR3 citation_journal_title=CMAJ; citation_title=Chronic cough and gastroesophageal reflux; citation_author=JM Fitzgerald, CJ Allen, MA Craven, MT Newhouse; citation_volume=140; citation_publication_date=1989; citation_pages=520-524; citation_id=CR4 citation_journal_title=Cochrane Database Syst Rev; citation_title=Gastro-oesophageal reflux treatment for prolonged non-specific cough in children and adults; citation_author=AB Chang, TJ Lasserson, J Gaffney, FL Connor, LA Garske; citation_volume=1; citation_publication_date=2011; citation_pages=CD004823; citation_id=CR5 citation_journal_title=Eur Respir J; citation_title=chronic cough and gastro-oesophageal reflux: a double-blind placebo-controlled study with omeprazole; citation_author=TO Kiljander, ER Salomaa, EK Hietanen, EO Terho; citation_volume=16; citation_publication_date=2000; citation_pages=633-638; citation_doi=10.1034/j.1399-3003.2000.16d11.x; citation_id=CR6 citation_journal_title=Am J Gastroenterol; citation_title=A prospective evaluation of esophageal testing and a double-blind, randomized study of omeprazole in a diagnostic and therapeutic algorithm for chronic cough; citation_author=TM Ours, MS Kavuru, RJ Schilz, JE Richter; citation_volume=94; citation_publication_date=1999; citation_pages=3131-3138; citation_doi=10.1111/j.1572-0241.1999.01504.x; citation_id=CR7 citation_journal_title=Respirology; citation_title=Chronic cough and esomeprazole: a double-blind placebo-controlled parallel study; citation_author=S Faruqi, ID Molyneux, H Fathi, C Wright, R Thompson, AH Morice; citation_volume=16; citation_publication_date=2011; citation_pages=1150-1156; citation_doi=10.1111/j.1440-1843.2011.02014.x; citation_id=CR8 citation_journal_title=Aliment Pharmacol Ther; citation_title=Randomised clinical trial: high-dose acid suppression for chronic cough - a double-blind, placebo-controlled study; citation_author=NJ Shaheen, SD Crockett, SD Bright, RD Madanick, R Buckmire, M Couch, ES Dellon, JA Galanko, G Sharpless, DR Morgan, MB Spacek, P Heidt-Davis, D Henke; citation_volume=33; citation_publication_date=2011; citation_pages=225-234; citation_doi=10.1111/j.1365-2036.2010.04511.x; citation_id=CR9 citation_journal_title=Clin Gastroenterol Hepatol; citation_title=Normal values of pharyngeal and esophageal twenty-four-hour ph impedance in individuals on and off therapy and interobserver reproducibility; citation_author=F Zerbib, S Roman, S Bruley Des Varannes, G Gourcerol, B Coffin, A Ropert, P Lepicard, F Mion; citation_volume=11; citation_issue=4; citation_publication_date=2013; citation_pages=366-72; citation_doi=10.1016/j.cgh.2012.10.041; citation_id=CR10 citation_journal_title=J Clin Gastroenterol; citation_title=Nonacid reflux episodes reaching the pharynx are important factors associated with cough; citation_author=N Patterson, I Mainie, G Rafferty, L McGarvey, L Heaney, R Tutuian, D Castell, BT Johnston; citation_volume=43; citation_publication_date=2009; citation_pages=414-419; citation_doi=10.1097/MCG.0b013e31818859a3; citation_id=CR11 citation_journal_title=Neurogastroenterol Motil; citation_title=Increase of weakly acidic gas esophagopharyngeal reflux (epr) and swallowing-induced acidic/weakly acidic epr in patients with chronic cough responding to proton pump inhibitors; citation_author=O Kawamura, Y Shimoyama, H Hosaka, S Kuribayashi, M Maeda, A Nagoshi, H Zai, M Kusano; citation_volume=23; citation_publication_date=2011; citation_pages=411-418; citation_doi=10.1111/j.1365-2982.2010.01658.x; citation_id=CR12 citation_title=Gastroesophageal reflux evaluation in patients affected by chronic cough: restech versus multichannel intraluminal impedance/ph metry; citation_inbook_title=Laryngoscope; citation_publication_date=2012; citation_id=CR13; citation_author=D Ummarino; citation_author=L Vandermeulen; citation_author=B Roosens; citation_author=D Urbain; citation_author=B Hauser; citation_author=Y Vandenplas citation_journal_title=J Gastrointest Surg; citation_title=First agreement analysis and day-to-day comparison of pharyngeal ph monitoring with ph/impedance monitoring in patients with suspected laryngopharyngeal reflux; citation_author=V Becker, S Graf, C Schlag, T Schuster, H Feussner, RM Schmid, M Bajbouj; citation_volume=16; citation_publication_date=2012; citation_pages=1096-1101; citation_doi=10.1007/s11605-012-1866-x; citation_id=CR14 citation_journal_title=World J Gastroenterol; citation_title=How many cases of laryngopharyngeal reflux suspected by laryngoscopy are gastroesophageal reflux disease-related?; citation_author=N de Bortoli, A Nacci, E Savarino, I Martinucci, M Bellini, B Fattori, L Ceccarelli, F Costa, MG Mumolo, A Ricchiuti, V Savarino, S Berrettini, S Marchi; citation_volume=18; citation_publication_date=2012; citation_pages=4363-4370; citation_doi=10.3748/wjg.v18.i32.4363; citation_id=CR15 citation_journal_title=Laryngoscope; citation_title=The reliability of the assessment of endoscopic laryngeal findings associated with laryngopharyngeal reflux disease; citation_author=RC Branski, N Bhattacharyya, J Shapiro; citation_volume=112; citation_publication_date=2002; citation_pages=1019-1024; citation_doi=10.1097/00005537-200206000-00016; citation_id=CR16 citation_journal_title=J Voice; citation_title=Reliability of speech-language pathologist and otolaryngologist ratings of laryngeal signs of reflux in an asymptomatic population using the reflux finding score; citation_author=LN Kelchner, J Horne, L Lee, B Klaben, JC Stemple, S Adam, T Kereiakes, L Levin; citation_volume=21; citation_publication_date=2007; citation_pages=92-100; citation_doi=10.1016/j.jvoice.2005.09.004; citation_id=CR17 citation_journal_title=J Voice; citation_title=A comparison of rating scales used in the diagnosis of extraesophageal reflux; citation_author=J Musser, L Kelchner, J Neils-Strunjas, M Montrose; citation_volume=25; citation_publication_date=2011; citation_pages=293-300; citation_doi=10.1016/j.jvoice.2009.11.009; citation_id=CR18 citation_journal_title=Chest; citation_title=Chronic cough: relationship between microaspiration, gastroesophageal reflux, and cough frequency; citation_author=S Decalmer, R Stovold, LA Houghton, J Pearson, C Ward, A Kelsall, H Jones, K McGuinness, A Woodcock, JA Smith; citation_volume=142; citation_publication_date=2012; citation_pages=958-964; citation_doi=10.1378/chest.12-0044; citation_id=CR19 citation_journal_title=Aliment Pharmacol Ther; citation_title=Improved diagnosis of gastro-oesophageal reflux in patients with unexplained chronic cough; citation_author=K Blondeau, LJ Dupont, V Mertens, J Tack, D Sifrim; citation_volume=25; citation_publication_date=2007; citation_pages=723-732; citation_doi=10.1111/j.1365-2036.2007.03255.x; citation_id=CR20 citation_journal_title=Gut; citation_title=Weakly acidic reflux in patients with chronic unexplained cough during 24 hour pressure, ph, and impedance monitoring; citation_author=D Sifrim, L Dupont, K Blondeau, X Zhang, J Tack, J Janssens; citation_volume=54; citation_publication_date=2005; citation_pages=449-454; citation_doi=10.1136/gut.2004.055418; citation_id=CR21 citation_journal_title=Am J Gastroenterol; citation_title=Twenty-four hour ambulatory simultaneous impedance and ph monitoring: a multicenter report of normal values from 60 healthy volunteers; citation_author=S Shay, R Tutuian, D Sifrim, M Vela, J Wise, N Balaji, X Zhang, T Adhami, J Murray, J Peters, D Castell; citation_volume=99; citation_publication_date=2004; citation_pages=1037-1043; citation_doi=10.1111/j.1572-0241.2004.04172.x; citation_id=CR22 citation_journal_title=Aliment Pharmacol Ther; citation_title=Normal values and day-to-day variability of 24-h ambulatory oesophageal impedance-ph monitoring in a belgian-french cohort of healthy subjects; citation_author=F Zerbib, SB Des Varannes, S Roman, P Pouderoux, F Artigue, U Chaput, F Mion, F Caillol, E Verin, G Bommelaer, P Ducrotte, JP Galmiche, D Sifrim; citation_volume=22; citation_publication_date=2005; citation_pages=1011-1021; citation_doi=10.1111/j.1365-2036.2005.02677.x; citation_id=CR23 citation_journal_title=Gut Liver; citation_title=Reflux episode reaching the proximal esophagus are associated with chronic cough; citation_author=JH Lee, SY Park, SB Cho, WS Lee, CH Park, YI Koh, YE Joo, HS Kim, SK Choi, JS Rew; citation_volume=6; citation_publication_date=2012; citation_pages=197-202; citation_doi=10.5009/gnl.2012.6.2.197; citation_id=CR24 citation_journal_title=Chest; citation_title=Characterization of the upper esophageal sphincter response during cough; citation_author=M Amaris, KS Dua, SR Naini, E Samuel, R Shaker; citation_volume=142; citation_publication_date=2012; citation_pages=1229-1236; citation_doi=10.1378/chest.12-0638; citation_id=CR25 citation_journal_title=Dis Esophagus; citation_title=Upper esophageal sphincter and esophageal motility in patients with chronic cough and reflux: Assessment by high-resolution manometry; citation_author=R Vardar, R Sweis, A Anggiansah, T Wong, MR Fox; citation_volume=26; citation_issue=3; citation_publication_date=2013; citation_pages=219-25; citation_doi=10.1111/j.1442-2050.2012.01354.x; citation_id=CR26 citation_journal_title=Thorax; citation_title=Abnormal oesophageal motility in patients with chronic cough; citation_author=JA Kastelik, AE Redington, I Aziz, GK Buckton, CM Smith, M Dakkak, AH Morice; citation_volume=58; citation_publication_date=2003; citation_pages=699-702; citation_doi=10.1136/thorax.58.8.699; citation_id=CR27 citation_journal_title=Am J Gastroenterol; citation_title=Ineffective esophageal motility: the most common motility abnormality in patients with gerd-associated respiratory symptoms; citation_author=YM Fouad, PO Katz, JG Hatlebakk, DO Castell; citation_volume=94; citation_publication_date=1999; citation_pages=1464-1467; citation_doi=10.1111/j.1572-0241.1999.1127_e.x; citation_id=CR28 citation_journal_title=Am J Physiol Gastrointest Liver Physiol; citation_title=Pharyngeal airway protective reflexes are triggered before the maximum volume of fluid that the hypopharynx can safely hold is exceeded; citation_author=K Dua, SN Surapaneni, S Kuribayashi, M Hafeezullah, R Shaker; citation_volume=301; citation_publication_date=2011; citation_pages=G197-202; citation_doi=10.1152/ajpgi.00046.2011; citation_id=CR29 citation_journal_title=Chest; citation_title=The differential effect of gastroesophageal reflux disease on mechanostimulation and chemostimulation of the laryngopharynx; citation_author=SY Phua, L McGarvey, M Ngu, A Ing; citation_volume=138; citation_publication_date=2010; citation_pages=1180-1185; citation_doi=10.1378/chest.09-2387; citation_id=CR30 citation_journal_title=Thorax; citation_title=Patients with gastro-oesophageal reflux disease and cough have impaired laryngopharyngeal mechanosensitivity; citation_author=SY Phua, LP McGarvey, MC Ngu, AJ Ing; citation_volume=60; citation_publication_date=2005; citation_pages=488-491; citation_doi=10.1136/thx.2004.033894; citation_id=CR31 citation_journal_title=Br J Anaesth; citation_title=Measurement of the sensitivity of upper airway reflexes; citation_author=JA Langton, PJ Murphy, P Barker, A Key, G Smith; citation_volume=70; citation_publication_date=1993; citation_pages=126-130; citation_doi=10.1093/bja/70.2.126; citation_id=CR32 citation_journal_title=Chest; citation_title=Cough and glottic-stop reflex sensitivity in health and disease; citation_author=B Prudon, SS Birring, DD Vara, AP Hall, JP Thompson, ID Pavord; citation_volume=127; citation_publication_date=2005; citation_pages=550-557; citation_doi=10.1378/chest.127.2.550; citation_id=CR33 citation_journal_title=Eur Respir J; citation_title=Sensitivity of the cough reflex in patients with chronic cough; citation_author=NB Choudry, RW Fuller; citation_volume=5; citation_publication_date=1992; citation_pages=296-300; citation_id=CR34 citation_journal_title=Am J Respir Crit Care Med; citation_title=Pepsin, a biomarker of gastric aspiration in lung allografts: a putative association with rejection; citation_author=R Stovold, IA Forrest, PA Corris, DM Murphy, JA Smith, S Decalmer, GE Johnson, JH Dark, JP Pearson, C Ward; citation_volume=175; citation_publication_date=2007; citation_pages=1298-1303; citation_doi=10.1164/rccm.200610-1485OC; citation_id=CR35 citation_journal_title=Respir Med; citation_title=Pepsin and bile acids in induced sputum of chronic cough patients; citation_author=M Grabowski, A Kasran, S Seys, A Pauwels, W Medrala, L Dupont, B Panaszek, D Bullens; citation_volume=105; citation_publication_date=2011; citation_pages=1257-1261; citation_doi=10.1016/j.rmed.2011.04.015; citation_id=CR36 citation_journal_title=Chest; citation_title=Bile acids in sputum and increased airway inflammation in patients with cystic fibrosis; citation_author=A Pauwels, A Decraene, K Blondeau, V Mertens, R Farre, M Proesmans, P Van Bleyenbergh, D Sifrim, LJ Dupont; citation_volume=141; citation_publication_date=2012; citation_pages=1568-1574; citation_doi=10.1378/chest.11-1573; citation_id=CR37 citation_journal_title=Gastroenterology; citation_title=Acoustic cough-reflux associations in chronic cough: potential triggers and mechanisms; citation_author=JA Smith, S Decalmer, A Kelsall, K McGuinness, H Jones, S Galloway, A Woodcock, LA Houghton; citation_volume=139; citation_publication_date=2010; citation_pages=754-762; citation_doi=10.1053/j.gastro.2010.06.050; citation_id=CR38 citation_journal_title=Aliment Pharmacol Ther; citation_title=Combined lung-sound and reflux-monitoring: a pilot study of a novel approach to detect nocturnal respiratory symptoms in gastro-oesophageal reflux disease; citation_author=S Kunsch, V Gross, A Neesse, K Sohrabi, C Nell, TM Gress, V Ellenrieder, U Koehler; citation_volume=33; citation_publication_date=2011; citation_pages=592-600; citation_doi=10.1111/j.1365-2036.2010.04559.x; citation_id=CR39 citation_journal_title=Scand J Gastroenterol; citation_title=Diagnostic yield of oesophageal ph monitoring in patients with chronic unexplained cough; citation_author=A Bogte, AJ Bredenoord, AJ Smout; citation_volume=43; citation_publication_date=2008; citation_pages=13-19; citation_doi=10.1080/00365520701580421; citation_id=CR40 citation_journal_title=Gastroenterology; citation_title=The symptom-association probability: an improved method for symptom analysis of 24-hour esophageal ph data; citation_author=BL Weusten, JM Roelofs, LM Akkermans, GP Van Berge-Henegouwen, AJ Smout; citation_volume=107; citation_publication_date=1994; citation_pages=1741-1745; citation_id=CR41 citation_journal_title=Am J Gastroenterol; citation_title=Symptom reports are not reliable during ambulatory reflux monitoring; citation_author=RT Kavitt, T Higginbotham, JC Slaughter, D Patel, ES Yuksel, Z Lominadze, A Abou-Ismail, T Pasricha, CG Garrett, D Hagaman, MF Vaezi; citation_volume=107; citation_issue=12; citation_publication_date=2012; citation_pages=1826-32; citation_doi=10.1038/ajg.2012.342; citation_id=CR42 citation_journal_title=Am J Respir Crit Care Med; citation_title=Patient registering of cough events during 24 hour oesophageal impedance monitoring [abstract]; citation_author=S Decalmer, A Kelsall, K McGuinness, A Woodcock, JA Smith; citation_volume=175; citation_issue=Abstract issue; citation_publication_date=2007; citation_pages=A380; citation_id=CR43 citation_journal_title=Neurogastroenterol Motil; citation_title=Motor events underlying gastro-oesophageal reflux in ambulant patients with reflux oesophagitis; citation_author=R Penagini, MN Schoeman, J Dent, MD Tippett, RH Holloway; citation_volume=8; citation_publication_date=1996; citation_pages=131-141; citation_doi=10.1111/j.1365-2982.1996.tb00253.x; citation_id=CR44 citation_journal_title=Gastroenterology; citation_title=Mechanisms of gastroesophageal reflux in ambulant healthy human subjects; citation_author=MN Schoeman, MD Tippett, LM Akkermans, J Dent, RH Holloway; citation_volume=108; citation_publication_date=1995; citation_pages=83-91; citation_doi=10.1016/0016-5085(95)90011-X; citation_id=CR45 citation_journal_title=Gastroenterology; citation_title=Excess gastroesophageal reflux in patients with hiatus hernia is caused by mechanisms other than transient les relaxations; citation_author=MA van Herwaarden, M Samsom, AJ Smout; citation_volume=119; citation_publication_date=2000; citation_pages=1439-1446; citation_doi=10.1053/gast.2000.20191; citation_id=CR46 citation_journal_title=Am J Respir Crit Care Med; citation_title=Pathogenesis of chronic persistent cough associated with gastroesophageal reflux; citation_author=AJ Ing, MC Ngu, AB Breslin; citation_volume=149; citation_publication_date=1994; citation_pages=160-167; citation_doi=10.1164/ajrccm.149.1.8111576; citation_id=CR47 citation_journal_title=Neurogastroenterol Motil; citation_title=Acidification of the oesophagus acutely increases the cough sensitivity in patients with gastro-oesophageal reflux and chronic cough; citation_author=N Javorkova, S Varechova, R Pecova, M Tatar, D Balaz, M Demeter, R Hyrdel, M Kollarik; citation_volume=20; citation_publication_date=2008; citation_pages=119-124; citation_id=CR48 citation_journal_title=Am J Gastroenterol; citation_title=The yield of upper gastrointestinal endoscopy in patients with suspected reflux-related chronic ear, nose, and throat symptoms; citation_author=J Poelmans, L Feenstra, I Demedts, P Rutgeerts, J Tack; citation_volume=99; citation_publication_date=2004; citation_pages=1419-1426; citation_doi=10.1111/j.1572-0241.2004.30066.x; citation_id=CR49 citation_journal_title=Dig Dis Sci; citation_title=Determinants of long-term outcome of patients with reflux-related ear, nose, and throat symptoms; citation_author=J Poelmans, L Feenstra, J Tack; citation_volume=51; citation_publication_date=2006; citation_pages=282-288; citation_doi=10.1007/s10620-006-3126-y; citation_id=CR50 citation_journal_title=Chest; citation_title=Gastroesophageal reflux-induced bronchoconstriction. Is microaspiration a factor?; citation_author=SM Harding, CA Schan, MR Guzzo, RW Alexander, LA Bradley, JE Richter; citation_volume=108; citation_publication_date=1995; citation_pages=1220-1227; citation_doi=10.1378/chest.108.5.1220; citation_id=CR51 citation_journal_title=Ann Allergy; citation_title=Gastroesophageal reflux and asthma: a possible reflex mechanism; citation_author=LE Mansfield, MR Stein; citation_volume=41; citation_publication_date=1978; citation_pages=224-226; citation_id=CR52 citation_journal_title=Gastroenterology; citation_title=Acid-induced esophagobronchial-cardiac reflexes in humans; citation_author=RA Wright, SA Miller, BF Corsello; citation_volume=99; citation_publication_date=1990; citation_pages=71-73; citation_id=CR53 citation_journal_title=An intraesophageal acid infusion study using state-of-the-art technology. Chest; citation_title=Gastroesophageal reflux-induced bronchoconstriction; citation_author=CA Schan, SM Harding, JM Haile, LA Bradley, JE Richter; citation_volume=106; citation_publication_date=1994; citation_pages=731-737; citation_id=CR54 citation_journal_title=Chest; citation_title=Effects of esophageal acid perfusion on cough responsiveness in patients with bronchial asthma; citation_author=DN Wu, K Yamauchi, H Kobayashi, Y Tanifuji, C Kato, K Suzuki, H Inoue; citation_volume=122; citation_publication_date=2002; citation_pages=505-509; citation_doi=10.1378/chest.122.2.505; citation_id=CR55 citation_journal_title=Arch Intern Med; citation_title=The efficacy of proton pump inhibitors for the treatment of asthma in adults: A meta-analysis; citation_author=WW Chan, E Chiou, KL Obstein, AS Tignor, TL Whitlock; citation_volume=171; citation_publication_date=2011; citation_pages=620-629; citation_doi=10.1001/archinternmed.2011.116; citation_id=CR56 citation_journal_title=J Clin Invest; citation_title=Mechanism of gastroesophageal reflux in recumbent asymptomatic human subjects; citation_author=J Dent, WJ Dodds, RH Friedman, T Sekiguchi, WJ Hogan, RC Arndorfer, DJ Petrie; citation_volume=65; citation_publication_date=1980; citation_pages=256-267; citation_doi=10.1172/JCI109667; citation_id=CR57 citation_journal_title=N Engl J Med; citation_title=Mechanisms of gastroesophageal reflux in patients with reflux esophagitis; citation_author=WJ Dodds, J Dent, WJ Hogan, JF Helm, R Hauser, GK Patel, MS Egide; citation_volume=307; citation_publication_date=1982; citation_pages=1547-1552; citation_doi=10.1056/NEJM198212163072503; citation_id=CR58 citation_journal_title=Chest; citation_title=Response of chronic cough to acid-suppressive therapy in patients with gastroesophageal reflux disease; citation_author=PJ Kahrilas, CW Howden, N Hughes, M Molloy-Bland; citation_volume=143; citation_issue=3; citation_publication_date=2013; citation_pages=605-612; citation_doi=10.1378/chest.12-1788; citation_id=CR59 citation_journal_title=Chest; citation_title=A novel approach to studying the relationship between subjective and objective measures of cough; citation_author=A Kelsall, LA Houghton, H Jones, S Decalmer, K McGuinness, JA Smith; citation_volume=139; citation_publication_date=2011; citation_pages=569-575; citation_doi=10.1378/chest.10-0438; citation_id=CR60 citation_journal_title=J Dig Dis; citation_title=Reflux inhibitor drugs: an emerging novel therapy for gastroesophageal reflux disease; citation_author=J Dent; citation_volume=11; citation_publication_date=2010; citation_pages=72-75; citation_doi=10.1111/j.1751-2980.2010.00418.x; citation_id=CR61 citation_journal_title=Gastroenterology; citation_title=Effects of lesogaberan on reflux and lower esophageal sphincter function in patients with gastroesophageal reflux disease; citation_author=GE Boeckxstaens, H Beaumont, V Mertens, H Denison, M Ruth, J Adler, DG Silberg, D Sifrim; citation_volume=139; citation_publication_date=2010; citation_pages=409-417; citation_doi=10.1053/j.gastro.2010.04.051; citation_id=CR62 citation_title=Efficacy and safety of lesogaberan in gastro-oesophageal reflux disease: a randomised controlled trial; citation_inbook_title=Gut; citation_publication_date=2012; citation_id=CR63; citation_author=NJ Shaheen; citation_author=H Denison; citation_author=K Bjorck; citation_author=M Karlsson; citation_author=DG Silberg citation_journal_title=Respiration; citation_title=Treatment of chronic, refractory cough with baclofen; citation_author=PV Dicpinigaitis, K Rauf; citation_volume=65; citation_publication_date=1998; citation_pages=86-88; citation_doi=10.1159/000029232; citation_id=CR64 citation_journal_title=Cough; citation_title=Successful resolution of refractory chronic cough induced by gastroesophageal reflux with treatment of baclofen; citation_author=X Xu, Q Chen, S Liang, H Lu, Z Qiu; citation_volume=8; citation_publication_date=2012; citation_pages=8; citation_doi=10.1186/1745-9974-8-8; citation_id=CR65 citation_journal_title=Gastroenterology; citation_title=Control of transient lower esophageal sphincter relaxations and reflux by the GABA(B) agonist baclofen in normal subjects; citation_author=I Lidums, A Lehmann, H Checklin, J Dent, RH Holloway; citation_volume=118; citation_publication_date=2000; citation_pages=7-13; citation_doi=10.1016/S0016-5085(00)70408-2; citation_id=CR66 citation_journal_title=J Clin Pharmacol; citation_title=Inhibition of capsaicin-induced cough by the gamma-aminobutyric acid agonist baclofen; citation_author=PV Dicpinigaitis, JB Dobkin, K Rauf, TK Aldrich; citation_volume=38; citation_publication_date=1998; citation_pages=364-367; citation_doi=10.1002/j.1552-4604.1998.tb04436.x; citation_id=CR67 citation_journal_title=Cough; citation_title=Antitussive effects of the peripherally restricted gabab receptor agonist lesogaberan in guinea pigs: comparison to baclofen and other gabab receptor-selective agonists; citation_author=BJ Canning, N Mori, A Lehmann; citation_volume=8; citation_publication_date=2012; citation_pages=7; citation_doi=10.1186/1745-9974-8-7; citation_id=CR68 citation_journal_title=Chest; citation_title=Application and validation of a computerized cough acquisition system for objective monitoring of acute cough: a meta-analysis; citation_author=L Pavesi, S Subburaj, K Porter-Shaw; citation_volume=120; citation_publication_date=2001; citation_pages=1121-1128; citation_doi=10.1378/chest.120.4.1121; citation_id=CR69 citation_journal_title=Chest; citation_title=Antitussive effects of memantine in guinea pigs; citation_author=JA Smith, EC Hilton, L Saulsberry, BJ Canning; citation_volume=141; citation_publication_date=2012; citation_pages=996-1002; citation_doi=10.1378/chest.11-0554; citation_id=CR70 citation_journal_title=Am J Respir Crit Care Med; citation_title=Does central up-regulation of the n-methyl-d-aspartate receptor contribute to cough reflex hypersensitivity?; citation_author=EC Young, H Sumner, S Decalmer, LA Houghton, A Woodcock, JA Smith; citation_volume=181; citation_issue=Meeting Abstracts; citation_publication_date=2010; citation_pages=A5906; citation_id=CR71 citation_journal_title=Am J Respir Crit Care Med; citation_title=Opiate therapy in chronic cough; citation_author=AH Morice, MS Menon, SA Mulrennan, CF Everett, C Wright, J Jackson, R Thompson; citation_volume=175; citation_publication_date=2007; citation_pages=312-315; citation_doi=10.1164/rccm.200607-892OC; citation_id=CR72 citation_journal_title=Am J Med; citation_title=Gabapentin in the treatment of intractable idiopathic chronic cough: case reports; citation_author=S Mintz, JK Lee; citation_volume=119; citation_publication_date=2006; citation_pages=e13-15; citation_doi=10.1016/j.amjmed.2005.10.046; citation_id=CR73 citation_journal_title=JAMA; citation_title=Laparoscopic antireflux surgery vs esomeprazole treatment for chronic gerd: The lotus randomized clinical trial; citation_author=JP Galmiche, J Hatlebakk, S Attwood, C Ell, R Fiocca, S Eklund, G Langstrom, T Lind, L Lundell; citation_volume=305; citation_publication_date=2011; citation_pages=1969-1977; citation_doi=10.1001/jama.2011.626; citation_id=CR74 citation_journal_title=J Gastrointest Surg; citation_title=Multivariate analysis of factors predicting outcome after laparoscopic nissen fundoplication; citation_author=GM Campos, JH Peters, TR DeMeester, S Oberg, PF Crookes, S Tan, SR DeMeester, JA Hagen, CG Bremner; citation_volume=3; citation_publication_date=1999; citation_pages=292-300; citation_doi=10.1016/S1091-255X(99)80071-7; citation_id=CR75 citation_journal_title=Gut; citation_title=Effects of anti-reflux surgery on weakly acidic reflux and belching; citation_author=JA Broeders, AJ Bredenoord, EJ Hazebroek, IA Broeders, HG Gooszen, AJ Smout; citation_volume=60; citation_publication_date=2011; citation_pages=435-441; citation_doi=10.1136/gut.2010.224824; citation_id=CR76 citation_journal_title=Thorax; citation_title=Gastro-oesophageal reflux related cough and its response to laparoscopic fundoplication; citation_author=CJ Allen, M Anvari; citation_volume=53; citation_publication_date=1998; citation_pages=963-968; citation_doi=10.1136/thx.53.11.963; citation_id=CR77 citation_journal_title=Surg Endosc; citation_title=Chronic cough due to gastroesophageal reflux disease: efficacy of antireflux surgery; citation_author=YW Novitsky, JK Zawacki, RS Irwin, CT French, VM Hussey, MP Callery; citation_volume=16; citation_publication_date=2002; citation_pages=567-571; citation_doi=10.1007/s00464-001-8328-y; citation_id=CR78 citation_journal_title=Langenbecks Arch Surg; citation_title=Proximal acid reflux treated by fundoplication predicts a good outcome for chronic cough attributable to gastro-oesophageal reflux disease; citation_author=J Kirkby-Bott, E Jones, S Perring, SW Hosking; citation_volume=396; citation_publication_date=2011; citation_pages=167-171; citation_doi=10.1007/s00423-010-0702-6; citation_id=CR79 citation_journal_title=Cough; citation_title=Fundoplication in chronic intractable cough; citation_author=S Faruqi, P Sedman, W Jackson, I Molyneux, AH Morice; citation_volume=8; citation_publication_date=2012; citation_pages=3; citation_doi=10.1186/1745-9974-8-3; citation_id=CR80 citation_journal_title=Chest; citation_title=Chronic cough due to gastroesophageal reflux disease: failure to resolve despite total/near-total elimination of esophageal acid; citation_author=RS Irwin, JK Zawacki, MM Wilson, CT French, MP Callery; citation_volume=121; citation_publication_date=2002; citation_pages=1132-1140; citation_doi=10.1378/chest.121.4.1132; citation_id=CR81 citation_journal_title=Chest; citation_title=Citric acid cough threshold in patients with gastroesophageal reflux disease rises after laparoscopic fundoplication; citation_author=D Ziora, W Jarosz, J Dzielicki, J Ciekalski, A Krzywiecki, S Dworniczak, J Kozielski; citation_volume=128; citation_publication_date=2005; citation_pages=2458-2464; citation_doi=10.1378/chest.128.4.2458; citation_id=CR82 citation_journal_title=Thorax; citation_title=Fundoplication eliminates chronic cough due to non-acid reflux identified by impedance ph monitoring; citation_author=I Mainie, R Tutuian, A Agrawal, A Hila, KB Highland, DB Adams, DO Castell; citation_volume=60; citation_publication_date=2005; citation_pages=521-523; citation_doi=10.1136/thx.2005.040139; citation_id=CR83 citation_journal_title=Chest; citation_title=Nonacid reflux in patients with chronic cough on acid-suppressive therapy; citation_author=R Tutuian, I Mainie, A Agrawal, D Adams, DO Castell; citation_volume=130; citation_publication_date=2006; citation_pages=386-391; citation_doi=10.1378/chest.130.2.386; citation_id=CR84 citation_journal_title=J Gastrointest Surg; citation_title=Laparoscopic antireflux surgery and its effect on cough in patients with gastroesophageal reflux disease; citation_author=DS Thoman, TT Hui, M Spyrou, EH Phillips; citation_volume=6; citation_publication_date=2002; citation_pages=17-21; citation_doi=10.1016/S1091-255X(01)00013-0; citation_id=CR85